IN2014MN01086A - - Google Patents

Info

Publication number
IN2014MN01086A
IN2014MN01086A IN1086MUN2014A IN2014MN01086A IN 2014MN01086 A IN2014MN01086 A IN 2014MN01086A IN 1086MUN2014 A IN1086MUN2014 A IN 1086MUN2014A IN 2014MN01086 A IN2014MN01086 A IN 2014MN01086A
Authority
IN
India
Prior art keywords
carbon atoms
ceramide
produced
optically active
optionally
Prior art date
Application number
Inventor
Kenya Ishida
Kenji Yagi
Original Assignee
Takasago Perfumery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takasago Perfumery Co Ltd filed Critical Takasago Perfumery Co Ltd
Publication of IN2014MN01086A publication Critical patent/IN2014MN01086A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Provided is a method for producing an optically active ceramide by an N acylation (amidation) reaction of an optically active aminodiol wherein a crude ceramide produced therein is purified by an industrially advantageous process. Namely provided is a method for producing a high purity ceramide that has high diastereo purity with high yield. A high purity ceramide is produced by: a step wherein a ceramide represented by general formula (1) is produced by reacting an aminodiol with an alkyl ester having 1 5 carbon atoms of an aliphatic carboxylic acid having 12 24 carbon atoms said aliphatic carboxylic acid optionally having a hydroxyl group in a hydrocarbon solvent having 5 10 carbon atoms; and a step wherein an alcohol having 1 3 carbon atoms is added into the reaction mixture obtained in the preceding step thereby causing crystals to precipitate. (In the formula R represents an alkyl group which has 13 17 carbon atoms and optionally has a carbon carbon unsaturated bond; R represents an alkyl group which has 11 23 carbon atoms and optionally has a hydroxyl group; and * represents an optically active state.)
IN1086MUN2014 2011-12-22 2012-11-07 IN2014MN01086A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011281654A JP5825672B2 (en) 2011-12-22 2011-12-22 Method for producing high purity ceramides
PCT/JP2012/007122 WO2013094108A1 (en) 2011-12-22 2012-11-07 Method for producing high-purity ceramide

Publications (1)

Publication Number Publication Date
IN2014MN01086A true IN2014MN01086A (en) 2015-07-03

Family

ID=48668028

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1086MUN2014 IN2014MN01086A (en) 2011-12-22 2012-11-07

Country Status (6)

Country Link
US (1) US9079826B2 (en)
EP (1) EP2796444B1 (en)
JP (1) JP5825672B2 (en)
CN (1) CN103974930B (en)
IN (1) IN2014MN01086A (en)
WO (1) WO2013094108A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6232008B2 (en) * 2015-03-19 2017-11-15 国立大学法人北海道大学 Oxidation inhibitor and oil-containing food and drink using the same
CN112759535B (en) * 2019-11-01 2024-04-05 广东东阳光药业股份有限公司 Preparation method of PF-06651600 intermediate
WO2023156605A1 (en) 2022-02-21 2023-08-24 Carbocode S.A. Sphingolipid production
CN117567311A (en) * 2023-11-28 2024-02-20 重庆智合生物医药有限公司 Method for efficiently preparing alpha-hydroxy fatty acid ceramide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692349B2 (en) * 1986-03-06 1994-11-16 和光純薬工業株式会社 A new method for producing optically active unsaturated amino alcohol derivatives.
US5840940A (en) 1994-03-18 1998-11-24 Gist-Brocades B.V. Linoleoylamide based ceramide derivative and its use in cosmetic preparations for the treatment of dry skin
EP0688871A3 (en) 1994-06-24 1998-07-08 Quest International B.V. Preparation of phytosphingosine derivative
FR2732680B1 (en) * 1995-04-05 1997-05-09 Oreal CERAMID-LIKE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND THEIR USE
JP4101320B2 (en) 1996-10-11 2008-06-18 高砂香料工業株式会社 Method for producing primary amide derivative
JP3148136B2 (en) 1996-12-26 2001-03-19 高砂香料工業株式会社 Novel chiral diphosphine compound, intermediate for producing the same, transition metal complex having the diphosphine compound as a ligand, and asymmetric hydrogenation catalyst containing the complex
JP3485232B2 (en) * 1997-01-31 2004-01-13 高砂香料工業株式会社 Optically active compound and method for producing the same
JP3549390B2 (en) 1998-03-23 2004-08-04 高砂香料工業株式会社 Ruthenium-phosphine complex and method for producing the same
EP2067769A1 (en) * 2006-09-26 2009-06-10 Kaneka Corporation Process for producing optically active beta-hydroxy-alpha-aminocarboxylic acid ester

Also Published As

Publication number Publication date
CN103974930B (en) 2016-09-28
CN103974930A (en) 2014-08-06
US9079826B2 (en) 2015-07-14
EP2796444B1 (en) 2017-03-15
WO2013094108A1 (en) 2013-06-27
JP2013129640A (en) 2013-07-04
EP2796444A1 (en) 2014-10-29
US20140364649A1 (en) 2014-12-11
EP2796444A4 (en) 2015-12-16
JP5825672B2 (en) 2015-12-02

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