IN2014CN03482A - - Google Patents
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- Publication number
- IN2014CN03482A IN2014CN03482A IN3482CHN2014A IN2014CN03482A IN 2014CN03482 A IN2014CN03482 A IN 2014CN03482A IN 3482CHN2014 A IN3482CHN2014 A IN 3482CHN2014A IN 2014CN03482 A IN2014CN03482 A IN 2014CN03482A
- Authority
- IN
- India
- Prior art keywords
- formula
- compound
- iii
- reduced
- resulting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 4
- XSTXAVWGXDQKEL-UHFFFAOYSA-N Trichloroethylene Chemical compound ClC=C(Cl)Cl XSTXAVWGXDQKEL-UHFFFAOYSA-N 0.000 abstract 1
- 238000007239 Wittig reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- -1 phenyl benzoyl protecting group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 abstract 1
- 229960002368 travoprost Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
- C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a process for the preparation of travoprost of formula(I) comprising that the compound of formula (II) is stereoselectively reduced the resulting compound of formula (III) is if desired crystallized the lactone group of the the compound of formula (III) is reduced the p phenyl benzoyl protecting group of the thus obtained compound of formula (IV) is removed the resulting triol of formula (V) is if desired after crystallization transformed by Wittig reaction into the acid of formula (VI) which is then esterified.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU1100701A HU231203B1 (en) | 2011-12-21 | 2011-12-21 | Novel process for the preparation of travoprost |
PCT/HU2012/000132 WO2013093528A1 (en) | 2011-12-21 | 2012-12-10 | Process for the preparation of travoprost |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014CN03482A true IN2014CN03482A (en) | 2015-07-03 |
Family
ID=89990547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN3482CHN2014 IN2014CN03482A (en) | 2011-12-21 | 2012-12-10 |
Country Status (19)
Country | Link |
---|---|
US (2) | US9212125B2 (en) |
EP (1) | EP2802562B1 (en) |
JP (1) | JP6174040B2 (en) |
KR (1) | KR102027889B1 (en) |
CN (1) | CN103998423B (en) |
BR (1) | BR112014014060A2 (en) |
CA (1) | CA2859923C (en) |
ES (1) | ES2721662T3 (en) |
HK (1) | HK1198584A1 (en) |
HU (1) | HU231203B1 (en) |
IL (1) | IL232625B (en) |
IN (1) | IN2014CN03482A (en) |
MX (1) | MX2014007684A (en) |
PL (1) | PL2802562T3 (en) |
RU (1) | RU2631316C2 (en) |
TR (1) | TR201905687T4 (en) |
TW (1) | TWI640500B (en) |
WO (1) | WO2013093528A1 (en) |
ZA (1) | ZA201404440B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3209613A1 (en) * | 2011-06-02 | 2012-12-06 | CHINOIN Zrt. | Novel processes for the preparation of prostaglandin amides |
US9115109B2 (en) | 2013-08-15 | 2015-08-25 | Chirogate International Inc. | Processes and intermediates for the preparations of isomer free prostaglandins |
HU231214B1 (en) * | 2014-03-13 | 2021-11-29 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | New process for preparing high purity prostaglandins |
WO2017062770A1 (en) | 2015-10-08 | 2017-04-13 | Silverberg Noah | Punctal plug and bioadhesives |
CA3132572A1 (en) * | 2019-03-27 | 2020-10-01 | Kyowa Pharma Chemical Co., Ltd. | Method for producing pkrostaglandin |
DK3861985T3 (en) | 2020-02-06 | 2023-07-24 | Ocular Therapeutix Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF EYE DISEASES |
WO2022138586A1 (en) * | 2020-12-23 | 2022-06-30 | 協和ファーマケミカル株式会社 | Method for separating geometrical isomer |
CN114671906B (en) * | 2020-12-24 | 2024-03-15 | 武汉武药制药有限公司 | Process for preparing travoprost intermediates |
CN115806517A (en) * | 2022-12-21 | 2023-03-17 | 上海彩迩文生化科技有限公司 | Preparation method of high-purity dinoprost |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2328131C3 (en) * | 1973-05-30 | 1986-11-13 | Schering AG, 1000 Berlin und 4709 Bergkamen | New process for the production of prostaglandin-F ↓ 2 ↓↓ α ↓ and its analogues |
HU184948B (en) * | 1981-04-14 | 1984-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing 5-substituted 4-oxo-pgi down 1 derivatives |
HU190007B (en) | 1982-05-06 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing new aromatic prostacylin analogues |
CS239696B1 (en) * | 1984-05-03 | 1986-01-16 | Jiri Hajek | Method of disintegration of 15s and 15r isonere 4-(4) substituted x-fenyloxy(-3-hydroxy-1-butenyl)hexahydroxy-2h-penta(b)furanone |
HU212570B (en) | 1991-06-24 | 1996-08-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
US7166730B2 (en) * | 2000-01-27 | 2007-01-23 | Fine Tech Laboratories, Ltd | Process for the preparation of prostaglandin derivatives |
GB0112699D0 (en) * | 2001-05-24 | 2001-07-18 | Resolution Chemicals Ltd | Process for the preparation of prostglandins and analogues thereof |
GB0329379D0 (en) * | 2003-12-19 | 2004-01-21 | Johnson Matthey Plc | Prostaglandin synthesis |
ES2767136T3 (en) * | 2004-01-05 | 2020-06-16 | Nicox Sa | Prostaglandin derivatives |
EP2143712A1 (en) * | 2008-07-10 | 2010-01-13 | Sandoz AG | Improved Process for the Production of Prostaglandins and Prostaglandin Analogs |
IT1393112B1 (en) * | 2009-02-27 | 2012-04-11 | Sifavitor S R L | PROCEDURE FOR THE PREPARATION OF PROSTAGLANDINE DERIVATIVES |
WO2011046569A1 (en) * | 2009-10-16 | 2011-04-21 | Cayman Chemical Company | Process for the preparation of f-series prostaglandins |
EP2496553A4 (en) * | 2009-11-05 | 2013-03-06 | Biocon Ltd | A novel process for the preparation of prostaglandins and intermediates thereof |
EP2495235B1 (en) | 2011-03-04 | 2015-08-05 | Newchem S.p.A. | Process for the synthesis of prostaglandins and intermediates thereof |
CA3209613A1 (en) | 2011-06-02 | 2012-12-06 | CHINOIN Zrt. | Novel processes for the preparation of prostaglandin amides |
-
2011
- 2011-12-21 HU HU1100701A patent/HU231203B1/en unknown
-
2012
- 2012-12-10 MX MX2014007684A patent/MX2014007684A/en unknown
- 2012-12-10 BR BR112014014060A patent/BR112014014060A2/en not_active Application Discontinuation
- 2012-12-10 ES ES12816098T patent/ES2721662T3/en active Active
- 2012-12-10 JP JP2014548213A patent/JP6174040B2/en active Active
- 2012-12-10 WO PCT/HU2012/000132 patent/WO2013093528A1/en active Application Filing
- 2012-12-10 US US14/367,317 patent/US9212125B2/en active Active
- 2012-12-10 TR TR2019/05687T patent/TR201905687T4/en unknown
- 2012-12-10 KR KR1020147020311A patent/KR102027889B1/en active IP Right Grant
- 2012-12-10 RU RU2014129492A patent/RU2631316C2/en active
- 2012-12-10 IN IN3482CHN2014 patent/IN2014CN03482A/en unknown
- 2012-12-10 PL PL12816098T patent/PL2802562T3/en unknown
- 2012-12-10 EP EP12816098.3A patent/EP2802562B1/en active Active
- 2012-12-10 CN CN201280063528.2A patent/CN103998423B/en active Active
- 2012-12-10 CA CA2859923A patent/CA2859923C/en active Active
- 2012-12-20 TW TW101148584A patent/TWI640500B/en active
-
2014
- 2014-05-14 IL IL232625A patent/IL232625B/en active IP Right Grant
- 2014-06-17 ZA ZA2014/04440A patent/ZA201404440B/en unknown
- 2014-12-01 HK HK14112063.1A patent/HK1198584A1/en unknown
-
2015
- 2015-10-30 US US14/928,629 patent/US20160137621A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP6174040B2 (en) | 2017-08-02 |
US20160137621A1 (en) | 2016-05-19 |
EP2802562A1 (en) | 2014-11-19 |
US9212125B2 (en) | 2015-12-15 |
PL2802562T3 (en) | 2019-08-30 |
KR102027889B1 (en) | 2019-10-04 |
JP2015506343A (en) | 2015-03-02 |
MX2014007684A (en) | 2014-07-28 |
TR201905687T4 (en) | 2019-05-21 |
ES2721662T3 (en) | 2019-08-02 |
WO2013093528A1 (en) | 2013-06-27 |
IL232625B (en) | 2019-03-31 |
EP2802562B1 (en) | 2019-01-23 |
CN103998423A (en) | 2014-08-20 |
HU231203B1 (en) | 2021-10-28 |
TW201336816A (en) | 2013-09-16 |
CA2859923C (en) | 2020-11-24 |
ZA201404440B (en) | 2015-12-23 |
TWI640500B (en) | 2018-11-11 |
RU2631316C2 (en) | 2017-09-21 |
CN103998423B (en) | 2018-04-27 |
CA2859923A1 (en) | 2013-06-27 |
BR112014014060A2 (en) | 2017-06-13 |
RU2014129492A (en) | 2016-02-10 |
US20140343299A1 (en) | 2014-11-20 |
HUP1100701A2 (en) | 2013-07-29 |
KR20140107541A (en) | 2014-09-04 |
IL232625A0 (en) | 2014-06-30 |
HK1198584A1 (en) | 2015-04-30 |
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