WO2011142825A3 - Novel sulfur containing compounds - Google Patents

Novel sulfur containing compounds Download PDF

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Publication number
WO2011142825A3
WO2011142825A3 PCT/US2011/000841 US2011000841W WO2011142825A3 WO 2011142825 A3 WO2011142825 A3 WO 2011142825A3 US 2011000841 W US2011000841 W US 2011000841W WO 2011142825 A3 WO2011142825 A3 WO 2011142825A3
Authority
WO
WIPO (PCT)
Prior art keywords
containing compounds
sulfur containing
novel sulfur
novel
intermediates
Prior art date
Application number
PCT/US2011/000841
Other languages
French (fr)
Other versions
WO2011142825A2 (en
Inventor
Satyanarayana Janagani
Venkateshwar Kumar
Vamaraju Ravisankar
Mandava V. Basaveswara Rao
Original Assignee
Dissymmetrix (P) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dissymmetrix (P) Ltd. filed Critical Dissymmetrix (P) Ltd.
Publication of WO2011142825A2 publication Critical patent/WO2011142825A2/en
Publication of WO2011142825A3 publication Critical patent/WO2011142825A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides

Abstract

Novel sulfur containing compounds are disclosed as intermediates for preparation of a Sitagliptin of formula (V). A novel synthetic method to prepare Sitagliptin using the said intermediates is also disclosed.
PCT/US2011/000841 2010-05-12 2011-05-12 Novel sulfur containing compounds WO2011142825A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33417210P 2010-05-12 2010-05-12
US61/334,172 2010-05-12

Publications (2)

Publication Number Publication Date
WO2011142825A2 WO2011142825A2 (en) 2011-11-17
WO2011142825A3 true WO2011142825A3 (en) 2012-01-05

Family

ID=44914885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/000841 WO2011142825A2 (en) 2010-05-12 2011-05-12 Novel sulfur containing compounds

Country Status (1)

Country Link
WO (1) WO2011142825A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108314688A (en) * 2018-04-28 2018-07-24 安徽海康药业有限责任公司 A kind of synthetic method of sitagliptin

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102627648B (en) * 2012-04-14 2014-11-12 江苏施美康药业股份有限公司 Preparation method of sitagliptin
EP2674432A1 (en) 2012-06-14 2013-12-18 LEK Pharmaceuticals d.d. New synthetic route for the preparation of ß aminobutyryl substituted 5,6,7,8-tetrahydro[1,4]diazolo[4,3-alpha]pyrazin-7-yl compounds
KR102157917B1 (en) * 2012-12-21 2020-09-21 레크 파마슈티칼스 디.디. AN ENZYMATIC ROUTE FOR THE PREPARATION OF CHIRAL γ-ARYL-β-AMINOBUTYRIC ACID DERIVATIVES
CN103483340B (en) * 2013-07-29 2016-09-07 无锡佰翱得生物科学有限公司 A kind of synthetic method of sitagliptin
CN105017099B (en) * 2015-07-15 2017-03-22 成都千禧莱医药科技有限公司 Sitagliptin chiral intermediate and asymmetric synthesis method thereof
CN108178761A (en) * 2017-12-28 2018-06-19 安庆奇创药业有限公司 A kind of synthetic method of Xi Gelieting
CN111763176A (en) * 2020-07-10 2020-10-13 常州制药厂有限公司 GnRH receptor antagonist key intermediate and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HANSEN ET AL.: "Highly Efficient Asymmetric Synthesis of Sitagliptin.", JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 131, 2009, pages 8798 - 8804, XP055012354, DOI: doi:10.1021/ja902462q *
ROBAK ET AL.: "Synthesis and Applications of tert-Butanesulfinamide.", CHEMICAL REVIEWS, vol. 110, 26 April 2010 (2010-04-26), pages 3600 - 3740 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108314688A (en) * 2018-04-28 2018-07-24 安徽海康药业有限责任公司 A kind of synthetic method of sitagliptin

Also Published As

Publication number Publication date
WO2011142825A2 (en) 2011-11-17

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