IN2014MN00850A - - Google Patents

Info

Publication number
IN2014MN00850A
IN2014MN00850A IN850MUN2014A IN2014MN00850A IN 2014MN00850 A IN2014MN00850 A IN 2014MN00850A IN 850MUN2014 A IN850MUN2014 A IN 850MUN2014A IN 2014MN00850 A IN2014MN00850 A IN 2014MN00850A
Authority
IN
India
Prior art keywords
methyl
compound
formula
preparation
methoxy group
Prior art date
Application number
Inventor
Dharmaraj Ramachandra Rao
Rajendra Narayanrao Kankan
Sanjay Naik
Maruti Ghagare
Sandip Vasant Chikhalikar
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cipla Ltd filed Critical Cipla Ltd
Priority to IN850MUN2014 priority Critical patent/IN2014MN00850A/en
Publication of IN2014MN00850A publication Critical patent/IN2014MN00850A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/313—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/716—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring

Abstract

The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.
IN850MUN2014 2011-10-19 2012-10-19 IN2014MN00850A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IN850MUN2014 IN2014MN00850A (en) 2011-10-19 2012-10-19

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2943MU2011 2011-10-19
PCT/GB2012/000798 WO2013057468A1 (en) 2011-10-19 2012-10-19 Process for the preparation of an endothelin receptor antagonist
IN850MUN2014 IN2014MN00850A (en) 2011-10-19 2012-10-19

Publications (1)

Publication Number Publication Date
IN2014MN00850A true IN2014MN00850A (en) 2015-04-17

Family

ID=47116083

Family Applications (1)

Application Number Title Priority Date Filing Date
IN850MUN2014 IN2014MN00850A (en) 2011-10-19 2012-10-19

Country Status (10)

Country Link
US (1) US20140256004A1 (en)
EP (1) EP2768811A1 (en)
JP (1) JP2015502916A (en)
KR (1) KR20140091700A (en)
AU (1) AU2012324612A1 (en)
BR (1) BR112014009437A2 (en)
CA (1) CA2852810A1 (en)
IN (1) IN2014MN00850A (en)
WO (1) WO2013057468A1 (en)
ZA (1) ZA201403245B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709106A (en) * 2013-12-06 2014-04-09 石家庄博策生物科技有限公司 Stereoselectivity preparation method for Letairis
US9133488B2 (en) 2013-12-30 2015-09-15 University Of Alaska Fairbanks Synthetic methods and compounds related thereto
CN106011194A (en) * 2016-06-14 2016-10-12 西安大唐制药集团有限公司 Preparation method of ambrisentan
CN110437063B (en) * 2018-05-03 2022-04-29 常州恒邦药业有限公司 Preparation method of ambrisentan key intermediate
CN111057725B (en) * 2019-07-01 2023-08-18 弈柯莱生物科技(上海)股份有限公司 Use of ketoreductase for preparing (S) -1, 1-di (4-fluorophenyl) -2-propanol and preparation method thereof
CN110423741B (en) * 2019-07-16 2021-08-17 浙江工业大学 Carbonyl reductase-coenzyme NADP+Co-immobilized enzyme and preparation and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19533023B4 (en) 1994-10-14 2007-05-16 Basf Ag New carboxylic acid derivatives, their preparation and use
WO1999023242A1 (en) 1997-11-04 1999-05-14 Eli Lilly And Company Ketoreductase gene and protein from yeast
DE19850301A1 (en) 1998-10-30 2000-05-04 Basf Ag Process for the resolution of racemates of 2-hydroxypropionic acids
WO2005017135A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved ketoreductase polypeptides and related polynucleotides
US8404840B2 (en) * 2008-11-05 2013-03-26 Msn Laboratories Limited Process for the preparation of endothelin receptor antagonists
WO2010091877A2 (en) 2009-02-13 2010-08-19 Ratiopharm Gmbh Process for producing ambrisentan
EP2451786B1 (en) 2009-07-10 2014-01-22 Cadila Healthcare Limited Improved process for the preparation of ambrisentan and novel intermediates thereof

Also Published As

Publication number Publication date
AU2012324612A1 (en) 2014-05-15
BR112014009437A2 (en) 2017-04-11
EP2768811A1 (en) 2014-08-27
KR20140091700A (en) 2014-07-22
US20140256004A1 (en) 2014-09-11
JP2015502916A (en) 2015-01-29
WO2013057468A1 (en) 2013-04-25
CA2852810A1 (en) 2013-04-25
ZA201403245B (en) 2015-06-24

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