IN2014DN06192A - - Google Patents

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Publication number
IN2014DN06192A
IN2014DN06192A IN6192DEN2014A IN2014DN06192A IN 2014DN06192 A IN2014DN06192 A IN 2014DN06192A IN 6192DEN2014 A IN6192DEN2014 A IN 6192DEN2014A IN 2014DN06192 A IN2014DN06192 A IN 2014DN06192A
Authority
IN
India
Prior art keywords
salts
preparing
compound
formula
methods
Prior art date
Application number
Inventor
Aaron J Cullen
Richard Hung Chiu Yu
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of IN2014DN06192A publication Critical patent/IN2014DN06192A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/16—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C329/00—Thiocarbonic acids; Halides, esters or anhydrides thereof
    • C07C329/12—Dithiocarbonic acids; Derivatives thereof
    • C07C329/14—Esters of dithiocarbonic acids
    • C07C329/16—Esters of dithiocarbonic acids having sulfur atoms of dithiocarbonic groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/16—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms
    • C07D203/20—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with acylated ring nitrogen atoms by carbonic acid, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/24—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Abstract

Methods and intermediates useful for preparing a compound of formula I and salts thereof.
IN6192DEN2014 2012-02-03 2013-02-01 IN2014DN06192A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261594686P 2012-02-03 2012-02-03
PCT/US2013/024431 WO2013116715A1 (en) 2012-02-03 2013-02-01 Methods and intermediates for preparing pharmaceutical agents

Publications (1)

Publication Number Publication Date
IN2014DN06192A true IN2014DN06192A (en) 2015-10-23

Family

ID=47754962

Family Applications (1)

Application Number Title Priority Date Filing Date
IN6192DEN2014 IN2014DN06192A (en) 2012-02-03 2013-02-01

Country Status (15)

Country Link
US (1) US9346796B2 (en)
EP (1) EP2809646A1 (en)
JP (1) JP2015510509A (en)
KR (1) KR20140128392A (en)
CN (1) CN104093702A (en)
AU (1) AU2013214879A1 (en)
BR (1) BR112014018738A8 (en)
CA (1) CA2862344A1 (en)
HK (1) HK1205095A1 (en)
IL (1) IL233654A0 (en)
IN (1) IN2014DN06192A (en)
MX (1) MX2014009344A (en)
RU (1) RU2014129937A (en)
SG (2) SG11201404527QA (en)
WO (1) WO2013116715A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104370777A (en) * 2013-08-13 2015-02-25 上海迪赛诺化学制药有限公司 Intermediates for synthesizing (2R,5R)-1,6-diphenylhexyl-2,5-diamine and salts thereof, preparation method and applications of the intermediates
WO2015083066A1 (en) 2013-12-03 2015-06-11 Mylan Laboratories Ltd. Preparation of cobicistat intermediates
CN104193643B (en) * 2014-09-12 2016-02-10 宁波九胜创新医药科技有限公司 For the synthesis of the intermediate of anti-AIDS drug toughener cobicistat
CN104557565B (en) * 2015-01-08 2016-07-06 浙江工业大学 The preparation method of anti-AIDS drug reinforcing agent Cobicistat key intermediate hydrochlorate
CN107513046B (en) * 2016-06-15 2019-12-13 江苏欧信制药有限公司 Synthesis method of Coxstat
CN112500367A (en) * 2020-12-16 2021-03-16 盐城迪赛诺制药有限公司 Refining method of ritonavir intermediate
CN112592324A (en) * 2020-12-16 2021-04-02 盐城迪赛诺制药有限公司 Method for purifying ritonavir intermediate raw material

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5142056A (en) 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
IE20010533A1 (en) 1990-11-20 2003-03-05 Abbott Lab Intermediates for preparing retroviral protease inhibiting compounds
JP2637847B2 (en) 1992-12-29 1997-08-06 アボツト・ラボラトリーズ Compounds that inhibit retroviral protease
US5763464A (en) 1995-11-22 1998-06-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Retroviral agents containing anthranilamide, substituted benzamide and other subunits, and methods of using same
US20030153771A1 (en) 2001-09-27 2003-08-14 Kolb Hartmuth C. Large scale synthesis of optically pure aziridines
WO2003106445A1 (en) 2002-06-12 2003-12-24 Qsi Pharma A/S Compounds and methods for controlling bacterial virulence
US7939553B2 (en) * 2006-07-07 2011-05-10 Gilead Sciences, Inc. Modulators of pharmacokinetic properties of therapeutics
EP2465856A3 (en) * 2006-08-31 2012-12-12 Abbott Laboratories Cytochrome P450 oxidase inhibitors and uses thereof
JP4881446B2 (en) 2007-02-23 2012-02-22 ギリアード サイエンシーズ， インコーポレイテッド Modulation of pharmacokinetic properties of therapeutic agents
PL2296633T3 (en) 2008-05-02 2016-03-31 Gilead Sciences Inc The use of solid carrier particles to improve the processability of a pharmaceutical agent
UA108738C2 (en) 2009-04-03 2015-06-10 METHOD OF PREPARATION OF CYTOCHROME INVENTOR P450 MONOOXYGENASES AND INTERMEDIATED INTERMEDIATES
CN101967130B (en) * 2010-07-02 2012-12-26 厦门市亨瑞生化有限公司 Synthesis method of ritonavir midbody
WO2012088153A1 (en) 2010-12-21 2012-06-28 Gilead Sciences, Inc. Inhibitors of cytochrome p450

Also Published As

Publication number Publication date
EP2809646A1 (en) 2014-12-10
SG11201404527QA (en) 2014-08-28
RU2014129937A (en) 2016-03-27
JP2015510509A (en) 2015-04-09
SG10201509336RA (en) 2015-12-30
BR112014018738A8 (en) 2017-07-11
CN104093702A (en) 2014-10-08
US20140364602A1 (en) 2014-12-11
BR112014018738A2 (en) 2017-06-20
US9346796B2 (en) 2016-05-24
HK1205095A1 (en) 2015-12-11
KR20140128392A (en) 2014-11-05
MX2014009344A (en) 2015-05-11
IL233654A0 (en) 2014-08-31
CA2862344A1 (en) 2013-08-08
AU2013214879A1 (en) 2014-08-07
WO2013116715A1 (en) 2013-08-08

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