IN2014KN01062A - - Google Patents

Info

Publication number
IN2014KN01062A
IN2014KN01062A IN1062KON2014A IN2014KN01062A IN 2014KN01062 A IN2014KN01062 A IN 2014KN01062A IN 1062KON2014 A IN1062KON2014 A IN 1062KON2014A IN 2014KN01062 A IN2014KN01062 A IN 2014KN01062A
Authority
IN
India
Prior art keywords
synthesis
intermediates
describes
well
field
Prior art date
Application number
Inventor
Borut Zupancic
Nenad Maras
Damjan Sterk
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11186817.0A external-priority patent/EP2586773A1/en
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of IN2014KN01062A publication Critical patent/IN2014KN01062A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The present invention relates to the field of organic synthesis and describes the synthesis of specific triazolopyrimidine compounds and intermediates thereof as well as related derivatives.
IN1062KON2014 2011-10-27 2012-10-26 IN2014KN01062A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11186817.0A EP2586773A1 (en) 2011-10-27 2011-10-27 Synthesis of Triazolopyrimidine Compounds
EP11195608 2011-12-23
PCT/EP2012/071252 WO2013060837A1 (en) 2011-10-27 2012-10-26 Synthesis of triazolopyrimidine compounds

Publications (1)

Publication Number Publication Date
IN2014KN01062A true IN2014KN01062A (en) 2015-10-09

Family

ID=47148745

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1062KON2014 IN2014KN01062A (en) 2011-10-27 2012-10-26

Country Status (10)

Country Link
US (1) US9469614B2 (en)
EP (1) EP2771326B1 (en)
CN (1) CN104024230B (en)
CA (1) CA2852652A1 (en)
ES (1) ES2665546T3 (en)
HR (1) HRP20180466T1 (en)
HU (1) HUE036244T2 (en)
IN (1) IN2014KN01062A (en)
PL (1) PL2771326T4 (en)
WO (1) WO2013060837A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103965198A (en) * 2013-02-05 2014-08-06 郝聪梅 Ticagrelor intermediate, preparation method of intermediate and method for preparing ticagrelor by using intermediate
CN107573333B (en) * 2013-04-10 2019-10-18 江苏恒瑞医药股份有限公司 Intermediate of ticagrelor and preparation method thereof and preparation method of ticagrelor
CN103275056B (en) * 2013-05-24 2015-06-17 浙江普洛医药科技有限公司 Preparation method of ticagrelor midbody
CN103360396B (en) * 2013-06-27 2015-07-01 苏州明锐医药科技有限公司 Method for preparing ticagrelor
UA116395C2 (en) 2013-09-06 2018-03-12 Ф. Хоффманн-Ля Рош Аг TRIASOL DERIVATIVES [4,5-b] PYRIMIDINE
EP3157907B1 (en) 2014-06-18 2018-08-29 Flamma S.P.A. Process for the preparation of triazolo[4,5-d]pyrimidine cyclopentane compounds
CN105985346B (en) * 2015-03-06 2019-10-18 苏州朗科生物技术股份有限公司 A new preparation method of ticagrelor compound and its intermediate compound
US11623927B2 (en) 2018-03-02 2023-04-11 The Trustees Of The University Of Pennsylvania Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR017014A1 (en) * 1997-07-22 2001-08-22 Astrazeneca Ab TRIAZOL COMPOUNDS [4,5-D] PYRIMIDINE, PHARMACEUTICAL COMPOSITIONS, USE OF THE SAME TO PREPARE MEDICATIONS AND PROCESSES FOR THE PREPARATION OF SUCH COMPOUNDS
SE9702773D0 (en) * 1997-07-22 1997-07-22 Astra Pharma Prod Novel compounds
TWI229674B (en) 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
CA2734454C (en) 2008-09-09 2016-09-13 Astrazeneca Ab A process for preparing [1s-[1-alpha,2-alpha,3-beta(1s*,2r*)5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and to its intermediates
EP2459564B1 (en) 2009-07-27 2016-09-07 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of p2y12 receptor

Also Published As

Publication number Publication date
EP2771326A1 (en) 2014-09-03
PL2771326T3 (en) 2018-06-29
ES2665546T3 (en) 2018-04-26
CA2852652A1 (en) 2013-05-02
US20140256747A1 (en) 2014-09-11
CN104024230A (en) 2014-09-03
US9469614B2 (en) 2016-10-18
EP2771326B1 (en) 2017-12-20
CN104024230B (en) 2016-05-04
PL2771326T4 (en) 2018-06-29
HUE036244T2 (en) 2018-06-28
HRP20180466T1 (en) 2018-07-27
WO2013060837A1 (en) 2013-05-02

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