IN2014KN01491A - - Google Patents

Info

Publication number
IN2014KN01491A
IN2014KN01491A IN1491KON2014A IN2014KN01491A IN 2014KN01491 A IN2014KN01491 A IN 2014KN01491A IN 1491KON2014 A IN1491KON2014 A IN 1491KON2014A IN 2014KN01491 A IN2014KN01491 A IN 2014KN01491A
Authority
IN
India
Prior art keywords
synthesis
ticagrelor
describes
preparation
field
Prior art date
Application number
Inventor
Nenad Maras
Smilovic Ivana Gazic
Damjan Sterk
Original Assignee
Lek Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP11195508.4A external-priority patent/EP2607355A1/en
Application filed by Lek Pharmaceuticals filed Critical Lek Pharmaceuticals
Publication of IN2014KN01491A publication Critical patent/IN2014KN01491A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/24—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/10—Systems containing only non-condensed rings with a five-membered ring the ring being unsaturated

Abstract

The present invention relates to the field of organic synthesis and describes the synthesis of specific intermediates suitable for the preparation of triazolopyrimidine compounds such as ticagrelor.
IN1491KON2014 2011-12-23 2012-12-20 IN2014KN01491A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11195508.4A EP2607355A1 (en) 2011-12-23 2011-12-23 Synthesis of triazolopyrimidine compounds
EP12169185 2012-05-24
PCT/EP2012/076458 WO2013092900A1 (en) 2011-12-23 2012-12-20 Synthesis of triazolopyrimidine compounds

Publications (1)

Publication Number Publication Date
IN2014KN01491A true IN2014KN01491A (en) 2015-10-23

Family

ID=47520984

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1491KON2014 IN2014KN01491A (en) 2011-12-23 2012-12-20

Country Status (6)

Country Link
US (1) US9278972B2 (en)
EP (1) EP2794575B1 (en)
CN (1) CN104114542B (en)
CA (1) CA2859580A1 (en)
IN (1) IN2014KN01491A (en)
WO (1) WO2013092900A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ307217B6 (en) * 2013-03-14 2018-04-04 Zentiva, K.S. An improved manufacturing process and new intermediates for synthesis of ticagrelor
CN104098553B (en) * 2013-04-10 2017-11-28 江苏恒瑞医药股份有限公司 The preparation method of intermediate of ticagrelor and preparation method thereof and ticagrelor
CN104610237B (en) * 2013-11-05 2018-03-30 正大天晴药业集团股份有限公司 A kind of Preparation Method And Their Intermediate of ticagrelor
CN103588750B (en) * 2013-11-07 2014-11-26 苏州明锐医药科技有限公司 Method for preparing ticagrelor intermediate
CZ2013866A3 (en) * 2013-11-08 2015-05-20 Zentiva, K.S. Novel crystalline form of ticagrelor synthesis intermediate and process for preparing thereof
CN104710425B (en) * 2013-12-16 2019-06-14 石药集团中奇制药技术（石家庄）有限公司 A kind of ticagrelor newly crystallizes and preparation method thereof
US10905691B2 (en) 2016-09-09 2021-02-02 Université de Liège Use of triazolo(4,5-d)pyrimidine derivatives for prevention and treatment of bacterial infection
ES2731658T3 (en) * 2016-09-09 2019-11-18 Univ Liege Triazolo (4,5-d) pyrimidine derivatives for use in the prevention and treatment of bacterial infection
EP3758696A4 (en) 2018-03-02 2021-12-08 The Trustees of the University of Pennsylvania [1,2,4]triazolo[1,5-a]pyrimidine compounds and use in stabilizing microtubules
CN109896934A (en) * 2019-03-08 2019-06-18 山东省药学科学院 A kind of preparation method of high-purity 2- benzyloxy bromoethane
CN110467619A (en) * 2019-08-08 2019-11-19 山西德元堂药业有限公司 A kind of preparation method of ticagrelor
CN112047919B (en) * 2020-09-16 2021-06-18 常州制药厂有限公司 Ticagrelor intermediate and preparation method thereof
CN113801090B (en) * 2021-11-18 2022-02-18 南京威凯尔生物医药科技有限公司 Ticagrelor key intermediate and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI229674B (en) * 1998-12-04 2005-03-21 Astra Pharma Prod Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB0013488D0 (en) 2000-06-02 2000-07-26 Astrazeneca Ab Chemical compound
KR101669297B1 (en) * 2008-09-09 2016-10-25 아스트라제네카 아베 A process for preparing [1s-[1-alpha,2-alpha,3-beta(1s*,2r*),5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and its intermediates
US8802850B2 (en) 2009-07-27 2014-08-12 Auspex Pharmaceuticals, Inc. Cyclopropyl modulators of P2Y12 receptor
IN2012DN01873A (en) 2009-08-31 2015-08-21 Lonza Ag
EP2694514A2 (en) * 2011-04-06 2014-02-12 Teva Pharmaceutical Industries Ltd. New intermediates and processes for preparing ticagrelor
CN102731467B (en) * 2011-04-15 2015-12-16 博瑞生物医药（苏州）股份有限公司 The intermediate of ADZ6140 and prepare the method for ADZ6140
EP2755957B2 (en) * 2011-09-14 2019-05-15 LEK Pharmaceuticals d.d. Synthesis of triazolopyrimidine compounds

Also Published As

Publication number Publication date
CN104114542A (en) 2014-10-22
US9278972B2 (en) 2016-03-08
CA2859580A1 (en) 2013-06-27
CN104114542B (en) 2017-11-14
US20140371449A1 (en) 2014-12-18
EP2794575B1 (en) 2018-12-05
WO2013092900A1 (en) 2013-06-27
EP2794575A1 (en) 2014-10-29

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