CN103923021B - 适用作e1活化酶抑制剂的杂芳基化合物 - Google Patents
适用作e1活化酶抑制剂的杂芳基化合物 Download PDFInfo
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- CN103923021B CN103923021B CN201410133207.6A CN201410133207A CN103923021B CN 103923021 B CN103923021 B CN 103923021B CN 201410133207 A CN201410133207 A CN 201410133207A CN 103923021 B CN103923021 B CN 103923021B
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- amino
- bases
- methyl esters
- sulfamic acids
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| AU2013204618B2 (en) * | 2007-08-02 | 2015-11-05 | Takeda Pharmaceutical Company Limited | Process for the synthesis of E1 activating enzyme inhibitors |
| WO2010103130A2 (en) | 2009-03-13 | 2010-09-16 | Katholieke Universiteit Leuven, K.U.Leuven R&D | Novel bicyclic heterocycles |
| SG175929A1 (en) | 2009-05-14 | 2011-12-29 | Millennium Pharm Inc | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| US20130096104A1 (en) * | 2010-03-17 | 2013-04-18 | Genentech, Inc. | Imidazopyridine compounds, compositions and methods of use |
| GB201012889D0 (en) | 2010-08-02 | 2010-09-15 | Univ Leuven Kath | Antiviral activity of novel bicyclic heterocycles |
| US8815881B2 (en) | 2010-08-09 | 2014-08-26 | Hoffmann-La Roche Inc. | 1,4,5,6-tetrahydro-pyrimidin-2-ylamine compounds |
| GB201015411D0 (en) | 2010-09-15 | 2010-10-27 | Univ Leuven Kath | Anti-cancer activity of novel bicyclic heterocycles |
| SG11201400102WA (en) * | 2011-08-24 | 2014-03-28 | Millennium Pharm Inc | Inhibitors of nedd8-activating enzyme |
| JP2015502137A (ja) * | 2011-10-07 | 2015-01-22 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | E1酵素変異体およびその用途 |
| JP6238900B2 (ja) | 2011-10-28 | 2017-11-29 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Nae阻害物質に対する応答のバイオマーカー |
| KR101987861B1 (ko) * | 2011-11-03 | 2019-06-11 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Nedd-8 활성화 효소 억제제 및 저메틸화제의 투여 |
| SG10201913554YA (en) | 2011-12-22 | 2020-03-30 | Alios Biopharma Inc | Substituted nucleosides, nucleotides and analogs thereof |
| CN104136399B (zh) * | 2012-02-17 | 2018-08-07 | 米伦纽姆医药公司 | 泛素活化酶的吡唑并嘧啶基抑制剂 |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
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| BR112015011148A8 (pt) | 2012-11-16 | 2019-10-01 | Merck Sharp & Dohme | composto, composição farmacêutica, e combinação |
| EP2764866A1 (en) * | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
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| BR112016030787B1 (pt) * | 2014-07-01 | 2022-12-20 | Takeda Pharmaceutical Company Limited | Entidade química, composição farmacêutica e seu uso |
| CN105111091A (zh) * | 2015-08-26 | 2015-12-02 | 吴玲 | 制备s-3-甲基-1-氨基茚满的方法 |
| CN105085279A (zh) * | 2015-08-26 | 2015-11-25 | 吴玲 | 制备r-5-氯-1-氨基茚满 |
| CN105061220A (zh) * | 2015-08-26 | 2015-11-18 | 吴玲 | 一种制备r-3-甲基-1-氨基茚满的方法 |
| CN105130824A (zh) * | 2015-08-31 | 2015-12-09 | 吴玲 | 一种制备s-5-溴-1-氨基茚满的方法 |
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| CN112079836B (zh) | 2019-06-13 | 2022-12-13 | 中国科学院上海药物研究所 | 三唑并嘧啶类化合物及其盐、组合物和应用 |
| US11540867B2 (en) | 2019-08-13 | 2023-01-03 | Pioneer Surgical Technology, Inc. | Driver for a bone screw |
| CN110563655A (zh) * | 2019-09-24 | 2019-12-13 | 上海毕得医药科技有限公司 | 一种5-(2-溴乙基)嘧啶的制备方法 |
| BR112022010924A2 (pt) | 2019-12-06 | 2022-09-06 | Vertex Pharma | Tetra-hidrofuranos substituídos como moduladores de canais de sódio |
| JP7736700B2 (ja) * | 2020-02-28 | 2025-09-09 | リミックス セラピューティクス インコーポレイテッド | 複素環アミド及びスプライシングを調節するためのその使用 |
| SMT202500481T1 (it) | 2021-06-04 | 2026-01-12 | Vertex Pharma | N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
| CN115124534B (zh) * | 2021-11-23 | 2023-09-15 | 中山大学 | 非核苷酸类prmt5小分子抑制剂、制备方法及用途 |
| US20260035382A1 (en) * | 2022-09-30 | 2026-02-05 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Compounds as sumo activating enzyme inhibitors |
| CN120112536A (zh) * | 2022-11-11 | 2025-06-06 | 微境生物医药科技(上海)有限公司 | 作为sumo活化酶抑制剂的化合物 |
| CN118812375A (zh) * | 2023-04-17 | 2024-10-22 | 中国科学院大连化学物理研究所 | 二芳基硼酸催化环氧化物立体选择性开环的方法 |
| CN119306612B (zh) * | 2023-07-14 | 2026-03-20 | 中国科学院大连化学物理研究所 | 一种反式氨基茚满的制备方法 |
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| JPH0714957B2 (ja) * | 1987-03-09 | 1995-02-22 | 理化学研究所 | 2′−デオキシ−5−フルオロウリジン誘導体及び制癌剤 |
| AU6500696A (en) * | 1995-07-28 | 1997-02-26 | Cubist Pharmaceuticals, Inc. | Aminoacyl adenylate mimics as novel antimicrobial and antiparasitic agents |
| AU2003291024A1 (en) * | 2002-11-13 | 2004-06-03 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| EP1680431A1 (en) * | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
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| PT1848718E (pt) | 2005-02-04 | 2012-10-11 | Millennium Pharm Inc | Inibidores de enzimas de activação e1 |
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