CN103781753B - 用于治疗ape1介导的疾病的醌化合物 - Google Patents
用于治疗ape1介导的疾病的醌化合物 Download PDFInfo
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- CN103781753B CN103781753B CN201280029978.XA CN201280029978A CN103781753B CN 103781753 B CN103781753 B CN 103781753B CN 201280029978 A CN201280029978 A CN 201280029978A CN 103781753 B CN103781753 B CN 103781753B
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- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
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- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
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- C—CHEMISTRY; METALLURGY
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
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PCT/US2012/039529 WO2012162589A1 (en) | 2011-05-26 | 2012-05-25 | Quinone compounds for treating ape1 mediated diseases |
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CN201610481762.7A Active CN106146337B (zh) | 2011-05-26 | 2012-05-25 | 用于治疗ape1介导的疾病的醌化合物 |
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US (3) | US9193700B2 (ja) |
EP (2) | EP3520860A1 (ja) |
JP (4) | JP6109821B2 (ja) |
KR (2) | KR20190060865A (ja) |
CN (2) | CN103781753B (ja) |
AU (1) | AU2012258665B2 (ja) |
BR (1) | BR112013030370A2 (ja) |
CA (1) | CA2837307C (ja) |
IL (1) | IL229590A0 (ja) |
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Publication number | Priority date | Publication date | Assignee | Title |
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AU2012258665B2 (en) | 2011-05-26 | 2017-05-25 | Apex Therapeutics, Inc. | Quinone compounds for treating Ape1 mediated diseases |
WO2012167122A1 (en) | 2011-06-03 | 2012-12-06 | Indiana University Research And Technology Corporation | Compounds, compositions and methods for treating oxidative dna damage disorders |
ES2689665T3 (es) * | 2012-03-14 | 2018-11-15 | Indiana University Research And Technology Corporation | Compuestos y métodos para tratar la leucemia |
CN106674146A (zh) * | 2015-11-05 | 2017-05-17 | 重庆大学 | 一种萘醌并吗啡啉化合物的制备方法 |
JP2020514349A (ja) * | 2017-03-20 | 2020-05-21 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | 癌の処置のための併用治療剤におけるape1/ref−1阻害剤の使用 |
US20190117602A1 (en) * | 2017-04-17 | 2019-04-25 | Indiana University Research And Technology Corporation | Prevention and reversal of inflammation induced dna damage |
NZ757526A (en) | 2017-04-21 | 2022-02-25 | Univ Tasmania | Naphthoquinones, their derivatives and uses thereof in methods for the treatment of mitochondrial dysfunction |
CA3090766A1 (en) * | 2018-02-08 | 2019-08-15 | Indiana University Research And Technology Corporation | Targeting ocular diseases with novel ape1/ref-1 inhibitors |
CN110917358A (zh) * | 2019-12-26 | 2020-03-27 | 成都医学院第一附属医院 | 一种逆转肺腺癌顺铂耐药性的药物 |
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JPS5479228A (en) * | 1977-12-02 | 1979-06-25 | Takeda Chem Ind Ltd | Glucosamine derivative and its preparation |
JPS5640651A (en) * | 1979-09-12 | 1981-04-16 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
JPS57109739A (en) * | 1980-12-27 | 1982-07-08 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
JPS56154433A (en) * | 1980-04-30 | 1981-11-30 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
JPS58177934A (ja) * | 1982-04-13 | 1983-10-18 | Takeda Chem Ind Ltd | ベンゾキノン誘導体 |
JPS5910541A (ja) * | 1982-07-09 | 1984-01-20 | Takeda Chem Ind Ltd | キノン化合物 |
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JP2639568B2 (ja) * | 1987-07-29 | 1997-08-13 | 武田薬品工業株式会社 | 細胞増殖抑制剤 |
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EP2203162B1 (en) * | 2007-09-26 | 2017-11-08 | Indiana University Research and Technology Corporation | Benzoquinone derivative e3330 in combination with chemotherapeutic agents for the treatment of cancer and angiogenesis |
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ES2689665T3 (es) * | 2012-03-14 | 2018-11-15 | Indiana University Research And Technology Corporation | Compuestos y métodos para tratar la leucemia |
-
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- 2012-05-25 CN CN201610481762.7A patent/CN106146337B/zh active Active
- 2012-05-25 KR KR1020197014420A patent/KR20190060865A/ko not_active Application Discontinuation
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US4533554A (en) * | 1979-05-18 | 1985-08-06 | Takeda Chemical Industries, Ltd. | Quinone derivatives and use |
CN1050182A (zh) * | 1989-09-11 | 1991-03-27 | 卫材株式会社 | 苯醌衍生物及其药用 |
CN1302287A (zh) * | 1998-05-22 | 2001-07-04 | 盐野义生物研究公司 | 生物还原性细胞毒试剂 |
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EP2718255A4 (en) | 2015-01-14 |
CA2837307A1 (en) | 2012-11-29 |
CA2837307C (en) | 2020-08-04 |
JP6272982B2 (ja) | 2018-01-31 |
MX357284B (es) | 2018-07-04 |
US20160045461A1 (en) | 2016-02-18 |
US20140094464A1 (en) | 2014-04-03 |
JP2018076361A (ja) | 2018-05-17 |
EP2718255A1 (en) | 2014-04-16 |
CN106146337A (zh) | 2016-11-23 |
JP6109821B2 (ja) | 2017-04-05 |
US10154973B2 (en) | 2018-12-18 |
US20180133175A1 (en) | 2018-05-17 |
BR112013030370A2 (pt) | 2017-08-08 |
AU2012258665B2 (en) | 2017-05-25 |
US9877936B2 (en) | 2018-01-30 |
US9193700B2 (en) | 2015-11-24 |
EP3520860A1 (en) | 2019-08-07 |
KR20140043900A (ko) | 2014-04-11 |
IL229590A0 (en) | 2014-01-30 |
WO2012162589A1 (en) | 2012-11-29 |
KR101982669B1 (ko) | 2019-05-27 |
JP2014516051A (ja) | 2014-07-07 |
MX2013013649A (es) | 2014-04-30 |
CN103781753A (zh) | 2014-05-07 |
RU2013152626A (ru) | 2015-07-10 |
JP2017101040A (ja) | 2017-06-08 |
KR20190060865A (ko) | 2019-06-03 |
EP2718255B1 (en) | 2019-02-13 |
JP2020063255A (ja) | 2020-04-23 |
CN106146337B (zh) | 2019-01-15 |
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