JPS5479228A - Glucosamine derivative and its preparation - Google Patents
Glucosamine derivative and its preparationInfo
- Publication number
- JPS5479228A JPS5479228A JP14541677A JP14541677A JPS5479228A JP S5479228 A JPS5479228 A JP S5479228A JP 14541677 A JP14541677 A JP 14541677A JP 14541677 A JP14541677 A JP 14541677A JP S5479228 A JPS5479228 A JP S5479228A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formulai
- alanyl
- preparation
- title compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
NEW MATERIAL:Title compounds of formulaI(R is lower alkyl; R1 is linear hydrocarbyl that may be substituted with cyclic hydrocarbyl group on the terminal; n is 0, 1-9, R2 is H or R when n is 0 and H when n is 1-9; R3 is R; R4-5 are H, R respectively; R6-7 are carboxyl groups that may be amidized respectively) or their salts.
EXAMPLE: 2-[2-Acetamide-2-deoxy-6-0-(geranylacetyl-β-alanyl)-D-glucose-3-0-yl]-D- propionyl-L-alanyl-D-iso-glutamine sodium salt.
USE: Title compounds have low toxicity and excellent action to increase immunological function thus being useful as anti-infective, carcinostatics, and synthetic intermediates of high-polymeric glucosamine derivatives.
PREPARATION: The condensation reaction between a compound of formula II (R4'-7' are R4-7 or the hydroxyl groups and others of which are protected and a compound of formula III is conducted and when necessary, protecting groups are removed to produce the objective compound of formulaI.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14541677A JPS5479228A (en) | 1977-12-02 | 1977-12-02 | Glucosamine derivative and its preparation |
DE7878101524T DE2862107D1 (en) | 1977-12-02 | 1978-12-02 | Glucosamine-peptide derivatives and their pharmaceutical compositions |
EP78101524A EP0002677B1 (en) | 1977-12-02 | 1978-12-02 | Glucosamine-peptide derivatives and their pharmaceutical compositions |
US06/393,870 US4430265A (en) | 1977-12-02 | 1982-06-30 | Glucosamine derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14541677A JPS5479228A (en) | 1977-12-02 | 1977-12-02 | Glucosamine derivative and its preparation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5479228A true JPS5479228A (en) | 1979-06-25 |
JPH0233719B2 JPH0233719B2 (en) | 1990-07-30 |
Family
ID=15384741
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP14541677A Granted JPS5479228A (en) | 1977-12-02 | 1977-12-02 | Glucosamine derivative and its preparation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5479228A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56128794A (en) * | 1980-02-15 | 1981-10-08 | Ciba Geigy Ag | Aldohexose derivatives, their manufacture and medicine containing them |
JPS56164196A (en) * | 1980-04-17 | 1981-12-17 | Merck & Co Inc | Immunologically active dipeptidyl-4-0-, 6-0-acyl-2-amino-2-deoxy-d-glucose derivative and manufacture |
JP2014516051A (en) * | 2011-05-26 | 2014-07-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | Quinone compounds for treating APE1-mediated diseases |
-
1977
- 1977-12-02 JP JP14541677A patent/JPS5479228A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS56128794A (en) * | 1980-02-15 | 1981-10-08 | Ciba Geigy Ag | Aldohexose derivatives, their manufacture and medicine containing them |
JPS56164196A (en) * | 1980-04-17 | 1981-12-17 | Merck & Co Inc | Immunologically active dipeptidyl-4-0-, 6-0-acyl-2-amino-2-deoxy-d-glucose derivative and manufacture |
JP2014516051A (en) * | 2011-05-26 | 2014-07-07 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーション | Quinone compounds for treating APE1-mediated diseases |
JP2018076361A (en) * | 2011-05-26 | 2018-05-17 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation | Quinone compounds for treating ape1 mediated diseases |
Also Published As
Publication number | Publication date |
---|---|
JPH0233719B2 (en) | 1990-07-30 |
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