CN103585621B - α-半乳糖苷酶缺陷的治疗 - Google Patents
α-半乳糖苷酶缺陷的治疗 Download PDFInfo
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- CN103585621B CN103585621B CN201310243356.3A CN201310243356A CN103585621B CN 103585621 B CN103585621 B CN 103585621B CN 201310243356 A CN201310243356 A CN 201310243356A CN 103585621 B CN103585621 B CN 103585621B
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- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/266,014 US6458574B1 (en) | 1996-09-12 | 1999-03-11 | Treatment of a α-galactosidase a deficiency |
| US09/266,014 | 1999-03-11 | ||
| CNB008073120A CN100417727C (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB008073120A Division CN100417727C (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103585621A CN103585621A (zh) | 2014-02-19 |
| CN103585621B true CN103585621B (zh) | 2016-08-10 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310243356.3A Expired - Lifetime CN103585621B (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
| CNA2007101482923A Withdrawn CN101219213A (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
| CN201610478912.9A Pending CN106110309A (zh) | 1999-03-11 | 2000-03-09 | α ‑半乳糖苷酶缺陷的治疗 |
| CNB008073120A Expired - Lifetime CN100417727C (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007101482923A Withdrawn CN101219213A (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
| CN201610478912.9A Pending CN106110309A (zh) | 1999-03-11 | 2000-03-09 | α ‑半乳糖苷酶缺陷的治疗 |
| CNB008073120A Expired - Lifetime CN100417727C (zh) | 1999-03-11 | 2000-03-09 | α-半乳糖苷酶缺陷的治疗 |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US6458574B1 (https=) |
| EP (6) | EP1163349B1 (https=) |
| JP (6) | JP2002538183A (https=) |
| KR (2) | KR100961740B1 (https=) |
| CN (4) | CN103585621B (https=) |
| AT (1) | ATE386808T1 (https=) |
| AU (1) | AU3519400A (https=) |
| CA (3) | CA3012663A1 (https=) |
| CY (3) | CY1107951T1 (https=) |
| DE (1) | DE60038104T2 (https=) |
| DK (3) | DK2314699T3 (https=) |
| ES (3) | ES2300256T3 (https=) |
| HK (2) | HK1043386B (https=) |
| HU (1) | HU228743B1 (https=) |
| IL (2) | IL145381A0 (https=) |
| MX (1) | MXPA01009222A (https=) |
| NO (2) | NO329689B1 (https=) |
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| PT (3) | PT1163349E (https=) |
| RU (1) | RU2248213C2 (https=) |
| WO (1) | WO2000053730A2 (https=) |
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| US6458574B1 (en) * | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
| US6083725A (en) * | 1996-09-13 | 2000-07-04 | Transkaryotic Therapies, Inc. | Tranfected human cells expressing human α-galactosidase A protein |
| IL155588A0 (en) * | 2003-04-27 | 2003-11-23 | Metabogal Ltd | Methods for expression of enzymatically active recombinant lysosomal enzymes in transgenic plant root cells and vectors used thereby |
| US20050032211A1 (en) * | 1996-09-26 | 2005-02-10 | Metabogal Ltd. | Cell/tissue culturing device, system and method |
| US7629309B2 (en) | 2002-05-29 | 2009-12-08 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20040005309A1 (en) * | 2002-05-29 | 2004-01-08 | Symbiontics, Inc. | Targeted therapeutic proteins |
| US7560424B2 (en) | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| ATE384736T1 (de) * | 2001-04-30 | 2008-02-15 | Zystor Therapeutics Inc | Subzelluläres targeting von therapeutischen proteinen |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| EP1503788B1 (en) * | 2002-04-25 | 2011-06-29 | Shire Human Genetic Therapies, Inc. | Treatment of alpha-galactosidase a deficiency |
| PT2441467E (pt) | 2003-01-31 | 2015-10-12 | Sinai School Medicine | Terapia combinada para o tratamento de transtornos associados a uma deficiência proteica |
| US7422310B2 (en) * | 2003-04-25 | 2008-09-09 | Hewlett-Packard Development Company, L.P. | Methods and apparatus for selecting image enhancement techniques |
| US20100196345A1 (en) * | 2003-04-27 | 2010-08-05 | Protalix | Production of high mannose proteins in plant culture |
| US7951557B2 (en) | 2003-04-27 | 2011-05-31 | Protalix Ltd. | Human lysosomal proteins from plant cell culture |
| US7442372B2 (en) † | 2003-08-29 | 2008-10-28 | Biomarin Pharmaceutical Inc. | Delivery of therapeutic compounds to the brain and other tissues |
| CN1922313B (zh) | 2004-02-10 | 2011-10-26 | 生物马林医药公司 | 酸性α-糖苷酶及其片段 |
| US20050208090A1 (en) * | 2004-03-18 | 2005-09-22 | Medtronic, Inc. | Methods and systems for treatment of neurological diseases of the central nervous system |
| JP2008503590A (ja) * | 2004-06-21 | 2008-02-07 | メドトロニック・インコーポレーテッド | 組成物を細胞にデリバリーするための医学用システム及び方法 |
| CN1308444C (zh) * | 2005-04-15 | 2007-04-04 | 中国人民解放军军事医学科学院野战输血研究所 | 基因重组α－半乳糖苷酶大批量发酵液的纯化方法 |
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| BRPI0618583A2 (pt) * | 2005-11-18 | 2011-09-06 | Tokyo Metropolitan Org Med Res | enzima altamente funcional tendo especifidade ao substrato modificada |
| WO2007086067A1 (en) * | 2006-01-30 | 2007-08-02 | Diagnostic Technologies Ltd. | Method for monitoring tocolytic treatment |
| US20090117091A1 (en) * | 2006-11-13 | 2009-05-07 | Lebowitz Jonathan | Methods for treating pompe disease |
| CN101861382B (zh) * | 2007-05-07 | 2015-07-15 | 普罗塔里克斯有限公司 | 大规模一次性生物反应器 |
| EP2185187A1 (en) * | 2007-08-29 | 2010-05-19 | Shire Human Genetic Therapies, Inc. | Subcutaneous administration of alpha-galatosidase a |
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