CN103396409B - 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 - Google Patents
作为akt蛋白激酶抑制剂的嘧啶基环戊烷 Download PDFInfo
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- CN103396409B CN103396409B CN201310128477.3A CN201310128477A CN103396409B CN 103396409 B CN103396409 B CN 103396409B CN 201310128477 A CN201310128477 A CN 201310128477A CN 103396409 B CN103396409 B CN 103396409B
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- ZUSWDTWYONAOPH-UHFFFAOYSA-N [2-(trifluoromethyl)phenyl]hydrazine;hydrochloride Chemical group [Cl-].[NH3+]NC1=CC=CC=C1C(F)(F)F ZUSWDTWYONAOPH-UHFFFAOYSA-N 0.000 claims description 10
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Classifications
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
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| US94813807P | 2007-07-05 | 2007-07-05 | |
| US60/948,138 | 2007-07-05 | ||
| US2008808P | 2008-01-09 | 2008-01-09 | |
| US61/020,088 | 2008-01-09 |
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| CN2008801058695A Division CN101801955B (zh) | 2007-07-05 | 2008-07-03 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
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| CN103396409A CN103396409A (zh) | 2013-11-20 |
| CN103396409B true CN103396409B (zh) | 2015-03-11 |
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| CN201310128477.3A Active CN103396409B (zh) | 2007-07-05 | 2008-07-03 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
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| EP (1) | EP2170863B1 (OSRAM) |
| JP (2) | JP5628028B2 (OSRAM) |
| KR (2) | KR20150089099A (OSRAM) |
| CN (2) | CN101801955B (OSRAM) |
| AR (1) | AR067413A1 (OSRAM) |
| AU (1) | AU2008272830B8 (OSRAM) |
| BR (1) | BRPI0813999A2 (OSRAM) |
| CA (1) | CA2692502C (OSRAM) |
| CO (1) | CO6251283A2 (OSRAM) |
| CR (1) | CR11229A (OSRAM) |
| EC (1) | ECSP109937A (OSRAM) |
| ES (1) | ES2551352T3 (OSRAM) |
| MA (1) | MA31679B1 (OSRAM) |
| NZ (1) | NZ582692A (OSRAM) |
| RU (1) | RU2486181C2 (OSRAM) |
| SG (1) | SG185274A1 (OSRAM) |
| TW (1) | TWI450720B (OSRAM) |
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| ES2729424T3 (es) | 2006-09-20 | 2019-11-04 | Aerie Pharmaceuticals Inc | Inhibidores de Rho cinasa |
| US8455513B2 (en) | 2007-01-10 | 2013-06-04 | Aerie Pharmaceuticals, Inc. | 6-aminoisoquinoline compounds |
| US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
| US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
| EP2242755B1 (en) | 2008-01-08 | 2012-09-12 | Array Biopharma, Inc. | Pyrrolopyridines as kinase inhibitors |
| WO2009089462A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | 5h-cyclopenta[d]pyrimidines as akt protein kinase inhibitors |
| CA2711692A1 (en) * | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentane as akt protein kinase inhibitor |
| WO2009089459A1 (en) | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
| JP5512545B2 (ja) * | 2008-01-09 | 2014-06-04 | アレイ バイオファーマ、インコーポレイテッド | Ａｋｔタンパク質キナーゼ阻害剤としてのピリミジルシクロペンタン類 |
| EP2242757B1 (en) | 2008-01-09 | 2012-08-01 | Array Biopharma, Inc. | Pyrazolopyridines as kinase inhibitors |
| US8450344B2 (en) | 2008-07-25 | 2013-05-28 | Aerie Pharmaceuticals, Inc. | Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds |
| CA2760562C (en) | 2009-05-01 | 2016-07-19 | Aerie Pharmaceuticals, Inc. | Dual mechanism inhibitors for the treatment of disease |
| KR20130058672A (ko) | 2010-04-16 | 2013-06-04 | 제넨테크, 인크. | ＰＩ3Ｋ/ＡＫＴ 키나제 경로 억제제 효능에 대한 예측 바이오마커로서의 ＦＯＸＯ３ａ |
| RU2635193C2 (ru) | 2011-04-01 | 2017-11-09 | Дженентек, Инк. | Биомаркеры для прогнозирования чувствительности к противоопухолевой терапии |
| HUE051254T2 (hu) | 2012-05-17 | 2021-03-01 | Genentech Inc | Egy AKT-gátló pirimidin-ciklopentán vegyület amorf formája, annak kompozíciói és eljárásai |
| US9452990B2 (en) | 2012-06-20 | 2016-09-27 | Novartis Ag | Complement pathway modulators and uses thereof |
| CA2901126C (en) | 2013-02-25 | 2022-01-25 | Genentech, Inc. | Methods and compositions for detecting and treating drug resistant akt mutant |
| PT3811943T (pt) | 2013-03-15 | 2023-03-15 | Aerie Pharmaceuticals Inc | Composto para uso no tratamento de distúrbios oculares |
| JP6832946B2 (ja) * | 2015-11-17 | 2021-02-24 | アエリエ ファーマシューティカルズ インコーポレイテッド | キナーゼ阻害剤およびその中間体の調製方法 |
| US9643927B1 (en) | 2015-11-17 | 2017-05-09 | Aerie Pharmaceuticals, Inc. | Process for the preparation of kinase inhibitors and intermediates thereof |
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