JP5628028B2 - Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン - Google Patents

Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン Download PDF

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JP5628028B2
JP5628028B2 JP2010515269A JP2010515269A JP5628028B2 JP 5628028 B2 JP5628028 B2 JP 5628028B2 JP 2010515269 A JP2010515269 A JP 2010515269A JP 2010515269 A JP2010515269 A JP 2010515269A JP 5628028 B2 JP5628028 B2 JP 5628028B2
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methyl
dihydro
cyclopenta
pyrimidin
piperazin
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JP2010532386A (ja
JP2010532386A5 (OSRAM
Inventor
ジョセフ ベンクシク，
ジョセフ ベンクシク，
ジェイムス エフ． ブレーク，
ジェイムス エフ． ブレーク，
ジェイムス エム． グラハム，
ジェイムス エム． グラハム，
マーティン エフ． ヘンテマン，
マーティン エフ． ヘンテマン，
ニコラス シー． カラン，
ニコラス シー． カラン，
イアン エス． ミッチェル，
イアン エス． ミッチェル，
スティーブン ティー． シェラクター，
スティーブン ティー． シェラクター，
キース エル． スペンサー，
キース エル． スペンサー，
デンミン シャオ，
デンミン シャオ，
ルイ スー，
ルイ スー，
マイク ウェルチ，
マイク ウェルチ，
ユン リャン，
ユン リャン，
ブライアン エス． サフィーナ，
ブライアン エス． サフィーナ，
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P35/00—Antineoplastic agents
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    • A61P37/02—Immunomodulators
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
JP2010515269A 2007-07-05 2008-07-03 Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン Active JP5628028B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US94813807P 2007-07-05 2007-07-05
US60/948,138 2007-07-05
US2008808P 2008-01-09 2008-01-09
US61/020,088 2008-01-09
PCT/US2008/069144 WO2009006567A2 (en) 2007-07-05 2008-07-03 Pyrimidyl cyclopentanes as akt protein kinase inhibitors

Related Child Applications (1)

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JP2013207007A Division JP2014028842A (ja) 2007-07-05 2013-10-02 Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン

Publications (3)

Publication Number Publication Date
JP2010532386A JP2010532386A (ja) 2010-10-07
JP2010532386A5 JP2010532386A5 (OSRAM) 2012-07-26
JP5628028B2 true JP5628028B2 (ja) 2014-11-19

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JP2010515269A Active JP5628028B2 (ja) 2007-07-05 2008-07-03 Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン
JP2013207007A Withdrawn JP2014028842A (ja) 2007-07-05 2013-10-02 Ａｋｔプロテインキナーゼ阻害剤としてのピリミジルシクロペンタン

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Country Status (19)

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US (1) US8618097B2 (OSRAM)
EP (1) EP2170863B1 (OSRAM)
JP (2) JP5628028B2 (OSRAM)
KR (2) KR20150089099A (OSRAM)
CN (2) CN103396409B (OSRAM)
AR (1) AR067413A1 (OSRAM)
AU (1) AU2008272830B8 (OSRAM)
BR (1) BRPI0813999A2 (OSRAM)
CA (1) CA2692502C (OSRAM)
CO (1) CO6251283A2 (OSRAM)
CR (1) CR11229A (OSRAM)
EC (1) ECSP109937A (OSRAM)
ES (1) ES2551352T3 (OSRAM)
MA (1) MA31679B1 (OSRAM)
NZ (1) NZ582692A (OSRAM)
RU (1) RU2486181C2 (OSRAM)
SG (1) SG185274A1 (OSRAM)
TW (1) TWI450720B (OSRAM)
WO (1) WO2009006567A2 (OSRAM)

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AU2019231689A1 (en) * 2018-03-06 2020-09-24 Icahn School Of Medicine At Mount Sinai Serine threonine kinase (AKT) degradation / disruption compounds and methods of use
JP7720698B2 (ja) * 2018-04-04 2025-08-08 アルビナス・オペレーションズ・インコーポレイテッド タンパク質分解の調節因子および関連する使用方法
WO2019246570A1 (en) 2018-06-21 2019-12-26 Icahn School Of Medicine At Mount Sinai Wd40 repeat domain protein 5 (wdr5) degradation / disruption compounds and methods of use
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