CN1033804A - 新的抗心律失常剂及其制备方法 - Google Patents

新的抗心律失常剂及其制备方法 Download PDF

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Publication number
CN1033804A
CN1033804A CN88108941A CN88108941A CN1033804A CN 1033804 A CN1033804 A CN 1033804A CN 88108941 A CN88108941 A CN 88108941A CN 88108941 A CN88108941 A CN 88108941A CN 1033804 A CN1033804 A CN 1033804A
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CN
China
Prior art keywords
compound
benzonitrile
amino
ethyl
propyl group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN88108941A
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English (en)
Chinese (zh)
Inventor
努特·奥利·塞韦德·艾尔姆格兰
本恩特·哥兰·杜克·杜卡
格特·克里斯特·斯特朗隆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hassle AB
Original Assignee
Hassle AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hassle AB filed Critical Hassle AB
Publication of CN1033804A publication Critical patent/CN1033804A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
CN88108941A 1987-12-23 1988-12-23 新的抗心律失常剂及其制备方法 Pending CN1033804A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8705150-4 1987-12-23
SE8705150A SE8705150D0 (sv) 1987-12-23 1987-12-23 Novel antiarrhythmic agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN94105497A Division CN1097736A (zh) 1987-12-23 1994-05-31 新的抗心律失常剂及其制备方法

Publications (1)

Publication Number Publication Date
CN1033804A true CN1033804A (zh) 1989-07-12

Family

ID=20370706

Family Applications (3)

Application Number Title Priority Date Filing Date
CN88108941A Pending CN1033804A (zh) 1987-12-23 1988-12-23 新的抗心律失常剂及其制备方法
CN89104335A Pending CN1048214A (zh) 1987-12-23 1989-06-22 新的抗心律失常药ii的制备方法
CN94105497A Pending CN1097736A (zh) 1987-12-23 1994-05-31 新的抗心律失常剂及其制备方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN89104335A Pending CN1048214A (zh) 1987-12-23 1989-06-22 新的抗心律失常药ii的制备方法
CN94105497A Pending CN1097736A (zh) 1987-12-23 1994-05-31 新的抗心律失常剂及其制备方法

Country Status (33)

Country Link
US (2) US5034411A (enExample)
EP (2) EP0322389B1 (enExample)
JP (2) JPH02502726A (enExample)
KR (2) KR900700441A (enExample)
CN (3) CN1033804A (enExample)
AR (1) AR247729A1 (enExample)
AT (2) ATE81848T1 (enExample)
AU (4) AU2824489A (enExample)
DD (2) DD277274A5 (enExample)
DE (2) DE3875934T2 (enExample)
DK (2) DK404789A (enExample)
EG (1) EG18681A (enExample)
ES (2) ES2043891T3 (enExample)
FI (2) FI893937A0 (enExample)
GR (2) GR3006241T3 (enExample)
HU (3) HUT54346A (enExample)
IE (2) IE883860L (enExample)
IL (2) IL88749A (enExample)
IS (1) IS1558B (enExample)
LT (4) LTIP1687A (enExample)
LV (1) LV10250A (enExample)
MX (1) MX174084B (enExample)
MY (1) MY103945A (enExample)
NO (2) NO171784C (enExample)
NZ (1) NZ227381A (enExample)
PH (2) PH25526A (enExample)
PL (2) PL157747B1 (enExample)
PT (2) PT89312B (enExample)
RU (3) RU1836342C (enExample)
SE (1) SE8705150D0 (enExample)
WO (3) WO1989005794A1 (enExample)
YU (2) YU47580B (enExample)
ZA (2) ZA889424B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE8902237D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel stereoisomers
SE8902235D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel cyclodextrin inclusion complexes
SE9003902D0 (sv) * 1990-12-07 1990-12-07 Astra Ab Solid dosage forms of a drug
SE8902236D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel polystyrenesulfonate
US5084463A (en) * 1989-12-11 1992-01-28 American Home Products Corporation N-quinolinyl alkyl-substituted 1-aryloxy-2-propanolamine and propylamine derivatives possessing class III antiarrhythmic activity
US5619274A (en) * 1990-09-10 1997-04-08 Starsight Telecast, Inc. Television schedule information transmission and utilization system and process
UA26190C2 (uk) * 1992-07-28 1999-07-19 Сейфтек Ай Лімітед Шприц
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US6143569A (en) * 1998-08-31 2000-11-07 The United States Of America As Represented By The Secretary Of The Navy Chelators exhibiting triple fluorescence
DE19947457A1 (de) * 1999-10-02 2001-04-05 Aventis Pharma Gmbh 2'-Substituierte 1,1'-Biphenyl-2-carbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie enthaltende pharmazeutische Zubereitungen
GB0123961D0 (en) 2001-10-05 2001-11-28 Astrazeneca Ab Process and intermediates
WO2004113305A2 (en) 2003-06-16 2004-12-29 Vertex Pharmaceuticals Incorporated Diamino substituted quinazoline derivatives as promoters of smn2
WO2005007215A2 (en) * 2003-07-09 2005-01-27 Glucolight Corporation Method and apparatus for tissue oximetry
RU2631231C1 (ru) * 2016-12-01 2017-09-19 Научно-производственная ассоциация "Технопарк Авиационных Технологий" Способ получения заготовки лопатки газотурбинного двигателя для линейной сварки трением
CN115417973B (zh) * 2022-11-03 2023-03-24 广东粤港澳大湾区黄埔材料研究院 抗菌聚氨酯材料及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149147A (en) * 1961-03-16 1964-09-15 Smith Kline French Lab Novel substituted phenylalkylamines
FR152F (enExample) * 1962-01-24
GB1069345A (en) * 1963-07-19 1967-05-17 Ici Ltd New alkanolamine derivatives
DE1593771A1 (de) * 1967-04-06 1970-04-30 Boehringer Sohn Ingelheim Verfahren zur Herstellung von 1-Phenoxy-2-amino-alkanen
BE757005A (fr) * 1969-10-02 1971-04-02 Bristol Myers Co Phenethanolamines substituees et procede pour leur preparation
GB1457876A (en) * 1972-12-15 1976-12-08 Ici Ltd Alkanolamine derivatives device for use in
SE404793B (sv) * 1973-05-25 1978-10-30 Boehringer Sohn Ingelheim Forfarande for framstellning av vissa angivna nitrilsubstituerade 1-fenoxi-2-hydroxi-3-lagalkylaminopropaner
GB1433920A (en) * 1973-10-01 1976-04-28 Ici Ltd Alkanolamine derivatives
FR2280376A1 (fr) * 1974-08-02 1976-02-27 Sogeras Nouveaux derives du piperidine-4 ethanol
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
SE421123B (sv) * 1976-08-25 1981-11-30 Boehringer Sohn Ingelheim Forfarande for framstellning av vissa angivna nitrilsubstituerade 1-fenoxi-2-hydroxi-3-alkylaminopropaner
US4283534A (en) * 1979-04-11 1981-08-11 Basf Aktiengesellschaft Reductive alkylation of nitrogen heterocycles
US4544654A (en) * 1984-03-20 1985-10-01 Schering A.G. Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof
US4614746A (en) * 1985-03-21 1986-09-30 American Cyanamid Company 5-fluorobenzonitrile derivatives for increasing the lean meat to fat ratio and/or enhancing the growth rate of warm-blooded animals
CA1267416A (en) * 1985-06-17 1990-04-03 Ila Sircar 1,4-dihydropyridine derivatives useful for the treatment of cardiovascular disorders
EG18188A (en) * 1986-05-01 1992-09-30 Pfizer Ltd Process for preparation anti-arhythmia agents
SE8705150D0 (sv) * 1987-12-23 1987-12-23 Haessle Ab Novel antiarrhythmic agents
SE8902236D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel polystyrenesulfonate
SE8902237D0 (sv) * 1989-06-20 1989-06-20 Haessle Ab Novel stereoisomers

Also Published As

Publication number Publication date
CN1048214A (zh) 1991-01-02
IS3425A7 (is) 1989-06-24
PT89311A (pt) 1989-12-29
LTIP1720A (en) 1995-07-25
AU2910389A (en) 1989-07-19
PL159551B1 (pl) 1992-12-31
GR3006912T3 (enExample) 1993-06-30
NO171724C (no) 1993-04-28
PL276698A1 (en) 1989-08-07
NO893376L (no) 1989-08-22
US5034411A (en) 1991-07-23
HU205895B (en) 1992-07-28
AU625774B2 (en) 1992-07-16
RU1836342C (ru) 1993-08-23
MY103945A (en) 1993-10-30
MX14310A (es) 1993-10-01
RU1836343C (ru) 1993-08-23
DE3875934D1 (de) 1992-12-17
EP0322389B1 (en) 1992-10-28
EP0322390B1 (en) 1992-11-11
PH25526A (en) 1991-07-24
JPH02502725A (ja) 1990-08-30
HU913679D0 (en) 1992-02-28
GR3006241T3 (enExample) 1993-06-21
FI893937A7 (fi) 1989-08-22
EP0322389A3 (en) 1989-09-06
LTIP1688A (en) 1995-07-25
ZA894441B (en) 1990-02-28
FI893936A0 (fi) 1989-08-22
LTIP1687A (en) 1995-07-25
PL157747B1 (pl) 1992-06-30
NO171784B (no) 1993-01-25
CN1097736A (zh) 1995-01-25
HUT54346A (en) 1991-02-28
AU2824189A (en) 1989-07-19
LV10250A (lv) 1994-10-20
DE3875600D1 (de) 1992-12-03
HUT54345A (en) 1991-02-28
PT89311B (pt) 1993-08-31
DK404889D0 (da) 1989-08-17
DK404789A (da) 1989-10-19
DK404789D0 (da) 1989-08-17
NZ227381A (en) 1992-07-28
FI893937L (fi) 1989-08-22
WO1989005794A1 (en) 1989-06-29
YU47580B (sh) 1995-10-24
YU19690A (en) 1992-05-28
SE8705150D0 (sv) 1987-12-23
PT89312B (pt) 1993-08-31
NO893375D0 (no) 1989-08-22
FI893936A7 (fi) 1989-08-22
ATE81848T1 (de) 1992-11-15
IL103741A (en) 1994-04-12
MX174084B (es) 1994-04-20
IE883860L (en) 1989-06-23
AU2824489A (en) 1989-07-19
AU625872B2 (en) 1992-07-16
FI92192B (fi) 1994-06-30
RU2024503C1 (ru) 1994-12-15
KR900700442A (ko) 1990-08-13
US5155133A (en) 1992-10-13
PH26828A (en) 1992-11-05
FI92192C (sv) 1994-10-10
WO1989005795A1 (en) 1989-06-29
EP0322390A3 (en) 1989-09-06
NO893375L (no) 1989-08-22
KR900700441A (ko) 1990-08-13
ZA889424B (en) 1989-08-30
NO171724B (no) 1993-01-18
IE883859L (en) 1989-06-23
NO893376D0 (no) 1989-08-22
DD277274A5 (de) 1990-03-28
DK404889A (da) 1989-10-19
DE3875934T2 (de) 1993-03-25
DE3875600T2 (de) 1993-03-11
JPH0637458B2 (ja) 1994-05-18
ES2043891T3 (es) 1994-01-01
WO1989005806A1 (en) 1989-06-29
DD295353A5 (de) 1991-10-31
FI893937A0 (fi) 1989-08-22
IS1558B (is) 1994-10-05
LTIP1752A (en) 1995-07-25
NO171784C (no) 1993-05-05
ES2045189T3 (es) 1994-01-16
JPH02502726A (ja) 1990-08-30
EP0322389A2 (en) 1989-06-28
EP0322390A2 (en) 1989-06-28
YU234088A (en) 1990-06-30
EG18681A (en) 1993-10-30
IL88749A (en) 1994-04-12
AR247729A1 (es) 1995-03-31
PT89312A (pt) 1989-12-29
ATE82257T1 (de) 1992-11-15

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