CN103271906A - 螺-吲哚酮化合物作为治疗剂的用途 - Google Patents
螺-吲哚酮化合物作为治疗剂的用途 Download PDFInfo
- Publication number
- CN103271906A CN103271906A CN2013101646702A CN201310164670A CN103271906A CN 103271906 A CN103271906 A CN 103271906A CN 2013101646702 A CN2013101646702 A CN 2013101646702A CN 201310164670 A CN201310164670 A CN 201310164670A CN 103271906 A CN103271906 A CN 103271906A
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- Prior art keywords
- alkyl
- heteroaryl
- cyclic hydrocarbon
- heterocyclic radical
- aryl
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US85178706P | 2006-10-12 | 2006-10-12 | |
US60/851,787 | 2006-10-12 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780038111A Division CN101631546A (zh) | 2006-10-12 | 2007-10-12 | 螺-吲哚酮化合物作为治疗剂的用途 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN103271906A true CN103271906A (zh) | 2013-09-04 |
Family
ID=39339863
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2013101646702A Pending CN103271906A (zh) | 2006-10-12 | 2007-10-12 | 螺-吲哚酮化合物作为治疗剂的用途 |
CN200780038111A Pending CN101631546A (zh) | 2006-10-12 | 2007-10-12 | 螺-吲哚酮化合物作为治疗剂的用途 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200780038111A Pending CN101631546A (zh) | 2006-10-12 | 2007-10-12 | 螺-吲哚酮化合物作为治疗剂的用途 |
Country Status (14)
Country | Link |
---|---|
US (1) | US8466188B2 (pt-PT) |
EP (1) | EP2073806B1 (pt-PT) |
JP (2) | JP5460324B2 (pt-PT) |
CN (2) | CN103271906A (pt-PT) |
AR (1) | AR063280A1 (pt-PT) |
AT (1) | ATE545416T1 (pt-PT) |
AU (1) | AU2007319580B2 (pt-PT) |
BR (1) | BRPI0719210A2 (pt-PT) |
CA (1) | CA2665698A1 (pt-PT) |
CL (1) | CL2007002950A1 (pt-PT) |
MX (1) | MX2009003876A (pt-PT) |
RU (1) | RU2009117642A (pt-PT) |
TW (1) | TW200833695A (pt-PT) |
WO (1) | WO2008060789A2 (pt-PT) |
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EP2350091B1 (en) * | 2008-10-17 | 2015-06-03 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
US8263606B2 (en) | 2008-10-17 | 2012-09-11 | Xenon Pharmaceuticals Inc. | Spiro-oxindole compounds and their use as therapeutic agents |
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AR077252A1 (es) * | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
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CN102321095B (zh) * | 2011-05-26 | 2014-09-10 | 兰州大学 | 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用 |
GB2499666A (en) * | 2012-02-27 | 2013-08-28 | Nanyang Polytechnic | Mcl-1 inhibitors for the treatment of conditions associated with proliferative disorders |
CN104350057A (zh) | 2012-04-12 | 2015-02-11 | 泽农医药公司 | 用作治疗剂的螺-羟吲哚化合物的不对称合成 |
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CN103554121B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物及其应用 |
CN103554120B (zh) * | 2013-10-16 | 2015-06-24 | 华东师范大学 | 3,3-螺(2-四氢呋喃)氧化吲哚多环状化合物的制备方法 |
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AR063280A1 (es) | 2009-01-21 |
US8466188B2 (en) | 2013-06-18 |
EP2073806B1 (en) | 2012-02-15 |
MX2009003876A (es) | 2009-05-11 |
TW200833695A (en) | 2008-08-16 |
ATE545416T1 (de) | 2012-03-15 |
CN101631546A (zh) | 2010-01-20 |
AU2007319580B2 (en) | 2012-11-29 |
BRPI0719210A2 (pt) | 2015-05-05 |
JP2013256539A (ja) | 2013-12-26 |
WO2008060789A3 (en) | 2008-07-24 |
US20100173967A1 (en) | 2010-07-08 |
US20110172282A9 (en) | 2011-07-14 |
RU2009117642A (ru) | 2010-11-20 |
JP2010506854A (ja) | 2010-03-04 |
CA2665698A1 (en) | 2008-05-22 |
AU2007319580A1 (en) | 2008-05-22 |
JP5460324B2 (ja) | 2014-04-02 |
EP2073806A2 (en) | 2009-07-01 |
CL2007002950A1 (es) | 2008-02-01 |
WO2008060789A2 (en) | 2008-05-22 |
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