CN102600104A - 可咀嚼的软胶囊 - Google Patents
可咀嚼的软胶囊 Download PDFInfo
- Publication number
- CN102600104A CN102600104A CN2012100748526A CN201210074852A CN102600104A CN 102600104 A CN102600104 A CN 102600104A CN 2012100748526 A CN2012100748526 A CN 2012100748526A CN 201210074852 A CN201210074852 A CN 201210074852A CN 102600104 A CN102600104 A CN 102600104A
- Authority
- CN
- China
- Prior art keywords
- gelatin
- soft capsules
- substrate
- chewable soft
- gel formation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/12—Mucolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Abstract
Description
成分 | wt% |
凝胶形成用组合物 | 15-80 |
聚合物改性剂 | 0.1-10 |
增塑剂 | 5-40 |
水 | 5-30 |
活性成分 | 0.01-70 |
其它成分,如,工业已知的风味剂,甜味剂和味道遮蔽剂 | 0.01-15 |
成分 | wt% |
凝胶形成用组合物 | 25-55 |
增塑剂 | 5-40 |
水 | 15-40 |
其它成分,如,着色剂,风味剂或甜味剂 | 0.1-10 |
成分 | wt% |
凝胶形成用组合物 | 30-70 |
聚合物改性剂 | 0.25-5 |
增塑剂 | 10-30 |
水 | 5-15 |
活性成分 | 1-25 |
其它成分 | 0.1-5 |
成分 | wt% |
凝胶形成用组合物 | 10-70 |
增塑剂 | 10-30 |
水 | 5-15 |
其它成分 | 0.1-10 |
成分 | wt% |
第一凝胶形成用聚合物 | 20-80 |
第二凝胶形成用聚合物 | 5-25 |
第一增塑剂 | 10-40 |
第二增塑剂 | 1-10 |
聚合物改性剂 | 0.5-10 |
活性成分 | 0.01-70 |
其它成分 | 0.1-15 |
水 | 5-20 |
1 | 2 | 3 | 4 | 5 | |
组分 | |||||
明胶 | 5.9 | 10 | 10 | 10 | 0 |
完全明胶水解物 | 5.9 | 10 | 10 | 10 | 10 |
山梨糖醇 | 14.1 | 10 | 20 | 0 | 10 |
甘油 | 5.9 | 0 | 10 | 10 | 10 |
水 | |||||
柠檬酸 | 1.4 | 1.0 | 1.0 | 1.0 | 1.0 |
硬度(g),通过质地分析仪 | 4 | 103 | 7 | 59 | 1 |
基质组合物 | 外鞘组合物 | |||
甘油 | 27.1 | 甘油 | 16.96 | |
明胶(60-80起霜值) | 9.03 | 山梨糖醇 | 16.96 | |
山梨糖醇 | 9.03 | 明胶(100起霜值) | 39.92 | |
凝胶水解物 | 27.1 | 柠檬酸 | 1 | |
柠檬酸 | 1.79 | 水 | 24.95 | |
三氯蔗糖(sucralose) | 0.15 | 香精 | 0.2 | |
水(干燥前) | 25.58 | 色料 | 0.004 | |
香精 | 0.2 | |||
色料 | 0.004 |
Claims (13)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37547902P | 2002-04-25 | 2002-04-25 | |
US60/375,479 | 2002-04-25 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038118246A Division CN1655770A (zh) | 2002-04-25 | 2003-04-24 | 可咀嚼的软胶囊 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102600104A true CN102600104A (zh) | 2012-07-25 |
CN102600104B CN102600104B (zh) | 2015-06-24 |
Family
ID=29270648
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038118246A Pending CN1655770A (zh) | 2002-04-25 | 2003-04-24 | 可咀嚼的软胶囊 |
CN201210074852.6A Expired - Lifetime CN102600104B (zh) | 2002-04-25 | 2003-04-24 | 可咀嚼的软胶囊 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA038118246A Pending CN1655770A (zh) | 2002-04-25 | 2003-04-24 | 可咀嚼的软胶囊 |
Country Status (9)
Country | Link |
---|---|
US (8) | US8097279B2 (zh) |
EP (1) | EP1496873B2 (zh) |
JP (1) | JP4995407B2 (zh) |
CN (2) | CN1655770A (zh) |
AT (1) | ATE387191T1 (zh) |
AU (1) | AU2003231126A1 (zh) |
DE (1) | DE60319355T3 (zh) |
ES (1) | ES2302926T5 (zh) |
WO (1) | WO2003090726A2 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107375229A (zh) * | 2017-06-26 | 2017-11-24 | 仙乐健康科技股份有限公司 | 一种咀嚼植物软胶囊及其制备方法 |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6616942B1 (en) * | 1999-03-29 | 2003-09-09 | Soft Gel Technologies, Inc. | Coenzyme Q10 formulation and process methodology for soft gel capsules manufacturing |
DE60319355T3 (de) * | 2002-04-25 | 2012-01-05 | Banner Pharmacaps Inc. | Kaubare weichkapsel |
US20080089877A1 (en) * | 2003-08-14 | 2008-04-17 | Udell Ronald G | Super Absorption Coenzyme Q10 |
US7169385B2 (en) * | 2003-09-29 | 2007-01-30 | Ronald G. Udell | Solubilized CoQ-10 and carnitine |
US8124072B2 (en) | 2003-09-29 | 2012-02-28 | Soft Gel Technologies, Inc. | Solubilized CoQ-10 |
EP1670325A1 (en) | 2003-09-29 | 2006-06-21 | Soft Gel Technologies, Inc. | SOLUBILIZED CoQ-10 |
US9241902B2 (en) * | 2003-12-17 | 2016-01-26 | R.P. Scherer Technologies, Llc | Chewable soft capsules containing ungelatinized starch |
US20060078608A1 (en) * | 2004-10-08 | 2006-04-13 | Jonathan Gilinski | Flavored gelatin capsule and method for producing said capsule |
US7485323B2 (en) | 2005-05-31 | 2009-02-03 | Gelita Ag | Process for making a low molecular weight gelatine hydrolysate and gelatine hydrolysate compositions |
US20070082982A1 (en) * | 2005-10-11 | 2007-04-12 | The Procter & Gamble Company | Water stable compositions and articles comprising starch and methods of making the same |
US20080020022A1 (en) * | 2006-06-05 | 2008-01-24 | Udell Ronald G | Chewable co-enzyme q-10 capsule |
US20070292501A1 (en) * | 2006-06-05 | 2007-12-20 | Udell Ronald G | Chewable soft gelatin capsules |
PE20081482A1 (es) * | 2006-12-20 | 2008-12-23 | Novartis Ag | Capsulas de gelatina que contienen un acido |
US8343541B2 (en) * | 2007-03-15 | 2013-01-01 | Soft Gel Technologies, Inc. | Ubiquinol and alpha lipoic acid compositions |
US8969324B2 (en) * | 2007-07-19 | 2015-03-03 | R-Tech Ueno, Ltd. | Pharmaceutical composition comprising 11-deoxy-prostaglandin compound and method for stabilizing the compound |
JP2010260812A (ja) * | 2009-05-01 | 2010-11-18 | Nakanihon Capsule Co Ltd | ソフトカプセル |
GB201006218D0 (en) * | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
GB201008049D0 (en) * | 2010-05-13 | 2010-06-30 | Ayanda As | Composition |
JP5618402B2 (ja) * | 2010-06-24 | 2014-11-05 | 三生医薬株式会社 | 咀嚼性ソフトカプセル剤の製造方法 |
JP5876695B2 (ja) * | 2011-09-29 | 2016-03-02 | 森下仁丹株式会社 | シームレスカプセルおよびその製造方法 |
EP3069708B1 (en) * | 2011-10-06 | 2018-05-09 | Combocap, Inc. | Capsule |
WO2013163240A1 (en) * | 2012-04-25 | 2013-10-31 | Church & Dwight Co., Inc. | Center-in-shell chewable compositions with functional components |
EP2968185A4 (en) * | 2013-03-15 | 2016-08-31 | Jaffe Russell M | ENCAPSULATION OF GEL MOU |
WO2014190324A2 (en) | 2013-05-23 | 2014-11-27 | Barlean's Organic Oils, Llc | Rotary die system |
EP3188718A1 (en) * | 2014-09-05 | 2017-07-12 | Santa Cruz Pharmaceuticals Inc. | Semi-solid chewable dosage form for over-the-counter medications and methods for producing same |
BR112017008715A2 (pt) | 2014-10-31 | 2018-01-30 | Barleans Organic Oils Llc | método e aparelho para a fabricação de cápsulas moles |
EP3682872B1 (en) * | 2015-03-26 | 2024-01-03 | Patheon Softgels Inc. | Liquisoft capsules |
CN106135376B (zh) * | 2015-03-30 | 2019-03-22 | 维斯克凡科技(苏州)有限公司 | 用于可食性胶原肠衣的端部封闭部以及获得该端部封闭部的方法 |
AU2016246580B2 (en) * | 2015-04-07 | 2020-12-17 | Church & Dwight Co., Inc. | Multicomponent gummy compositions with hard core |
US9867834B2 (en) | 2015-06-15 | 2018-01-16 | Banner Life Sciences Llc | Non-systemic topical compositions comprising corticosteroids |
WO2016205172A1 (en) * | 2015-06-15 | 2016-12-22 | Banner Life Sciences Llc | Soft lozenges comprising corticosteroids |
US11273123B2 (en) | 2018-07-18 | 2022-03-15 | USpharma Ltd | Chewable pharmaceutical dosage forms |
CN110150703B (zh) * | 2019-05-13 | 2021-08-31 | 广州普正生物科技有限公司 | 一种防粘连咀嚼软胶囊皮及其制备方法 |
CN112336700B (zh) * | 2019-08-08 | 2023-12-01 | 河北菲尼斯生物技术有限公司 | 一种稳定的含丁苯酞药物及其制备方法 |
US11316894B1 (en) | 2019-09-03 | 2022-04-26 | Trend Micro Incorporated | System and method for detecting leakage of email addresses |
US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
EP4243602A1 (en) * | 2020-11-16 | 2023-09-20 | Orcosa Inc. | Improved use of cannabinoids in the treatment of alzheimer's disease |
Family Cites Families (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3126321A (en) | 1964-03-24 | Table vii | ||
US730826A (en) | 1903-01-21 | 1903-06-09 | Coronation Embroidery Hoop Company | Means for holding embroidery goods. |
US1061111A (en) | 1912-12-10 | 1913-05-06 | Gummi U S A Ltd | Manufacture of elastic materials. |
US2349430A (en) | 1941-05-15 | 1944-05-23 | Eastman Kodak Co | Medical capsule |
GB610538A (en) | 1945-11-05 | 1948-10-18 | Gelatin Products Corp | Enteric gelatin capsule shell or envelope |
FR959520A (zh) | 1947-01-11 | 1950-03-31 | ||
US2851364A (en) | 1956-06-21 | 1958-09-09 | Foremost Dairies Inc | Gelatin product and process of manufacture |
US2853421A (en) | 1956-10-04 | 1958-09-23 | Merck & Co Inc | Gelatin pan coating |
US3057723A (en) | 1959-06-24 | 1962-10-09 | Eastman Kodak Co | Hardening of gelatin with oxystarch |
US3138532A (en) * | 1962-04-02 | 1964-06-23 | Hoffmann La Roche | Water-dispersible gelatin compositions containing fat-soluble vitamin-active material, and preparation of droplets and beadlets |
US3228789A (en) | 1962-10-22 | 1966-01-11 | Jacob A Glassman | Peroral capsules and tablets and the method for making same |
US3427378A (en) | 1965-02-12 | 1969-02-11 | American Cyanamid Co | Sustained release encapsulated formula |
JPS444408Y1 (zh) * | 1967-01-28 | 1969-02-18 | ||
US3515781A (en) | 1967-10-12 | 1970-06-02 | Johnson & Johnson | Cold capsule |
US3851051A (en) † | 1970-07-17 | 1974-11-26 | Scherer R Corp | Soft gelatin capsule containing high water content fill |
US3765917A (en) | 1970-11-24 | 1973-10-16 | Ken Hayashibara O | Shaped body of gelatin containing amylose and/or amylitol |
SU432703A3 (zh) | 1971-08-24 | 1974-06-15 | Фридрих Боссерт, Вульф Фатер, Курт Бауер | |
US3865603A (en) | 1972-07-17 | 1975-02-11 | Nat Starch Chem Corp | Modified starch-extended gelatin compositions |
US4198391A (en) | 1973-07-20 | 1980-04-15 | R. P. Scherer Ltd. | Pharmaceutical compositions |
NL7510104A (nl) | 1975-08-27 | 1977-03-01 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat. |
JPS5238954A (en) | 1975-09-23 | 1977-03-25 | Mitsutoyo Mfg Co Ltd | Cam measuring device |
US4187119A (en) | 1976-05-13 | 1980-02-05 | Service D'exploitation Industrielle Des Tabacs Et Des Allumettes | Glue for articles in the tobacco industry |
US4246410A (en) * | 1976-06-01 | 1981-01-20 | Ciba -Geigy Aktiengesellschaft | Naphtholactam dyestuffs |
FR2444080A1 (fr) | 1978-12-11 | 1980-07-11 | Roquette Freres | Hydrolysat d'amidon hydrogene non cariogene pour la confiserie et procede de preparation de cet hydrolysat |
US4346116A (en) | 1978-12-11 | 1982-08-24 | Roquette Freres | Non-cariogenic hydrogenated starch hydrolysate, process for the preparation and applications of this hydrolysate |
JPS5944096B2 (ja) * | 1979-12-24 | 1984-10-26 | 森下仁丹株式会社 | 親水性物質を充填物とするゼラチンカプセルの製造方法 |
US4374146A (en) | 1980-11-26 | 1983-02-15 | Burroughs Wellcome Co. | Topical inflammatory pharmaceutical formulations |
US4428927A (en) | 1981-05-11 | 1984-01-31 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4532126A (en) | 1982-05-07 | 1985-07-30 | R. P. Scherer Corporation | Masticatory soft elastic gelatin capsules and method for the manufacture thereof |
US4450179A (en) | 1982-06-25 | 1984-05-22 | Nabisco Brands, Inc. | Two component soft candy |
JPS5939834A (ja) * | 1982-08-31 | 1984-03-05 | Morishita Jintan Kk | 製剤用皮膜組成物 |
JPS5944096A (ja) | 1982-09-06 | 1984-03-12 | ヤマハ株式会社 | 電子楽器のデイジタルフイルタ装置 |
US4719112A (en) | 1982-10-29 | 1988-01-12 | Warner-Lambert Company | Foam capsules |
FR2535608B1 (fr) | 1982-11-04 | 1986-05-02 | Dubarry Philippe | Capsule a base de xylitol adapte a la succion par l'homme, son procede d'obtention et dispositif pour la mise en oeuvre de ce procede |
DE3307353C2 (de) | 1983-03-02 | 1985-01-31 | R.P. Scherer GmbH, 6930 Eberbach | Polyethylenglykolhaltige Weichgelatinekapsel und Verfahren zu ihrer Herstellung |
GB8305693D0 (en) | 1983-03-02 | 1983-04-07 | Scherer Ltd R P | Pharmaceutical compositions |
US4486412A (en) | 1983-03-15 | 1984-12-04 | Pharmacaps, Inc. | Encapsulated antacid dispersions |
US4673438A (en) | 1984-02-13 | 1987-06-16 | Warner-Lambert Company | Polymer composition for injection molding |
US4595583A (en) | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
JPS60239418A (ja) * | 1984-05-15 | 1985-11-28 | Nippon Kayaku Co Ltd | エトポシド軟カプセル製剤 |
FR2575180B1 (fr) | 1984-12-20 | 1987-02-06 | Roquette Freres | Produit a haute teneur en maltitol, ses applications et son procede de fabrication |
JPS61189230A (ja) * | 1985-02-19 | 1986-08-22 | Nippon Kayaku Co Ltd | エトポシド製剤 |
DE3529694A1 (de) | 1985-08-20 | 1987-02-26 | Scherer Gmbh R P | Gelatinekapseln und verfahren zu ihrer herstellung |
US4778676A (en) * | 1985-12-20 | 1988-10-18 | Warner-Lambert Company | Confectionery delivery system for actives |
US4795642A (en) | 1986-05-01 | 1989-01-03 | Pharmacaps, Inc. | Gelatin-encapsulated controlled-release composition |
US4708834A (en) | 1986-05-01 | 1987-11-24 | Pharmacaps, Inc. | Preparation of gelatin-encapsulated controlled release composition |
DE3629386A1 (de) * | 1986-08-29 | 1988-03-03 | Scherer Gmbh R P | Gelatinekapseln und verfahren zu ihrer herstellung |
US5071643A (en) | 1986-10-17 | 1991-12-10 | R. P. Scherer Corporation | Solvent system enhancing the solubility of pharmaceuticals for encapsulation |
JPS6420078A (en) | 1987-03-26 | 1989-01-24 | Suntory Ltd | Hydrophilic material-containing soft capsule |
US4950689A (en) | 1987-03-31 | 1990-08-21 | Yang Robert K | Pectin delivery system |
US4935243A (en) | 1988-12-19 | 1990-06-19 | Pharmacaps, Inc. | Chewable, edible soft gelatin capsule |
EP0380219B1 (en) | 1989-01-24 | 1995-10-11 | SPI POLYOLS, Inc. | Cryoprotectant sorbitol crystal spherules |
GB8909793D0 (en) | 1989-04-28 | 1989-06-14 | Beecham Group Plc | Pharmaceutical formulation |
ES2097155T3 (es) † | 1989-10-02 | 1997-04-01 | Cima Labs Inc | Forma de dosificacion efervescente y metodo de administracion. |
JPH04145017A (ja) | 1990-10-03 | 1992-05-19 | Shiseido Co Ltd | ゼラチンカプセル組成物 |
JPH04364131A (ja) * | 1991-04-03 | 1992-12-16 | Sanwa Kagaku Kenkyusho Co Ltd | 易吸収性モチリン製剤 |
US5236719A (en) * | 1991-09-27 | 1993-08-17 | Wm. Wrigley Jr. Company | Chewing gum and other comestibles containing purified indigestible dextrin |
JP3136310B2 (ja) * | 1992-02-26 | 2001-02-19 | 東洋カプセル株式会社 | 咀嚼服用に適した担体 |
US5837277A (en) | 1992-06-04 | 1998-11-17 | Smithkline Beecham Corporation | Palatable pharmaceutical compositions |
US5376688A (en) | 1992-12-18 | 1994-12-27 | R. P. Scherer Corporation | Enhanced solubility pharmaceutical solutions |
US5496558A (en) * | 1993-03-02 | 1996-03-05 | Block Drug Company Inc. | Solid form xerostomia product |
US5955089A (en) | 1993-04-20 | 1999-09-21 | Uab Research Foundation | Strain selection of pneumococcal surface proteins |
JPH0730826A (ja) | 1993-07-06 | 1995-01-31 | Toshiba Corp | テレビジョン信号受信装置 |
EP0713389A4 (en) | 1993-08-13 | 1997-05-21 | Bayer Ag | HYDROLYSED GELATINE AS A TASTE IMPROVER IN A CHEWABLE TABLET |
JPH0844096A (ja) | 1994-07-29 | 1996-02-16 | Ricoh Co Ltd | 電子写真感光体および電子写真装置 |
US5637313A (en) | 1994-12-16 | 1997-06-10 | Watson Laboratories, Inc. | Chewable dosage forms |
US5736688A (en) | 1995-08-02 | 1998-04-07 | The Graphics Technology Company, Inc. | Curvilinear linearization device for touch systems |
US5955098A (en) | 1996-04-12 | 1999-09-21 | Flemington Pharmaceutical Corp. | Buccal non polar spray or capsule |
WO1997038662A2 (en) | 1996-04-12 | 1997-10-23 | Flemington Pharmaceutical Corporation | Buccal polar spray or capsule |
JP3555640B2 (ja) | 1996-05-10 | 2004-08-18 | ライオン株式会社 | 天然カロチノイドを包含した多芯型構造のマイクロカプセル並びに錠剤、食品用及び医薬品用配合剤 |
GB9610441D0 (en) * | 1996-05-17 | 1996-07-24 | Tbs Eng Ltd | Loading apparatus |
JP3370517B2 (ja) | 1996-06-14 | 2003-01-27 | ペンタックス株式会社 | サーマルラインプリンタの構造 |
JP2999414B2 (ja) | 1996-07-09 | 2000-01-17 | 核燃料サイクル開発機構 | 光化学分離抽出装置 |
WO1998002185A1 (fr) | 1996-07-12 | 1998-01-22 | Daiichi Pharmaceutical Co., Ltd. | Materiaux moules par compression, a desagregation rapide, et leur procede de production |
US5753255A (en) | 1997-02-11 | 1998-05-19 | Chavkin; Leonard | Chewable molded tablet containing medicinally active substances |
US6027746A (en) | 1997-04-23 | 2000-02-22 | Warner-Lambert Company | Chewable soft gelatin-encapsulated pharmaceutical adsorbates |
US5928664A (en) | 1998-02-11 | 1999-07-27 | Fuisz Technologies Ltd. | Consumable gummy delivery system |
US6020003A (en) | 1998-02-23 | 2000-02-01 | Basf Corporation | Method of making spray-dried powders with high edible-oil loadings based on non-hydrolyzed gelatin |
US6432442B1 (en) | 1998-02-23 | 2002-08-13 | Mcneil-Ppc, Inc. | Chewable product |
US5948388A (en) | 1998-06-12 | 1999-09-07 | Soft Gel Technologies, Inc. | Chewable softgel oral hygiene product |
GB2338896B (en) | 1998-07-02 | 2003-05-21 | Reckitt & Colmann Prod Ltd | Chewable Capsules |
US6060078A (en) | 1998-09-28 | 2000-05-09 | Sae Han Pharm Co., Ltd. | Chewable tablet and process for preparation thereof |
US6258380B1 (en) | 1999-03-05 | 2001-07-10 | Banner Pharmacaps, Inc. | Chewable soft capsule |
US6132442A (en) | 1999-03-25 | 2000-10-17 | Smith & Nephew | Graft clamp |
US6322806B1 (en) | 1999-04-06 | 2001-11-27 | Wm. Wrigley Jr. Company | Over-coated chewing gum formulations including tableted center |
CA2376261A1 (en) * | 1999-06-09 | 2000-12-14 | Mochida Pharmaceutical Co., Ltd. | System for release in lower gastrointestinal tract |
US6251426B1 (en) * | 1999-09-02 | 2001-06-26 | Banner Pharmacaps, Inc. | Ibuprofen-containing softgels |
US6322828B1 (en) | 1999-09-13 | 2001-11-27 | Deseret Laboratories, Inc. | Process for manufacturing a pharmaceutical chewing gum |
ES2242371T3 (es) | 1999-11-19 | 2005-11-01 | Swiss Caps Rechte Und Lizenzen Ag | Procedimiento para producir un cuerpo moldeado que contiene almidon, masa homogeneizada que contiene almidon y dispostivo para prooducir una capsula blanda. |
IT1320163B1 (it) † | 2000-02-15 | 2003-11-18 | Novamont Spa | Foglia e prodotti formati a base di amido espanso. |
DE60319355T3 (de) * | 2002-04-25 | 2012-01-05 | Banner Pharmacaps Inc. | Kaubare weichkapsel |
US20040076664A1 (en) | 2002-10-22 | 2004-04-22 | Bonura Michael P. | Chewable, soft gel, high potency vitamins and method of manufacture |
US9241902B2 (en) | 2003-12-17 | 2016-01-26 | R.P. Scherer Technologies, Llc | Chewable soft capsules containing ungelatinized starch |
US20070292501A1 (en) | 2006-06-05 | 2007-12-20 | Udell Ronald G | Chewable soft gelatin capsules |
-
2003
- 2003-04-24 DE DE2003619355 patent/DE60319355T3/de not_active Expired - Lifetime
- 2003-04-24 ES ES03724255T patent/ES2302926T5/es not_active Expired - Lifetime
- 2003-04-24 CN CNA038118246A patent/CN1655770A/zh active Pending
- 2003-04-24 US US10/512,318 patent/US8097279B2/en active Active
- 2003-04-24 EP EP03724255A patent/EP1496873B2/en not_active Expired - Lifetime
- 2003-04-24 CN CN201210074852.6A patent/CN102600104B/zh not_active Expired - Lifetime
- 2003-04-24 AT AT03724255T patent/ATE387191T1/de not_active IP Right Cessation
- 2003-04-24 AU AU2003231126A patent/AU2003231126A1/en not_active Abandoned
- 2003-04-24 JP JP2003587363A patent/JP4995407B2/ja not_active Expired - Lifetime
- 2003-04-24 WO PCT/US2003/012983 patent/WO2003090726A2/en active IP Right Grant
-
2011
- 2011-10-10 US US13/270,005 patent/US8241665B2/en not_active Expired - Lifetime
- 2011-12-15 US US13/327,293 patent/US8765174B2/en not_active Expired - Lifetime
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2012
- 2012-06-08 US US13/491,670 patent/US8414916B2/en not_active Expired - Lifetime
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2014
- 2014-06-27 US US14/316,831 patent/US9072677B2/en not_active Expired - Lifetime
-
2015
- 2015-07-02 US US14/790,624 patent/US9668976B2/en not_active Expired - Lifetime
-
2017
- 2017-05-09 US US15/590,369 patent/US9861586B2/en not_active Expired - Lifetime
- 2017-12-05 US US15/831,866 patent/US10342763B2/en not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107375229A (zh) * | 2017-06-26 | 2017-11-24 | 仙乐健康科技股份有限公司 | 一种咀嚼植物软胶囊及其制备方法 |
Also Published As
Publication number | Publication date |
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US20120091605A1 (en) | 2012-04-19 |
DE60319355D1 (de) | 2008-04-10 |
EP1496873B2 (en) | 2011-08-10 |
US20120258169A1 (en) | 2012-10-11 |
US8765174B2 (en) | 2014-07-01 |
US20050169983A1 (en) | 2005-08-04 |
US8414916B2 (en) | 2013-04-09 |
AU2003231126A1 (en) | 2003-11-10 |
US20170239188A1 (en) | 2017-08-24 |
WO2003090726A3 (en) | 2004-03-25 |
DE60319355T3 (de) | 2012-01-05 |
DE60319355T2 (de) | 2009-02-19 |
JP4995407B2 (ja) | 2012-08-08 |
ES2302926T5 (es) | 2012-08-23 |
US9668976B2 (en) | 2017-06-06 |
CN1655770A (zh) | 2005-08-17 |
WO2003090726A2 (en) | 2003-11-06 |
JP2005529128A (ja) | 2005-09-29 |
US20140363503A1 (en) | 2014-12-11 |
ATE387191T1 (de) | 2008-03-15 |
US20180092853A1 (en) | 2018-04-05 |
EP1496873B1 (en) | 2008-02-27 |
US10342763B2 (en) | 2019-07-09 |
EP1496873A2 (en) | 2005-01-19 |
US20120034298A1 (en) | 2012-02-09 |
US9072677B2 (en) | 2015-07-07 |
US9861586B2 (en) | 2018-01-09 |
US20150313840A1 (en) | 2015-11-05 |
CN102600104B (zh) | 2015-06-24 |
US8241665B2 (en) | 2012-08-14 |
US8097279B2 (en) | 2012-01-17 |
ES2302926T3 (es) | 2008-08-01 |
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