JP5243434B2 - 急速に崩壊する錠剤 - Google Patents
急速に崩壊する錠剤 Download PDFInfo
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- JP5243434B2 JP5243434B2 JP2009527912A JP2009527912A JP5243434B2 JP 5243434 B2 JP5243434 B2 JP 5243434B2 JP 2009527912 A JP2009527912 A JP 2009527912A JP 2009527912 A JP2009527912 A JP 2009527912A JP 5243434 B2 JP5243434 B2 JP 5243434B2
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
Description
この発明のこれらおよびその他の特徴は、本発明の様々な態様の以下の詳細な説明を、本発明の様々な実施形態を示す添付の図面と関連付けて読むことにより、より容易に理解されるであろう。
本発明は、以下の態様に関し得る。
(態様1)少なくとも1本の細長溝を有するコアと、前記コアの第1の端部上の第1のコーティング端部と、前記コアの第2の端部上の第2のコーティング端部とを備える錠剤であって、前記少なくとも1本の細長溝の第1の部分が露出され、前記少なくとも1本の細長溝の第2の部分が前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方の下に延びるように、前記第1のコーティング端部および前記第2のコーティング端部が前記コアの全体よりも小さい部分を覆う錠剤。
(態様2)前記少なくとも1本の細長溝が、前記コアの長手軸に対して実質的に平行に向けられる、態様1に記載の錠剤。
(態様3)前記コアが、圧縮タブレットおよび成形タブレットのうちの一方である、態様1に記載の錠剤。
(態様4)前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、ゼラチンを含有する、態様1に記載の錠剤。
(態様5)前記コアが、互いに対して実質的に平行に向けられた少なくとも2本の細長溝を備える、態様1に記載の錠剤。
(態様6)前記少なくとも1本の細長溝が、溝を有さない同一サイズのコアの表面積よりも大きい前記コアの表面積をもたらす、態様1に記載の錠剤。
(態様7)前記コアが、溝を有さない同一サイズのコアよりも速い溶解速度および崩壊速度のうちの少なくとも一方を有する、態様6に記載の錠剤。
(態様8)前記少なくとも1本の細長溝の前記第1の部分の長さが、前記少なくとも一方の細長溝の前記第2の部分の長さの約1%から約75%の間を含む、態様1に記載の錠剤。
(態様9)錠剤錠剤における崩壊速度および崩壊程度のうちの少なくとも一方を改善するための方法であって、錠剤の表面内に少なくとも1本の溝を形成するステップを含み、前記少なくとも1本の溝が、前記錠剤の表面積を増大させる方法。
(態様10)前記少なくとも1本の溝が細長く、前記錠剤の長手軸に対して実質的に平行に向けられる、態様9に記載の方法。
(態様11)前記錠剤が、圧縮タブレットおよび成形タブレットのうちの一方である、態様9に記載の方法。
(態様12)前記溝を形成するステップが、前記錠剤の前記表面内に、互いに対して実質的に平行に向けられる少なくとも2本の溝を形成するステップを含む、態様9に記載の方法。
(態様13)錠剤を製造するための方法であって、少なくとも1本の細長溝を有するコアの第1の端部に、第1のコーティング端部を適用するステップと、前記コアの第2の端部に第2のコーティング端部を適用するステップとを含み、前記第1および第2のコーティング端部が共に、前記コアの全体より小さい部分を覆い、前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、前記少なくとも1本の細長溝の第1の部分を覆い、前記第1のコーティング端部または前記第2のコーティング端部のいずれも、前記少なくとも1本の細長溝の第2の部分を覆わない方法。
(態様14)前記少なくとも1本の細長溝が、前記コアの長手軸に対して実質的に平行に向けられる、態様13に記載の方法。
(態様15)前記コアが、圧縮タブレットおよび成形タブレットのうちの一方である、態様13に記載の方法。
(態様16)前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、ゼラチンを含有する、態様13に記載の方法。
(態様17)前記コアが、互いに対して実質的に平行に向けられた少なくとも2本の細長溝を備える、態様13に記載の方法。
(態様18)前記少なくとも1本の細長溝が、溝を有さない同一サイズのコアの表面積よりも大きい前記コアの表面積をもたらす、態様13に記載の方法。
(態様19)前記コアが、少なくとも1本の細長溝を有さない同一サイズのコアよりも速い溶解速度および崩壊速度のうちの少なくとも一方を有する、態様18に記載の方法。
(態様20)前記コアの表面内に前記少なくとも1本の細長溝を形成するステップをさらに含む、態様13に記載の方法。
本明細書で使用される「錠剤」とは、薬剤、ビタミン、またはその他の活性成分など、所定の投与量の成分を含有する、任意の固体、半固体、または液体組成物を含む。本発明による錠剤は、たとえば固体物体であるが、半固体または液体成分を含有することもできる。より具体的には、本発明による錠剤は、固体のタブレットコアを備える。そのようなタブレットコアは、医薬分野で知られているように、成形または圧縮錠剤とすることができ、任意の形状をとることができるが、特に卵形を形成するようにいくらか平坦にされた、細長円柱形が有益である。
図4Bの線Gに沿った断面図である図4Cに見られるように、タブレットコア410は、6本の溝460、462、464、466、468、470を備え、これらの溝は、3つの対向する対(すなわち460と466、462と468、464と470)として構成される。当然、その他の構成が可能であり、また上記で説明したように、特定の実施形態は、コア410の円周上に均等に分布させられた溝を有することができるが、これは必須ではない。
Claims (16)
- 少なくとも1本の細長溝を有するコアと、
前記コアの第1の端部上の第1のコーティング端部と、
前記コアの第2の端部上の第2のコーティング端部とを備える錠剤であって、前記少なくとも1本の細長溝の第1の部分が露出され、前記少なくとも1本の細長溝の第2の部分が前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方の下に延びるように、前記第1のコーティング端部および前記第2のコーティング端部が前記コアの全体よりも小さい部分を覆う錠剤。 - 前記少なくとも1本の細長溝が、前記コアの長手軸に対して実質的に平行に向けられる、請求項1に記載の錠剤。
- 前記コアが、圧縮タブレットおよび成形タブレットのうちの一方である、請求項1に記載の錠剤。
- 前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、ゼラチンを含有する、請求項1に記載の錠剤。
- 前記コアが、互いに対して実質的に平行に向けられた少なくとも2本の細長溝を備える、請求項1に記載の錠剤。
- 前記少なくとも1本の細長溝が、溝を有さない同一サイズのコアの表面積よりも大きい前記コアの表面積をもたらす、請求項1に記載の錠剤。
- 前記コアが、溝を有さない同一サイズのコアよりも速い溶解速度および崩壊速度のうちの少なくとも一方を有する、請求項6に記載の錠剤。
- 前記少なくとも1本の細長溝の前記第1の部分の長さが、前記少なくとも一方の細長溝の前記第2の部分の長さの1%から75%の間を含む、請求項1に記載の錠剤。
- 錠剤を製造するための方法であって、
少なくとも1本の細長溝を有するコアの第1の端部に、第1のコーティング端部を適用するステップと、
前記コアの第2の端部に第2のコーティング端部を適用するステップとを含み、
前記第1および第2のコーティング端部が共に、前記コアの全体より小さい部分を覆い、前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、前記少なくとも1本の細長溝の第1の部分を覆い、前記第1のコーティング端部または前記第2のコーティング端部のいずれも、前記少なくとも1本の細長溝の第2の部分を覆わない方法。 - 前記少なくとも1本の細長溝が、前記コアの長手軸に対して実質的に平行に向けられる、請求項9に記載の方法。
- 前記コアが、圧縮タブレットおよび成形タブレットのうちの一方である、請求項9に記載の方法。
- 前記第1のコーティング端部および前記第2のコーティング端部のうちの少なくとも一方が、ゼラチンを含有する、請求項9に記載の方法。
- 前記コアが、互いに対して実質的に平行に向けられた少なくとも2本の細長溝を備える、請求項9に記載の方法。
- 前記少なくとも1本の細長溝が、溝を有さない同一サイズのコアの表面積よりも大きい前記コアの表面積をもたらす、請求項9に記載の方法。
- 前記コアが、少なくとも1本の細長溝を有さない同一サイズのコアよりも速い溶解速度および崩壊速度のうちの少なくとも一方を有する、請求項14に記載の方法。
- 前記コアの表面内に前記少なくとも1本の細長溝を形成するステップをさらに含む、請求項9に記載の方法。
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US60/845,123 | 2006-09-15 | ||
PCT/IB2007/002621 WO2008032183A2 (en) | 2006-09-15 | 2007-09-07 | Rapidly disintegrating dosage form |
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FR2966731B1 (fr) * | 2010-11-03 | 2013-04-26 | Sanofi Aventis | Forme pharmaceutique solide marquee et son procede de fabrication par marquage laser |
MX359529B (es) | 2012-02-07 | 2018-10-01 | Mcneil Ppc Inc | Tabletas recubiertas de desintegración rápida. |
EP2844234B1 (de) | 2012-04-27 | 2020-01-08 | Merck Patent GmbH | Tabletten mit überzug und deren herstellung |
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US2052376A (en) * | 1933-05-18 | 1936-08-25 | Edgar G Zellers | Insoluble pill or tablet for internal medicinal uses |
JPS5331211B2 (ja) * | 1972-09-28 | 1978-09-01 | ||
US3883647A (en) * | 1972-12-06 | 1975-05-13 | Ives Lab | Tablet formulation |
JPS603286B2 (ja) * | 1977-03-03 | 1985-01-26 | 日本化薬株式会社 | 定速溶出性製剤 |
US4503031A (en) * | 1982-12-17 | 1985-03-05 | Glassman Jacob A | Super-fast-starting-sustained release tablet |
US5464631A (en) | 1990-06-27 | 1995-11-07 | Warner-Lambert Company | Encapsulated dosage forms |
US5460824A (en) | 1990-06-27 | 1995-10-24 | Warner-Lambert Company | Method for the preparation of an encapsulated medicament |
US5317849A (en) | 1992-08-07 | 1994-06-07 | Sauter Manufacturing Corporation | Encapsulation equipment and method |
PT797424E (pt) | 1994-12-16 | 2000-10-31 | Warner Lambert Co | Processo para a encapsulacao de "caplets" numa capsula e formas de dosagem solida por tal processo |
US6245350B1 (en) | 1994-12-16 | 2001-06-12 | Warner-Lambert Company | Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process |
EP1396263A1 (en) | 2002-08-09 | 2004-03-10 | Warner-Lambert Company | Film coating for tablets and caplets |
DE10352961A1 (de) * | 2003-11-13 | 2005-06-23 | Henkel Kgaa | Stoßbelastungsresistente Tablette |
US8067029B2 (en) * | 2004-01-13 | 2011-11-29 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
US7879354B2 (en) * | 2004-01-13 | 2011-02-01 | Mcneil-Ppc, Inc. | Rapidly disintegrating gelatinous coated tablets |
EP1858483A4 (en) * | 2005-03-16 | 2009-07-15 | Reddys Lab Ltd Dr | SYSTEM FOR THE DELIVERY OF MULTIPLE MEDICAMENTS |
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EP2433621B1 (en) | 2013-05-01 |
WO2008032183A3 (en) | 2008-07-17 |
EP2433621A1 (en) | 2012-03-28 |
JP2010503655A (ja) | 2010-02-04 |
WO2008032183A2 (en) | 2008-03-20 |
US20100086591A1 (en) | 2010-04-08 |
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