CN1023765C - 持久释药的基质配方 - Google Patents

持久释药的基质配方 Download PDF

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Publication number
CN1023765C
CN1023765C CN88101062A CN88101062A CN1023765C CN 1023765 C CN1023765 C CN 1023765C CN 88101062 A CN88101062 A CN 88101062A CN 88101062 A CN88101062 A CN 88101062A CN 1023765 C CN1023765 C CN 1023765C
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CN
China
Prior art keywords
weight
tablets
tablet
polymer
prescription
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN88101062A
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English (en)
Chinese (zh)
Other versions
CN88101062A (zh
Inventor
彼得·劳埃德·奥伦
沃纳·马克斯·卡尔·塞德勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN88101062A publication Critical patent/CN88101062A/zh
Application granted granted Critical
Publication of CN1023765C publication Critical patent/CN1023765C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
CN88101062A 1987-02-27 1988-02-26 持久释药的基质配方 Expired - Lifetime CN1023765C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1991587A 1987-02-27 1987-02-27
US019,915 1987-02-27

Publications (2)

Publication Number Publication Date
CN88101062A CN88101062A (zh) 1988-09-07
CN1023765C true CN1023765C (zh) 1994-02-16

Family

ID=21795732

Family Applications (1)

Application Number Title Priority Date Filing Date
CN88101062A Expired - Lifetime CN1023765C (zh) 1987-02-27 1988-02-26 持久释药的基质配方

Country Status (26)

Country Link
EP (1) EP0280571B1 (enExample)
JP (1) JPH082793B2 (enExample)
KR (1) KR960005140B1 (enExample)
CN (1) CN1023765C (enExample)
AR (1) AR243376A1 (enExample)
AT (1) ATE92309T1 (enExample)
AU (1) AU604849B2 (enExample)
CA (1) CA1316110C (enExample)
CY (1) CY1741A (enExample)
DE (2) DE3882739T2 (enExample)
DK (1) DK175620B1 (enExample)
EG (1) EG18523A (enExample)
ES (1) ES2044825T3 (enExample)
GR (1) GR930300027T1 (enExample)
HK (1) HK125793A (enExample)
HU (1) HU202747B (enExample)
IE (1) IE61419B1 (enExample)
IL (1) IL85538A (enExample)
LV (1) LV10184B (enExample)
MX (1) MX10558A (enExample)
NZ (1) NZ223619A (enExample)
PH (1) PH24358A (enExample)
PT (1) PT86831B (enExample)
RU (1) RU1831337C (enExample)
UA (1) UA18251A (enExample)
ZA (1) ZA881301B (enExample)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0527942T3 (da) * 1990-05-04 2000-03-27 Yissum Res Dev Co System til frigivelse af et lægemiddel i tyktarmen
IL98087A (en) * 1990-05-04 1996-11-14 Perio Prod Ltd Preparation for dispensing drugs in the colon
FR2667242B1 (fr) * 1990-09-28 1994-11-25 Rhone Poulenc Sante Nouvelles formes orales a liberation prolongee avec un temps de latence au niveau stomacal amoindri.
IT1250654B (it) * 1991-07-08 1995-04-21 Farcon Ag Metodo per la preparazione di forme farmaceutiche orali a rilascio prolungato contenenti sostanze attive a solubilita' dipendente dal valore di ph.
CN1137238A (zh) * 1993-10-22 1996-12-04 株式会社津村 一种持续释放药物制剂的基料,一种持续释放药物制剂,以及该药物制剂的一种生产方法
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
US5840332A (en) * 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
CN1159000C (zh) * 1996-05-13 2004-07-28 诺瓦提斯消费者保健股份有限公司 口腔释放系统
CA2209868C (en) * 1997-08-15 2001-08-14 Bernard Charles Sherman Pharmaceutical compositions comprising cefuroxime axetil
DE69905452D1 (de) * 1998-03-03 2003-03-27 Daewoong Pharmaceutical Co Feuchtigkeitsstabile cefuroxim axetil enthaltende pharmazeutische zusammenstellungen
KR100296413B1 (ko) * 1998-04-01 2001-11-14 김선진 세파클러함유서방성정제
AT413647B (de) 1998-11-26 2006-04-15 Sandoz Ag Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten
EP1027885B1 (en) 1999-02-09 2008-07-09 Pfizer Products Inc. Basic drug compositions with enhanced bioavailability
KR100647901B1 (ko) * 1999-07-09 2006-11-17 보령제약 주식회사 세파클러-함유 서방성 약제조성물 및 그의 제조방법
AT500063A1 (de) * 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
DE60038980D1 (de) 1999-12-28 2008-07-03 Kimberly Clark Co Antimikrobielles wischtuch mit kontrollierter abgabe für harte oberflächen
WO2001048303A2 (en) 1999-12-28 2001-07-05 Kimberly-Clark Worldwide, Inc. A wiper containing a controlled-release anti-microbial agent
CA2393542C (en) 1999-12-28 2011-08-16 Kimberly-Clark Worldwide, Inc. Use-dependent indicator system for absorbent articles
US6372252B1 (en) * 2000-04-28 2002-04-16 Adams Laboratories, Inc. Guaifenesin sustained release formulation and tablets
US6419954B1 (en) * 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
WO2002036126A1 (en) * 2000-10-30 2002-05-10 Lupin Limited Rapidly disintegrating sustained release cefuroxime axetil composition
US7910128B2 (en) * 2003-01-03 2011-03-22 Supernus Pharmaceuticals, Inc. Use of a mixture of two or more enteric materials to regulate drug release via membrane or matrix for systemic therapeutics
DE102005019458A1 (de) * 2005-04-25 2006-10-26 Grünenthal GmbH Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil
EP1837020A1 (en) * 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
MX2008013675A (es) 2006-04-26 2009-03-06 Supernus Pharmaceuticals Inc Preparaciones de liberacion controlada de oxcarbacepina que tienen perfil de liberacion sigmoidal.
EP2090298A4 (en) * 2006-11-13 2014-02-26 Kyorin Seiyaku Kk METHOD FOR PRODUCING A TABLET WITH DELAYED RELEASE
KR20120003906A (ko) 2009-03-27 2012-01-11 교린 세이야꾸 가부시키 가이샤 염기성 첨가제를 함유하는 매트릭스형 서방성 제제
US20120039999A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
US20120040008A1 (en) * 2010-08-11 2012-02-16 Ashish Chatterji Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists
CN101912373B (zh) * 2010-08-24 2012-01-04 北京京丰制药有限公司 稳定的头孢克洛分散片及其制备方法
WO2015190456A1 (ja) * 2014-06-10 2015-12-17 ライオン株式会社 清酒酵母を含有する錠剤
JP7426685B2 (ja) * 2018-06-14 2024-02-02 株式会社東洋新薬 錠剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151913B (enExample) * 1980-01-11 1983-09-03 Boots Co Ltd
JPS6024765B2 (ja) * 1981-11-27 1985-06-14 辰巳化学株式会社 セフアレキシンの持続性製剤の製造方法
JPS601128A (ja) * 1983-06-15 1985-01-07 Shionogi & Co Ltd 作用持続型セフアクロル製剤
LU85058A1 (fr) * 1983-10-24 1985-06-19 Pharlyse Comprimes pharmaceutiques a liberation prolongee,leur preparation et leur utilisation
US4520009A (en) * 1983-11-28 1985-05-28 Verex Laboratories, Inc. Sustained released aspirin formulation
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
JPS61286330A (ja) * 1985-06-11 1986-12-16 Teijin Ltd 経口徐放性製剤
JPS62120315A (ja) * 1985-11-20 1987-06-01 Shin Etsu Chem Co Ltd 経口投与型徐放性錠剤の製造方法

Also Published As

Publication number Publication date
EG18523A (en) 1993-04-30
JPH082793B2 (ja) 1996-01-17
NZ223619A (en) 1990-10-26
IL85538A (en) 1991-09-16
ATE92309T1 (de) 1993-08-15
JPS63227519A (ja) 1988-09-21
KR960005140B1 (ko) 1996-04-22
ES2044825T3 (es) 1994-11-16
DE3882739T2 (de) 1994-02-17
KR880009639A (ko) 1988-10-04
UA18251A (uk) 1997-12-25
ES2044825T1 (es) 1994-01-16
RU1831337C (ru) 1993-07-30
CA1316110C (en) 1993-04-13
EP0280571A3 (en) 1989-01-04
DE280571T1 (de) 1993-08-12
DK98088A (da) 1988-08-28
GR930300027T1 (enExample) 1993-05-24
CY1741A (en) 1995-02-17
IE61419B1 (en) 1994-11-02
IL85538A0 (en) 1988-08-31
HUT46531A (en) 1988-11-28
AU604849B2 (en) 1991-01-03
AU1219388A (en) 1988-09-01
DE3882739D1 (de) 1993-09-16
IE880545L (en) 1988-08-27
MX10558A (es) 1993-11-01
DK98088D0 (da) 1988-02-25
PT86831B (pt) 1992-05-29
ZA881301B (en) 1989-10-25
EP0280571A2 (en) 1988-08-31
PH24358A (en) 1990-06-13
LV10184B (en) 1995-04-20
CN88101062A (zh) 1988-09-07
DK175620B1 (da) 2004-12-27
EP0280571B1 (en) 1993-08-04
HK125793A (en) 1993-11-19
AR243376A1 (es) 1993-08-31
PT86831A (pt) 1988-03-01
HU202747B (en) 1991-04-29
LV10184A (lv) 1994-10-20

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C17 Cessation of patent right
CX01 Expiry of patent term