ES2044825T3 - Formulaciones de matriz de liberacion retardada. - Google Patents
Formulaciones de matriz de liberacion retardada.Info
- Publication number
- ES2044825T3 ES2044825T3 ES88301684T ES88301684T ES2044825T3 ES 2044825 T3 ES2044825 T3 ES 2044825T3 ES 88301684 T ES88301684 T ES 88301684T ES 88301684 T ES88301684 T ES 88301684T ES 2044825 T3 ES2044825 T3 ES 2044825T3
- Authority
- ES
- Spain
- Prior art keywords
- release
- polymer
- sustained release
- hydrophilic polymer
- delayed release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
ESTA INVENCION PROPORCIONA UNA COMPOSICION MATRIZ PARA LIBERACION SOSTENIDA DE FARMACOS, QUE ESTA FORMADA POR UN AGENTE ACTIVO, UN POLIMERO HIDROFILICO Y UN POLIMERO ENTERICO. ESTE ULTIMO ES IMPERMEBALE A LOS FLUIDOS GASTRICOS Y AYUDA A RETARDAR LA LIBERACION DEL FARMACO EN REGIONES DE PH BAJO, PERMITIENDO ASI EMPLEAR NIVELES MAS BAJOS DE POLIMERO HIDROFILICO. EN LA GAMA DE PH DE LOS FLUIDOS INTESTINALES, ESTE POLIMERO SE DISOLVERA Y AUMENTARA ASI LA PERMEABILIDAD DE LA FORMA DE DOSIFICACION. ESTE PROCEDIMIENTO ES UTIL PARA PROLONGAR LA LIBERACION DE NUMEROSOS AGENTES ACTIVOS CUYA SOLUBILIDAD DISMINUYE AL AUMENTAR EL PH, UNA CARACTERISTICA DE FARMACOS DEBILMENTE BASICOS. ESTAS FORMAS DE DOSIFICACION DE LIBERACION SOSTENIDA QUE RESPONDEN A CAMBIOS EN EL PH FISIOLOGICO, TIENEN UN COMPORTAMIENTO ACEPTABLE, A PESAR DE LA VARIABILIDAD EN LOS TIEMPOS DE TRANSITO GASTROINTESTINAL DE LA FORMULACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1991587A | 1987-02-27 | 1987-02-27 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2044825T1 ES2044825T1 (es) | 1994-01-16 |
ES2044825T3 true ES2044825T3 (es) | 1994-11-16 |
Family
ID=21795732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88301684T Expired - Lifetime ES2044825T3 (es) | 1987-02-27 | 1988-02-26 | Formulaciones de matriz de liberacion retardada. |
Country Status (26)
Country | Link |
---|---|
EP (1) | EP0280571B1 (es) |
JP (1) | JPH082793B2 (es) |
KR (1) | KR960005140B1 (es) |
CN (1) | CN1023765C (es) |
AR (1) | AR243376A1 (es) |
AT (1) | ATE92309T1 (es) |
AU (1) | AU604849B2 (es) |
CA (1) | CA1316110C (es) |
CY (1) | CY1741A (es) |
DE (2) | DE3882739T2 (es) |
DK (1) | DK175620B1 (es) |
EG (1) | EG18523A (es) |
ES (1) | ES2044825T3 (es) |
GR (1) | GR930300027T1 (es) |
HK (1) | HK125793A (es) |
HU (1) | HU202747B (es) |
IE (1) | IE61419B1 (es) |
IL (1) | IL85538A (es) |
LV (1) | LV10184B (es) |
MX (1) | MX10558A (es) |
NZ (1) | NZ223619A (es) |
PH (1) | PH24358A (es) |
PT (1) | PT86831B (es) |
RU (1) | RU1831337C (es) |
UA (1) | UA18251A (es) |
ZA (1) | ZA881301B (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2048133T3 (es) * | 1990-05-04 | 2000-01-16 | Perio Prod Ltd | Sistema de descarga de farmacos para el colon. |
IL98087A (en) * | 1990-05-04 | 1996-11-14 | Perio Prod Ltd | Preparation for dispensing drugs in the colon |
FR2667242B1 (fr) * | 1990-09-28 | 1994-11-25 | Rhone Poulenc Sante | Nouvelles formes orales a liberation prolongee avec un temps de latence au niveau stomacal amoindri. |
IT1250654B (it) * | 1991-07-08 | 1995-04-21 | Farcon Ag | Metodo per la preparazione di forme farmaceutiche orali a rilascio prolungato contenenti sostanze attive a solubilita' dipendente dal valore di ph. |
EP0724886A4 (en) * | 1993-10-22 | 1996-11-06 | Tsumura & Co | BASE FOR A DELAYED-RELEASE PREPARATION, DELAYED-RELEASE PREPARATION AND METHOD FOR PRODUCING THIS PREPARATION |
US5695781A (en) * | 1995-03-01 | 1997-12-09 | Hallmark Pharmaceuticals, Inc. | Sustained release formulation containing three different types of polymers |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
ES2206709T3 (es) * | 1996-05-13 | 2004-05-16 | Novartis Consumer Health S.A. | Sistema de suministro bucal. |
CA2209868C (en) * | 1997-08-15 | 2001-08-14 | Bernard Charles Sherman | Pharmaceutical compositions comprising cefuroxime axetil |
ATE232728T1 (de) * | 1998-03-03 | 2003-03-15 | Dae Woong Pharma | Feuchtigkeitsstabile cefuroxim axetil enthaltende pharmazeutische zusammenstellungen |
KR100296413B1 (ko) * | 1998-04-01 | 2001-11-14 | 김선진 | 세파클러함유서방성정제 |
AT413647B (de) | 1998-11-26 | 2006-04-15 | Sandoz Ag | Verwendung eines copolymerisats aus 1-vinyl-2-pyrrolidon und vinylacetat zur herstellung von cefuroximaxetil-hältigen tabletten |
EP1027885B1 (en) * | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
KR100647901B1 (ko) * | 1999-07-09 | 2006-11-17 | 보령제약 주식회사 | 세파클러-함유 서방성 약제조성물 및 그의 제조방법 |
AT500063A1 (de) * | 1999-11-23 | 2005-10-15 | Sandoz Ag | Beschichtete tablettenkerne |
US6734157B2 (en) | 1999-12-28 | 2004-05-11 | Kimberly-Clark Worldwide, Inc. | Controlled release anti-microbial hard surface wiper |
AU774993B2 (en) | 1999-12-28 | 2004-07-15 | Kimberly-Clark Worldwide, Inc. | Use-dependent indicator system for absorbent articles |
US6372252B1 (en) * | 2000-04-28 | 2002-04-16 | Adams Laboratories, Inc. | Guaifenesin sustained release formulation and tablets |
US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
EP1330250B1 (en) | 2000-10-30 | 2004-05-12 | Lupin Limited | Rapidly disintegrating sustained release cefuroxime axetil composition |
WO2004062577A2 (en) | 2003-01-03 | 2004-07-29 | Shire Laboratories Inc. | Two or more enteric materials to regulate drug release |
DE102005019458A1 (de) | 2005-04-25 | 2006-10-26 | Grünenthal GmbH | Darreichungsform mit verbesserter Freisetzung von Cefuroximaxetil |
EP1837020A1 (en) * | 2006-03-24 | 2007-09-26 | Bioalliance Pharma | Mucosal bioadhesive slow release carrier for delivering active principles |
US7722898B2 (en) | 2006-04-26 | 2010-05-25 | Supernus Pharmaceuticals, Inc. | Modified-release preparations containing oxcarbazepine and derivatives thereof |
JP5245175B2 (ja) * | 2006-11-13 | 2013-07-24 | 杏林製薬株式会社 | 持続放出型錠剤の製造方法 |
US20120029032A1 (en) | 2009-03-27 | 2012-02-02 | Kyorin Pharmaceutical Co., Ltd. | Matrix-type sustained release preparation containing basic additive |
US20120039999A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
US20120040008A1 (en) * | 2010-08-11 | 2012-02-16 | Ashish Chatterji | Pharmaceutical compositions of metabotropic glutamate 5 receptor (mglu5) antagonists |
CN101912373B (zh) * | 2010-08-24 | 2012-01-04 | 北京京丰制药有限公司 | 稳定的头孢克洛分散片及其制备方法 |
KR20170015315A (ko) * | 2014-06-10 | 2017-02-08 | 라이온 가부시키가이샤 | 청주 효모를 함유하는 정제 |
JP7426685B2 (ja) * | 2018-06-14 | 2024-02-02 | 株式会社東洋新薬 | 錠剤 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN151913B (es) * | 1980-01-11 | 1983-09-03 | Boots Co Ltd | |
JPS6024765B2 (ja) * | 1981-11-27 | 1985-06-14 | 辰巳化学株式会社 | セフアレキシンの持続性製剤の製造方法 |
JPS601128A (ja) * | 1983-06-15 | 1985-01-07 | Shionogi & Co Ltd | 作用持続型セフアクロル製剤 |
LU85058A1 (fr) * | 1983-10-24 | 1985-06-19 | Pharlyse | Comprimes pharmaceutiques a liberation prolongee,leur preparation et leur utilisation |
US4520009A (en) * | 1983-11-28 | 1985-05-28 | Verex Laboratories, Inc. | Sustained released aspirin formulation |
US4680323A (en) * | 1983-12-01 | 1987-07-14 | Hans Lowey | Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration |
JPS61286330A (ja) * | 1985-06-11 | 1986-12-16 | Teijin Ltd | 経口徐放性製剤 |
JPS62120315A (ja) * | 1985-11-20 | 1987-06-01 | Shin Etsu Chem Co Ltd | 経口投与型徐放性錠剤の製造方法 |
-
1988
- 1988-02-24 IL IL85538A patent/IL85538A/xx not_active IP Right Cessation
- 1988-02-24 CA CA000559656A patent/CA1316110C/en not_active Expired - Lifetime
- 1988-02-24 NZ NZ223619A patent/NZ223619A/xx unknown
- 1988-02-24 ZA ZA881301A patent/ZA881301B/xx unknown
- 1988-02-25 MX MX1055888A patent/MX10558A/es unknown
- 1988-02-25 PT PT86831A patent/PT86831B/pt not_active IP Right Cessation
- 1988-02-25 DK DK198800980A patent/DK175620B1/da not_active IP Right Cessation
- 1988-02-25 EG EG109/88A patent/EG18523A/xx active
- 1988-02-25 AU AU12193/88A patent/AU604849B2/en not_active Expired
- 1988-02-25 AR AR88310159A patent/AR243376A1/es active
- 1988-02-26 IE IE54588A patent/IE61419B1/en not_active IP Right Cessation
- 1988-02-26 KR KR1019880001974A patent/KR960005140B1/ko not_active IP Right Cessation
- 1988-02-26 HU HU88930A patent/HU202747B/hu unknown
- 1988-02-26 UA UA4355273A patent/UA18251A/uk unknown
- 1988-02-26 AT AT88301684T patent/ATE92309T1/de not_active IP Right Cessation
- 1988-02-26 PH PH36560A patent/PH24358A/en unknown
- 1988-02-26 EP EP88301684A patent/EP0280571B1/en not_active Expired - Lifetime
- 1988-02-26 JP JP63045703A patent/JPH082793B2/ja not_active Expired - Lifetime
- 1988-02-26 ES ES88301684T patent/ES2044825T3/es not_active Expired - Lifetime
- 1988-02-26 DE DE88301684T patent/DE3882739T2/de not_active Expired - Lifetime
- 1988-02-26 DE DE198888301684T patent/DE280571T1/de active Pending
- 1988-02-26 RU SU884355273A patent/RU1831337C/ru active
- 1988-02-26 CN CN88101062A patent/CN1023765C/zh not_active Expired - Lifetime
-
1993
- 1993-05-24 GR GR930300027T patent/GR930300027T1/el unknown
- 1993-06-08 LV LVP-93-513A patent/LV10184B/lv unknown
- 1993-11-11 HK HK1257/93A patent/HK125793A/xx not_active IP Right Cessation
-
1995
- 1995-02-17 CY CY174195A patent/CY1741A/xx unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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