CN102369291A - 效应子功能降低的稳定Fc多肽及使用方法 - Google Patents

效应子功能降低的稳定Fc多肽及使用方法 Download PDF

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Publication number
CN102369291A
CN102369291A CN2010800134542A CN201080013454A CN102369291A CN 102369291 A CN102369291 A CN 102369291A CN 2010800134542 A CN2010800134542 A CN 2010800134542A CN 201080013454 A CN201080013454 A CN 201080013454A CN 102369291 A CN102369291 A CN 102369291A
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China
Prior art keywords
polypeptide
binding
region
amino acid
stabilized
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Pending
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CN2010800134542A
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English (en)
Chinese (zh)
Inventor
C.L.雷耶斯
E.钱
F.R.泰勒
E.加伯
B.R.米勒
S.德马雷斯特
S.格拉泽
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Biogen MA Inc
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Biogen Idec MA Inc
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Publication of CN102369291A publication Critical patent/CN102369291A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2010800134542A 2009-01-23 2010-01-22 效应子功能降低的稳定Fc多肽及使用方法 Pending CN102369291A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14695009P 2009-01-23 2009-01-23
US61/146,950 2009-01-23
PCT/US2010/021853 WO2010085682A2 (en) 2009-01-23 2010-01-22 Stabilized fc polypeptides with reduced effector function and methods of use

Publications (1)

Publication Number Publication Date
CN102369291A true CN102369291A (zh) 2012-03-07

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US (1) US20120100140A1 (https=)
EP (1) EP2389192A4 (https=)
JP (1) JP2012515556A (https=)
CN (1) CN102369291A (https=)
AU (1) AU2010206681A1 (https=)
BR (1) BRPI1006998A2 (https=)
CA (1) CA2750533A1 (https=)
IL (1) IL214259A0 (https=)
MX (1) MX2011007833A (https=)
WO (1) WO2010085682A2 (https=)

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CN104520316A (zh) * 2012-06-29 2015-04-15 百时美施贵宝公司 减少糖蛋白聚集的方法
CN104955844A (zh) * 2013-02-01 2015-09-30 瑞泽恩制药公司 包含嵌合恒定结构域的抗体
CN105143253A (zh) * 2013-03-14 2015-12-09 美国安进公司 用于t调节性细胞的扩增的白细胞介素-2突变蛋白
CN106459221A (zh) * 2014-04-23 2017-02-22 艾伯维公司 单链trail受体激动剂蛋白
CN108026179A (zh) * 2015-10-02 2018-05-11 豪夫迈·罗氏有限公司 结合间皮素和cd3的双特异性t细胞活化性抗原结合分子
CN112142844A (zh) * 2015-02-05 2020-12-29 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用
CN112867394A (zh) * 2018-06-04 2021-05-28 马萨诸塞州渤健公司 具有降低的效应功能的抗vla-4抗体
CN114423785A (zh) * 2019-07-01 2022-04-29 通尼克斯制药有限公司 抗-cd154抗体及其用途
US12169205B2 (en) 2014-12-19 2024-12-17 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use
US12516115B2 (en) 2016-08-05 2026-01-06 Chugai Seiyaku Kabushiki Kaisha Composition for prophylaxis or treatment of IL-8 related diseases

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