CN101970476B - 具有超延迟时效特征的胰岛素衍生物 - Google Patents

具有超延迟时效特征的胰岛素衍生物 Download PDF

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Publication number
CN101970476B
CN101970476B CN200980101942.6A CN200980101942A CN101970476B CN 101970476 B CN101970476 B CN 101970476B CN 200980101942 A CN200980101942 A CN 200980101942A CN 101970476 B CN101970476 B CN 101970476B
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China
Prior art keywords
pro
exendin
lys
asp
arg
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN200980101942.6A
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English (en)
Chinese (zh)
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CN101970476A (zh
Inventor
P·哈伯曼
G·赛普克
R·库尔勒
G·米勒
M·佐默费尔德
N·特纳格尔斯
G·钱克
U·沃纳
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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Priority claimed from DE102008003566A external-priority patent/DE102008003566A1/de
Priority claimed from DE200810025007 external-priority patent/DE102008025007A1/de
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Publication of CN101970476A publication Critical patent/CN101970476A/zh
Application granted granted Critical
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200980101942.6A 2008-01-09 2009-01-06 具有超延迟时效特征的胰岛素衍生物 Expired - Fee Related CN101970476B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DE102008003566.1 2008-01-09
DE102008003566A DE102008003566A1 (de) 2008-01-09 2008-01-09 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
US4466208P 2008-04-14 2008-04-14
US61/044,662 2008-04-14
DE200810025007 DE102008025007A1 (de) 2008-05-24 2008-05-24 Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025007.4 2008-05-24
PCT/EP2009/000018 WO2009087082A2 (de) 2008-01-09 2009-01-06 Neue insulinderivate mit extrem verzögertem zeit- / wirkungsprofil

Publications (2)

Publication Number Publication Date
CN101970476A CN101970476A (zh) 2011-02-09
CN101970476B true CN101970476B (zh) 2014-08-27

Family

ID=40473425

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980101942.6A Expired - Fee Related CN101970476B (zh) 2008-01-09 2009-01-06 具有超延迟时效特征的胰岛素衍生物

Country Status (20)

Country Link
US (1) US8633156B2 (https=)
EP (1) EP2229406B1 (https=)
JP (1) JP5695909B2 (https=)
KR (1) KR20100111683A (https=)
CN (1) CN101970476B (https=)
AR (1) AR070119A1 (https=)
AU (1) AU2009203810B2 (https=)
BR (1) BRPI0907119A2 (https=)
CA (1) CA2711752A1 (https=)
CL (1) CL2009000018A1 (https=)
CO (1) CO6290770A2 (https=)
IL (1) IL206843A0 (https=)
MA (1) MA31997B1 (https=)
NZ (1) NZ586589A (https=)
PA (1) PA8811501A1 (https=)
PE (1) PE20091305A1 (https=)
TW (1) TWI433681B (https=)
UY (1) UY31597A1 (https=)
WO (1) WO2009087082A2 (https=)
ZA (1) ZA201003927B (https=)

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CN102596175A (zh) 2009-07-06 2012-07-18 赛诺菲-安万特德国有限公司 含有甲硫氨酸的水性胰岛素制备物
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PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
US20120283169A1 (en) 2010-11-08 2012-11-08 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
KR20140043709A (ko) 2011-01-20 2014-04-10 질랜드 파마 에이/에스 아실화 글루카곤 유사체와 인슐린 유사체의 조합
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
UA113626C2 (xx) * 2011-06-02 2017-02-27 Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії
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TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
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US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
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CN105829339B (zh) 2013-11-06 2021-03-12 西兰制药公司 胰高血糖素-glp-1-gip三重激动剂化合物
MX2016008978A (es) 2014-01-09 2016-10-04 Sanofi Sa Formulaciones farmaceuticas de analogos de insulina y/o derivados de insulina estabilizadas y que estan libres de glicerol.
MX2016008979A (es) 2014-01-09 2016-10-04 Sanofi Sa Formulaciones farmaceuticas estabilizadas de analogos de insulina y/o derivados de insulina.
BR112016015851A2 (pt) 2014-01-09 2017-08-08 Sanofi Sa Formulações farmacêuticas estabilizadas de insulina aspart
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TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
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KR102629006B1 (ko) 2017-03-23 2024-01-25 한미약품 주식회사 인슐린 수용체와의 결합력이 감소된 인슐린 아날로그의 결합체 및 이의 용도
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US20110173722A1 (en) 2011-07-14
UY31597A1 (es) 2009-08-31
MA31997B1 (fr) 2011-01-03
KR20100111683A (ko) 2010-10-15
PE20091305A1 (es) 2009-09-26
AR070119A1 (es) 2010-03-17
US8633156B2 (en) 2014-01-21
HK1148542A1 (en) 2011-09-09
CL2009000018A1 (es) 2009-06-05
WO2009087082A2 (de) 2009-07-16
TW200942257A (en) 2009-10-16
ZA201003927B (en) 2011-04-28
AU2009203810B2 (en) 2013-07-25
BRPI0907119A2 (pt) 2015-07-14
CO6290770A2 (es) 2011-06-20
IL206843A0 (en) 2010-12-30
EP2229406A2 (de) 2010-09-22
JP2011509269A (ja) 2011-03-24
EP2229406B1 (de) 2015-04-22
CA2711752A1 (en) 2009-07-16
JP5695909B2 (ja) 2015-04-08
AU2009203810A1 (en) 2009-07-16
WO2009087082A3 (de) 2009-09-24
TWI433681B (zh) 2014-04-11
PA8811501A1 (es) 2009-09-17
CN101970476A (zh) 2011-02-09
NZ586589A (en) 2012-04-27

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