UY31597A1 - Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado - Google Patents
Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardadoInfo
- Publication number
- UY31597A1 UY31597A1 UY031597A UY31597A UY31597A1 UY 31597 A1 UY31597 A1 UY 31597A1 UY 031597 A UY031597 A UY 031597A UY 31597 A UY31597 A UY 31597A UY 31597 A1 UY31597 A1 UY 31597A1
- Authority
- UY
- Uruguay
- Prior art keywords
- action profile
- delayed time
- insulin derivatives
- new insulin
- extremely delayed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
Abstract
La invención se refiere a nuevos análogos de insulina con pefil basal de tiempo/acción, que se caracterizan por la adición y/o sustitución de residuos aminoácidos cargados negativa y positivamente, y una amidación del grupo carboxi C-terminal de la cadena B e histidina en la posición 8 de la cadena A de la insulina, a su preparación y uso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008003566A DE102008003566A1 (de) | 2008-01-09 | 2008-01-09 | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
DE200810025007 DE102008025007A1 (de) | 2008-05-24 | 2008-05-24 | Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil |
Publications (1)
Publication Number | Publication Date |
---|---|
UY31597A1 true UY31597A1 (es) | 2009-08-31 |
Family
ID=40473425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY031597A UY31597A1 (es) | 2008-01-09 | 2009-01-07 | Nuevos derivados de insulina con perfil tiempo/accion extremadamente retardado |
Country Status (21)
Country | Link |
---|---|
US (1) | US8633156B2 (es) |
EP (1) | EP2229406B1 (es) |
JP (1) | JP5695909B2 (es) |
KR (1) | KR20100111683A (es) |
CN (1) | CN101970476B (es) |
AR (1) | AR070119A1 (es) |
AU (1) | AU2009203810B2 (es) |
BR (1) | BRPI0907119A2 (es) |
CA (1) | CA2711752A1 (es) |
CL (1) | CL2009000018A1 (es) |
CO (1) | CO6290770A2 (es) |
HK (1) | HK1148542A1 (es) |
IL (1) | IL206843A0 (es) |
MA (1) | MA31997B1 (es) |
NZ (1) | NZ586589A (es) |
PA (1) | PA8811501A1 (es) |
PE (1) | PE20091305A1 (es) |
TW (1) | TWI433681B (es) |
UY (1) | UY31597A1 (es) |
WO (1) | WO2009087082A2 (es) |
ZA (1) | ZA201003927B (es) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005046113A1 (de) * | 2005-09-27 | 2007-03-29 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Amidierung von Polypetiden mit C-terminalen basischen Aminosäuren unter Verwendung spezifischer Endoproteasen |
MY152979A (en) | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
KR101939557B1 (ko) | 2008-10-17 | 2019-01-17 | 사노피-아벤티스 도이칠란트 게엠베하 | 인슐린과 glp-1 효능제의 병용물 |
UA104605C2 (uk) | 2008-12-15 | 2014-02-25 | Зіленд Фарма А/С | Аналоги глюкагону |
ES2477880T3 (es) | 2008-12-15 | 2014-07-18 | Zealand Pharma A/S | Análogos del glucagón |
DK2370462T3 (da) | 2008-12-15 | 2014-09-08 | Zealand Pharma As | Glucagon-analoger |
MX2011006320A (es) | 2008-12-15 | 2011-09-22 | Zealand Pharma As | Analogos de glucagon. |
DK2454282T3 (en) | 2009-07-13 | 2015-05-04 | Zealand Pharma As | acetylated glucagonanaloger |
AU2010317994B2 (en) | 2009-11-13 | 2014-03-06 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical composition comprising a GLP-1 agonist and methionine |
RU2537239C2 (ru) | 2009-11-13 | 2014-12-27 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин |
UY33462A (es) | 2010-06-23 | 2012-01-31 | Zealand Pharma As | Analogos de glucagon |
WO2011160633A1 (en) | 2010-06-24 | 2011-12-29 | Zealand Pharma A/S | Glucagon analogues |
EP3725325B1 (en) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetes therapy |
CN103179978A (zh) | 2010-08-30 | 2013-06-26 | 赛诺菲-安万特德国有限公司 | Ave0010用于制造供治疗2型糖尿病用的药物的用途 |
US20120283169A1 (en) | 2010-11-08 | 2012-11-08 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
EP2665487A1 (en) | 2011-01-20 | 2013-11-27 | Zealand Pharma A/S | Combination of acylated glucagon analogues with insulin analogues |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
UA113626C2 (xx) * | 2011-06-02 | 2017-02-27 | Композиція для лікування діабету, що містить кон'югат інсуліну тривалої дії та кон'югат інсулінотропного пептиду тривалої дії | |
JP6367115B2 (ja) | 2011-08-29 | 2018-08-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 2型糖尿病患者の血糖コントロールに使用する組合せ医薬 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
MX356641B (es) | 2012-05-03 | 2018-06-07 | Zealand Pharma As | Compuestos agonistas dobles de gip-glp-1 y procedimientos. |
NZ704043A (en) | 2012-07-23 | 2017-07-28 | Zealand Pharma As | Glucagon analogues |
TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
TWI780236B (zh) | 2013-02-04 | 2022-10-11 | 法商賽諾菲公司 | 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物 |
US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
PL3057984T3 (pl) | 2013-10-17 | 2018-12-31 | Zealand Pharma A/S | Acylowane analogi glukagonu |
MX369770B (es) | 2013-11-06 | 2019-11-21 | Zealand Pharma As | Compuestos agonistas triples de glucagón-glp-1-gip. |
EP3065767B1 (en) | 2013-11-06 | 2020-12-30 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
CA2932873A1 (en) | 2014-01-09 | 2015-07-16 | Sanofi | Stabilized pharmaceutical formulations of insulin aspart |
RU2016132386A (ru) | 2014-01-09 | 2018-02-14 | Санофи | Стабилизированные фармацевтические составы без глицерина на основе инсулиновых аналогов и/или инсулиновых производных |
CN112957455A (zh) | 2014-01-09 | 2021-06-15 | 赛诺菲 | 胰岛素类似物和/或胰岛素衍生物的稳定化药物制剂 |
EP3098235A4 (en) | 2014-01-20 | 2017-10-18 | Hanmi Pharm. Co., Ltd. | Long-acting insulin and use thereof |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
CA2965732A1 (en) | 2014-10-29 | 2016-05-06 | Zealand Pharma A/S | Gip agonist compounds and methods |
NZ733670A (en) | 2014-12-12 | 2021-12-24 | Sanofi Aventis Deutschland | Insulin glargine/lixisenatide fixed ratio formulation |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患之治療 |
JP6989385B2 (ja) | 2015-04-16 | 2022-01-05 | ジーランド ファーマ アクティーゼルスカブ | アシル化グルカゴン類似体 |
UY36870A (es) | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
EP3517544A4 (en) | 2016-09-23 | 2020-06-03 | Hanmi Pharm. Co., Ltd. | INSULIN ANALOG HAVING REDUCED INSULIN RECEPTOR BINDING FORCE AND USE THEREOF |
JP2020511513A (ja) | 2017-03-23 | 2020-04-16 | ハンミ ファーマシューティカル カンパニー リミテッド | インスリン受容体との結合力が減少されたインスリンアナログの結合体及びその用途 |
CN110615836B (zh) * | 2018-06-20 | 2022-09-13 | 鲁南制药集团股份有限公司 | 一种利拉鲁肽的固相合成方法 |
CN115702880B (zh) * | 2021-08-12 | 2023-11-03 | 山东新时代药业有限公司 | 一种重组甘精胰岛素注射液及其制备工艺 |
Family Cites Families (37)
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US5008241A (en) * | 1985-03-12 | 1991-04-16 | Novo Nordisk A/S | Novel insulin peptides |
DK347086D0 (da) * | 1986-07-21 | 1986-07-21 | Novo Industri As | Novel peptides |
DK113585D0 (da) | 1985-03-12 | 1985-03-12 | Novo Industri As | Nye peptider |
WO1988006599A1 (en) | 1987-02-25 | 1988-09-07 | Novo Industri A/S | Novel insulin derivatives |
DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
DE3837825A1 (de) * | 1988-11-08 | 1990-05-10 | Hoechst Ag | Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung |
US5225323A (en) * | 1988-11-21 | 1993-07-06 | Baylor College Of Medicine | Human high-affinity neurotransmitter uptake system |
DK134189D0 (da) * | 1989-03-20 | 1989-03-20 | Nordisk Gentofte | Insulinforbindelser |
GR1005153B (el) | 1989-08-29 | 2006-03-13 | The General Hospital Corporation | Πρωτεινες συντηξεως, παρασκευη τους και χρηση τους. |
DK10191D0 (da) * | 1991-01-22 | 1991-01-22 | Novo Nordisk As | Hidtil ukendte peptider |
DE4405388A1 (de) | 1994-02-19 | 1995-08-24 | Hoechst Ag | Verfahren zur Herstellung von Polyalkyl-1-oxa-diazaspirodecan-Verbindungen |
CA2223272A1 (en) | 1995-05-05 | 1996-11-07 | Ronald Eugene Chance | Single chain insulin with high bioactivity |
DE69737479T4 (de) | 1996-08-30 | 2010-05-06 | Novo Nordisk A/S | Glp-1 derivate |
DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
IL134901A0 (en) * | 1997-10-24 | 2001-05-20 | Lilly Co Eli | Insoluble insulin compositions |
US6444641B1 (en) * | 1997-10-24 | 2002-09-03 | Eli Lilly Company | Fatty acid-acylated insulin analogs |
CA2322666A1 (en) | 1998-03-12 | 1999-09-16 | Biopore, Inc. | Enhancement of the pro-fertility action of a molecule involved in sperm-egg binding |
EP1076066A1 (en) | 1999-07-12 | 2001-02-14 | Zealand Pharmaceuticals A/S | Peptides for lowering blood glucose levels |
DE19947456A1 (de) * | 1999-10-02 | 2001-04-05 | Aventis Pharma Gmbh | C-Peptid zur verbesserten Herstellung von Insulin und Insulinanaloga |
US7060675B2 (en) * | 2001-02-15 | 2006-06-13 | Nobex Corporation | Methods of treating diabetes mellitus |
DE10108211A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Verwendung von Fusionsproteinen, deren N-terminaler Anteil aus einem Hirudinderivat besteht, zur Herstellung rekombinanter Proteine über Sekretion durch Hefen |
DE10108212A1 (de) | 2001-02-20 | 2002-08-22 | Aventis Pharma Gmbh | Fusionsprotein zur Sekretion von Wertprotein in bakterielle Überstände |
EP1377608B1 (en) * | 2001-04-02 | 2009-09-16 | Novo Nordisk A/S | Insulin precursors and a process for their preparation |
EP1545460A4 (en) * | 2001-12-20 | 2005-11-16 | Lilly Co Eli | INSULIN MOLECULE WITH TEMPORARY EFFECT |
US8058233B2 (en) * | 2002-01-10 | 2011-11-15 | Oregon Health And Science University | Modification of feeding behavior using PYY and GLP-1 |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
AU2003243929B2 (en) | 2002-07-04 | 2009-06-04 | Zp Holding Spv K/S | GLP-1 and methods for treating diabetes |
KR20050083713A (ko) * | 2002-10-02 | 2005-08-26 | 질랜드 파마 에이/에스 | 안정화된 엑센딘-4 화합물 |
CA2518776A1 (en) | 2003-04-29 | 2004-11-11 | Eli Lilly And Company | Insulin analogs having protracted time action |
CN1780854A (zh) * | 2003-04-29 | 2006-05-31 | 伊莱利利公司 | 具有延长时间作用的胰岛素类似物 |
BRPI0512396A (pt) * | 2004-07-21 | 2008-03-11 | Ambrx Inc | polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente |
JP2008513384A (ja) | 2004-09-17 | 2008-05-01 | ノボ ノルディスク アクティーゼルスカブ | インスリンおよびインスリン分泌性ペプチドを含有する医薬組成物 |
DE102004058306A1 (de) | 2004-12-01 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Carboxy-terminal amidierten Peptiden |
KR101304958B1 (ko) | 2005-09-14 | 2013-09-17 | 에프. 호프만-라 로슈 아게 | 트립신 변이체에 의한 인슐린 전구체의 절단 |
WO2007081824A2 (en) * | 2006-01-06 | 2007-07-19 | Case Western Reserve University | Fibrillation resistant proteins |
EP1972149B1 (en) | 2006-01-10 | 2017-12-13 | Thomson Licensing DTV | Methods and apparatus for parallel implementations of 4:4:4 coding |
MY152979A (en) | 2008-01-09 | 2014-12-15 | Sanofi Aventis Deutschland | Novel insulin derivatives having an extremely delayed time-action profile |
-
2009
- 2009-01-06 BR BRPI0907119-9A patent/BRPI0907119A2/pt not_active Application Discontinuation
- 2009-01-06 CN CN200980101942.6A patent/CN101970476B/zh not_active Expired - Fee Related
- 2009-01-06 EP EP09700949.2A patent/EP2229406B1/de active Active
- 2009-01-06 JP JP2010541744A patent/JP5695909B2/ja not_active Expired - Fee Related
- 2009-01-06 KR KR1020107014964A patent/KR20100111683A/ko not_active Application Discontinuation
- 2009-01-06 WO PCT/EP2009/000018 patent/WO2009087082A2/de active Application Filing
- 2009-01-06 NZ NZ586589A patent/NZ586589A/en not_active IP Right Cessation
- 2009-01-06 CA CA2711752A patent/CA2711752A1/en not_active Abandoned
- 2009-01-06 AU AU2009203810A patent/AU2009203810B2/en not_active Ceased
- 2009-01-07 AR ARP090100036A patent/AR070119A1/es unknown
- 2009-01-07 UY UY031597A patent/UY31597A1/es not_active Application Discontinuation
- 2009-01-07 PA PA20098811501A patent/PA8811501A1/es unknown
- 2009-01-07 TW TW098100283A patent/TWI433681B/zh not_active IP Right Cessation
- 2009-01-07 CL CL2009000018A patent/CL2009000018A1/es unknown
- 2009-01-07 PE PE2009000010A patent/PE20091305A1/es not_active Application Discontinuation
-
2010
- 2010-06-02 ZA ZA2010/03927A patent/ZA201003927B/en unknown
- 2010-06-22 US US12/820,727 patent/US8633156B2/en not_active Expired - Fee Related
- 2010-06-25 CO CO10076884A patent/CO6290770A2/es not_active Application Discontinuation
- 2010-07-05 MA MA32984A patent/MA31997B1/fr unknown
- 2010-07-06 IL IL206843A patent/IL206843A0/en unknown
-
2011
- 2011-03-17 HK HK11102681.7A patent/HK1148542A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CN101970476B (zh) | 2014-08-27 |
JP5695909B2 (ja) | 2015-04-08 |
CO6290770A2 (es) | 2011-06-20 |
AU2009203810A1 (en) | 2009-07-16 |
MA31997B1 (fr) | 2011-01-03 |
HK1148542A1 (en) | 2011-09-09 |
ZA201003927B (en) | 2011-04-28 |
CA2711752A1 (en) | 2009-07-16 |
AR070119A1 (es) | 2010-03-17 |
TW200942257A (en) | 2009-10-16 |
IL206843A0 (en) | 2010-12-30 |
JP2011509269A (ja) | 2011-03-24 |
PE20091305A1 (es) | 2009-09-26 |
US20110173722A1 (en) | 2011-07-14 |
NZ586589A (en) | 2012-04-27 |
BRPI0907119A2 (pt) | 2015-07-14 |
EP2229406B1 (de) | 2015-04-22 |
WO2009087082A2 (de) | 2009-07-16 |
CL2009000018A1 (es) | 2009-06-05 |
PA8811501A1 (es) | 2009-09-17 |
TWI433681B (zh) | 2014-04-11 |
AU2009203810B2 (en) | 2013-07-25 |
CN101970476A (zh) | 2011-02-09 |
KR20100111683A (ko) | 2010-10-15 |
US8633156B2 (en) | 2014-01-21 |
EP2229406A2 (de) | 2010-09-22 |
WO2009087082A3 (de) | 2009-09-24 |
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