CN101965350A - 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 - Google Patents

作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 Download PDF

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Publication number
CN101965350A
CN101965350A CN2009801083051A CN200980108305A CN101965350A CN 101965350 A CN101965350 A CN 101965350A CN 2009801083051 A CN2009801083051 A CN 2009801083051A CN 200980108305 A CN200980108305 A CN 200980108305A CN 101965350 A CN101965350 A CN 101965350A
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CN
China
Prior art keywords
pyrazolo
pyrimidine
phenyl
amine
formula
Prior art date
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Pending
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CN2009801083051A
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English (en)
Chinese (zh)
Inventor
D·P·科恩凯奇
苏巴·劳·普拉
拉克西米·安南特内利
R·皮利
穆达萨尼·普拉雷迪
布疆加·劳·阿迪巴特拉卡利萨蒂亚
纳纳潘尼·委卡拉筹德利
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Natco Pharma Ltd
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Natco Pharma Ltd
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Publication of CN101965350A publication Critical patent/CN101965350A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801083051A 2008-01-11 2009-01-12 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物 Pending CN101965350A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
IN109/CHE/2008 2008-01-11
PCT/IN2009/000037 WO2009098715A2 (en) 2008-01-11 2009-01-12 Novel pyrazolo [3, 4 -d] pyrimidine derivatives as anti -cancer agents

Publications (1)

Publication Number Publication Date
CN101965350A true CN101965350A (zh) 2011-02-02

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ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801083051A Pending CN101965350A (zh) 2008-01-11 2009-01-12 作为抗癌剂的新的吡唑并[3,4-d]嘧啶衍生物

Country Status (18)

Country Link
US (1) US8349847B2 (https=)
EP (1) EP2247596A2 (https=)
JP (1) JP2011509290A (https=)
KR (1) KR20100116607A (https=)
CN (1) CN101965350A (https=)
AP (1) AP2010005347A0 (https=)
AU (1) AU2009211004C1 (https=)
BR (1) BRPI0906475A2 (https=)
CA (1) CA2711777A1 (https=)
CO (1) CO6382174A2 (https=)
EA (1) EA201070841A1 (https=)
GE (1) GEP20135780B (https=)
IL (1) IL206811A0 (https=)
MA (1) MA32009B1 (https=)
MX (1) MX2010007523A (https=)
NZ (1) NZ586642A (https=)
WO (1) WO2009098715A2 (https=)
ZA (1) ZA201004823B (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746309A (zh) * 2012-07-09 2012-10-24 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307A (zh) * 2012-07-09 2012-10-24 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202A (zh) * 2014-05-21 2014-08-06 马宝花 二环稠合杂环化合物、其制备方法及用途
CN106008527A (zh) * 2016-06-29 2016-10-12 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607A (zh) * 2022-07-06 2022-11-08 华南农业大学 吡唑并嘧啶衍生物的制备方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104945420A (zh) 2009-06-29 2015-09-30 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR102507287B1 (ko) 2011-09-02 2023-03-07 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
SI3831833T1 (sl) 2015-02-27 2023-03-31 Incyte Holdings Corporation Postopki za pripravo inhibitorja PI3K
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CA3101323A1 (en) 2018-06-01 2019-12-05 Incyte Corporation Dosing regimen for the treatment of pi3k related disorders
EP4081528A4 (en) * 2019-12-23 2024-03-13 Sanford Burnham Prebys Medical Discovery Institute ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3000688A (en) 1961-09-19 Process for vatting of vat dyestuffs
US3551428A (en) 1956-02-10 1970-12-29 Ciba Geigy Corp New 1- (or 2-) substituted 4-mercapto-pyrazolo(3,4-d)pyrimidines
JPS5439096A (en) 1977-08-27 1979-03-24 Lion Dentifrice Co Ltd 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5877178A (en) 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
MX9800215A (es) 1995-07-06 1998-03-31 Novartis Ag Pirrolopirimidas y procesos para su preparacion.
ATE217873T1 (de) 1996-01-23 2002-06-15 Novartis Erfind Verwalt Gmbh Pyrrolopyrimidinen und verfahren zu deren herstellung
CH690773A5 (de) 1996-02-01 2001-01-15 Novartis Ag Pyrrolo(2,3-d)pyrimide und ihre Verwendung.
US6537999B2 (en) 1996-06-06 2003-03-25 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
WO1998007726A1 (en) 1996-08-23 1998-02-26 Novartis Ag Substituted pyrrolopyrimidines and processes for their preparation
DE19709488A1 (de) 1997-03-07 1998-09-10 Basf Ag Verfahren zur N-Alkylierung von Aminen
ID24300A (id) 1997-08-05 2000-07-13 Pfizer Prod Inc 4-AMINOPIROL(3,2-d)PIRIMIDIN SEBAGAI ANTAGONIS-ANTAGONIS RESEPTOR NEUROPEPTIDA Y
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6423871B1 (en) 1999-02-26 2002-07-23 University Of South Florida Efficient synthesis of secondary amines by selective alkylation of primary amines
DE60026297T2 (de) 1999-05-21 2006-11-02 Bristol-Myers Squibb Co. Pyrrolotriazin kinasehemmer
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
WO2001072751A1 (en) 2000-03-29 2001-10-04 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
AP1893A (en) 2000-12-01 2008-09-23 Osi Pharm Inc Compounds specific to adenosine A1, A2A and A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
AU2002315389A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
GB0115393D0 (en) 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
ATE323702T1 (de) 2002-08-06 2006-05-15 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
US20040138238A1 (en) 2002-08-08 2004-07-15 Dhanoa Dale S. Substituted aminopyrimidine compounds as neurokinin antagonists

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102746309A (zh) * 2012-07-09 2012-10-24 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307A (zh) * 2012-07-09 2012-10-24 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202A (zh) * 2014-05-21 2014-08-06 马宝花 二环稠合杂环化合物、其制备方法及用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
CN106008527A (zh) * 2016-06-29 2016-10-12 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CN115304607A (zh) * 2022-07-06 2022-11-08 华南农业大学 吡唑并嘧啶衍生物的制备方法

Also Published As

Publication number Publication date
EA201070841A1 (ru) 2011-02-28
IL206811A0 (en) 2010-12-30
AP2010005347A0 (en) 2010-08-31
MX2010007523A (es) 2010-08-18
AU2009211004C1 (en) 2013-08-01
WO2009098715A2 (en) 2009-08-13
AU2009211004A1 (en) 2009-08-13
WO2009098715A4 (en) 2009-12-10
WO2009098715A3 (en) 2009-10-15
US20100298351A1 (en) 2010-11-25
KR20100116607A (ko) 2010-11-01
NZ586642A (en) 2012-04-27
AU2009211004B2 (en) 2011-09-01
ZA201004823B (en) 2011-09-28
CA2711777A1 (en) 2009-08-13
JP2011509290A (ja) 2011-03-24
BRPI0906475A2 (pt) 2015-07-14
GEP20135780B (en) 2013-03-11
AU2009211004A2 (en) 2011-01-27
US8349847B2 (en) 2013-01-08
CO6382174A2 (es) 2012-02-15
EP2247596A2 (en) 2010-11-10
MA32009B1 (fr) 2011-01-03

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Application publication date: 20110202