KR20100116607A - 항암제로서의 신규한 피라졸로[3,4-ｄ]피리미딘 유도체 - Google Patents

항암제로서의 신규한 피라졸로[3,4-ｄ]피리미딘 유도체 Download PDF

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Publication number
KR20100116607A
KR20100116607A KR1020107017777A KR20107017777A KR20100116607A KR 20100116607 A KR20100116607 A KR 20100116607A KR 1020107017777 A KR1020107017777 A KR 1020107017777A KR 20107017777 A KR20107017777 A KR 20107017777A KR 20100116607 A KR20100116607 A KR 20100116607A
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KR
South Korea
Prior art keywords
pyrazolo
pyrimidin
phenyl
amine
formula
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Withdrawn
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KR1020107017777A
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English (en)
Korean (ko)
Inventor
두르가 프라사드 코나칸치
수바 라오 풀라
락쉬미 아난타네니
라마크리시나 필리
레디 무다사니 풀라
칼리 사탸 부장아 라오 아디바틀라
초우다리 난나파네니 벤카이아
Original Assignee
낫코 파마 리미티드
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Publication of KR20100116607A publication Critical patent/KR20100116607A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020107017777A 2008-01-11 2009-01-12 항암제로서의 신규한 피라졸로[3,4-ｄ]피리미딘 유도체 Withdrawn KR20100116607A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN109CH2008 2008-01-11
IN109/CHE/2008 2008-01-11

Publications (1)

Publication Number Publication Date
KR20100116607A true KR20100116607A (ko) 2010-11-01

Family

ID=40933862

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107017777A Withdrawn KR20100116607A (ko) 2008-01-11 2009-01-12 항암제로서의 신규한 피라졸로[3,4-ｄ]피리미딘 유도체

Country Status (18)

Country Link
US (1) US8349847B2 (https=)
EP (1) EP2247596A2 (https=)
JP (1) JP2011509290A (https=)
KR (1) KR20100116607A (https=)
CN (1) CN101965350A (https=)
AP (1) AP2010005347A0 (https=)
AU (1) AU2009211004C1 (https=)
BR (1) BRPI0906475A2 (https=)
CA (1) CA2711777A1 (https=)
CO (1) CO6382174A2 (https=)
EA (1) EA201070841A1 (https=)
GE (1) GEP20135780B (https=)
IL (1) IL206811A0 (https=)
MA (1) MA32009B1 (https=)
MX (1) MX2010007523A (https=)
NZ (1) NZ586642A (https=)
WO (1) WO2009098715A2 (https=)
ZA (1) ZA201004823B (https=)

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US8680108B2 (en) * 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
AR081823A1 (es) 2010-04-14 2012-10-24 Incyte Corp DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR102507287B1 (ko) 2011-09-02 2023-03-07 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
CN102746309B (zh) * 2012-07-09 2013-06-05 四川大学 1-N-乙基-4-N-2′-取代酰基肼-1H-吡唑[3,4-d]嘧啶类衍生物及其制备方法和用途
CN102746307B (zh) * 2012-07-09 2013-07-31 四川大学 1-n-苄基别嘌醇衍生物及其制备方法和用途
CN103965202B (zh) * 2014-05-21 2016-01-20 邹宏丽 二环稠合杂环化合物、其制备方法及用途
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
SI3831833T1 (sl) 2015-02-27 2023-03-31 Incyte Holdings Corporation Postopki za pripravo inhibitorja PI3K
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
CN106008527B (zh) * 2016-06-29 2018-05-15 四川大学华西医院 吡唑并[3,4-d]嘧啶衍生物
CN107698596A (zh) * 2017-11-15 2018-02-16 双鹤药业（商丘）有限责任公司 一种别嘌醇的合成方法
CA3101323A1 (en) 2018-06-01 2019-12-05 Incyte Corporation Dosing regimen for the treatment of pi3k related disorders
EP4081528A4 (en) * 2019-12-23 2024-03-13 Sanford Burnham Prebys Medical Discovery Institute ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF
CN115304607B (zh) * 2022-07-06 2023-06-27 华南农业大学 吡唑并嘧啶衍生物的制备方法

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JPS5439096A (en) 1977-08-27 1979-03-24 Lion Dentifrice Co Ltd 11phenyll1hhpyrazolo*3*44d*pyrimidinee44 carbonitrile
US5958930A (en) 1991-04-08 1999-09-28 Duquesne University Of The Holy Ghost Pyrrolo pyrimidine and furo pyrimidine derivatives
US5877178A (en) 1991-04-08 1999-03-02 Duquesne University Of The Holy Ghost Pyrimidine derivatives and methods of making and using these derivatives
US5593997A (en) 1995-05-23 1997-01-14 Pfizer Inc. 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors
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ATE217873T1 (de) 1996-01-23 2002-06-15 Novartis Erfind Verwalt Gmbh Pyrrolopyrimidinen und verfahren zu deren herstellung
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ID24300A (id) 1997-08-05 2000-07-13 Pfizer Prod Inc 4-AMINOPIROL(3,2-d)PIRIMIDIN SEBAGAI ANTAGONIS-ANTAGONIS RESEPTOR NEUROPEPTIDA Y
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6423871B1 (en) 1999-02-26 2002-07-23 University Of South Florida Efficient synthesis of secondary amines by selective alkylation of primary amines
DE60026297T2 (de) 1999-05-21 2006-11-02 Bristol-Myers Squibb Co. Pyrrolotriazin kinasehemmer
ITMI992711A1 (it) 1999-12-27 2001-06-27 Novartis Ag Composti organici
WO2001072751A1 (en) 2000-03-29 2001-10-04 Knoll Gesellschaft Mit Beschraenkter Haftung Pyrrolopyrimidines as tyrosine kinase inhibitors
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
AP1893A (en) 2000-12-01 2008-09-23 Osi Pharm Inc Compounds specific to adenosine A1, A2A and A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
DE10060388A1 (de) * 2000-12-05 2002-06-06 Merck Patent Gmbh Verwendung von Pyrazolo [4,3-d]pyrimidinen
AR035885A1 (es) 2001-05-14 2004-07-21 Novartis Ag Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica
AU2002315389A1 (en) 2001-06-21 2003-01-08 Ariad Pharmaceuticals, Inc. Novel pyrazolo-and pyrrolo-pyrimidines and uses thereof
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ATE323702T1 (de) 2002-08-06 2006-05-15 Astrazeneca Ab Kondensierte pyridine und pyrimidine mit tie2 (tek) aktivität
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Also Published As

Publication number Publication date
EA201070841A1 (ru) 2011-02-28
IL206811A0 (en) 2010-12-30
AP2010005347A0 (en) 2010-08-31
MX2010007523A (es) 2010-08-18
AU2009211004C1 (en) 2013-08-01
WO2009098715A2 (en) 2009-08-13
AU2009211004A1 (en) 2009-08-13
WO2009098715A4 (en) 2009-12-10
WO2009098715A3 (en) 2009-10-15
US20100298351A1 (en) 2010-11-25
NZ586642A (en) 2012-04-27
CN101965350A (zh) 2011-02-02
AU2009211004B2 (en) 2011-09-01
ZA201004823B (en) 2011-09-28
CA2711777A1 (en) 2009-08-13
JP2011509290A (ja) 2011-03-24
BRPI0906475A2 (pt) 2015-07-14
GEP20135780B (en) 2013-03-11
AU2009211004A2 (en) 2011-01-27
US8349847B2 (en) 2013-01-08
CO6382174A2 (es) 2012-02-15
EP2247596A2 (en) 2010-11-10
MA32009B1 (fr) 2011-01-03

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PA0105 International application

Patent event date: 20100810

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid