CN101855232A - 植物培养物中高甘露糖蛋白的生产 - Google Patents

植物培养物中高甘露糖蛋白的生产 Download PDF

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CN101855232A
CN101855232A CN200880023217A CN200880023217A CN101855232A CN 101855232 A CN101855232 A CN 101855232A CN 200880023217 A CN200880023217 A CN 200880023217A CN 200880023217 A CN200880023217 A CN 200880023217A CN 101855232 A CN101855232 A CN 101855232A
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cell
people
lysosomal protein
protein
lysosomal
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Chinese (zh)
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Y·沙尔蒂尔
G·鲍姆
D·巴特费尔德
S·哈什米利
A·勒科夫斯基
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Protalix Ltd
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    • C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
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CN200880023217A 2007-04-30 2008-04-30 植物培养物中高甘露糖蛋白的生产 Pending CN101855232A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/790,991 2007-04-30
US11/790,991 US7951557B2 (en) 2003-04-27 2007-04-30 Human lysosomal proteins from plant cell culture
PCT/IL2008/000576 WO2008132743A2 (en) 2007-04-30 2008-04-30 Production of high mannose proteins in plant culture

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CN101855232A true CN101855232A (zh) 2010-10-06

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US (8) US7951557B2 (enExample)
EP (1) EP2220105A4 (enExample)
JP (1) JP2010525806A (enExample)
KR (1) KR20100023833A (enExample)
CN (1) CN101855232A (enExample)
AU (1) AU2008243744A1 (enExample)
BR (1) BRPI0810003A2 (enExample)
CA (1) CA2685400A1 (enExample)
MX (1) MX2009011751A (enExample)
RU (1) RU2009143751A (enExample)
WO (1) WO2008132743A2 (enExample)
ZA (1) ZA200908423B (enExample)

Cited By (5)

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CN103443270A (zh) * 2011-01-20 2013-12-11 普罗塔里克斯有限公司 用于在植物和植物细胞中表达α-半乳糖苷酶的核酸构建体
US9708595B2 (en) 2009-11-17 2017-07-18 Protalix Ltd. Stabilized alpha-galactosidase and uses thereof
CN107429257A (zh) * 2015-03-17 2017-12-01 格林诺瓦森生物技术股份有限公司 糖基化溶酶体蛋白、生产方法和用途
CN114364794A (zh) * 2019-09-09 2022-04-15 豪夫迈·罗氏有限公司 葡糖脑苷脂酶突变体
CN120695154A (zh) * 2025-08-28 2025-09-26 山东大学 豌豆肽在制备防治卵巢损伤药物中的应用

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US20030100945A1 (en) * 2001-11-23 2003-05-29 Mindguard Ltd. Implantable intraluminal device and method of using same in treating aneurysms
US20100196345A1 (en) * 2003-04-27 2010-08-05 Protalix Production of high mannose proteins in plant culture
US7951557B2 (en) * 2003-04-27 2011-05-31 Protalix Ltd. Human lysosomal proteins from plant cell culture
KR20080083060A (ko) * 2006-01-04 2008-09-12 베링거 인겔하임 인터내셔날 게엠베하 중등 지속성 천식의 치료에서 티오트로퓸 염의 용도
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CA2787099A1 (en) 2009-03-30 2010-10-14 Anice C. Lowen Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof
AU2010281403B2 (en) 2009-07-28 2016-03-10 Takeda Pharmaceutical Company Limited Compositions and methods for treating Gaucher disease
CA2773133A1 (en) 2009-08-28 2011-03-03 Edward H. Schuchman Dose escalation enzyme replacement therapy for treating acid sphingomyelinase deficiency
WO2011061736A1 (en) 2009-11-17 2011-05-26 Protalix Ltd. Alkaline alpha galactosidase for the treatment of fabry disease
CA2782269C (en) * 2009-12-01 2019-06-11 Shire Human Genetic Therapies, Inc. Enzymatic activity based-detection
US20130017169A1 (en) 2010-03-02 2013-01-17 Protalix Ltd. Multimeric forms of therapeutic proteins and uses thereof
DK2865751T3 (en) 2010-03-02 2017-01-09 Protalix Ltd Stabilized alpha-galactosidase and uses thereof
US20130198897A1 (en) * 2010-03-22 2013-08-01 Philip Morris Products S.A. Modifying enzyme activity in plants
WO2011123495A1 (en) 2010-03-30 2011-10-06 Mount Sinai School Of Medicine Influenza virus vaccines and uses thereof
CN103154243A (zh) 2010-10-15 2013-06-12 日本化学研究株式会社 糖链的非还原末端为甘露糖残基的糖蛋白的制造方法
EP2471929A1 (en) * 2010-12-29 2012-07-04 Algenics Production of high mannose glycosylated proteins stored in the plastid of microalgae
JP5809817B2 (ja) * 2011-03-09 2015-11-11 本田技研工業株式会社 タンパク質の植物細胞内への蓄積方法
EP2718459B1 (en) 2011-06-08 2018-02-28 Shire Human Genetic Therapies, Inc. Competition-based detection assays
EP2758075B1 (en) 2011-09-20 2023-05-03 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
WO2013114371A1 (en) 2012-02-01 2013-08-08 Protalix Ltd. Dry powder formulations of dnase i
IN2014MN01806A (enExample) 2012-02-19 2015-07-03 Protalix Ltd
WO2013130963A1 (en) 2012-03-02 2013-09-06 Shire Human Genetic Therapies, Inc. Compositions and methods for treating type iii gaucher disease
CN112400900A (zh) 2012-03-09 2021-02-26 韦斯塔隆公司 毒肽产生、植物中的肽表达和富含半胱氨酸的肽的组合
US11692016B2 (en) 2012-03-09 2023-07-04 Vestaron Corporation High gene expression yeast strain
EP2662083A1 (en) 2012-05-08 2013-11-13 CSL Behring GmbH Sugar compositions for treating hemophilia a and/or von willebrand disease
EP2934581B1 (en) 2012-12-18 2022-09-14 Icahn School of Medicine at Mount Sinai Influenza virus vaccines and uses thereof
EP2964668B1 (en) 2013-03-06 2019-11-27 Protalix Ltd. Tnf alpha inhibitor polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
US9908930B2 (en) 2013-03-14 2018-03-06 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
US20170101633A1 (en) 2014-02-10 2017-04-13 Protalix Ltd. Method of maintaining disease stability in a subject having gaucher's disease
US10000551B2 (en) 2014-09-11 2018-06-19 Protalix Ltd. Chimeric polypeptides, polynucleotides encoding same, cells expressing same and methods of producing same
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
JP2018504412A (ja) 2015-01-23 2018-02-15 アイカーン スクール オブ メディシン アット マウント サイナイ インフルエンザウイルスワクチン接種レジメン
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EP3471767A4 (en) 2016-06-15 2020-01-15 Icahn School of Medicine at Mount Sinai Influenza virus hemagglutinin proteins and uses thereof
US11535653B2 (en) * 2016-10-21 2022-12-27 Vestaron Corporation Cleavable peptides and insecticidal and nematicidal proteins comprising same
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