CN101854930A - 一类新的stat3通路抑制剂和癌干细胞通路抑制剂 - Google Patents
一类新的stat3通路抑制剂和癌干细胞通路抑制剂 Download PDFInfo
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- CN101854930A CN101854930A CN200880115250A CN200880115250A CN101854930A CN 101854930 A CN101854930 A CN 101854930A CN 200880115250 A CN200880115250 A CN 200880115250A CN 200880115250 A CN200880115250 A CN 200880115250A CN 101854930 A CN101854930 A CN 101854930A
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Abstract
Description
化合物# | Stat3-Luc测定中的IC50 |
401 | ~0.25μM |
416 | ~0.75μM |
418 | ~0.75μM |
301 | ~2μM |
IC50(μM)化合物 NSP SP |
401 0.33 0.34418 0.33 0.344011 0.34 0.384012 0.81 0.57 |
IC50(μM)化合物 CD44low CD44high |
4011 0.42 0.274012 0.76 1.05 |
Claims (114)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610134121.4A CN105963289B (zh) | 2007-09-10 | 2008-09-10 | 一类stat3通路抑制剂和癌干细胞通路抑制剂 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US97114407P | 2007-09-10 | 2007-09-10 | |
US60/971,144 | 2007-09-10 | ||
US1337207P | 2007-12-13 | 2007-12-13 | |
US61/013,372 | 2007-12-13 | ||
PCT/US2008/075903 WO2009036099A1 (en) | 2007-09-10 | 2008-09-10 | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
Related Child Applications (1)
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CN201610134121.4A Division CN105963289B (zh) | 2007-09-10 | 2008-09-10 | 一类stat3通路抑制剂和癌干细胞通路抑制剂 |
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CN101854930A true CN101854930A (zh) | 2010-10-06 |
CN101854930B CN101854930B (zh) | 2016-05-04 |
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
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CN200880115250.2A Active CN101854930B (zh) | 2007-09-10 | 2008-09-10 | 一类新的stat3通路抑制剂和癌干细胞通路抑制剂 |
CN200880115249.XA Active CN101854802B (zh) | 2007-09-10 | 2008-09-10 | 用于癌症治疗的组合物和方法 |
CN201410583457.XA Active CN104586832B (zh) | 2007-09-10 | 2008-09-10 | 用于癌症治疗的组合物和方法 |
CN2008801152470A Active CN101854937B (zh) | 2007-09-10 | 2008-09-10 | 新的stat3途径抑制剂和癌症干细胞抑制剂 |
CN201610134121.4A Active CN105963289B (zh) | 2007-09-10 | 2008-09-10 | 一类stat3通路抑制剂和癌干细胞通路抑制剂 |
CN201310052882.1A Active CN103288787B (zh) | 2007-09-10 | 2008-09-10 | 新的stat3 途径抑制剂和癌症干细胞抑制剂 |
Family Applications After (5)
Application Number | Title | Priority Date | Filing Date |
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CN200880115249.XA Active CN101854802B (zh) | 2007-09-10 | 2008-09-10 | 用于癌症治疗的组合物和方法 |
CN201410583457.XA Active CN104586832B (zh) | 2007-09-10 | 2008-09-10 | 用于癌症治疗的组合物和方法 |
CN2008801152470A Active CN101854937B (zh) | 2007-09-10 | 2008-09-10 | 新的stat3途径抑制剂和癌症干细胞抑制剂 |
CN201610134121.4A Active CN105963289B (zh) | 2007-09-10 | 2008-09-10 | 一类stat3通路抑制剂和癌干细胞通路抑制剂 |
CN201310052882.1A Active CN103288787B (zh) | 2007-09-10 | 2008-09-10 | 新的stat3 途径抑制剂和癌症干细胞抑制剂 |
Country Status (15)
Country | Link |
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US (12) | US9745278B2 (zh) |
EP (6) | EP2190429B1 (zh) |
JP (16) | JP5872160B2 (zh) |
CN (6) | CN101854930B (zh) |
CA (4) | CA2736563C (zh) |
CY (3) | CY1117604T1 (zh) |
DK (4) | DK3050566T3 (zh) |
ES (3) | ES2583010T3 (zh) |
HK (3) | HK1148942A1 (zh) |
HR (3) | HRP20160430T1 (zh) |
HU (3) | HUE027443T2 (zh) |
PL (4) | PL2190429T3 (zh) |
PT (2) | PT2194987T (zh) |
SI (3) | SI2190429T1 (zh) |
WO (3) | WO2009036059A2 (zh) |
Cited By (12)
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WO2012119265A1 (en) * | 2011-03-04 | 2012-09-13 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | NOVEL ESTERS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR DISEASE THERAPIES |
WO2013120229A1 (en) * | 2012-02-17 | 2013-08-22 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | METHOD FOR PREPARING AQUEOUS MANO PARTICLE SUSPENSIONS OF DERIVATIVES OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURAN ALIPHATIC ACID ESTERS |
WO2013166618A1 (en) * | 2012-05-08 | 2013-11-14 | Zhoushan Haizhongzhou Xinsheng Pharmaceuticals Co., Ltd. | PRODRUGS OF 4,9-DIHYDROXY-NAPHTHO[2,3-b]FURANS FOR CIRCUMVENTING CANCER MULTIDRUG RESISTANCE |
CN104693280A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 信号传导及转录激活因子抑制多肽及其应用 |
CN104693279A (zh) * | 2015-04-06 | 2015-06-10 | 苏州普罗达生物科技有限公司 | 关于信号传导及转录激活因子抑制多肽及其应用 |
CN104725480A (zh) * | 2015-04-06 | 2015-06-24 | 苏州普罗达生物科技有限公司 | 一种信号传导及转录激活因子抑制多肽及其应用 |
CN106132412A (zh) * | 2014-01-27 | 2016-11-16 | 北京强新生物科技有限公司 | 治疗癌症的新方法 |
CN106211758A (zh) * | 2013-04-09 | 2016-12-07 | 北京强新生物科技有限公司 | 2‑乙酰基萘并[2,3‑b]呋喃‑4,9‑二酮用于治疗癌症的用途 |
CN107835687A (zh) * | 2015-05-14 | 2018-03-23 | 努卡那有限公司 | 癌症治疗 |
CN107847481A (zh) * | 2015-06-03 | 2018-03-27 | 波士顿生物医药有限公司 | 包含癌症干性抑制剂的组合物和用于治疗癌症的免疫治疗剂 |
CN108012529A (zh) * | 2015-05-15 | 2018-05-08 | 诺华股份有限公司 | 治疗egfr突变的癌症的方法 |
CN114286684A (zh) * | 2020-07-27 | 2022-04-05 | 华中科技大学 | 与stat3相关的疾病的预防和/或治疗 |
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PT1848414E (pt) | 2005-02-03 | 2011-05-25 | Gen Hospital Corp | M?todo para tratamento de cancro resistente a gefitinib |
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DK3050566T3 (en) * | 2007-09-10 | 2019-03-11 | Boston Biomedical Inc | NEW GROUP OF STAT3 PATHWAY INHIBITORS AND CANCERCELLE-PATHWAY INHIBITORS |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
US20130331294A1 (en) | 2007-11-09 | 2013-12-12 | Fox Chase Cancer Center | Egfr/nedd9/tgf-beta interactome and methods of use thereof for the identification of agents having efficacy in the treatment of hyperproliferative disorders |
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KR20140069340A (ko) | 2008-08-04 | 2014-06-09 | 와이어쓰 엘엘씨 | 4-아닐리노-3-사이아노퀴놀린과 카페시타빈의 항신생물성 조합물 |
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