CN101828744A - Anti-fatigue total nutrition high activity seacucumber drinking liquid capable of improving immunity and preparation method thereof - Google Patents
Anti-fatigue total nutrition high activity seacucumber drinking liquid capable of improving immunity and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a functional drinking liquid, in particular to an anti-fatigue total nutrition high activity seacucumber drinking liquid capable of improving immunity, which is prepared by the following raw materials in parts by weight: 50-85 parts of seacucumber, 10-30 parts of oyster and 5-20 parts of medlar. The preparation method of the invention has the advantages that nutritive effect ingredients in seacucumber and oyster are almost completely extracted by utilizing an ultrasound extraction and biological enzyme technology; 2) heavy metal in the drinking liquid is effectively removed by utilizing chitosan adsorption and an ultra filter membrane concentration process on the basis that nutritive ingredients are not lost; 3) the nutritive ingredients in the invention are comprehensive, are most equivalent to those in fresh seacucumber and oyster, and are water soluble micromolecule absorbable state.
Description
Technical field
The present invention relates to a kind of function drink liquid, particularly a kind of is the function drink liquid of primary raw material with the sea cucumber, the invention still further relates to the method for making of drink liquid in addition.
Background technology
Sea cucumber is positioned at first of the seafood delights eight delicacies, is the high tonic of nutritive value, also is rare Chinese medicine simply.Sea cucumber contains abundant collagen, amino acid, various trace elements and vitamin and the distinctive bioactivator sea cucumber mucopolysaccharide of sea cucumber, selenka etc.Sea cucumber is extremely low because of containing cholesterol, is the food of a kind of typical high protein, low fat, low cholesterol, again because of the help effect is remarkable, so the human that is fit to very much have a delicate constitution in nourishing, also be always after being ill, the first-selected tonic of postpartum and sub-health population.
But fresh and alive sea cucumbers is because the interaction energy of body endoenzyme produces self-dissolving, and sea cucumber is difficult to storage and transport after fishing for and leaving seawater, so people generally are processed into dry product.The existing sea cucumber goods that we are eaten mainly contain that salt marsh, salt are done, light doing and freeze-drying sea cucumber etc.These sea cucumber goods will pass through boiling, salt mostly and flood, mix ash, operation such as dry in process, and the water when edible to send out process loaded down with trivial details, caused the serious loss of nutritional labeling.
Oyster also is the outstanding person in the marine product, just is considered to " your person in the extra large family " in ancient times.It not only has higher edibility, but also has higher medical value.Oyster meat contains multiple nutrients compositions such as rich in protein, vitamin, carbohydrate, amino acid and mineral matter, has multiple efficacies such as enriching yin and nourishing kidney and brain healthy.Though the oyster delicious flavour, because transportation, fresh-keeping and store the inconvenience of processing aspect, the resident of non-coastal area can not usually have bright product, and the nutrition of dried product is had a greatly reduced quality.
In addition, sea cucumber, oyster dry product are when edible, because contained collagen is a macromolecular substances, the absorption of human body utilization rate is very low, and in recent years along with increasing the weight of that offshore sea waters water pollutes, heavy metals exceeding standard phenomenon in the marine product such as sea cucumber, oyster occurs repeatedly, and the edible safety problem of marine product also becomes increasingly conspicuous.In order to improve the absorption rate of nutrition, had sea cucumber and oyster oral liquid at present on the market, but these product ubiquity nutrient composition contents are low, mouthfeel is not good enough, only extract defectives such as the part nutriment that has kept in sea cucumber, the oyster, ineffective removal heavy metal.And the concentrated type function of whole nutritions drink liquid does not appear in the newspapers so far in complete extraction and reservation fresh and alive sea cucumbers and the oyster.
Summary of the invention
The objective of the invention is for overcoming the deficiency of above-mentioned sea cucumber, oyster goods, the full nutrition high activity sea cucumber drink liquid of a kind of antifatigue, raising immunity is provided, its reasonable raw material proportioning, nutrient keep comprehensively, effective component content is high, absorption is fast, mouthfeel is good, the help effect is remarkable, and edible easy to carry.Another object of the present invention provides the method for making of this drink liquid, and method for making is simple, effectively removes heavy metal, keeps nutritional labeling comprehensively.
The present invention is achieved by the following technical programs: the full nutrition high activity sea cucumber drink liquid of antifatigue, raising immunity, mainly make by the raw material of following weight parts:
Sea cucumber 50～85
Oyster 10～30
Matrimony vine 5～20.
The vitamin that also contains 0～2.5 weight portion in the described drink liquid.Vitamin is one or more in the following vitamin: vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, VB7, VB11 or cobalamin.
Described sea cucumber is 3～5 years extra large stichopus japonicus of fresh work; Oyster is bright oyster; Matrimony vine is a lycium barbarum.
The method for making of function drink liquid of the present invention comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned with pure water; Matrimony vine is cleaned and dries, and is crushed to 80～100 orders;
The second step enzymolysis liquid preparation: take by weighing sea cucumber after cleaning by composition of raw materials, oyster carries out the meat mincing homogenized, join in the ultrasonic wave extractor, add the matrimony vine after pulverizing in proportion, the pure water that adds 3～10 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 2～4 hours under the conditions that the back is 30～65 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 50～75 degree, continue ultrasonic extraction 3～5 hours, heat temperature raising to 100 is spent then, keep cooling after 1 minute, be cooled to after the room temperature high speed centrifugation under 3500～6000r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, in filtrate, add the shitosan that accounts for filtrate weight 0.1%～0.6%, stirring reaction leaves standstill centrifugal again after 1 hour, this process can effectively remove heavy metal, collect centrifuged supernatant and mix, promptly make enzymolysis liquid with concentrate merging after the above-mentioned ultrafiltration;
The 3rd step concentrating drinking liquid prepares: above-mentioned enzymolysis liquid decompression distillation is concentrated promptly make concentrating drinking liquid of the present invention.
The described drink liquid method for making that contains vitamin: when the 3rd step, concentrating drinking liquid prepared, add vitamin mixing homogeneous in proportion in above-mentioned enzymolysis liquid, decompression distillation concentrates and promptly makes concentrating drinking liquid of the present invention.
Eating method of the present invention: get 5～10 of concentrating drinking liquids of the present invention, be added in one glass of about pure water of 200 milliliters, promptly drinkable after stirring evenly.
It can be common drink liquid that the present invention drinks liquid, it also can be concentrating drinking liquid, its effective ingredient all comes from famous and precious ocean elite and pure natural plant raw material, wherein sea cucumber have the laudatory title of " marine genseng ", contain abundant collagen, amino acid, various trace elements and vitamin, and distinctive bioactivator sea cucumber mucopolysaccharide, selenka etc.It is rich in 18 seed amino acids, and especially arginine content is high especially, and arginine is the main component that constitutes male sex's spermatid, is again the primary raw material of synthesized human collagen, can impel cytothesis, repairs the body after damaging, and eliminates fatigue, regains one's strength fast; Sea cucumber mucopolysaccharide and selenka are the main active in the sea cucumber, and modern pharmacology studies show that: sea cucumber mucopolysaccharide has the antitumor action of wide spectrum.Through test, mouse through the abdominal cavity or intravenous injection sea cucumber mucopolysaccharide extract metastatic tumo(u)r is had significant inhibitory effect, particularly the effect to MA737 breast cancer reaches 88%, is 55-61% to the inhibiting rate of murine sarcoma S180; Sea cucumber mucopolysaccharide also have improve immunity, strengthen the brain memory ability, multiple efficacies such as antithrombotic, hypoglycemic, antiviral, radioresistance; The sea cucumber saponin is that first that find in the world derives from the saponin of animal, also be that the first is found the animal component that suppresses the tumor growth effect in the body, can suppress the P338 cancer cell, to experimental tumor cell such as mouse S-180 cell and human oncocyte's showed cell toxic action, the twin property of apoplexy convulsion paralysis there is the obvious treatment effect, also has very strong antimycotic, radiation resistance.Therefore sea cucumber is except that having tonic effect, improve in addition body immunity, antitumor, antithrombotic, hypoglycemic, delay senility, antifatigue, enhancing memory and multiple efficacies such as antimycotic.
Oyster meat contains rich in protein, glycogen, amino acid, vitamin and mineralogical composition, and the content of its taurine and trace element zinc occupies first of the marine product.Modern pharmacology studies show that: taurine have promote children's brain development, strengthen immunity of organisms, different physiological roles such as antifatigue, reducing blood lipid, hypoglycemic and hepatic cholagogic; Trace element zinc is the intelligence development element, can also promote sexual gland secretion, participate in the synthetic of multiple important biomolecule enzyme in the body, and effects such as anticancer, antifatigue and promotion wound healing are arranged; Glycogen can directly be absorbed by body, thereby alleviates the pancreas burden, and is significant to the control of diabetes, and simultaneously glycogen also is the material guarantee of mental activity of preserving one's strength, and can effectively improve heart and blood circulation function, and hepatoprotective effect is remarkable.Therefore oyster has the immunity of organisms of enhancing, antifatigue, anti-ageing, reducing blood lipid, hypoglycemic, antiviral and nourishing and strengthening vital, protects the liver multi-efficiencies such as kidney-nourishing, brain healthy as the marine product of medicine-food two-purpose.
The fruits nutrition of matrimony vine is abundant.Matrimony vine has consequence in the traditional medicine of motherland, its medical value enjoys the high praise of ancient Chinese medicine doctor.The fruit of Chinese wolfberry sweet property of distinguishing the flavor of is flat, kidney tonifying, enriching yin, nourishing the liver are arranged, makes eye bright, effect such as beneficial gas, diseases such as being applicable to deficiency of the kidney seminal emission, soreness and weakness of waist and knees, having a dizzy spell, be bleary-eyed.Analysis and research show: it is high especially that matrimony vine contains abundant LBP-X, free amino acid, taurine, betaine and multivitamin and mineral element, particularly carotenoid content.Matrimony vine can significantly strengthen the cellular immunity and the humoral immunity of body; and have and promote hematopoiesis, reduce blood sugar and liver-protective effect; can reduce cholesterol, excited cerebral nerve, enhancing immunologic function, anti-curing cancers, anti-ageing and beauty treatment, health be play a part extremely useful.It is major ingredient that concentrating drinking liquid of the present invention adopts fresh sea cucumber, fresh oyster and dried fruit of lycium barbarum are auxiliary material, the preparation of applying biological enzymolysis and ultrasonic wave extraction and modern concentration technology comprises sea cucumber, the whole nutritions of oyster, and heavy metals such as not leaded, mercury, cadmium, arsenic.This drink liquid is rich in bioactivators such as sea cucumber mucopolysaccharide, selenka, polypeptide, amino acid, taurine, various trace elements and vitamin; the effect that have antifatigue, improves immunity; mouthfeel is good, and is edible easy to carry, has brilliant market developing prospect.
1), utilize ultrasonic extraction and particular organisms zymolysis technique the advantage that method for making of the present invention is outstanding is:, the nutritive effect composition in sea cucumber and the oyster is almost intactly extracted.2) utilize shitosan suction-operated and milipore filter concentration technology, on the basis of not losing nutritional labeling, effectively removed the heavy metal in the drink liquid.3) nutrition among the present invention is comprehensive, almost is equal to fresh and alive sea cucumbers, oyster, but and all is water-soluble little molecule absorbing state.
Four, the specific embodiment:
Below in conjunction with the specific embodiment the present invention is described in further detail, but the invention is not restricted to specific embodiment.
Embodiment 1
The full nutrition high activity sea cucumber concentrating drinking liquid of a kind of antifatigue, raising immunity is mainly made by the raw material of following weight parts: sea cucumber 70; Oyster 25; Matrimony vine 5; 0.2 part vitamin C; 0.2 part vitamin B1; 0.2 part vitamin B2; 0.4 part vitamin B6.
Concrete method for making comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: at first fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to 80～100 orders, and is standby;
The second step enzymolysis liquid preparation: take by weighing 70 parts of sea cucumbers after cleaning by composition of raw materials, oyster carries out the meat mincing homogenized for 25 parts, join in the ultrasonic wave extractor, 5 parts of matrimony vines after adding is pulverized in proportion, the pure water that adds 8 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 3 hours under the conditions that the back is 55 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 60 degree, continue ultrasonic extraction 5 hours, heat temperature raising to 100 is spent then, kept 1 minute, be cooled to room temperature again, high speed centrifugation under the 6000r/min rotating speed is got supernatant through milipore filter equipment filtering and concentrating then, collect concentrate and molecular mass filtrate respectively less than 10000Da, add the shitosan that accounts for filtrate weight 0.3% in filtrate, stirring reaction leaves standstill centrifugal again after 1 hour, the mixed enzymolysis liquid that gets of the concentrate after collection centrifuged supernatant and the above-mentioned ultrafiltration;
The concentrating drinking liquid preparation of the 3rd step: add 0.2 part of vitamin C, 0.2 part of vitamin B1,0.2 part of vitamin B2,0.4 part of vitamin B6 again in above-mentioned enzymolysis liquid, mix homogeneous, decompression distillation concentrates and promptly makes concentrating drinking liquid of the present invention then.
Embodiment 2
The full nutrition high activity sea cucumber concentrating drinking liquid of a kind of antifatigue, raising immunity is mainly made by following method, comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to 80～100 orders;
The second step enzymolysis liquid preparation: take by weighing 60 parts of sea cucumbers after cleaning by composition of raw materials, oyster carries out the meat mincing homogenized for 30 parts, join in the ultrasonic wave extractor, 10 parts of matrimony vines after adding is pulverized, the pure water that adds 10 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 4 hours under the conditions that the back is 35 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 75 degree, continue ultrasonic extraction 3 hours, heat temperature raising to 100 is spent then, keep cooling after 1 minute, be cooled to after the room temperature high speed centrifugation under the 5000r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, in filtrate, add the shitosan that accounts for filtrate weight 0.6%, stirring reaction leaves standstill centrifugal again after 1 hour, this process can effectively remove heavy metal, the concentrate of collecting after centrifuged supernatant and the above-mentioned ultrafiltration also mixes, and promptly makes enzymolysis liquid;
The concentrating drinking liquid preparation of the 3rd step: add 0.3 part of vitamin C, 0.3 part of vitamin B2,0.3 part of VB7,0.3 part of VB11 and 0.3 part of cobalamin mixing homogeneous in above-mentioned enzymolysis liquid, decompression distillation concentrates and promptly makes concentrating drinking liquid of the present invention.
Embodiment 3
The full nutrition high activity sea cucumber concentrating drinking liquid of a kind of antifatigue, raising immunity is mainly made by following, comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to 80～100 orders;
The second step enzymolysis liquid preparation: take by weighing 80 parts of sea cucumbers after cleaning by composition of raw materials, oyster carries out the meat mincing homogenized for 15 parts, join in the ultrasonic wave extractor, 5 parts of matrimony vines after adding is pulverized, the pure water that adds 8 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 3 hours under the conditions that the back is 30 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 70 degree, continue ultrasonic extraction 3 hours, heat temperature raising to 100 is spent then, keep cooling after 1 minute, be cooled to after the room temperature high speed centrifugation under the 3500r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, in filtrate, add the shitosan that accounts for filtrate weight 0.4%, stirring reaction leaves standstill centrifugal again after 1 hour, this process can effectively remove heavy metal, the concentrate of collecting after centrifuged supernatant and the above-mentioned ultrafiltration also mixes, and promptly makes enzymolysis liquid;
The concentrating drinking liquid preparation of the 3rd step: add 0.8 part of vitamin C mixing homogeneous in above-mentioned enzymolysis liquid, decompression distillation concentrates and promptly makes concentrating drinking liquid of the present invention.
Embodiment 4
The full nutrition high activity sea cucumber concentrating drinking liquid of a kind of antifatigue, raising immunity is mainly made by following, comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to about 80～100 orders;
The second step enzymolysis liquid preparation: take by weighing 50 parts of sea cucumbers after cleaning, oyster carries out the meat mincing homogenized for 30 parts, join in the ultrasonic wave extractor, 20 parts of matrimony vines after adding is pulverized, the pure water that adds 3 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 2 hours under the conditions that the back is 45 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 65 degree, continue ultrasonic extraction 4 hours, heat temperature raising to 100 is spent then, keep cooling after 1 minute, be cooled to after the room temperature high speed centrifugation under the 3500r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, in filtrate, add the shitosan that accounts for filtrate weight 0.5%, stirring reaction leaves standstill centrifugal again after 1 hour, this process can effectively remove heavy metal, the concentrate of collecting after centrifuged supernatant and the above-mentioned ultrafiltration also mixes, and promptly makes enzymolysis liquid;
The 3rd step concentrating drinking liquid preparation: in above-mentioned enzymolysis liquid, add 0.2 part of vitamin C, 0,1 part of vitamin B1,0.1 vitamin B2,0.2 part of vitamin B3,0.4 part of vitamin B5,0.3 part of VB7,0.3 part of VB11 and 0.4 part of cobalamin mixing homogeneous, decompression distillation concentrate and promptly make concentrating drinking liquid of the present invention.
Embodiment 5
The full nutrition high activity sea cucumber concentrating drinking liquid of a kind of antifatigue, raising immunity is mainly made by following, comprises that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to 100 orders;
The second step enzymolysis liquid preparation: take by weighing 85 parts of sea cucumbers after cleaning, oyster carries out the meat mincing homogenized for 10 parts, join in the ultrasonic wave extractor, add the matrimony vine after 5 parts of pulverizing, the pure water that adds 6 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 3 hours under the conditions that the back is 65 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 50 degree, continue ultrasonic extraction 4 hours, heat temperature raising to 100 is spent then, keep after 1 minute cooling, be cooled to after the room temperature high speed centrifugation under the 4500r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, add the shitosan that accounts for filtrate weight 0.1% in filtrate, stirring reaction leaves standstill centrifugal again after 1 hour, and this process can effectively remove heavy metal, the concentrate of collecting after centrifuged supernatant and the above-mentioned ultrafiltration also mixes, and promptly makes enzymolysis liquid;
The 3rd step concentrating drinking liquid prepares: above-mentioned enzymolysis liquid decompression distillation is concentrated promptly make concentrating drinking liquid of the present invention.
Claims (6)
1. the full nutrition high activity sea cucumber of antifatigue, raising immunity drinks liquid, it is characterized in that: mainly made by the raw material of following weight parts:
Sea cucumber 50～85
Oyster 10～30
Matrimony vine 5～20.
2. the full nutrition high activity sea cucumber drink liquid of antifatigue according to claim 1, raising immunity is characterized in that: the vitamin that also contains 0～2.5 weight portion in the drink liquid.
3. the full nutrition high activity sea cucumber drink liquid of antifatigue according to claim 2, raising immunity, it is characterized in that: vitamin is one or more in the following vitamin: vitamin C, vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, VB7, VB11 or cobalamin.
4. according to the full nutrition high activity sea cucumber drink liquid of the arbitrary described antifatigue of claim 1-3, raising immunity, it is characterized in that: sea cucumber is 3～5 years extra large stichopus japonicus of fresh work; Oyster is bright oyster; Matrimony vine is a lycium barbarum.
5. the method for making of the full nutrition high activity sea cucumber drink liquid of antifatigue according to claim 1, raising immunity is characterized in that: comprise that raw material is handled, enzymolysis liquid prepares and concentrating drinking liquid prepared for three steps:
First step raw material is handled: fresh and alive extra large stichopus japonicus is cut open along belly, gilled, clean with pure water; The impurity elimination of shelling of bright oyster is cleaned; Matrimony vine is cleaned and dries, and is crushed to about 80～100 orders;
The second step enzymolysis liquid preparation: take by weighing sea cucumber after cleaning by composition of raw materials, oyster carries out the meat mincing homogenized, join in the ultrasonic wave extractor, add the matrimony vine after pulverizing in proportion, the pure water that adds 3～10 times of bright sea cucumber and oyster gross weights again, account for the neutral proteinase of cleaning bright sea cucumber in back and oyster gross weight 0.2%, mix ultrasonic extraction 2～4 hours under the conditions that the back is 30～65 degree in temperature, add again and account for the compound protease of cleaning bright sea cucumber in back and oyster gross weight 0.8%, in temperature is under the condition of 50～75 degree, continue ultrasonic extraction 3～5 hours, heat temperature raising to 100 is spent then, keep cooling after 1 minute, be cooled to after the room temperature high speed centrifugation under 3500～6000r/min rotating speed, get supernatant through the ultrafiltration apparatus filtering and concentrating, collect concentrate and molecular mass filtrate respectively less than 10000Da, in filtrate, add and account for filtrate weight 0.1%～0.6% shitosan, stirring reaction leaves standstill centrifugal again after 1 hour, this process can effectively remove heavy metal, the concentrate of collecting after centrifuged supernatant and the above-mentioned ultrafiltration also mixes, and promptly makes enzymolysis liquid;
The 3rd step concentrating drinking liquid prepares: above-mentioned enzymolysis liquid decompression distillation is concentrated promptly make concentrating drinking liquid of the present invention.
6. the method for making of the full nutrition high activity sea cucumber drink liquid of antifatigue according to claim 5, raising immunity, it is characterized in that: the drink liquid method for making that contains vitamin: when the 3rd step, concentrating drinking liquid prepared, add vitamin mixing homogeneous in above-mentioned enzymolysis liquid in proportion, decompression distillation concentrates and promptly makes concentrating drinking liquid of the present invention.
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