CN100544617C - A kind of clinical enternal nutrition made from halobios - Google Patents
A kind of clinical enternal nutrition made from halobios Download PDFInfo
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- CN100544617C CN100544617C CNB2006101238065A CN200610123806A CN100544617C CN 100544617 C CN100544617 C CN 100544617C CN B2006101238065 A CNB2006101238065 A CN B2006101238065A CN 200610123806 A CN200610123806 A CN 200610123806A CN 100544617 C CN100544617 C CN 100544617C
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Abstract
The present invention relates to a kind of clinical enternal nutrition made from halobios, feature is that its raw material is formed by mass fraction 100%, by enzymolyzed shellfish meat 25%～40%, powder of pork and/or powdered beef and/or chicken meal and/or fish powder 15%～30%, seawater spirulina powder and/or chlorella powder and/or Dunaliella peircei powder 10%～20%, sea-tangle powder and/or laver powder and/or sea mustard powder and/or ulva lactuca powder 10%～20%, agar-agar 0.1%～5.0%, carragheen 0.1%～5.0%, eicosapentaenoic acid 0.1%～0.5%, DHA 0.1%～0.5% is formed.Clinical nutrition agent manufacture craft of the present invention is simple, nutritional labeling is constant comprehensively, nutrition arrangement is reasonable, constant product quality, instant and natural having no side effect, can be used as bread and cheese and give old man, children, crowd such as in poor health or normal population edible, can also be applied to give in the hospital common patient, critically ill patient, patient in imminent danger that the clinical nutrition support is provided.
Description
Technical field
The present invention relates to a kind of clinical enternal nutrition, relate to a kind of clinical enternal nutrition made from halobios specifically.
Background technology
Scientific research and medical practice show; compare with the parenteral nutrition agent; Elental can be protected intestinal mucosal barrier, promotes the gastrointestinal motility functional rehabilitation, increases the portalsystem blood circulation, promotes the gastrointestinal hormone secretion, improve the tolerance of liver to nutriment; and the validity height, cheap.Therefore Elental is considered to the prefered method that clinical nutrition is supported.
Elental in the market mainly with the fowl domestic animals of land and terrestrial plant class such as cereal, vegetables, fruit etc. as raw material, its processing method is simple, but taste has certain limitation.And taking place frequently of fowl such as bird flu, aftosa domestic animals infectious disease in recent years, agricultural chemicals and antibiotic a large amount of use in addition, make fowl domestic animals and terrestrial plant quasi-tradition raw-food material exist great security hidden danger, it is single, unbalanced that land animal-plant kind raw material ubiquity of while the trophic function composition, shortcoming such as that amino acid is tired is not high, functional component is limited has seriously limited the development of Elental.
Summary of the invention
It is comprehensive to the objective of the invention is to develop a kind of nutritional labeling, the Elental of multiple tastes.
We pass through enzymolyzed shellfish meat, powder of pork or powdered beef or chicken meal or fish powder, seawater spirulina powder or chlorella powder or Dunaliella peircei powder, sea-tangle powder or laver powder or sea mustard powder or ulva lactuca powder, agar-agar, carragheen, eicosapentaenoic acid and DHA mix, and the marine organisms Elental that obtains contains amounts of protein, amino acid, vitamin, mineral matter and trace element, thus realized purpose of the present invention.
A kind of clinical enternal nutrition made from halobios of the present invention, feature is that its raw material is formed by gross mass mark 100%, by enzymolyzed shellfish meat 25%～40%, powder of pork and/or powdered beef and/or chicken meal and/or fish powder 15%～30%, seawater spirulina powder and/or chlorella powder and/or Dunaliella peircei powder 10%～20%, sea-tangle powder and/or laver powder and/or sea mustard powder and/or ulva lactuca powder 10%～20%, agar-agar 0.1%～5.0%, carragheen 0.1%～5.0%, eicosapentaenoic acid 0.1%～0.5%, DHA 0.1%～0.5% is formed.
Described enzymolyzed shellfish meat can be an oyster, scallop, pearl shell, mussel, in the meat zymolytes such as clam one or more, its raw material is formed by mass fraction 100%, preferably by Carnis Ostreae zymolyte 10%～25%, scallop fermented product 10%～25%, pearl oyster meat zymolyte 10%～25%, mussel meat zymolyte 10%～25%, Conch Meretricis seu Cyclinae zymolyte 10%～25% is formed, described enzymolyzed shellfish meat can directly be bought from the market, also can prepare with reference to prior art, for example with reference to the preparation method of shellfish zymolyte among the Chinese invention patent CN1703978, be about to meet the oyster of the edible relevant criterion of national shellfish, scallop, pearl shell, mussel and clam are cleaned, remove shell, the shellfish limit, leftover bits and pieces such as internal organ, with the homogenate of shellfish meat, through enzymolysis, deodorizing removes raw meat, concentrate with drying and crushing and obtain enzymolyzed shellfish meat, described enzymolysis can adopt papain, trypsase, subtilopeptidase A, neutral proteinase, the protease of one or more in the composite flavor enzyme etc., described deodorizing removes raw meat and can adopt conventional physics or chemical method to carry out, boiling method for example, absorption method or interpolation citric acid, Radix Glycyrrhizae etc., described concentrating, dry, pulverising step all can adopt conventional method, described powder of pork, powdered beef, chicken meal, fish powder, seawater spirulina powder, chlorella powder, Dunaliella peircei powder, the sea-tangle powder, laver powder, sea mustard powder, ulva lactuca powder can be bought from the market, also can be according to existing method preparation, agar-agar, carragheen, eicosapentaenoic acid, DHA etc. all can be bought from the market.
The preparation method of a kind of clinical enternal nutrition made from halobios of the present invention is that each raw material is mixed back dry (baking temperature preferably is controlled at 80～90 ℃), is crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtains product.
Analyze the nutritional labeling of clinical enternal nutrition made from halobios of the present invention, the results are shown in Table 1.
The nutritional labeling of table 1 clinical enternal nutrition made from halobios
Contain amounts of protein class material (animal protein, algae albumen, vegetable protein etc.), peptide matters (polypeptide, functional small peptide etc.) in the clinical enternal nutrition of the present invention; amino acids material (multiple essential amino acid, taurine etc.), vitamins (vitamin A, C, E, B
1, B
2, B
6, B
12, carrotene, nicotinic acid, choline, inositol, folic acid etc.), mineral matter (calcium, phosphorus, potassium, magnesium, iron etc.), starchy material (marine alga starch, plant amylum), prebiotics class material (algal polysaccharides, agar-agar, carragheen, algin, seaweed diet fiber etc.) and other abundant physiological activators (glucose, tartaric acid, citric acid, malic acid etc.).Enzymolyzed shellfish meat wherein contains amounts of protein; polypeptide; functional small peptide; essential amino acid; taurine; vitamin; material compositions such as trace element; cooperate powder of pork; powdered beef; chicken meal; fish powder; can be used as the basis, source of protein and energy matter; also has simultaneously the raising body immunity; health-care effect such as build up resistance; the seawater spirulina powder; chlorella powder; Dunaliella peircei powder; the sea-tangle powder; laver powder; sea mustard powder; ulva lactuca powders etc. contain the nutrition and the trace element of a large amount of needed by human; wherein contain 10%～48% crude protein; 30%～60% contain no nitrogen organic compound such as algin; starch; sweet mellow wine; polysaccharide such as cellulose; also contain miscellaneous mineral element such as calcium; potassium; sodium; magnesium; iron; copper; iodine; phosphorus; zinc; manganese; selenium; cobalt; strontiums etc. also contain vitamin A in the marine alga simultaneously; C; E; B
1, B
2, B
6, B
12Nicotinic acid, choline, inositol, multivitamins such as folic acid, also contain multiple pigment and many active materials that can promote biological growth, and agar-agar and carragheen belong to algal polysaccharides class material, they can not only improve body's immunity, and have antitumor, antiviral, radioresistance, multiple biologically active such as reducing blood lipid and anticoagulation, can provide sufficient carbohydrate material for marine organisms type clinical nutrition product of the present invention, eicosapentaenoic acid, DHA is polyunsaturated fatty acid class material, be people's bulk-growth and healthy necessary material, but in human body, can not synthesize, must from food, obtain, has the important function that brain nourishing and eyesight improving delays senility, the diabetes effect is remarkable for preventing and treating, can also prevent the generation of brain function decline and senile dementia, and have important physiological function, can be used as the infant for nervous system and eye retina, the important additives component of old man and other types patients clinical nutriment.
Choose acute gastroenteritis patient 12 examples, childhood dystrophy patient 8 examples, cat fever patient 15 examples, senile dementia 4 examples, totally 39 routine patients, wherein male 23 examples, women 16 examples, the clinical nutrition agent is 30 days in the edible marine organisms intestines of the present invention.Heat is only given patients clinical nutrition agent of the present invention according to 25～30kal/kg/ day at normal ingest time, and duration of test will not be taken in other food, health of per 10 days records and physical signs after the beginning meals.The result adopts the biostatistics processing method, averages ± standard deviation.The results are shown in Table 2.
Table 2 clinical enternal nutrition made from halobios is to patient's nutritive validity
Clinical nutrition agent manufacture craft of the present invention is simple; nutritional labeling is constant comprehensively; nutrition arrangement is reasonable; constant product quality; instant and natural having no side effect; the every day of satisfying that Chinese Soclety of Nutrition recommends for the adult nutrient in the meals supply standard; can also be common patient; critically ill patient; patients in imminent danger etc. provide sufficient energy and nutrition; keep the normal function of health; build up health; and raising immunity of organisms; protect gastrointestinal tract mucous barrier; relax bowel, the diabetes patient is had certain hypoglycemic; the effect of reducing blood lipid, and mouthfeel is moderate; taste is fit to the patients of all age group; appetite generally strengthens behind the patients, and none routine appetite reduces, and gastrointestinal reaction is normal; abdominal distension does not appear; bad reactions such as diarrhoea, non-evident effect.Take the present invention after 30 days, patient's body weight and constitutional index have increase trend, arm flesh encloses normally, lymphocyte number rises, blood sugar and the solid fat content of total courage have the trend of reduction, therefore clinical nutrition product of the present invention not only can be used as bread and cheese and gives old man, children, crowd such as in poor health or normal population edible, can also be applied to hospital clinical nutritional support, family's clinical nutrition support etc., thereby have huge market application foreground.
The specific embodiment
Following examples are to further specify of the present invention, are not limitations of the present invention.
Embodiment 1:
Preparation shellfish zymolyte: oyster meat is cleaned, get oyster meat 1kg after removing leftover bits and pieces, papain 20g enzymolysis will be added after its homogenate, enzymatic hydrolysis condition is PH7,55 ℃ of operative temperatures, enzymolysis time is 5h, in zymolyte, add the deodorizing of 10g citric acid and remove raw meat, vacuum concentrates 1h under 90 ℃ of conditions, after 85 ℃ of oven dry, promptly obtain Carnis Ostreae zymolyte, get scallop, pearl oyster meat, mussel meat and each 1kg of clam meat in addition, make scallop fermented product according to above-mentioned method respectively, the pearl oyster meat zymolyte, mussel meat zymolyte and Conch Meretricis seu Cyclinae zymolyte.
The preparation powder of pork: with fresh pork, cleaning is removed impurity, boiling 30min in boiling water after rubbing, remove by filter the mixture of profit, the pork that obtains is conventional sterilization treatment 10min in the high-temperature sterilization pot, and 80 ℃ of dryings are 3 hours in the baking oven, be crushed to below the particle diameter 0.18mm, obtain product.
Preparation seawater spirulina powder and sea-tangle powder: get seawater spirulina or sea-tangle 1kg after fresh or drying, through fully cleaning back homogenate, add citric acid 10g and take off the raw meat processing, remove by filter impurity, the back is 100 ℃ of oven dry 45min in baking oven,, be crushed to below the particle diameter 0.18mm, make seawood meal or sea-tangle powder.
Get the above-mentioned Carnis Ostreae zymolyte 0.625kg that makes, scallop fermented product 0.625kg, pearl oyster meat zymolyte 0.625kg, mussel meat zymolyte 0.25kg, Conch Meretricis seu Cyclinae zymolyte 0.375kg, obtain enzymolyzed shellfish meat 2.5kg, other gets powder of pork 3.0kg, seawater spirulina powder 1.4kg, sea-tangle powder 2kg, agar-agar 0.5kg and carragheen 0.5kg that Putian City East Sea fruit and vegetable product Co., Ltd sells, eicosapentaenoic acid 0.05kg and DHA 0.05kg that the Shanghai refined health products of letter Co., Ltd sells mix each component according to quality order from big to small, dry in 90 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 2: shellfish zymolyte, powder of pork and seawater spirulina powder make according to the method for embodiment 1, and laver powder obtains with reference to the seawater spirulina powder, preparation method thereof of embodiment 1.
Get the Carnis Ostreae zymolyte 0.4kg that makes, scallop fermented product 0.8kg, pearl oyster meat zymolyte 0.8kg, mussel meat zymolyte 1kg, Conch Meretricis seu Cyclinae zymolyte 1kg, obtain enzymolyzed shellfish meat 4kg, other gets powder of pork 1.5kg, seawater spirulina powder 2.0kg, laver powder 2kg, agar-agar 0.01kg and carragheen 0.47g that Guangzhou thousand standing grain commerce and trade Co., Ltd sells, eicosapentaenoic acid 0.01kg and DHA 0.01kg that Qingdao Yi Likesi industry and trade Co., Ltd sells mix each component according to quality order from big to small, dry in 85 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 3:
Buy Carnis Ostreae zymolyte 0.8kg from Guangzhou Xingyi Marine Organisms Engineering Co., Ltd., scallop fermented product 0.36kg, pearl oyster meat zymolyte 0.75kg, mussel meat zymolyte 0.79kg, Conch Meretricis seu Cyclinae zymolyte 0.9kg, obtain enzymolyzed shellfish meat 3.6kg, other gets the powdered beef 2.7kg that fragrant garden, sky, Zhuhai Special Economic Zone Food Co., Ltd sells, the chlorella powder 1.7kg that the strong bio tech ltd in sky, Binzhou, Shandong is sold, the sea mustard powder 1.85kg that Dalian Fang Hai International Trading Company Ltd sells, agar-agar 0.09kg and carragheen 0.01kg that Shantou Jiecheng Food Additives Co., Ltd. sells, eicosapentaenoic acid 0.02kg and DHA 0.03kg that Jinan intelligent bodyguard Industrial Co., Ltd. sells, according to quality order from big to small each component is mixed, dry in 85 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 4:
Method according to embodiment 1 makes Carnis Ostreae zymolyte 0.775kg, scallop fermented product 0.465kg, pearl oyster meat zymolyte 0.31kg, mussel meat zymolyte 0.775kg, Conch Meretricis seu Cyclinae zymolyte 0.775kg, obtain enzymolyzed shellfish meat 3.1kg, other gets the chicken meal 3kg that the green friendly Food Co., Ltd in Beijing sells, the Dunaliella peircei powder 1kg that Salt Research Institute China National Salt Industry Corporation sells, the ulva lactuca powder 2kg that sea, Xiamen City silver-colored aquatic products trading company sells, the agar-agar 0.42kg and the carragheen 0.4kg of just industrial chemicals Co., Ltd sale closed in Shanghai, eicosapentaenoic acid 0.04kg and DHA 0.04kg that Shenzhen mores hall biotechnology development corporation, Ltd. sells, according to quality order from big to small each component is mixed, dry in 80 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 5:
Buy Carnis Ostreae zymolyte 0.8kg from Dalian Haiyantang Biological Co., Ltd., scallop fermented product 0.7kg, pearl oyster meat zymolyte 0.78kg, mussel meat zymolyte 0.6kg, Conch Meretricis seu Cyclinae zymolyte 0.32kg, obtain enzymolyzed shellfish meat 3.2kg, other gets the fish powder 2.9kg that Zhanjiang aquatic products economic trade development company sells, the chlorella powder 2kg that Wuxi green strange bioengineering Co., Ltd sells, the sea-tangle powder 1.0kg that gold bay, Binzhou bio tech ltd is sold, agar-agar 0.50g and carragheen 0.32kg that Longhai City, Zhengzhou beer goods and materials Co., Ltd sells, eicosapentaenoic acid 0.045kg and DHA 0.035kg that Deyang Ou Bo Bioisystech Co., Ltd sells, according to quality order from big to small each component is mixed, dry in 85 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 6:
Enzymolyzed shellfish meat, seawater spirulina powder, sea-tangle powder, powder of pork make according to the method for embodiment 1, chlorella powder, Dunaliella peircei powder all obtain with reference to the seawater spirulina powder, preparation method thereof of embodiment 1, and laver powder, sea mustard powder, ulva lactuca powder all obtain with reference to the preparation method of sea-tangle powder among the embodiment 1.
Get the Carnis Ostreae zymolyte 1kg that makes according to embodiment 1 method, scallop fermented product 1kg, pearl oyster meat zymolyte 0.8kg, mussel meat zymolyte 0.8kg, Conch Meretricis seu Cyclinae zymolyte 0.4kg, get enzymolyzed shellfish meat 4kg, other gets powder of pork 0.5kg, seawater spirulina powder 1.0kg, chlorella powder 0.5kg, Dunaliella peircei powder 0.5kg, sea-tangle powder 0.5kg, laver powder 0.5kg, sea mustard powder 0.5kg, ulva lactuca powder 0.5kg, the powdered beef 0.2kg that Zhanjiang aquatic products economic trade development company sells, chicken meal 0.1kg, fish powder 0.7kg, agar-agar 0.01kg and carragheen 0.47kg that Guangzhou thousand standing grain commerce and trade Co., Ltd sells, eicosapentaenoic acid 0.01kg and DHA 0.01kg that Qingdao Yi Likesi industry and trade Co., Ltd sells mix each component according to quality order from big to small, dry in 82 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 7:
Carnis Ostreae zymolyte 3.4kg buys in aquatic products economic trade development company from Zhanjiang, other gets the fish powder 0.15kg that fragrant garden, sky, Zhuhai Special Economic Zone Food Co., Ltd sells, chicken meal 1.1kg, powdered beef 1.6kg, the Dunaliella peircei powder 0.8kg that the strong bio tech ltd in sky, Binzhou, Shandong is sold, chlorella powder 1.0kg, the laver powder 0.7kg that Dalian Fang Hai International Trading Company Ltd sells, ulva lactuca powder 0.1kg, sea mustard powder 1.0kg, agar-agar 0.07kg and carragheen 0.03kg that Shantou Jiecheng Food Additives Co., Ltd. sells, eicosapentaenoic acid 0.025kg and DHA 0.025kg that Jinan intelligent bodyguard Industrial Co., Ltd. sells, according to quality order from big to small each component is mixed, dry in 87 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 8:
Method according to embodiment 1 makes pearl oyster meat zymolyte 1.5kg, Conch Meretricis seu Cyclinae zymolyte 1.6kg, other gets the powdered beef 1.5kg that the green friendly Food Co., Ltd in Beijing sells, chicken meal 1.5kg, the seawater spirulina powder 0.4kg that Salt Research Institute China National Salt Industry Corporation sells, chlorella powder 0.9kg, the sea-tangle powder 1kg that sea, Xiamen City silver-colored aquatic products trading company sells, ulva lactuca powder 1kg, the agar-agar 0.45kg and the carragheen 0.1kg of just industrial chemicals Co., Ltd sale closed in Shanghai, eicosapentaenoic acid 0.01kg and DHA 0.04kg that Shenzhen mores hall biotechnology development corporation, Ltd. sells, according to quality order from big to small each component is mixed, dry in 84 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Embodiment 9:
Buy Carnis Ostreae zymolyte 0.4kg from Dalian Haiyantang Biological Co., Ltd., scallop fermented product 1.6kg, mussel meat zymolyte 1.2kg, obtain enzymolyzed shellfish meat 3.2kg, other gets the powder of pork 1.25kg that Zhanjiang aquatic products economic trade development company sells, fish powder 1.62kg, the seawater spirulina powder 1.5kg that Wuxi green strange bioengineering Co., Ltd sells, Dunaliella peircei powder 0.5kg, the laver powder 0.8kg that gold bay, Binzhou bio tech ltd is sold, sea mustard powder 0.53kg, agar-agar 0.50g and carragheen 0.02kg that Longhai City, Zhengzhou beer goods and materials Co., Ltd sells, eicosapentaenoic acid 0.05kg and DHA 0.03kg that Deyang Ou Bo Bioisystech Co., Ltd sells, according to quality order from big to small each component is mixed, dry in 86 ℃ baking oven, be crushed to below the particle diameter 0.18mm, behind high-temperature sterilization, obtain the marine organisms Elental.
According to above-mentioned clinical testing, proved that this Elental is suitable for patients.
Claims (2)
1. clinical enternal nutrition made from halobios, feature is that its raw material is formed by mass fraction 100%, by enzymolyzed shellfish meat 25%～40%, powder of pork and/or powdered beef and/or chicken meal and/or fish powder 15%～30%, seawater spirulina powder and/or chlorella powder and/or Dunaliella peircei powder 10%～20%, sea-tangle powder and/or laver powder and/or sea mustard powder and/or ulva lactuca powder 10%～20%, agar-agar 0.1%～5.0%, carragheen 0.1%～5.0%, eicosapentaenoic acid 0.1%～0.5%, DHA 0.1%～0.5% is formed, and by each raw material is mixed the back 80～90 ℃ of dryings, be crushed to below the particle diameter 0.18mm, prepare through high-temperature sterilization.
2. according to a kind of clinical enternal nutrition made from halobios of claim 1, the raw material that it is characterized in that described enzymolyzed shellfish meat is formed by mass fraction 100%, by Carnis Ostreae zymolyte 10%～25%, scallop fermented product 10%～25%, pearl oyster meat zymolyte 10%～25%, mussel meat zymolyte 10%～25%, Conch Meretricis seu Cyclinae zymolyte 10%～25% is formed.
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101361804B (en) * | 2008-09-25 | 2011-04-27 | 中国科学院南海海洋研究所 | Enteral nutrition emulsion for tumor patient |
| CN101703248B (en) * | 2009-10-23 | 2013-04-03 | 中国科学院南海海洋研究所 | Enteral nutritional preparation containing marine bioactivity polysaccharide as well as preparation method and application thereof |
| CN102077942B (en) * | 2010-09-20 | 2013-04-24 | 王强 | Marine special dietary food special for patient with bone disease |
| CN106036885B (en) * | 2016-06-08 | 2019-05-28 | 裴刚 | Severe and the postoperative Elental and preparation method thereof through nasointestinal tube row |
| CN106072652A (en) * | 2016-06-13 | 2016-11-09 | 合肥赛为智慧医疗有限公司 | A kind of salt algae powder/DHA goods |
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| CN1120908A (en) * | 1994-10-20 | 1996-04-24 | 国家海洋局第三海洋研究所 | Choice seafood extract product and its production process and uses |
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