CN107029109A - One kind softening blood vessel enhancing flexible health products of blood vessel and preparation method thereof - Google Patents
One kind softening blood vessel enhancing flexible health products of blood vessel and preparation method thereof Download PDFInfo
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- CN107029109A CN107029109A CN201710285707.5A CN201710285707A CN107029109A CN 107029109 A CN107029109 A CN 107029109A CN 201710285707 A CN201710285707 A CN 201710285707A CN 107029109 A CN107029109 A CN 107029109A
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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Abstract
One kind softening blood vessel enhancing flexible health products of blood vessel and preparation method thereof；The health products include the raw material of following parts by weight：28 parts of sea cucumber extract, 40 60 parts of watermelon bark extract, 10 30 parts of Rhizoma Polygonati extract, 5 10 parts of wolfberry fruit powder, 0.1 0.22 parts of vitamin C, 0.08 0.18 parts of vitamin E, 0.001 0.002 parts of vitamin B1,0.0001 0.0006 parts of 0.0007 0.002 parts of vitamin B6,0.000001 0.000006 parts of vitamin B12 and folic acid.Its preparation method is to mix taken sea cucumber extract and watermelon bark extract, add water, and 30 35 DEG C of 8 10h of insulation, cooling obtains mixture A, adds other raw materials, and auxiliary material prepares the softening blood vessel enhancing flexible health products of blood vessel；The suitable long-term taking of the present invention, can soften blood vessel enhancing blood vessel pliability, have preferably prevention and adjuvant treatment effect to cardiovascular and cerebrovascular disease.
Description
Technical field
The present invention relates to a kind of health products, specifically a kind of softening blood vessel enhancing flexible health products of blood vessel and its
Preparation method.
Background technology
Cardiovascular and cerebrovascular disease is exactly that cardiovascular and cerebrovascular disease are referred to as.Also referred to as " rich man's disease " " three is high
Disease ".Hyperglycaemia or high fat of blood are also suffered from while 40%~45% suffers from hypertension in more than 60 years old the elderlys, according to the Ministry of Public Health
Statistics are shown within 2007, show that 50% or so diabetes patient is associated with hypertension, high fat of blood etc. according to external data
A variety of infirmitiess of age.Cardiovascular and cerebrovascular disease has " incidence of disease is high, disability rate is high, the death rate is high, high recurrence rate, and complication is more "
I.e. " more than four high one " the characteristics of, at present, China's Patients with Cardiovascular/Cerebrovascular Diseases alreadys exceed 2.7 hundred million people.China dies from heart and brain every year
Nearly 3,000,000 people of vascular diseases, accounts for the 51% of the annual total Death causes of China.
Cardiovascular and cerebrovascular disease key is to prevent, and is a kind of high disease of disability rate.Once this kind of disease must be gone up, oneself is very
Difficulty is taken care of oneself, and very big financial burden and psychological pressure are caused to family.Patient oneself is also usually because tied down household, the heart
Feelings are not smooth, and the treatment of disease is have impact on the contrary.For cardiovascular and cerebrovascular disease, either economically, family's angle, still
For health perspectives, have prevention only and be only completely safe plan, brilliant act.Prevent within early one day, earlier feel at ease.
The content of the invention
The present invention provides a kind of softening blood vessel enhancing flexible health products of blood vessel and preparation method thereof, prepared softening
Blood vessel strengthens the flexible health products of blood vessel, is adapted to long-term taking, can soften blood vessel enhancing blood vessel pliability, to cardiovascular and cerebrovascular disease
Disease has preferably prevention and adjuvant treatment effect.
The present invention is for the technical scheme that is used of solution above-mentioned technical problem：
One kind softening blood vessel enhancing flexible health products of blood vessel, include the raw material of following parts by weight：Sea cucumber extract 2-8
Part, 40-60 parts of watermelon bark extract, 10-30 parts of Rhizoma Polygonati extract, 5-10 parts of wolfberry fruit powder, 0.1-0.22 parts of vitamin C, dimension life
Plain E 0.08-0.18 parts, 0.001-0.002 parts of vitamin B1,0.0007-0.002 parts of vitamin B6, vitamin B12
0.000001-0.000006 parts, 0.0001-0.0006 parts of folic acid.
The softening blood vessel strengthens the flexible health products of blood vessel, and the parts by weight of its raw material are preferably：Sea cucumber extract 6
Part, 50 parts of watermelon bark extract, 20 parts of Rhizoma Polygonati extract, 8 parts of wolfberry fruit powder, 0.15 part of vitamin C, 0.12 part of vitamin E, dimension
Raw 0.0015 part of element B1,0.0015 part of vitamin B6,0.000003 part of vitamin B12,0.0004 part of folic acid.
The preparation method of the sea cucumber extract is：New fresh sea cucumber is taken, internal organ are removed, cleaned, crushes, add 0.2%-1%'s
Vitamin C, colloid mill grinds to form colloidal, pH is transferred into 1.5-3.0 with hydrochloric acid, is added according to the 0.05%-0.1% of sea cucumber weight
Enzyme-activity unit is 15000U/g pepsins, digests 3-5h at 30-40 DEG C；Then pH value is adjusted to 7.5-8.5 with NaOH, pressed
The 0.01%-0.05% of Zhaohai ginseng weight adds the 32-40 DEG C of enzymolysis 2-6h of trypsase of enzyme activity for 100000U/g, then freezes
Do or be spray-dried to obtain sea cucumber extract.
The preparation method of the watermelon bark extract：By fresh watermelon peel, clean, be crushed to 20-40 mesh, add pectin
Enzyme and cellulase, 30-40 DEG C of insulation 3-5h, filter to take clear liquid, concentrate, dry, crush to obtain watermelon bark extract.
The preparation method of the Rhizoma Polygonati extract is：Prepared slices of Chinese crude drugs sealwort is taken, 20-50 times of water of its quality is added, 20- is soaked
30min, 100 DEG C of boiling 30min, filters to take clear liquid, is concentrated and dried to obtain Rhizoma Polygonati extract.
The softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, comprises the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: after taken sea cucumber extract 2-8 parts and watermelon bark extract are mixed first, plus its quality 0.2-0.3 water
It is incubated 8-10h at 30-35 DEG C, taking-up is cooled to room temperature, obtains mixture A, it is standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, obtain mixture A, mixture A is prepared into required agent
Type, that is, prepare the softening blood vessel enhancing flexible health products of blood vessel.
The auxiliary material is dextrin or starch.
The formulation is tablet, capsule, pulvis or granule.
The preparation method of the tablet is that its weight 2%-3% drinking water is added in mixture A, is stirred, with granulation
The particle of 10-20 mesh is made in machine, and it is less than 4% to be placed in 50-70 DEG C of drying to moisture, and tablet is made using tabletting machine.
Beneficial effect is：
1st, present invention softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, prepared softening blood vessel enhancing blood vessel
Flexible health products, each reasonable raw material proportioning；Under the processing of technique, each mutual synergy of medicine more preferably, is adapted to long-term
Take, test result indicates that, with preferable preventive effect；The heart can be significantly improved when coordinating cardiovascular medicament treatment to use
The therapeutic effect of cranial vascular disease, makes treated effect up to raising 11%；
The effective ingredient in sea cucumber and watermelon bark extract in the present invention is organically combined under the PROCESS FOR TREATMENT of the application, with reference to
The public effect of Rhizoma Polygonati extract, wolfberry fruit powder, with the booster action of other raw materials, clearing up blood vessel rubbish, softening blood vessel improves
Hypertension caused by blood vessel pliability, effectively prevention and alleviation cardiovascular and cerebrovascular disease, and the blood vessel caused by blood vessel aging
Wall elasticity is not enough, and vascular wall, which becomes fragile, waits the organic disease of blood vessel, is finally reached effectively prevention and auxiliary treatment person in middle and old age's heart and brain
The purpose of vascular diseases.
2nd, the sea cucumber extract rational technology employed in the present invention, is to ensure that softening blood vessel enhancing blood vessel is flexible to protect
The critical process of strong product, the technique saves sea cucumber complete nutrients matter, and abundant L-arginine, L- are contained particularly in sea cucumber
Arginine produces nitric oxide in the presence of nitricoxide synthase in vivo, and nitric oxide is as a kind of signaling molecule in relaxation
Blood vessel, regulating blood flow amount and improvement ischemic conditions play very important effect；Sea cucumber extraction process overall process low temperature control
System, preserves the bioactive substance of sea cucumber to greatest extent；Protein digestion in technique divides macro-molecular protein in sea cucumber
Solution is into small-molecular peptides, it is easier to absorb.Verify, pass through, can often take, have no side effect for a long time that safety is inhaled by clinical test
Keep well, prevention cardiovascular and cerebrovascular disease effect is notable.
Embodiment
One kind softening blood vessel enhancing flexible health products of blood vessel, include the raw material of following parts by weight：Sea cucumber extract
2-8 parts, 40-60 parts of watermelon bark extract, 10-30 parts of Rhizoma Polygonati extract, 5-10 parts of wolfberry fruit powder, 0.1-0.22 parts of vitamin C,
0.08-0.18 parts of vitamin E, 0.001-0.002 parts of vitamin B1,0.0007-0.002 parts of vitamin B6, vitamin B12
0.000001-0.000006 parts and 0.0001-0.0006 parts of folic acid.
The softening blood vessel strengthens the flexible health products of blood vessel, and the parts by weight of its raw material are preferably：Sea cucumber extract 6
Part, 50 parts of watermelon bark extract, 20 parts of Rhizoma Polygonati extract, 8 parts of wolfberry fruit powder, 0.15 part of vitamin C, 0.12 part of vitamin E, dimension
0.0004 part of raw 0.0015 part of element B1,0.0015 part of vitamin B6,0.000003 part of vitamin B12 and folic acid.
The preparation method of the sea cucumber extract is：New fresh sea cucumber is taken, internal organ are removed, cleaned, crushes, add 0.2%-1%'s
Vitamin C, colloid mill grinds to form colloidal, pH is transferred into 1.5-3.0 with hydrochloric acid, is added according to the 0.05%-0.1% of sea cucumber weight
Enzyme-activity unit is 15000U/g pepsins, digests 3-5h at 30-40 DEG C；Then pH value is adjusted to 7.5-8.5 with NaOH, according to
The 0.01%-0.05% of sea cucumber weight adds the 32-40 DEG C of enzymolysis 2-6h of trypsase of enzyme activity for 100000U/g, then freezes
Or it is spray-dried to obtain sea cucumber extract.
The preparation method of the watermelon bark extract：By fresh watermelon peel, clean, be crushed to 20-40 mesh, add pectin
Enzyme and cellulase, 30-40 DEG C of insulation 3-5h, filter to take clear liquid, concentrate, dry, crush to obtain watermelon bark extract.
The preparation method of the Rhizoma Polygonati extract is：Prepared slices of Chinese crude drugs sealwort is taken, 20-50 times of water of its quality is added, 20- is soaked
30min, 100 DEG C of boiling 30min, filters to take clear liquid, is concentrated and dried to obtain Rhizoma Polygonati extract.
The softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, comprises the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: after taken sea cucumber extract 2-8 parts and watermelon bark extract are mixed first, plus its quality 0.2-0.3 water
It is incubated 8-10h at 30-35 DEG C, taking-up is cooled to room temperature, obtains mixture A, it is standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, obtain mixture A, mixture A is prepared into required agent
Type, that is, prepare the softening blood vessel enhancing flexible health products of blood vessel.
The auxiliary material is dextrin or starch.
The formulation is tablet, capsule, pulvis or granule.
The preparation method of the tablet is that its weight 2%-3% drinking water is added in mixture A, is stirred, with granulation
The particle of 10-20 mesh is made in machine, and it is less than 4% to be placed in 50-70 DEG C of drying to moisture, and tablet is made using tabletting machine.
Embodiment 1
One kind softening blood vessel enhancing flexible health products of blood vessel, include the raw material of following parts by weight：6 parts of sea cucumber extract,
50 parts of watermelon bark extract, 20 parts of Rhizoma Polygonati extract, 8 parts of wolfberry fruit powder, 0.15 part of vitamin C, 0.12 part of vitamin E, vitamin
0.0004 part of 0.0015 part of B1,0.0015 part of vitamin B6,0.000003 part of vitamin B12 and folic acid.
The preparation method of the sea cucumber extract is：New fresh sea cucumber is taken, internal organ are removed, cleaned, 0.5% dimension life is crushed, adds
Plain C, colloid mill grinds to form colloidal, pH is transferred into 1.5 with hydrochloric acid, is according to 0.08% addition enzyme-activity unit of sea cucumber weight
15000U/g pepsins, digest 4h at 32 DEG C；Then pH value is adjusted to 8.0 with NaOH, added according to the 0.04% of sea cucumber weight
Enzyme activity is 100000U/g 35 DEG C of enzymolysis 4h of trypsase, then freezes or be spray-dried to obtain sea cucumber extract.
The preparation method of the watermelon bark extract：By fresh watermelon peel, clean, be crushed to 20 mesh, add pectase
And cellulase, 30 DEG C of insulation 5h, clear liquid is filtered to take, is concentrated, is dried, crushes to obtain watermelon bark extract.
The preparation method of the Rhizoma Polygonati extract is：Prepared slices of Chinese crude drugs sealwort is taken, 20 times of water of its quality are added, 30min is soaked,
100 DEG C of boiling 30min, filter to take clear liquid, are concentrated and dried to obtain Rhizoma Polygonati extract.
The softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, comprises the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: after taken sea cucumber extract and watermelon bark extract are mixed first, plus its quality 0.2 water, stir
Afterwards, it is placed at 35 DEG C and is incubated 8h, taking-up is cooled to room temperature, obtains mixture A, it is standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, obtain mixture A, mixture A is prepared into required piece
Agent, that is, prepare the softening blood vessel enhancing flexible health products of blood vessel.
The auxiliary material is dextrin.
The preparation method of the tablet is that its weight 2%-3% drinking water is added in mixture A, is stirred, with granulation
The particle of 10-20 mesh is made in machine, and it is less than 4% to be placed in 50-70 DEG C of drying to moisture, and tablet is made using tabletting machine.
Embodiment 2
One kind softening blood vessel enhancing flexible health products of blood vessel, include the raw material of following parts by weight：2 parts of sea cucumber extract,
40 parts of watermelon bark extract, 10 parts of Rhizoma Polygonati extract, 5 parts of wolfberry fruit powder, 0.1 part of vitamin C, 0.08 part of vitamin E, vitamin
0.0001 part of 0.001 part of B1,0.0007 part of vitamin B6,0.0000012 part of vitamin B12 and folic acid.
The preparation method of the sea cucumber extract is：New fresh sea cucumber is taken, internal organ are removed, cleaned, 1% vitamin is crushed, adds
C, colloid mill grinds to form colloidal, pH is transferred into 3.0 with hydrochloric acid, is according to 0.1% addition enzyme-activity unit of sea cucumber weight
15000U/g pepsins, digest 3h at 40 DEG C；Then pH value is adjusted to 8.5 with NaOH, added according to the 0.05% of sea cucumber weight
Enter 40 DEG C of enzymolysis 2h of trypsase that enzyme activity is 100000U/g, then freeze or be spray-dried to obtain sea cucumber extract.
The preparation method of the watermelon bark extract：By fresh watermelon peel, clean, be crushed to 40 mesh, add pectase
And cellulase, 40 DEG C of insulation 3h, clear liquid is filtered to take, is concentrated, is dried, crushes to obtain watermelon bark extract.
The preparation method of the Rhizoma Polygonati extract is：Prepared slices of Chinese crude drugs sealwort is taken, 50 times of water of its quality are added, 20min is soaked,
100 DEG C of boiling 30min, filter to take clear liquid, are concentrated and dried to obtain Rhizoma Polygonati extract.
The softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, comprises the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: being incubated after first mixing taken sea cucumber extract and watermelon bark extract, plus at 35 DEG C of the water of its quality 0.3
8h, taking-up is cooled to room temperature, obtains mixture A, standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, are prepared into pulvis, that is, prepare softening blood vessel enhancing blood vessel
Flexible health products.
Embodiment 3
One kind softening blood vessel enhancing flexible health products of blood vessel, include the raw material of following parts by weight：8 parts of sea cucumber extract,
60 parts of watermelon bark extract, 30 parts of Rhizoma Polygonati extract, 10 parts of wolfberry fruit powder, 0.22 part of vitamin C, 0.18 part of vitamin E, dimension life
0.0006 part of plain 0.002 part of B1,0.002 part of vitamin B6,0.000006 part of vitamin B12 and folic acid.
The preparation method of the sea cucumber extract is：
New fresh sea cucumber is taken, internal organ are removed, cleaned, 0.2% vitamin C is crushed, adds, colloid mill grinds to form colloidal, incited somebody to action with hydrochloric acid
PH is transferred to 1.5, adds enzyme-activity unit for 15000U/g pepsins according to the 0.05%% of sea cucumber weight, 5h is digested at 30 DEG C；So
PH value is adjusted to 7.5 with NaOH afterwards, 38 DEG C of the trypsase that enzyme activity is 100000U/g is added according to the 0.01% of sea cucumber weight
4h is digested, sea cucumber extract is then freezed or be spray-dried to obtain.
The preparation method of the watermelon bark extract：By fresh watermelon peel, clean, be crushed to 30 mesh, add pectase
And cellulase, 35 DEG C of insulation 4h, clear liquid is filtered to take, is concentrated, is dried, crushes to obtain watermelon bark extract.
The preparation method of the Rhizoma Polygonati extract is：Prepared slices of Chinese crude drugs sealwort is taken, 30 times of water of its quality are added, 25min is soaked,
100 DEG C of boiling 30min, filter to take clear liquid, are concentrated and dried to obtain Rhizoma Polygonati extract.
The softening blood vessel strengthens the preparation method of the flexible health products of blood vessel, comprises the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: after taken sea cucumber extract and watermelon bark extract are mixed first, plus its quality 0.2-0.3 water 30-35
It is incubated 8-10h at DEG C, taking-up is cooled to room temperature, obtains mixture A, it is standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, are prepared into granule, that is, prepare softening blood vessel enhancing blood
Manage flexible health products；
The auxiliary material is starch.
Relevant clinical prophylactic tria data：
1st, subjects：The age is selected at 40-65 Sui at random from through healthy population of the Health Certificate without cardiovascular and cerebrovascular disease
The elderly 400, wherein male 200, women 200, are divided into two groups, often by above-mentioned 400 experimental subjects stochastic averaginas
Group 200, one group is clinical test group, and another group is control group.
2nd, test method：Experimental group takes the present invention softening blood vessel enhancing flexible health products of blood vessel；The clothes of granule
It is with method, 1 times a day, once oral one bag, every bag of 1g；The instructions of taking of tablet is, 1 times a day, once oral 2.It is right
Starch granules or starch piece are taken according to group.After 2 years, 400 experimenters are checked UP again.
3rd, result of the test：There is no the appearance of cardiovascular and cerebrovascular disease in 200 experimental subjects of experimental group after 2 years, control group has
11 there is cardiovascular and cerebrovascular related symptoms, wherein hyperpietic 5, atherosclerotic 3, blood viscousness 3.
As a result show, cardiovascular and cerebrovascular disease prevention of the present invention and auxiliary treatment composition can effectively prevent cardiovascular and cerebrovascular disease
Disease, effective prevention rate reaches 100%.
Relevant clinical auxiliary treatment test data
1st, subjects：Select the Patients with Cardiovascular/Cerebrovascular Diseases 200 made a definite diagnosis through three-level to go to the hospital, wherein hyperpietic 79
Example, hyperlipidemia patient 35, blood viscousness patient 22, atherosclerosis 64.By above-mentioned experimental subjects stochastic averagina
It is divided into two groups, one group is experimental group, and another group is control group.
2nd, test method：
Experimental group takes the present invention softening blood vessel enhancing flexible health products of blood vessel, and the instructions of taking of granule is, one day 2
It is secondary, once oral one bag, every bag of 1g；The instructions of taking of tablet is that 2 times a day, once oral 2, the time limit of experiment is 1 year.Together
When prescribed according to doctor or other treatment mode continual cure；
Control group：Prescribed according to doctor or other treatment mode continual cure；
3rd, evaluation criterion is treated：
Cure：Related symptoms disappear.
It is effective：Related symptoms substantially mitigate；
Effectively：Meet effective or criterion of cure；
It is invalid：The state of an illness is unchanged on inspection.
4th, therapeutic effect：
Test group：100 patients treated, hyperpietic 38 according to statistics, hyperlipidemia patient 21, blood viscousness is suffered from
Person 10, atherosclerosis 31.Wherein 8 healings of hyperpietic, 18 effective, and 11 effectively, and 1 invalid；High fat
4 healings of mass formed by blood stasis patient, 10 effective, and 5 effectively, and 2 invalid；4 healings of blood viscousness patient, 3 are effective, and 2 are effectively,
1 invalid；17 healings of atherosclerotic, 12 effective, and 2 effectively, and 0 invalid；Total effective rate 96%；
Control group：100 patients treated, hyperpietic 41 according to statistics, hyperlipidemia patient 14, blood viscousness is suffered from
Person 12, atherosclerosis 33.Wherein 5 healings of hyperpietic, 13 effective, and 19 effectively, and 4 invalid；High fat
3 healings of mass formed by blood stasis patient, 4 effective, and 6 effectively, and 1 invalid；3 healings of blood viscousness patient, 2 are effective, and 5 are effectively, and 2
Example is invalid；6 healings of atherosclerotic, 9 effective, and 10 effectively, and 8 invalid.Total effective rate 85%.
As a result show that the present invention softening blood vessel enhancing flexible health products reasonable recipe of blood vessel can improve cardiovascular and cerebrovascular
The cure rate and therapeutic effect of disease, make treated effect up to raising 11%.
Claims (9)
1. one kind softening blood vessel enhancing flexible health products of blood vessel, it is characterised in that：Include the raw material of following parts by weight：Sea
2-8 parts of conopsea extraction, 40-60 parts of watermelon bark extract, 10-30 parts of Rhizoma Polygonati extract, 5-10 parts of wolfberry fruit powder, vitamin C 0.1-
0.22 part, 0.08-0.18 parts of vitamin E, 0.001-0.002 parts of vitamin B1,0.0007-0.002 parts of vitamin B6, dimension
0.0001-0.0006 parts of 0.000001-0.000006 parts of life element B12 and folic acid.
2. softening blood vessel strengthens the flexible health products of blood vessel as claimed in claim 1, it is characterised in that：Including following parts by weight
Several raw materials：2-8 parts of sea cucumber extract, 40-60 parts of watermelon bark extract, 10-30 parts of Rhizoma Polygonati extract, 5-10 parts of wolfberry fruit powder,
0.1-0.22 parts of vitamin C, 0.08-0.18 parts of vitamin E, 0.001-0.002 parts of vitamin B1, vitamin B6
0.0007-0.002 parts, 0.0001-0.0006 parts of 0.000001-0.000006 parts of vitamin B12 and folic acid.
3. softening blood vessel strengthens the flexible health products of blood vessel as claimed in claim 1 or 2, it is characterised in that：The sea cucumber carries
The preparation method for taking thing is：New fresh sea cucumber is taken, internal organ are removed, cleaned, 0.2%-1% vitamin C, colloid mill grinding is crushed, adds
1.5-3.0 is transferred into colloidal, with hydrochloric acid by pH, it is 15000U/g to add enzyme-activity unit according to the 0.05%-0.1% of quality of sea cucumber
Pepsin, digests 3-5h at 30-40 DEG C；Then pH value is adjusted to 7.5-8.5 with NaOH, according to the 0.01%- of quality of sea cucumber
0.05% adds the 32-40 DEG C of enzymolysis 2-6h of trypsase of enzyme activity for 100000U/g.
4. softening blood vessel strengthens the flexible health products of blood vessel as claimed in claim 1 or 2, it is characterised in that：The watermelon peel
The preparation method of extract：By fresh watermelon peel, clean, be crushed to 20-40 mesh, add pectase and cellulase, 30-40
DEG C insulation 3-5h, filters to take clear liquid, concentration, dries, crushes to obtain watermelon bark extract.
5. softening blood vessel strengthens the flexible health products of blood vessel as claimed in claim 1 or 2, it is characterised in that：The sealwort is carried
The preparation method for taking thing is：Prepared slices of Chinese crude drugs sealwort is taken, 20-50 times of water of its quality is added, 20-30min, 100 DEG C of boilings is soaked
30min, filters to take clear liquid, is concentrated and dried to obtain Rhizoma Polygonati extract.
6. softening blood vessel strengthens the preparation method of the flexible health products of blood vessel as claimed in claim 1 or 2, it is characterised in that：
Comprise the following steps：
Step 1: each raw material is taken according to parts by weight, it is standby；
Step 2: after taken sea cucumber extract 2-8 parts and watermelon bark extract are mixed first, plus its quality 0.2-0.3 water
It is incubated 8-10h at 30-35 DEG C, taking-up is cooled to room temperature, obtains mixture A, it is standby；
Step 3: Rhizoma Polygonati extract is added in gained mixture A, wolfberry fruit powder, vitamin C, vitamin E, vitamin B1, dimension life
Plain B6, vitamin B12 and folic acid, after being well mixed, add auxiliary material, obtain mixture A, needed for mixture A is prepared into
Formulation, that is, prepare the softening blood vessel enhancing flexible health products of blood vessel.
7. softening blood vessel strengthens the preparation method of the flexible health products of blood vessel as claimed in claim 6, it is characterised in that：It is described
Auxiliary material is dextrin or starch.
8. softening blood vessel strengthens the preparation method of the flexible health products of blood vessel as claimed in claim 6, it is characterised in that：It is described
Formulation is tablet, capsule, pulvis or granule.
9. softening blood vessel strengthens the preparation method of the flexible health products of blood vessel as claimed in claim 8, it is characterised in that：It is described
The preparation method of tablet is that its weight 2%-3% drinking water is added in mixture A, stirs, 10-20 is made with granulator
Purpose particle, it is less than 4% to be placed in 50-70 DEG C of drying to moisture, and tablet is made using tabletting machine.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739397A (en) * | 2004-08-25 | 2006-03-01 | 郭石 | Production process of freeze dried sea cucumber, sea cucumber capsule and sea cucumber mucopolysaccharide capsule |
| CN101015591A (en) * | 2007-02-09 | 2007-08-15 | 姜玉宝 | Oral liquor made of sea cucumber and sea dragon and its preparation method |
| CN101828744A (en) * | 2010-05-13 | 2010-09-15 | 大连蓝德奥科技有限公司 | Anti-fatigue total nutrition high activity seacucumber drinking liquid capable of improving immunity and preparation method thereof |
| CN102406112A (en) * | 2011-11-30 | 2012-04-11 | 山东大学 | Nourishing health-care buccal tablet |
| CN104208654A (en) * | 2014-09-05 | 2014-12-17 | 洛阳华以生物工程有限公司 | Healthcare prescription mainly containing earthworm protein extract |
| CN105748585A (en) * | 2016-03-12 | 2016-07-13 | 李新民 | Compound traditional Chinese medicine formula for treating cardio-cerebral vessel embolism |
| CN106539079A (en) * | 2016-11-27 | 2017-03-29 | 威海蓝印海洋生物科技有限公司 | A kind of marine organism health food and preparation method thereof |
-
2017
- 2017-04-27 CN CN201710285707.5A patent/CN107029109A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1739397A (en) * | 2004-08-25 | 2006-03-01 | 郭石 | Production process of freeze dried sea cucumber, sea cucumber capsule and sea cucumber mucopolysaccharide capsule |
| CN101015591A (en) * | 2007-02-09 | 2007-08-15 | 姜玉宝 | Oral liquor made of sea cucumber and sea dragon and its preparation method |
| CN101828744A (en) * | 2010-05-13 | 2010-09-15 | 大连蓝德奥科技有限公司 | Anti-fatigue total nutrition high activity seacucumber drinking liquid capable of improving immunity and preparation method thereof |
| CN102406112A (en) * | 2011-11-30 | 2012-04-11 | 山东大学 | Nourishing health-care buccal tablet |
| CN104208654A (en) * | 2014-09-05 | 2014-12-17 | 洛阳华以生物工程有限公司 | Healthcare prescription mainly containing earthworm protein extract |
| CN105748585A (en) * | 2016-03-12 | 2016-07-13 | 李新民 | Compound traditional Chinese medicine formula for treating cardio-cerebral vessel embolism |
| CN106539079A (en) * | 2016-11-27 | 2017-03-29 | 威海蓝印海洋生物科技有限公司 | A kind of marine organism health food and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 郭振东: "高血压病食疗方", 《药膳食疗》 * |
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Application publication date: 20170811 |