CN105535541A - Traditional Chinese medicine composition for strengthening yang and tonifying kidney and preparation method thereof - Google Patents
Traditional Chinese medicine composition for strengthening yang and tonifying kidney and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition mainly used for strengthening yang and tonifying kidney and a preparation method thereof. The traditional Chinese medicine composition is mainly prepared from an oyster extracting solution, a sea cucumber extracting solution, a dendrobium officinale extracting solution, xylitol and microcrystalline cellulose. The traditional Chinese medicine composition can be used for being made into various dosage forms, such as oral liquid, tablets, capsules, pills, granules, powder, medicinal liquor and paste. The traditional Chinese medicine composition and the preparation method thereof have the advantages that a remarkable effect is achieved on the aspect of improvement of the sexual function, experimental results show that sexual vitality of mice taking the composition is improved remarkably, the content of serum testosterone of normal mice and emasculated mice taking the composition is increased obviously, and it is thus clear that the traditional Chinese medicine composition can remarkably improve sexuality. The traditional Chinese medicine composition is a pure natural traditional Chinese medicine preparation, the untoward effect and side effect caused by irritation of the stomach and intestines can be reduced, the effectiveness is achieved fast, and the composition can be made into various dosage forms for a user to take.
Description
[technical field]
The invention belongs to the field of Chinese medicines, be specifically related to a kind of Chinese medicine composition for strengthening yang and invigorating kidney and preparation method thereof.
[background technology]
Along with the raising of socioeconomic development and living standards of the people, the live and work rhythm of people is obviously accelerated, the increasing pressure born is large, many people especially men's health level are on a declining curve year by year, and occur suffering from a deficiency of the kidney, insufficiency of vital energy and blood etc., thus cause the generation of many diseases, as body alopecia, have a dizzy spell, the disease such as sore waist and aching in the waist and the back, insomnia dysphoria with smothery sensation, and the sexual disorder such as impotence and premature ejaculation, prostatosis.Because relevant knowledge lacks or idea constraint, many people are ashamed of seeking medical advice and various analeptic in abuse of market voluntarily, not only accelerate body health level decrease speed, also may bring out other serious diseases.
The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, built-in nephroyin and nephroyang, suffer from a deficiency of the kidney point deficiency of the kidney yin and insufficiency of kidney-YANG, will do Coryza Treated by Syndrome Differentiation according to different symptoms.The living habit accumulation mostly being bad for a long time of suffering from a deficiency of the kidney forms, medicine of can't blindly disorderly nourishing, or with the not clear kidney invigorating and YANG supporting medicine of composition.Suffer from a deficiency of the kidney aching and limp based on lumbago companion, dizziness and tinnitus, desire for being robbed and pressed, lower limb knee joint is unable, meets labor more very, sleeping then alleviate, normal recurrent exerbation.That sell in the market or the common Western medicine with kidney invigorating and YANG supporting and alleviating physical fatigue is cured the symptoms, not the disease, and side effect is comparatively large, and the curative effect of Chinese patent medicine is not obvious, and health food permanence operation is not good and expend higher.
[summary of the invention]
The technical problem to be solved in the present invention is to provide a kind of Chinese medicine composition being mainly used in kidney invigorating and YANG supporting, this Chinese medicine composition has effect of remarkable improvement ability, health invigorating, alleviating physical fatigue, also have that preparation technology is simple, good effect, without any side effects, taking convenience and be easy to advantages such as applying, in addition, Chinese medicine composition of the present invention can also be made and facilitated other easy-to-use dosage forms under the prerequisite ensureing curative effect.
The present invention seeks to be achieved through the following technical solutions: a kind of strengthening yang and invigorating kidney Chinese medicine composition, is prepared from primarily of following raw material: oyster extract, sea cucumber extract, Herba Dendrobii extracting solution, xylitol, microcrystalline Cellulose;
The preparation method of described oyster extract is: cleaned up by fresh and alive Concha Ostreae, shell and get its meat, Carnis ostreae is rubbed, the pure water of 1 ~ 2 times is added by Carnis ostreae weight ratio, then by cumulative volume than the protease adding 2%, constant temperature 36 DEG C, stirring reaction 40 ~ 50min, add phosphoric acid solution again and adjust PH to 5.0 ~ 5.5, continue stirring 10 ~ 20min, then 5 ~ 8 DEG C are cooled to rapidly, be separated with centrifuge, rotating speed 8000rpm/min, time 15 ~ 20min, Concha Ostreae filter cake 4 DEG C saves backup, filtrate adjusts PH to 8 ~ 9 with NaOH, by volume weight ratio adds the kieselguhr of 2%, abundant stirring 5 ~ 10min, filter, get filtrate, be evaporated to solid content 15 ~ 35%, obtained oyster extract,
The preparation method of described sea cucumber extract is: cleaned up by fresh and alive sea cucumbers, gill, and rubs, add ethanol and carry out ultrasonic wave added countercurrent extraction, extract after terminating and filter, Stichopus japonicus filter cake 4 DEG C saves backup, filtrate carrying out is evaporated to solid content 5 ~ 30%, obtains sea cucumber extract;
The preparation method of described Herba Dendrobii extracting solution is: the root of Herba Dendrobii and stipes are cleaned natural drying post-drying, Herba Dendrobii after oven dry is ground into the granule of below 20 orders, by the weight ratio of 1 ~ 3:1:1, Herba Dendrobii granule and Concha Ostreae filter cake, Stichopus japonicus filter cake are put into container, add the food-grade anhydrous ethanol of gross weight 1 ~ 2 times, immersion 6 ~ 8h is stirred under 8 ~ 10 DEG C of conditions, then carry out reflux, extract, 4 ~ 5h, cooled and filtered, get filtrate and get final product.
Preferably, each component is by following percentage by weight composition: oyster extract 30 ~ 36%, sea cucumber extract 30 ~ 40%, Herba Dendrobii extracting solution 20 ~ 30%, xylitol 5 ~ 8%, microcrystalline Cellulose 3 ~ 5%.
Preferably, each component is by following percentage by weight composition: oyster extract 32%, sea cucumber extract 34%, Herba Dendrobii extracting solution 24%, xylitol 6%, microcrystalline Cellulose 4%.
In each material combination ratio by after oyster extract, sea cucumber extract, the mixing of Herba Dendrobii extracting solution, then add xylitol, microcrystalline Cellulose fully stirs evenly, and crosses 0.5u micro-filtration membrane, fill, sterilizing, detection are qualified, i.e. obtained oral liquid.
In the present invention, the correlation properties of each raw material are as follows:
Concha Ostreae is the formal name used at school of " oysters ".So far in west, Concha Ostreae is still described as " god grant evil spirit food ", " marine milk ", and Japanese is then described as " source of root ".Oysters contains abundant zinc element and ferrum, phosphorus, calcium, high-quality protein, saccharide agent multivitamin.On the Pharmacopoeia of the People's Republic of China, then " tranquillization with heavy prescription, for cloudy YANG invigorating, hard masses softening and resolving, restrains astringent or styptic treatment for spontaneous sweating, and for insomnia of palpitating with fear, vertigo and tinnitus, the sick productive cough of scrofula, lump in the abdomen painful abdominal mass is determined, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, gastric acid pantothenic acid to remember Concha Ostreae.
In Concha Ostreae, Zn content is the hat of food.Zinc is referred to as " flowers of life ", and it plays a part very important in the growth promoter of human body: enhancing development, improve the sense of taste, appetite stimulator, immunity moderation, the normal development of promotion sperm, improving function.Zinc has antibacterial action in prostatic fluid or seminal fluid, improves the immunity of prostate local.
Stichopus japonicus, is that to live in the ocean sour jujube skin on seashore to 8000 meter biological, apart from the history of modern existing more than 600,000,000 year, is the living species of earliest extant, has the title of ocean living fossil.In order to ensure not being exterminated of race, select in evolutionary process in long-term self-heating, Stichopus japonicus has superpower reproductive performance.Stichopus japonicus, except containing except protein, calcium, potassium, zinc, ferrum, selenium, manganese isoreactivity material, also contains other active component as holothurin, acid mucopolysaccharide and selenka etc., in addition also containing 18 seed amino acids and not containing cholesterol.The same Radix Ginseng of Stichopus japonicus, Nidus collocaliae, Fin Mustetus manazo are equally celebrated for their achievements, are one of large treasures in the world eight.
Stichopus japonicus is not only precious food, is also famous and precious medical material.Record according in supplementary Amplifications of the Compendium of Materia Medica: Stichopus japonicus, taste is done salty, the kidney invigorating, and beneficial marrow, takes the photograph urine, and flaccidity is treated in tonifying YANG, its benefit warm in nature, sufficient enemy's ginseng, therefore named Stichopus japonicus.Stichopus japonicus has raising memory, delays gonad aging, prevents the effects such as arteriosclerosis, diabetes and antitumor.
Herba Dendrobii, containing chrysotoxene (chrysoxene), EN (erianin) etc.Suppression or role of correcting is had to the active ANOMALOUS VARIATIONS of aldose reductase, polyol dehydrogenase in the cataractous lens caused by galactose.Dendrobium polysaccharide has the effect strengthening T cell and macrophage immunity activity; Superoxide dismutase (SOD) level can be significantly improved, thus play the effect reducing lipid peroxide (LPO).
Successive dynasties peculiar effect of medicine and pharmacology works Herba Dendrobii has clear and definite record, thinks that it is the superfine product of YIN nourishing tonify deficiency.Modern medicine and pharmacology research proves active component dendrobium polysaccharide contained in Herba Dendrobii, has immune dual regulation, to immunocompromised person, resists the invasion and attack of disease by immunity moderation systemic-function; To immunologic function hyperthyroid, by immunity moderation systemic-function, recover its normal level.
Chinese medicine composition of the present invention is with traditional Chinese medical science compatibility theory for instructing, and by warming and recuperating the kidney-YANG, boosting qi and nourishing yin, strong body, reaches to improve and suffer from a deficiency of the kidney and improve the effect of body fatigue resistance, fundamentally solves that health is tired, the problem of sexual disorder.Wherein, oyster extract, oysters extracting solution, Herba Dendrobii extracting solution play a major role, and xylitol, microcrystalline Cellulose play auxiliary and guiding drug effect, by compatibility and the synergism of five, reach better curative effect.
The Chinese medicine composition that the present invention has strengthening yang and invigorating kidney function can apply other dosage forms that preparation has kidney invigorating and Yang strengthening function, as tablet, capsule, pill, granule, powder, medicated wine, unguentum etc.Both be suitable for the body of vital essence deficiency, be suitable for again the people of YIN fluid deficiency, for deficiency of both the lung and kidney, deficiency of both vital energy and Yin, fatigue and weakness, soreness of waist and knee joint, the few expectorant of cough, dry mouth and throat, deficient pulse weak person.
The Chinese medicine composition that the present invention has strengthening yang and invigorating kidney function is applicable to asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus person, middle-aged and elderly people and is in all kinds of crowds of sub-health state, also can be used for the rehabilitation after cancer patient chemicotherapy.
Compared with prior art, the present invention has following beneficial effect:
1, the present invention has significant effect in improvement function aspects, experimental result shows, the mice Sexual potency taking the present composition significantly improves, and the Serum testosterone content of the normal mouse and castration mouse of taking the present composition also obviously increases, visible, Chinese medicine composition of the present invention can significantly improve sexuality.
2, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, can reduce untoward reaction and side effect that stimulating intestine and stomach causes, and rapid-action, can make various dosage form person easy to use and take.
[detailed description of the invention]
The following examples can help the present invention of those skilled in the art's comprehend, but cannot limit the present invention by any way.
A kind of strengthening yang and invigorating kidney Chinese medicine composition, is prepared from primarily of following raw material: oyster extract, sea cucumber extract, Herba Dendrobii extracting solution, xylitol, microcrystalline Cellulose;
The preparation method of described oyster extract is: cleaned up by fresh and alive Concha Ostreae, shell and get its meat, Carnis ostreae is rubbed, the pure water of 1 ~ 2 times is added by Carnis ostreae weight ratio, then by cumulative volume than the protease adding 2%, constant temperature 36 DEG C, stirring reaction 40 ~ 50min, add phosphoric acid solution again and adjust PH to 5.0 ~ 5.5, continue stirring 10 ~ 20min, then 5 ~ 8 DEG C are cooled to rapidly, be separated with centrifuge, rotating speed 8000rpm/min, time 15 ~ 20min, Concha Ostreae filter cake 4 DEG C saves backup, filtrate adjusts PH to 8 ~ 9 with NaOH, by volume weight ratio adds the kieselguhr of 2%, abundant stirring 5 ~ 10min, filter, get filtrate, be evaporated to solid content 15 ~ 35%, obtained oyster extract,
The preparation method of described sea cucumber extract is: cleaned up by fresh and alive sea cucumbers, gill, and rubs, add ethanol and carry out ultrasonic wave added countercurrent extraction, extract after terminating and filter, Stichopus japonicus filter cake 4 DEG C saves backup, filtrate carrying out is evaporated to solid content 5 ~ 30%, obtains sea cucumber extract;
The preparation method of described Herba Dendrobii extracting solution is: the root of Herba Dendrobii and stipes are cleaned natural drying post-drying, Herba Dendrobii after oven dry is ground into the granule of below 20 orders, by the weight ratio of 1 ~ 3:1:1, Herba Dendrobii granule and Concha Ostreae filter cake, Stichopus japonicus filter cake are put into container, add the food-grade anhydrous ethanol of gross weight 1 ~ 2 times, immersion 6 ~ 8h is stirred under 8 ~ 10 DEG C of conditions, then carry out reflux, extract, 4 ~ 5h, cooled and filtered, get filtrate and get final product.
Embodiment 1
Take by weight percentage: oyster extract 32%, sea cucumber extract 34%, Herba Dendrobii extracting solution 24%, xylitol 6%, microcrystalline Cellulose 4%.After oyster extract, sea cucumber extract, the mixing of Herba Dendrobii extracting solution, then add xylitol, microcrystalline Cellulose, fully stir evenly, use 0.5u micro-filtrate membrane filtration, then fill, sterilizing, detection, be i.e. obtained oral liquid.
Embodiment 2
Take by weight percentage: oyster extract 30%, sea cucumber extract 30%, Herba Dendrobii extracting solution 30%, xylitol 5%, microcrystalline Cellulose 5%.Preparation method is with embodiment 1.
Embodiment 3
Take by weight percentage: oyster extract 30%, sea cucumber extract 40%, Herba Dendrobii extracting solution 20%, xylitol 7%, microcrystalline Cellulose 3%.Preparation method is with embodiment 1.
Embodiment 4
Take by weight percentage: oyster extract 34%, sea cucumber extract 30%, Herba Dendrobii extracting solution 27%, xylitol 6%, microcrystalline Cellulose 3%.Preparation method is with embodiment 1.
Embodiment 5
Take by weight percentage: oyster extract 36%, sea cucumber extract 34%, Herba Dendrobii extracting solution 22%, xylitol 5%, microcrystalline Cellulose 3%.Preparation method is with embodiment 1.
Embodiment 6
Take by weight percentage: oyster extract 35%, sea cucumber extract 36%, Herba Dendrobii extracting solution 20%, xylitol 5%, microcrystalline Cellulose 4%.Preparation method is with embodiment 1.
Embodiment 7
Take by weight percentage: oyster extract 31%, sea cucumber extract 38%, Herba Dendrobii extracting solution 21%, xylitol 5.5%, microcrystalline Cellulose 4.5%.Preparation method is with embodiment 1.
Animal Efficacy experiments is as follows:
1, Drug toxicity trails
The test of rat acute Oral toxicity is as follows: adopt maximum tolerated dose method, by oral liquid obtained for embodiment 1 to 7, with 20.0ml/kg body weight dose to each 10 the per os gavages contamination of male and female rat (180-220g).Give by 20mL/kg body weight secondary gavage, interval 4h.After contamination, observe the general status of rat, poisoning symptom and death condition, observe two weeks time limits.Result of the test: sample is all greater than 20.0g/kg body weight to the maximum tolerated dose of the acute oral of male and female mice.
The test of chmice acute Oral toxicity is as follows: adopt maximum tolerated dose method, by oral liquid obtained for embodiment 1 to 7, with 20.0g/kg body weight dose to each 10 the per os gavages contamination of male and female mice (18-22g).Give by 20mL/kg body weight secondary gavage, interval 4h.After contamination, observe the general status of mice, poisoning symptom and death condition, observe two weeks time limits.Result of the test: sample is all greater than 20.0g/kg body weight to the maximum tolerated dose of the acute oral of male and female mice.
Mouse marrow cell micro nuclear test is as follows: be used for doing experimental group by oral liquid obtained for embodiment 1 to 7, separately establish negative control (distilled water) and positive controls (cyclophosphamide 60mg/kg body weight), often organize 10 mice (25-30g, male and female half and half), interval is adopted to give sample in 24 hours, by 20mL/kg body weight, respectively to each treated animal gavage.Once a day, continuous 2 days.Last puts to death animal to 6h after sample, and get its bone marrow of sternum film-making, methanol is fixed, and Giemsa dyes.Sample Bone Marrow cell micronucleus test result is negative.
Sperm malformation test is as follows: be used for doing experimental group by oral liquid obtained for embodiment 1 to 7, separately establish negative control (distilled water) and positive controls (ametycin 2.0mg/kg body weight), often organize 10 male mices (25-30g).By 20mL/kg body weight, respectively to each treated animal gavage.Once a day, continuous 5 days.In giving after sample the 35th day first, getting two side epididymis and shredding, getting filtrate film-making.Microscopy is observed, and every Mus counts the lopsided number of 1000 sperms.Sample sperm malformation test result is negative.
Salmonella reversion test is as follows: be used for doing experimental group by oral liquid obtained for embodiment 1 to 7, select histidine auxotroph Salmonella typhimurium TA97, TA98, TA100, TA102, adopt dull and stereotyped incorporation methods, proof load is 40 μ l/ wares, 200 μ l/ wares, 1000 μ l/ wares, 5000 μ l/ wares.In direct counting culture medium, returning of each bacterial strain becomes clump count.Detection repeats once.Sample Salmonella reversion test result is negative.
Within 30 days, feeding trial is as follows: be used for testing by oral liquid obtained for embodiment 1 to 7, give, continuous 30 days by 10mL/kg body weight per os gavage.Separately establish negative control (distilled water), give distilled water, free diet, feed 30 days continuously.SD rat 100 (55-80g), male and female half and half, random packet, single cage is raised.Continuous Observation 30 days, record body weight and food-intake weekly, and calculate food utilization, test end of term taking blood from jugular vein carries out hematological examination, broken end is got blood and is carried out blood bio-chemistry checking, internal organs gross examination of skeletal muscle is carried out to every rat, gets liver,kidney,spleen simultaneously, testis (ovary) weighs and calculate dirty body ratio, and get liver,kidney,spleen, stomach, intestinal, testis (ovary) carry out histopathologic examination.Result: laboratory animal growing state is good, hematological examination, biochemical analysis, main dirty body when histological indications compared with matched group, equal no significant difference.
Above-mentioned acute toxicity test, micronucleus test, sperm malformation test, Salmonella reversion test, that 30 days feeding trial results show this product safety is nontoxic.
Stability test is as follows: oral liquid obtained for embodiment 1 to 7 is respectively got three batch samples and places 3 months at 37 ~ 40 DEG C of temperature and 75% relative humidities by commercially available back, in 0 month, January, February, respectively all events detection is carried out to three batch samples March and (comprise organoleptic indicator, identification, total ash, disintegration, acid value, peroxide value, plumbous arsenic hydrargyrum, Gamma Hexaochlorocyclohexane, clofenotane, net content minus deviation, total plate count, coliform, mycete, yeast, Salmonella, shigella, golden yellow Portugal coccus, hemolytic), testing result all meets the regulation of this target level of product quality (company standard).
2, enhancing immunity
This Chinese medicine composition oral liquid human body recommended dose is 10ml/60kg body weight every day, and be used for doing experimental group by oral liquid obtained for embodiment 1 to 7, per os gives sample 30 days continuously, and matched group is with distilled water gavage.
Experimental result shows: compare with matched group, and given the test agent mice spleen lymphocytes proliferation ability all strengthens, and difference all has significance (q checks, P < 0.05); Compare with matched group, the phagocytic index that given the test agent Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell all raises, and difference all has significance (q checks, P < 0.05).Compare with matched group, the phagocytic percentage that given the test agent Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell all raises, and difference all has significance (q checks, P < 0.05), illustrates that the present invention has enhancing immunity function.
(3) resisting fatigue
Be used for testing by oral liquid obtained for embodiment 1 to 7, per os gives sample 30 days continuously, and matched group is with distilled water gavage.
Experimental result shows: compare with matched group, and given the test agent all can obviously extend the mice burden swimming time, and difference all has significance (q checks, P < 0.05); Tested material all obviously can reduce mice swimming latter 0 minute Serum lactic acid content and blood lactase acid area under curve, and difference all has significance (q checks, P < 0.05), and interpret sample has antifatigue effect.
3, kidney invigorating and YANG supporting effect
(1) on the impact of castration male rat penile erectile function and genitals's organ index
Chinese medicine composition oral liquid grouping obtained for embodiment 1 to 7 is tested, test dose 0.2g/kg, be equivalent to 10 times of human body recommended amounts, after the breast castration of adult male rats of 1 month, 4 days per os give sample 30 days continuously, matched group is with distilled water gavage, 1h after last administration, the stimulating electrode of electrostimulator is positioned over rat penis position, give surface element electricity irritation, current intensity 4mA, cycle 50ms, pulsewidth lms, train of pulse .10, records from stimulation to erection time (erecing incubation period).Again rat put to death immediately and dissect each group of rat, taking preputial glands immediately, the weight of seminal vesicle, calculating organ index.
Experimental result shows: each experimental group eclipse period of penile erection compares with matched group significant difference (P<0.05).Preputial glands index and the matched group of each experimental group more all have significant difference (P<0.05), and the seminal vesicle index of each experimental group compares with matched group significant difference (P<0.05).
(2) on the impact of male rat mating ability
Chinese medicine composition oral liquid grouping obtained for embodiment 1 to 7 is tested, test dose 0.2g/kg, be equivalent to 10 times of human body recommended amounts, Adult male rats per os gives sample 30 days continuously, after last administration, male rat list is only put into cage and make its 30min that conforms, then put into 1 female Mus, start to record following index: be fed into male Mus from female Mus and flutter the time (catching incubation period) of catching female Mus for the first time; The time (ejaculation latency) of male Mus first time ejaculation is fed into from female Mus; In 30min, male Mus flutters the number of times and ejaculation frequency of catching female Mus; In 30min, each group is flutterred flutterring of number of animals of catching and ejaculate and is caught percentage rate and ejaculation percentage rate.
Experimental result shows: the seizure of each experimental group more all has significant difference (P<0.05) with matched group incubation period, the ejaculation latency of each experimental group, catch number of times, ejaculation frequency and matched group more all have significant difference (P<0.05).
1 is affected on male rat mating ability
2 are affected on male rat mating ability
(3) on the impact of male rat penile erectile function and genitals's organ index
After male rat carries out mating test, the stimulating electrode of electrostimulator is positioned over rat penis position, gives surface element electricity irritation, current intensity 4mA, cycle 50ms, pulsewidth lms, train of pulse .10, record to erection time (erecing incubation period) from stimulation, then draw neck to put to death male rat, and dissect each group of rat, take preputial glands immediately, seminal vesicle, the weight of testis and penis, calculates organ index.
Experimental result shows: the erection incubation period of each experimental group, and preputial glands, seminal vesicle, testis index and penis index and matched group more all have significant difference (P<0.05).
Rat yin channel to be erected the impact of incubation period, preputial glands, seminal vesicle, testis and yin channel index
Experimental result shows that Chinese medicine composition of the present invention has significant strengthening yang and invigorating kidney, the effect of sexual function improving.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (4)
1. a strengthening yang and invigorating kidney Chinese medicine composition, is characterized in that, described Chinese medicine composition is prepared from primarily of following raw material: oyster extract, sea cucumber extract, Herba Dendrobii extracting solution, xylitol, microcrystalline Cellulose;
The preparation method of described oyster extract is: cleaned up by fresh and alive Concha Ostreae, shell and get its meat, Carnis ostreae is rubbed, the pure water of 1 ~ 2 times is added by Carnis ostreae weight ratio, then by cumulative volume than the protease adding 2%, constant temperature 36 DEG C, stirring reaction 40 ~ 50min, add phosphoric acid solution again and adjust PH to 5.0 ~ 5.5, continue stirring 10 ~ 20min, then 5 ~ 8 DEG C are cooled to rapidly, be separated with centrifuge, rotating speed 8000rpm/min, time 15 ~ 20min, Concha Ostreae filter cake 4 DEG C saves backup, filtrate adjusts PH to 8 ~ 9 with NaOH, by volume weight ratio adds the kieselguhr of 2%, abundant stirring 5 ~ 10min, filter, get filtrate, be evaporated to solid content 15 ~ 35%, obtained oyster extract,
The preparation method of described sea cucumber extract is: cleaned up by fresh and alive sea cucumbers, gill, and rubs, add ethanol and carry out ultrasonic wave added countercurrent extraction, extract after terminating and filter, Stichopus japonicus filter cake 4 DEG C saves backup, filtrate carrying out is evaporated to solid content 5 ~ 30%, obtains sea cucumber extract;
The preparation method of described Herba Dendrobii extracting solution is: the root of Herba Dendrobii and stipes are cleaned natural drying post-drying, Herba Dendrobii after oven dry is ground into the granule of below 20 orders, by the weight ratio of 1 ~ 3:1:1, Herba Dendrobii granule and Concha Ostreae filter cake, Stichopus japonicus filter cake are put into container, add the food-grade anhydrous ethanol of gross weight 1 ~ 2 times, immersion 6 ~ 8h is stirred under 8 ~ 10 DEG C of conditions, then carry out reflux, extract, 4 ~ 5h, cooled and filtered, get filtrate and get final product.
2. a kind of strengthening yang and invigorating kidney Chinese medicine composition according to claim 1, is characterized in that: each component forms by following percentage by weight: oyster extract 30 ~ 36%, sea cucumber extract 30 ~ 40%, Herba Dendrobii extracting solution 20 ~ 30%, xylitol 5 ~ 8%, microcrystalline Cellulose 3 ~ 5%.
3. a kind of strengthening yang and invigorating kidney Chinese medicine composition according to claim 2, is characterized in that: each component forms by following percentage by weight: oyster extract 32%, sea cucumber extract 34%, Herba Dendrobii extracting solution 24%, xylitol 6%, microcrystalline Cellulose 4%.
4. a kind of strengthening yang and invigorating kidney Chinese medicine composition according to any one of claims 1 to 3, it is characterized in that: in proportion by after oyster extract, sea cucumber extract, the mixing of Herba Dendrobii extracting solution, add xylitol again, microcrystalline Cellulose fully stirs evenly, cross 0.5u micro-filtration membrane, fill, sterilizing, detection are qualified, i.e. obtained oral liquid.
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| CN107095299A (en) * | 2017-05-26 | 2017-08-29 | 广西本草坊保健品有限公司 | A kind of oyster ginseng pupa tablet of nourishing and strengthening vital and preparation method thereof |
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| CN109363157A (en) * | 2018-09-19 | 2019-02-22 | 广东精核生物科技发展有限公司 | A kind of energy is hypoglycemic and improves the nutriment and preparation method thereof of immunity |
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