CN101522637A - 可用于治疗香草素受体1相关病症的苯并咪唑衍生物 - Google Patents

可用于治疗香草素受体1相关病症的苯并咪唑衍生物 Download PDF

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Publication number
CN101522637A
CN101522637A CNA2007800380988A CN200780038098A CN101522637A CN 101522637 A CN101522637 A CN 101522637A CN A2007800380988 A CNA2007800380988 A CN A2007800380988A CN 200780038098 A CN200780038098 A CN 200780038098A CN 101522637 A CN101522637 A CN 101522637A
Authority
CN
China
Prior art keywords
ethyl
cyano group
benzoglyoxaline
ethanamide
methylethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2007800380988A
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English (en)
Chinese (zh)
Inventor
威廉·布朗
肖恩·约翰斯通
丹尼斯·拉布雷克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
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AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39033277&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN101522637(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN101522637A publication Critical patent/CN101522637A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2007800380988A 2006-08-11 2007-08-10 可用于治疗香草素受体1相关病症的苯并咪唑衍生物 Pending CN101522637A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83724906P 2006-08-11 2006-08-11
US60/837,249 2006-08-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201010003679A Division CN101792436A (zh) 2006-08-11 2007-08-10 可用于治疗香草素受体1相关病症的苯并咪唑衍生物

Publications (1)

Publication Number Publication Date
CN101522637A true CN101522637A (zh) 2009-09-02

Family

ID=39033277

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201010003679A Pending CN101792436A (zh) 2006-08-11 2007-08-10 可用于治疗香草素受体1相关病症的苯并咪唑衍生物
CNA2007800380988A Pending CN101522637A (zh) 2006-08-11 2007-08-10 可用于治疗香草素受体1相关病症的苯并咪唑衍生物

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201010003679A Pending CN101792436A (zh) 2006-08-11 2007-08-10 可用于治疗香草素受体1相关病症的苯并咪唑衍生物

Country Status (25)

Country Link
US (2) US7906654B2 (enExample)
EP (1) EP2051967B1 (enExample)
JP (1) JP5140077B2 (enExample)
KR (1) KR101412881B1 (enExample)
CN (2) CN101792436A (enExample)
AR (1) AR062299A1 (enExample)
AU (1) AU2007282186B2 (enExample)
BR (1) BRPI0715746B8 (enExample)
CA (1) CA2660529C (enExample)
CL (1) CL2007002343A1 (enExample)
CO (1) CO6150176A2 (enExample)
ES (1) ES2533971T3 (enExample)
IL (1) IL196672A0 (enExample)
MX (1) MX2009001496A (enExample)
MY (1) MY147649A (enExample)
NO (1) NO20091054L (enExample)
NZ (1) NZ575416A (enExample)
PE (1) PE20081315A1 (enExample)
RU (1) RU2458055C2 (enExample)
SG (1) SG173360A1 (enExample)
TW (1) TWI433839B (enExample)
UA (1) UA96764C2 (enExample)
UY (1) UY30533A1 (enExample)
WO (1) WO2008018827A1 (enExample)
ZA (1) ZA200900961B (enExample)

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KR101293384B1 (ko) 2010-10-13 2013-08-05 주식회사 대웅제약 신규 피리딜 벤조옥사진 유도체, 이를 포함하는 약학 조성물 및 이의 용도
US8716226B2 (en) 2012-07-18 2014-05-06 Saint Louis University 3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
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JP2018052817A (ja) * 2015-01-21 2018-04-05 大日本住友製薬株式会社 新規ベンズイミダゾール誘導体およびその医薬用途
HK1244806A1 (zh) 2015-12-30 2018-08-17 Saint Louis University 作為過氧乙醯硝酸整聯蛋白拮抗劑的間氮雜環氨基苯甲酸衍生物
JP2022516362A (ja) * 2019-01-08 2022-02-25 ネオメド インスティテュート－インスティテュート ネオメド （ｓ）－２－（７－シアノ－１ｈ－ベンズイミダゾール－１イル）－ｎ－｛１－［４－（１－シアノ－１－メチルエチル）フェニル］エチル｝アセトアミドの結晶形態
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CN117623972A (zh) * 2022-08-17 2024-03-01 上海慧聚药业有限公司 非离子型造影剂中间体的合成

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Also Published As

Publication number Publication date
RU2009103675A (ru) 2010-09-20
CA2660529A1 (en) 2008-02-14
US8093402B2 (en) 2012-01-10
BRPI0715746B8 (pt) 2021-05-25
BRPI0715746B1 (pt) 2020-09-24
NO20091054L (no) 2009-03-09
ES2533971T3 (es) 2015-04-16
PE20081315A1 (es) 2008-11-08
AU2007282186A1 (en) 2008-02-14
UY30533A1 (es) 2008-03-31
CL2007002343A1 (es) 2008-04-04
EP2051967A1 (en) 2009-04-29
US20080221188A1 (en) 2008-09-11
UA96764C2 (ru) 2011-12-12
AR062299A1 (es) 2008-10-29
ZA200900961B (en) 2010-07-28
US20110137045A1 (en) 2011-06-09
US7906654B2 (en) 2011-03-15
JP2010500345A (ja) 2010-01-07
RU2458055C2 (ru) 2012-08-10
WO2008018827A1 (en) 2008-02-14
AU2007282186B2 (en) 2011-07-07
MX2009001496A (es) 2009-02-18
EP2051967A4 (en) 2011-06-29
CN101792436A (zh) 2010-08-04
TW200817338A (en) 2008-04-16
KR20090035701A (ko) 2009-04-10
KR101412881B1 (ko) 2014-06-26
IL196672A0 (en) 2009-11-18
CO6150176A2 (es) 2010-04-20
JP5140077B2 (ja) 2013-02-06
SG173360A1 (en) 2011-08-29
TWI433839B (zh) 2014-04-11
MY147649A (en) 2012-12-31
CA2660529C (en) 2014-10-21
NZ575416A (en) 2011-10-28
WO2008018827A8 (en) 2009-02-19
EP2051967B1 (en) 2014-12-31
BRPI0715746A2 (pt) 2013-07-16

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