CN101490249A - 提高平衡反应的产量的方法和系统 - Google Patents

提高平衡反应的产量的方法和系统 Download PDF

Info

Publication number
CN101490249A
CN101490249A CNA200780027087XA CN200780027087A CN101490249A CN 101490249 A CN101490249 A CN 101490249A CN A200780027087X A CNA200780027087X A CN A200780027087XA CN 200780027087 A CN200780027087 A CN 200780027087A CN 101490249 A CN101490249 A CN 101490249A
Authority
CN
China
Prior art keywords
reaction
booth
product
enzyme
promotor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200780027087XA
Other languages
English (en)
Chinese (zh)
Inventor
B·H·希尔伯特
C·索尔海德
S·C·麦克法伦
A·B·哈雷
F·A·桑切斯-列拉
K·弗洛伊
P·M·希克斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cargill Inc
Original Assignee
Cargill Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cargill Inc filed Critical Cargill Inc
Publication of CN101490249A publication Critical patent/CN101490249A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size-selective separation, e.g. size-exclusion chromatography; Gel filtration; Permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CNA200780027087XA 2006-05-24 2007-05-23 提高平衡反应的产量的方法和系统 Pending CN101490249A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80310506P 2006-05-24 2006-05-24
US60/803,105 2006-05-24

Publications (1)

Publication Number Publication Date
CN101490249A true CN101490249A (zh) 2009-07-22

Family

ID=38779330

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200780027087XA Pending CN101490249A (zh) 2006-05-24 2007-05-23 提高平衡反应的产量的方法和系统

Country Status (8)

Country Link
US (1) US7888081B2 (enExample)
EP (1) EP2038405A4 (enExample)
JP (1) JP2009538145A (enExample)
CN (1) CN101490249A (enExample)
AU (1) AU2007267618B2 (enExample)
BR (1) BRPI0711972A2 (enExample)
CA (1) CA2653054A1 (enExample)
WO (1) WO2007140195A2 (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7297800B2 (en) * 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
US8372989B2 (en) * 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US7572607B2 (en) * 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
RU2307871C2 (ru) 2002-08-26 2007-10-10 Адзиномото Ко., Инк. НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ
EP2050821A3 (en) 2002-12-09 2009-05-13 Ajinomoto Co., Inc. Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
US7556660B2 (en) * 2003-06-11 2009-07-07 James Kevin Shurtleff Apparatus and system for promoting a substantially complete reaction of an anhydrous hydride reactant
KR20060061811A (ko) * 2003-08-01 2006-06-08 카아길, 인코포레이팃드 모나틴 식탁용 감미제 조성물 및 이의 제조 방법
EP1653810B1 (en) * 2003-08-14 2007-04-25 Cargill, Incorporated Chewing gum compositions comprising monatin and methods of making same
EP1657985A1 (en) * 2003-08-25 2006-05-24 Cargill Inc. Beverage compositions comprising monatin and methods of making same
ATE498691T1 (de) * 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
US8158389B2 (en) * 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
JP5059746B2 (ja) * 2005-04-20 2012-10-31 カーギル，インコーポレイティド モナチンの生体内分泌のための生成物及び方法
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US7582455B2 (en) * 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
US20080020260A1 (en) * 2005-11-12 2008-01-24 Brydon Chris A Apparatus, system, and method for manifolded integration of a humidification chamber for input gas for a proton exchange membrane fuel cell
ES2416104T3 (es) * 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas
US20090198072A1 (en) * 2006-05-24 2009-08-06 Cargill, Incorporated Methods and systems for increasing production of equilibrium reactions
US7651542B2 (en) 2006-07-27 2010-01-26 Thulite, Inc System for generating hydrogen from a chemical hydride
US7648786B2 (en) 2006-07-27 2010-01-19 Trulite, Inc System for generating electricity from a chemical hydride
US8357214B2 (en) 2007-04-26 2013-01-22 Trulite, Inc. Apparatus, system, and method for generating a gas from solid reactant pouches
KR20100061453A (ko) 2007-07-25 2010-06-07 트루라이트 인크. 하이브리드 전력의 생성 및 사용을 관리하는 장치, 시스템 및 방법
US20090025293A1 (en) * 2007-07-25 2009-01-29 John Patton Apparatus, system, and method for processing hydrogen gas
US8076107B2 (en) 2007-10-01 2011-12-13 Cargill, Incorporated Production of monatin stereoisomers
US8367847B2 (en) * 2007-10-01 2013-02-05 Cargill, Incorporated Production of monatin enantiomers
US8003361B2 (en) * 2007-10-01 2011-08-23 Cargill Incorporated Production of monatin enantiomers
JP5683962B2 (ja) * 2008-01-03 2015-03-11 カーギル・インコーポレイテッド アミノトランスフェラーゼおよびオキシドレダクターゼの核酸およびポリペプチドおよび使用方法
WO2009088949A1 (en) * 2008-01-03 2009-07-16 Verenium Corporation Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them
US8857279B2 (en) * 2008-03-03 2014-10-14 William P. Hanson Analyte screening and detection systems and methods
WO2011082353A1 (en) * 2009-12-30 2011-07-07 Cargill, Incorporated Separation and purification of monatin
EP2519406A4 (en) * 2009-12-30 2014-03-26 Cargill Inc POLYMER AND METHODS FOR PREPARING AND USING POLYMER
US20120264948A1 (en) * 2009-12-30 2012-10-18 Cargill, Incorporated Membrane separation and purification of monatin
WO2012166406A1 (en) * 2011-05-31 2012-12-06 Cargill, Incorporated Increasing product yield and/or throughput by supersaturation of substrate
JP2015533501A (ja) * 2012-10-18 2015-11-26 サンド・アクチエンゲゼルシヤフト インドリン誘導体の調製方法
CN106470744B (zh) 2014-06-13 2020-03-27 波乐思来技术股份有限公司 水上乘坐设施

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002889A (en) 1960-06-20 1961-10-03 Kyowa Hakko Kogyo Kk Method of producing l-glutamic acid
US3751458A (en) 1972-03-02 1973-08-07 Miles Lab Citroylformic acid and its production
US4010204A (en) 1974-04-09 1977-03-01 Studiengesellschaft Kohle M.B.H. Process for preparing condensation products
US6846654B1 (en) 1983-11-29 2005-01-25 Igen International, Inc. Catalytic antibodies as chemical sensors
GB2205834B (en) 1987-06-15 1990-10-31 South African Inventions 3-(1-amino-1,3-dicarboxy-3-hydroxy-but-4-yl)-indole compounds
WO1989011212A2 (en) 1989-08-30 1989-11-30 Wm. Wrigley Jr. Company Method of controlling release of cyclamate in chewing gum and gum produced thereby
ES2063443T3 (es) 1990-01-19 1995-01-01 Technology Finance Corp Procedimiento para la produccion de 3-(1-amino-1,3-dicarboxi-3-hidroxi-but-4-il) indol.
US6264999B1 (en) 1993-09-30 2001-07-24 Wm. Wrigley Jr. Company Chewing gum containing erythritol and method of making
JP3698742B2 (ja) 1994-03-01 2005-09-21 協和醗酵工業株式会社 光学活性４−ヒドロキシ−２−ケトグルタル酸の製造法
US5728555A (en) 1996-09-30 1998-03-17 Monsanto Company Preparation of d-amino acids by direct fermentative means
US5994559A (en) 1998-08-06 1999-11-30 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Synthesis of monatin-A high intensity natural sweetener
JP2002060382A (ja) 2000-08-22 2002-02-26 Ajinomoto Co Inc モナティンの立体異性体及びその使用、並びにモナティン類の製造方法及びそのための中間体
EP2409968A1 (en) 2001-11-30 2012-01-25 Ajinomoto Co., Inc. Crystals of non-natural-type stereoisomer salt of monatin and use thereof
JP2003171365A (ja) 2001-11-30 2003-06-20 Ajinomoto Co Inc モナティン類及びその製造中間体の製造方法並びに新規中間体
CN100465156C (zh) 2001-12-27 2009-03-04 味之素株式会社 谷氨酸化合物及其制备中间体的制造方法与为此所用的新型中间体
DE60239072D1 (de) 2001-12-27 2011-03-10 Ajinomoto Kk Verfahren zur herstellung von glutaminsäurederivaten
US7297800B2 (en) 2001-12-27 2007-11-20 Ajinomoto Co., Inc. Process of producing glutamate derivatives
JP2003292484A (ja) 2002-04-01 2003-10-15 Ajinomoto Co Inc γ−ヒドロキシアミノ酸誘導体及びモナティン類の製造方法
US7572607B2 (en) 2002-04-23 2009-08-11 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
US8372989B2 (en) 2002-04-23 2013-02-12 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of monatin and its precursors
KR100902813B1 (ko) 2002-04-23 2009-06-12 카길 인코포레이티드 폴리펩티드 및 생합성 경로
RU2307871C2 (ru) 2002-08-26 2007-10-10 Адзиномото Ко., Инк. НОВАЯ АЛЬДОЛАЗА И СПОСОБ ПОЛУЧЕНИЯ ЗАМЕЩЕННЫХ α-КЕТОКИСЛОТ
EP2050821A3 (en) 2002-12-09 2009-05-13 Ajinomoto Co., Inc. Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same
CA2512752C (en) 2003-01-09 2012-05-29 Ajinomoto Co., Inc. Process for manufacturing a glutamic acid derivative and a pyroglutamic acid derivative and a novel intermediate in the manufacture thereof
JP4239600B2 (ja) 2003-01-24 2009-03-18 味の素株式会社 ２ｒ−モナティンの製造方法
JP2004331644A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
JP2004331650A (ja) 2003-04-14 2004-11-25 Kanazawa Univ Tlo Inc モナチン類の製造法
WO2005001105A1 (ja) 2003-06-26 2005-01-06 Ajinomoto Co., Inc. モナティンの製造方法
KR20060061811A (ko) 2003-08-01 2006-06-08 카아길, 인코포레이팃드 모나틴 식탁용 감미제 조성물 및 이의 제조 방법
EP1653810B1 (en) 2003-08-14 2007-04-25 Cargill, Incorporated Chewing gum compositions comprising monatin and methods of making same
EP1657985A1 (en) 2003-08-25 2006-05-24 Cargill Inc. Beverage compositions comprising monatin and methods of making same
ATE498691T1 (de) 2003-10-21 2011-03-15 Cargill Inc Herstellung von monatin und monatinvorstufen
JP4500977B2 (ja) 2003-11-05 2010-07-14 味の素株式会社 新規アミノ酸誘導体及び甘味剤
JP5113978B2 (ja) 2003-11-21 2013-01-09 味の素株式会社 グルタミン酸誘導体の有機アミン塩及びその利用
EP1719758B1 (en) 2004-02-27 2012-02-22 Ajinomoto Co., Inc. Process for producing monatin
JP4604524B2 (ja) 2004-03-16 2011-01-05 味の素株式会社 変異型アルドラーゼ、並びにこれを用いた光学活性ｉｈｏｇ及び光学活性モナティンの製造方法
JP4604537B2 (ja) 2004-03-31 2011-01-05 味の素株式会社 Ｌ−システイン生産菌及びｌ−システインの製造法
US7935377B2 (en) 2004-06-04 2011-05-03 Ajinomoto Co., Inc. Crystals of free (2R, 4R)-monatin and use thereof
CA2506247C (en) 2004-06-07 2012-02-21 Ajinomoto Co., Inc. Novel aldolase, and method for producing optically active ihog and monatin
KR101216575B1 (ko) 2004-07-14 2012-12-31 아지노모토 가부시키가이샤 (2ｒ,4ｒ)-모나틴 칼륨 염 결정 및 이를 함유하는 감미료조성물
JP2007284349A (ja) 2004-07-27 2007-11-01 Ajinomoto Co Inc モナティンまたはその塩の製造方法
BRPI0517419A (pt) 2004-10-15 2008-10-07 Ajinomoto Kk composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico, estabilizador de conservação para monatina ou um sal da mesma, métodos de conservação de monatina ou de um sal da mesma e de composição adoçante, bebida, alimento, composição para cavidade bucal ou produto farmacêutico compreendendo monatina ou um sal da mesma, e, monatina ou um sal da mesma
US7923231B2 (en) 2004-12-17 2011-04-12 Cargill, Incorporated Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans
US8158389B2 (en) 2005-04-20 2012-04-17 Cargill, Incorporated Products and methods for in vivo secretion of monatin
JP5059746B2 (ja) 2005-04-20 2012-10-31 カーギル，インコーポレイティド モナチンの生体内分泌のための生成物及び方法
US7582455B2 (en) 2005-04-26 2009-09-01 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
JP5336182B2 (ja) 2005-04-26 2013-11-06 カーギル，インコーポレイティド モナティンの立体異性体及びそれらの前駆体の製造のためのポリペプチド及び生合成経路
US8076108B2 (en) 2005-04-26 2011-12-13 Cargill, Incorporated Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
ES2416104T3 (es) 2006-03-07 2013-07-30 Cargill, Incorporated Aldolasas, ácidos nucleicos que las codifican y métodos para producir y usar las mismas

Also Published As

Publication number Publication date
AU2007267618A1 (en) 2007-12-06
EP2038405A4 (en) 2009-10-21
US20080015361A1 (en) 2008-01-17
WO2007140195A3 (en) 2008-10-16
CA2653054A1 (en) 2007-12-06
JP2009538145A (ja) 2009-11-05
AU2007267618B2 (en) 2013-07-18
EP2038405A2 (en) 2009-03-25
US7888081B2 (en) 2011-02-15
WO2007140195A2 (en) 2007-12-06
BRPI0711972A2 (pt) 2012-01-10

Similar Documents

Publication Publication Date Title
CN101490249A (zh) 提高平衡反应的产量的方法和系统
US20090198072A1 (en) Methods and systems for increasing production of equilibrium reactions
JP2010507367A (ja) モナチンの立体異性体およびそれらの前駆体の生成のためのポリペプチドおよび生合成経路
CN101466830A (zh) 用于生成莫纳甜异构体及其前体的多肽和生物合成途径
JP2009529856A (ja) 新規アルドラーゼ及び４−ヒドロキシ−ｌ−イソロイシンの製造方法
EP0278787B1 (en) A process for enzymatic production of dipeptides
DK1268399T3 (da) Fremgangsmåde til separering af en basisk aminosyre fra fermenteringsvæske
KR900004070B1 (ko) 펩티드의 합성 및 분리를 위한 효소막법
CN101365787A (zh) 用于生产莫纳甜的立体异构体和其前体的多肽和生物合成途径
CN112626142A (zh) 利用生物多酶偶联法制备l-草铵膦的方法
WO2011082365A2 (en) Improved bioreactor performance in the production of monatin
EP3676387B1 (en) Method for producing chiral amines
WO2006104186A1 (ja) ジペプチドの結晶およびその製造法
DK1165489T3 (da) Fremgangsmåde til fremstilling af gabapentin
CN113462623A (zh) 微生物发酵法制备d-丙氨酸的方法
ES2773889T3 (es) Hidroxilasa en la posición 4 de ácido pipecolínico y método para producir 4-hidroxiaminoácido usando la misma
AU598452B2 (en) Method and apparatus for enzymatic synthesis
JPH05236986A (ja) 安定同位体標識蛋白質の製造法および試薬キット
UA73743C2 (en) A method for the production of l-amino acids from their racemic n-acetyl-d,l-derivatives using enzymatic racemate cleavage by means of isolated recombinant enzymes
Markvicheva et al. Gel-immobilized enzymes as promising biocatalysts: Results from Indo-Russian collaborative studies
CN118931984A (zh) 一种制备β-氨基酸的方法
Tachiki et al. Separation of L-leucine-pyruvate and L-leucine-α-ketoglutarate transaminases in Acetobacter suboxydans and identification of their reaction products
Wendisch et al. Microbial production of amines and amino acids by fermentation
Cao et al. Continuous preparation and characterization of immunomodulatory peptides from type II collagen by a novel immobilized enzyme membrane reactor with improved performance
Aghajanyan et al. Development of the efficient technology for isolating proline from culture liquid

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
AD01 Patent right deemed abandoned
AD01 Patent right deemed abandoned

Effective date of abandoning: 20090722