CN101475754A - 不对称菁类荧光染料,组合物及在生物样品染色中的用途 - Google Patents

不对称菁类荧光染料,组合物及在生物样品染色中的用途 Download PDF

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Publication number
CN101475754A
CN101475754A CNA2008100025037A CN200810002503A CN101475754A CN 101475754 A CN101475754 A CN 101475754A CN A2008100025037 A CNA2008100025037 A CN A2008100025037A CN 200810002503 A CN200810002503 A CN 200810002503A CN 101475754 A CN101475754 A CN 101475754A
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China
Prior art keywords
alkyl
compound
dye
benzyl
fluorescence
Prior art date
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Pending
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CNA2008100025037A
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English (en)
Chinese (zh)
Inventor
邵建辉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shenzhen Mindray Bio Medical Electronics Co Ltd
Beijing Shen Mindray Medical Electronics Technology Research Institute Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Application filed by Shenzhen Mindray Bio Medical Electronics Co Ltd filed Critical Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority to CN201510881799.4A priority Critical patent/CN105440725A/zh
Priority to CNA2008100025037A priority patent/CN101475754A/zh
Priority to US12/334,274 priority patent/US8067602B2/en
Publication of CN101475754A publication Critical patent/CN101475754A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
CNA2008100025037A 2008-01-04 2008-01-04 不对称菁类荧光染料,组合物及在生物样品染色中的用途 Pending CN101475754A (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201510881799.4A CN105440725A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料，组合物及在生物样品染色中的用途
CNA2008100025037A CN101475754A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料,组合物及在生物样品染色中的用途
US12/334,274 US8067602B2 (en) 2008-01-04 2008-12-12 Asymmetric cyanine fluorescent dyes, compositions and their use in staining biological samples

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2008100025037A CN101475754A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料,组合物及在生物样品染色中的用途

Related Child Applications (1)

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CN201510881799.4A Division CN105440725A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料，组合物及在生物样品染色中的用途

Publications (1)

Publication Number Publication Date
CN101475754A true CN101475754A (zh) 2009-07-08

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CN201510881799.4A Pending CN105440725A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料，组合物及在生物样品染色中的用途
CNA2008100025037A Pending CN101475754A (zh) 2008-01-04 2008-01-04 不对称菁类荧光染料,组合物及在生物样品染色中的用途

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Country Status (2)

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US (1) US8067602B2 (US08067602-20111129-C00005.png)
CN (2) CN105440725A (US08067602-20111129-C00005.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101750274A (zh) * 2008-12-17 2010-06-23 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒以及白细胞分类计数的方法
CN102115610B (zh) * 2010-01-05 2014-07-02 大连理工大学 一类荧光染料、制备方法及其应用
CN104749144A (zh) * 2013-12-31 2015-07-01 深圳迈瑞生物医疗电子股份有限公司 血细胞检测试剂及血细胞处理方法和识别方法
CN113686943A (zh) * 2021-08-03 2021-11-23 苏州优逸兰迪生物科技有限公司 一种多功能核酸染料及其制备方法与应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101349644B (zh) * 2007-07-20 2012-06-27 深圳迈瑞生物医疗电子股份有限公司 一种白细胞分类试剂和其使用方法
CN105440725A (zh) 2008-01-04 2016-03-30 深圳迈瑞生物医疗电子股份有限公司 不对称菁类荧光染料，组合物及在生物样品染色中的用途
CN101726579B (zh) 2008-10-17 2014-06-18 深圳迈瑞生物医疗电子股份有限公司 血液检测试剂和方法
CN101988082B (zh) * 2009-07-31 2015-04-08 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒及其制备方法和白细胞分类计数的方法
CN108036988A (zh) * 2017-12-15 2018-05-15 黄道连 一种精子快速染液

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386146A (en) * 1980-10-23 1983-05-31 Ishihara Sangyo Kaisha, Ltd. Dye sensitized titanium dioxide electrophotographic photosensitive materials
JP2006318212A (ja) * 2005-05-12 2006-11-24 Ricoh Co Ltd 文書データ配信システム

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2114067A5 (US08067602-20111129-C00005.png) 1970-11-13 1972-06-30 Sigma
US4146604A (en) 1973-05-31 1979-03-27 Block Engineering, Inc. Differential counting of leukocytes and other cells
US3883247A (en) 1973-10-30 1975-05-13 Bio Physics Systems Inc Method for fluorescence analysis of white blood cells
IL49622A0 (en) 1976-05-21 1976-07-30 Elscint Ltd A method and apparatus for classifying biological cells
US4286963A (en) 1979-11-23 1981-09-01 Coulter Electronics, Inc. Differential lymphoid-myeloid determination of leukocytes in whole blood
US4332785A (en) 1980-04-09 1982-06-01 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
US4447547A (en) 1980-04-09 1984-05-08 University Patents, Inc. Immunoassay for measurement of reticulocytes, and immunoreactive reagents for use therein
US4544546A (en) 1980-04-21 1985-10-01 Abbott Laboratories Fluorescent nucleic acid stains
US4325706A (en) 1980-08-15 1982-04-20 Ortho Diagnostic Systems Inc. Automated detection of platelets and reticulocytes in whole blood
US4336029A (en) 1980-08-15 1982-06-22 Ortho Diagnostic Systems Inc. Method and reagents for quantitative determination of reticulocytes and platelets in whole blood
JPS5747493A (en) 1980-09-02 1982-03-18 Fuji Photo Film Co Ltd Method of determining a trace amount of enzyme
US4528274A (en) 1982-07-06 1985-07-09 Coulter Electronics, Inc. Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes
US4485175A (en) 1983-01-03 1984-11-27 Coulter Electronics, Inc. Method for three-volume differential determination of lymphocyte, monocyte and granulocyte populations of leukocytes
US4571388A (en) 1983-01-24 1986-02-18 Becton Dickinson And Company Detection of reticulocytes
US4529705A (en) 1983-06-06 1985-07-16 Coulter Electronics, Inc. Reagent for combined diluting and lysing whole blood
US4596035A (en) 1983-06-27 1986-06-17 Ortho Diagnostic Systems Inc. Methods for enumerating 3-part white cell differential clusters
US4637986A (en) 1983-08-22 1987-01-20 Ortho Diagnostic Systems, Inc. Flow cytometry lysing reagent with leukoprotective agent for producing a 3-part WBC count
JPS6073356A (ja) 1983-09-29 1985-04-25 Toa Medical Electronics Co Ltd 血液分析用試薬
US4751179A (en) 1984-05-31 1988-06-14 Coulter Electronics, Inc. Method and reagents for differential determination of four populations of leukocytes in blood
US5188935A (en) 1984-05-31 1993-02-23 Coulter Electronics, Inc. Reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes
CA1255197A (en) 1984-09-24 1989-06-06 Joseph L. Orlik Leukocyte differentiation composition and method
JPS61280565A (ja) 1985-06-06 1986-12-11 Toa Medical Electronics Co Ltd フロ−サイトメトリ−用網状血球測定試薬
US4745071A (en) 1985-09-05 1988-05-17 Sequoia-Turner Corporation Method for the volumetric differentiation of blood cells types
US4978624A (en) 1985-09-06 1990-12-18 Technicon Instruments Corporation Reagent for the determination of a differential white blood cell count
US4707451A (en) 1985-09-18 1987-11-17 Becton, Dickinson And Company Detection of reticulocytes
US4883867A (en) 1985-11-01 1989-11-28 Becton, Dickinson And Company Detection of reticulocytes, RNA or DNA
US4957870A (en) 1985-11-01 1990-09-18 Becton, Dickinson And Company Detection of Reticulocytes, RNA and DNA
JPH06100596B2 (ja) 1986-09-10 1994-12-12 東亜医用電子株式会社 フロ−サイトメトリ−による白血球の分類方法
US5175109A (en) 1986-09-10 1992-12-29 Toa Medical Electronics Co., Ltd. Reagent for classifying leukocytes by flow cytometry
US5039613A (en) 1986-11-27 1991-08-13 Toa Medical Electronics Co., Ltd. Reagents used in a method of classifying leukocytes by flow cytometry
US5179026A (en) 1986-11-27 1993-01-12 Toa Medical Electronics Co., Ltd. Method of classifying leukocytes by flow cytometry and reagents used in the method
US4822745A (en) 1986-12-05 1989-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method for quantifying human reticulocytes
IL85532A (en) 1987-03-13 1992-03-29 Coulter Electronics Method and lytic reagent system for isolation,identification and/or analysis of leukocytes from whole blood samples
US5155044A (en) 1987-03-13 1992-10-13 Coulter Electronics, Inc. Lysing reagent system for isolation, identification and/or analysis of leukocytes from whole blood samples
US4882284A (en) 1987-04-13 1989-11-21 Ortho Pharmaceutical Corporation Method for quantitating and differentiating white blood cells
US5389549A (en) 1987-05-29 1995-02-14 Toa Medical Electronics Co., Ltd. Method for classifying leukocytes and a reagent used therefor
JP2549665B2 (ja) 1987-07-31 1996-10-30 東亜医用電子株式会社 フロ−サイトメトリ用網状赤血球測定試薬
JPH0746102B2 (ja) 1987-07-31 1995-05-17 東亜医用電子株式会社 フロ−サイトメトリ用網状赤血球測定試薬
JP2619900B2 (ja) 1988-01-27 1997-06-11 東亜医用電子株式会社 血液中の白血球およびヘモグロビンの測定用試薬および方法
US5180677A (en) 1988-07-05 1993-01-19 Fisher Scientific Company Lysing reagent for leukocyte differentiation method
CA2016699C (en) 1989-05-15 2003-11-18 Paul N. Marshall Lytic agents and uses thereof
JP2836865B2 (ja) 1989-10-23 1998-12-14 東亜医用電子株式会社 血液中の白血球およびヘモグロビンの測定用試薬
FR2654744B1 (fr) 1989-11-20 1992-03-13 Abx Sa Reactif et methode d'utilisation de celui-ci pour la determination automatique en cytometrie de flux d'au moins une sous-population leucocytaire a partir du sang total.
US5075556A (en) 1989-12-01 1991-12-24 Technicon Instruments Corporation Acridine orange derivatives and their use in the quantitation of reticulocytes in whole blood
US5242832A (en) 1990-03-01 1993-09-07 Toa Medical Electronics Co., Ltd. Reagent for measurement of leukocytes and hemoglobin in blood
US5227304A (en) 1991-01-16 1993-07-13 Sequoia Turner Corporation Method for counting whole blood diluent and detergent reagent system
US5316725A (en) 1991-06-07 1994-05-31 Edward Lawrence Carver, Jr. Reagent system for the improved determination of white blood cell subpopulations
US5316951A (en) 1991-06-07 1994-05-31 Carver Jr Edward L Method for the improved determination of white blood cell subpopulations
US5262329A (en) 1991-06-13 1993-11-16 Carver Jr Edward L Method for improved multiple species blood analysis
JP3048260B2 (ja) 1991-07-29 2000-06-05 シスメックス株式会社 白血球分類計数用試料調製方法
US5284771A (en) 1991-12-05 1994-02-08 Miles Inc. Reagent compositions and their use in sphering cells
US5360739A (en) 1991-12-05 1994-11-01 Miles Inc. Methods for the identification and characterization of reticulocytes in whole blood
US5350695A (en) 1991-12-05 1994-09-27 Miles Inc. Methods for the identification and characterization of reticulocytes in whole blood
JP3232145B2 (ja) 1991-12-27 2001-11-26 シスメックス株式会社 網赤血球測定方法
CA2087086A1 (en) 1992-01-22 1993-07-23 Leon Wmm Terstappen Multidimensional cell differential analysis
US5321130A (en) 1992-02-10 1994-06-14 Molecular Probes, Inc. Unsymmetrical cyanine dyes with a cationic side chain
DE69327775T2 (de) 1992-11-19 2000-06-21 Sysmex Corp Verfahren zur Vorbehandlung für Blutanalyse
AU6235994A (en) 1993-02-25 1994-09-14 Abbott Laboratories Multipurpose reagent system for rapid lysis of whole blood samples
JP3301646B2 (ja) 1993-03-19 2002-07-15 シスメックス株式会社 幼若細胞測定用試薬
EP0698211B1 (en) 1993-05-14 2003-04-02 Coulter International Corporation Reticulocyte analyzing method and apparatus utilizing light scatter techniques
US5563070A (en) 1993-05-28 1996-10-08 Omron Corporation Method of counting reticulocytes
JP3320869B2 (ja) 1993-12-22 2002-09-03 シスメックス株式会社 白血球分析用試薬
JP3467310B2 (ja) 1994-04-21 2003-11-17 シスメックス株式会社 白血球分析用試薬及び白血球の分類方法
IL113805A0 (en) 1994-05-23 1995-08-31 Coulter Corp Detection of reticulocytes
JP3355038B2 (ja) 1994-08-03 2002-12-09 シスメックス株式会社 白血球分類方法
JP3324050B2 (ja) 1994-10-31 2002-09-17 日本光電工業株式会社 白血球分類用試薬および白血球分類方法
US5879900A (en) 1994-12-15 1999-03-09 Abbott Laboratories Method for simultaneous analysis of cell viability, nucleated red blood cells and white blood cell differentials
US5559037A (en) 1994-12-15 1996-09-24 Abbott Laboratories Method for rapid and simultaneous analysis of nucleated red blood cells
US5656449A (en) 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
US5691204A (en) 1995-04-21 1997-11-25 Abbott Laboratories Compositions and methods for the rapid analysis of reticulocytes
US5639630A (en) 1995-05-16 1997-06-17 Bayer Corporation Method and reagent composition for performing leukocyte differential counts on fresh and aged whole blood samples, based on intrinsic peroxidase activity of leukocytes
US5686308A (en) 1995-06-08 1997-11-11 Coulter Corporation Reagent and method for differential determination of leukocytes in blood
US5843608A (en) 1995-06-08 1998-12-01 Coulter International Corp. Reagent and method for differential determination of leukocytes in blood
FR2735578B1 (fr) 1995-06-13 1997-09-05 Hycel Groupe Lisabio Reactif de lyse des erythrocytes, et son utilisation dans des procedes d'isolement et de discrimination des leucocytes
FR2735579B1 (fr) 1995-06-13 1997-09-19 Hycel Groupe Lisabio Procede de discrimination et d'isolement de sous-populations de leucocytes a partir d'echantillons sanguins par traitement par du polyoxyethylene 9-lauryl ether, et reactif pour sa mise en oeuvre
US5786224A (en) 1995-06-29 1998-07-28 Coulter Corporation Reagent and method for differential determination of leukocytes in blood
JP3425830B2 (ja) 1995-10-06 2003-07-14 シスメックス株式会社 新規化合物とその用途
US5733784A (en) 1995-11-20 1998-03-31 Abbott Laboratories Reagent system and method for the differentiation and identification of reticulocytes
US5817518A (en) 1995-12-18 1998-10-06 Coulter International Corp. Reagent and method for differential determination of leukocytes in blood
EP0794435B1 (en) 1996-03-07 2003-01-02 Coulter International Corp. Cyanide-free reagent and method for hemoglobin determination and leukocyte differentiation
TW379284B (en) 1996-04-12 2000-01-11 Toa Medical Electronics Agent for detecting reticulocyte
CN1149397C (zh) 1996-04-12 2004-05-12 希森美康株式会社 网织红细胞测定用试剂
US6245499B1 (en) 1996-04-30 2001-06-12 Fuji Photo Film Co., Ltd. Photothermographic material
US5858667A (en) 1996-09-06 1999-01-12 Litron Laboratories Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer
US6100038A (en) 1996-09-06 2000-08-08 Litron Laboratories Limited Method for the enumeration of micronucleated erythrocyte populations with a single laser flow cytometer
JP4042925B2 (ja) 1996-11-20 2008-02-06 シスメックス株式会社 幼若白血球の分類計数法
US6495692B1 (en) 1996-12-10 2002-12-17 Abbott Laboratories Helium-neon excitable reticulocyte dyes derivable from halolepidines
US5763280A (en) 1997-01-21 1998-06-09 Coulter International Corp. Cyanide-free lytic reagent composition and method for hemoglobin and cell analysis
US5882934A (en) 1997-01-21 1999-03-16 Coulter International Corp. Composition and method for hemoglobin and cell analysis
FR2759166B1 (fr) 1997-01-31 1999-04-23 Abx Sa Reactif de coloration pour la determination de cellules sanguines
US6114173A (en) 1997-04-03 2000-09-05 Bayer Corporation Fully automated method and reagent composition therefor for rapid identification and characterization of reticulocytes erythrocytes and platelets in whole blood
JP3830613B2 (ja) 1997-04-18 2006-10-04 シスメックス株式会社 血液中の白血球及びヘモグロビン濃度測定試薬
US5994089A (en) 1997-05-16 1999-11-30 Coulter International Corp. Simultaneous analyses of white blood cell subsets using multi-color, multi-intensity fluorescent markers in flow cytometry
JP3783808B2 (ja) 1997-05-19 2006-06-07 シスメックス株式会社 白血球分類計数用試薬
US5874311A (en) 1997-11-21 1999-02-23 Coulter International Corp. Method for differentiation of reticulocytes in blood
US6350613B1 (en) 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US6074232A (en) 1998-06-01 2000-06-13 Hon Hai Precision Ind. Co., Ltd. Board to board electrical connector with releaseable actuator
FR2782166B1 (fr) 1998-08-04 2000-10-06 Abx Sa Reactif pour la mesure de l'hemoglobine et la determination des leucocytes dans un echantillon de sang
US6060322A (en) 1998-10-20 2000-05-09 Coulter International Corp. Method for identification of reticulated cells
US6197593B1 (en) 1998-10-20 2001-03-06 Coulter International Corp. Method for enumerating blood cells
US6271035B1 (en) 1998-10-20 2001-08-07 Coulter International Corp. Methods and compositions for rapid staining of nucleic acids in whole cells
JP3886271B2 (ja) 1998-11-27 2007-02-28 シスメックス株式会社 赤芽球の分類計数用試薬及び分類計数方法
WO2000058727A1 (en) 1999-03-31 2000-10-05 Bayer Corporation Single channel, single dilution detection method
US6900023B1 (en) 1999-09-02 2005-05-31 Sysmex Corporation Method for classifying and counting leukocytes
US20020098589A1 (en) 2001-01-19 2002-07-25 Crews Harold Richardson Multi-purpose reagent system and method for enumeration of red blood cells, white blood cells and thrombocytes and differential determination of white blood cells
US6632676B1 (en) 1999-09-24 2003-10-14 Clinical Diagnostic Solutions Multi-purpose reagent system and method for enumeration of red blood cells, white blood cells and thrombocytes and differential determination of white blood cells
CN1101982C (zh) 1999-10-29 2003-02-19 富士康(昆山)电脑接插件有限公司 插座连接器及其导电端子
JP2001267149A (ja) 2000-03-21 2001-09-28 Mitsubishi Electric Corp タップ切換装置
US6368864B1 (en) 2000-05-05 2002-04-09 Coulter International Corp. Dyes and methods of reticulocyte enumeration
JP3493575B2 (ja) 2000-07-28 2004-02-03 Ｎｅｃエレクトロニクス株式会社 半導体装置、チャージポンプ回路およびｐｌｌ回路
FR2813891B1 (fr) 2000-09-14 2005-01-14 Immunotech Sa Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications
US6794152B2 (en) 2000-12-22 2004-09-21 Streck Laboratories Inc. Flow cytometry reagent and system
FR2821428B1 (fr) 2001-02-23 2004-08-06 Abx Sa Reactif et procede pour l'identification et le comptage de cellules biologiques
US6630990B2 (en) 2001-06-05 2003-10-07 Abbott Laboratories Optical method and apparatus for red blood cell differentiation on a cell-by-cell basis, and simultaneous analysis of white blood cell differentiation
CA2489099C (en) 2002-06-11 2012-12-18 Chempaq A/S A disposable cartridge for characterizing particles suspended in a liquid
JP4324552B2 (ja) 2002-06-24 2009-09-02 シスメックス株式会社 白血球の分類計数方法
US7405082B2 (en) 2002-09-10 2008-07-29 Sysmex Corporation Methods and devices for measuring reticulocytes
EP1422509A1 (en) 2002-11-01 2004-05-26 Streck Laboratories, Inc. Lysing Reagent and Method of Lysing Red Blood Cells for Hematology
US6955872B2 (en) 2003-03-20 2005-10-18 Coulter International Corp. Dye compositions which provide enhanced differential fluorescence and light scatter characteristics
US6869798B2 (en) 2003-04-17 2005-03-22 Clinical Diagnostics Solutions, Inc. Lytic reagent composition for leukocyte differential analysis
JP4509607B2 (ja) 2004-03-17 2010-07-21 シスメックス株式会社 細胞分析装置および方法
US7465584B2 (en) 2005-01-24 2008-12-16 Sysmex Corporation Method and reagent for classifying leukocytes in animal blood
US7235404B2 (en) 2005-05-04 2007-06-26 Beckman Coulter, Inc. Cyanide-free lytic reagent composition and method of use for hemoglobin and white blood cell measurement
US7625757B2 (en) 2006-01-27 2009-12-01 Sysmex Corporation Reagent for immature leukocyte analysis and reagent kit
JP4806334B2 (ja) 2006-11-27 2011-11-02 シスメックス株式会社 血液学的試料の測定方法および測定装置
US7449337B2 (en) 2007-01-24 2008-11-11 Idexx Laboratories, Inc. Lytic reagent and method for leukocytes differential in whole blood
EP2166354B1 (en) 2007-06-25 2012-11-07 Sysmex Corporation Reagent and reagent kit for analysis of primitive leukocyte
CN101349644B (zh) 2007-07-20 2012-06-27 深圳迈瑞生物医疗电子股份有限公司 一种白细胞分类试剂和其使用方法
CN105440725A (zh) 2008-01-04 2016-03-30 深圳迈瑞生物医疗电子股份有限公司 不对称菁类荧光染料，组合物及在生物样品染色中的用途
CN101750274B (zh) 2008-12-17 2014-06-25 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒以及白细胞分类计数的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4386146A (en) * 1980-10-23 1983-05-31 Ishihara Sangyo Kaisha, Ltd. Dye sensitized titanium dioxide electrophotographic photosensitive materials
JP2006318212A (ja) * 2005-05-12 2006-11-24 Ricoh Co Ltd 文書データ配信システム

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101750274A (zh) * 2008-12-17 2010-06-23 深圳迈瑞生物医疗电子股份有限公司 白细胞分类计数试剂、试剂盒以及白细胞分类计数的方法
CN102115610B (zh) * 2010-01-05 2014-07-02 大连理工大学 一类荧光染料、制备方法及其应用
CN104749144A (zh) * 2013-12-31 2015-07-01 深圳迈瑞生物医疗电子股份有限公司 血细胞检测试剂及血细胞处理方法和识别方法
CN113686943A (zh) * 2021-08-03 2021-11-23 苏州优逸兰迪生物科技有限公司 一种多功能核酸染料及其制备方法与应用
CN113686943B (zh) * 2021-08-03 2024-01-26 苏州优逸兰迪生物科技有限公司 一种多功能核酸染料及其制备方法与应用

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