CN101450918A - 盐酸二甲双胍纯化方法 - Google Patents
盐酸二甲双胍纯化方法 Download PDFInfo
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- CN101450918A CN101450918A CNA2007101147605A CN200710114760A CN101450918A CN 101450918 A CN101450918 A CN 101450918A CN A2007101147605 A CNA2007101147605 A CN A2007101147605A CN 200710114760 A CN200710114760 A CN 200710114760A CN 101450918 A CN101450918 A CN 101450918A
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- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 title claims abstract description 57
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 229960004329 metformin hydrochloride Drugs 0.000 title claims abstract description 14
- 238000000034 method Methods 0.000 title claims abstract description 11
- 238000000746 purification Methods 0.000 title claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000012043 crude product Substances 0.000 claims abstract description 22
- 239000008213 purified water Substances 0.000 claims abstract description 12
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims abstract description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 36
- 239000000463 material Substances 0.000 claims description 35
- 238000001914 filtration Methods 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 20
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000012266 salt solution Substances 0.000 claims description 16
- 239000012452 mother liquor Substances 0.000 claims description 10
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- 230000006837 decompression Effects 0.000 claims description 8
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 8
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 10
- 229960004756 ethanol Drugs 0.000 description 6
- 238000007670 refining Methods 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010060766 Heteroplasia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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Abstract
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101147605A CN101450918B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍纯化方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101147605A CN101450918B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍纯化方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101450918A true CN101450918A (zh) | 2009-06-10 |
| CN101450918B CN101450918B (zh) | 2011-08-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007101147605A Active CN101450918B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍纯化方法 |
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| CN (1) | CN101450918B (zh) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| WO2014041566A2 (en) * | 2012-09-17 | 2014-03-20 | Laurus Labs Private Limited | An improved process for the preparation of metformin hydrochloride |
| CN104829495A (zh) * | 2015-04-24 | 2015-08-12 | 青岛中科荣达新材料有限公司 | 一种双组份溶剂制备高纯度高收率盐酸二甲双胍的方法 |
| CN105968032A (zh) * | 2016-05-12 | 2016-09-28 | 宁夏思科达生物科技有限公司 | 盐酸二甲双胍的合成方法 |
| CN106278953A (zh) * | 2015-04-24 | 2017-01-04 | 泰山医学院 | 一种提高盐酸二甲双胍纯度的生产方法 |
| CN110194727A (zh) * | 2018-12-05 | 2019-09-03 | 武汉武药制药有限公司 | 一种盐酸二甲双胍的精制方法 |
| CN110256300A (zh) * | 2019-06-26 | 2019-09-20 | 武汉大学 | 一种盐酸二甲双胍化合物及盐酸二甲双胍片组合物 |
| CN112645845A (zh) * | 2021-01-05 | 2021-04-13 | 海南海力制药有限公司 | 盐酸二甲双胍的纯化方法、盐酸二甲双胍缓释片及其制备方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391939C (zh) * | 2006-05-10 | 2008-06-04 | 翟树军 | 盐酸二甲双胍的生产方法 |
-
2007
- 2007-11-30 CN CN2007101147605A patent/CN101450918B/zh active Active
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| WO2014041566A2 (en) * | 2012-09-17 | 2014-03-20 | Laurus Labs Private Limited | An improved process for the preparation of metformin hydrochloride |
| WO2014041566A3 (en) * | 2012-09-17 | 2014-05-08 | Laurus Labs Private Limited | Improved process for the preparation of metformin hydrochloride |
| CN107245042B (zh) * | 2015-04-24 | 2019-03-05 | 韩光琨 | 一种复合溶剂生产盐酸二甲双胍的方法 |
| CN104829495A (zh) * | 2015-04-24 | 2015-08-12 | 青岛中科荣达新材料有限公司 | 一种双组份溶剂制备高纯度高收率盐酸二甲双胍的方法 |
| CN106278953A (zh) * | 2015-04-24 | 2017-01-04 | 泰山医学院 | 一种提高盐酸二甲双胍纯度的生产方法 |
| CN106278953B (zh) * | 2015-04-24 | 2017-09-29 | 泰山医学院 | 一种提高盐酸二甲双胍纯度的生产方法 |
| CN107245042A (zh) * | 2015-04-24 | 2017-10-13 | 韩光琨 | 一种复合溶剂生产盐酸二甲双胍的方法 |
| CN107337618A (zh) * | 2015-04-24 | 2017-11-10 | 青岛中科荣达新材料有限公司 | 一种同时提高盐酸二甲双胍纯度及收率的生产方法 |
| CN105968032A (zh) * | 2016-05-12 | 2016-09-28 | 宁夏思科达生物科技有限公司 | 盐酸二甲双胍的合成方法 |
| CN105968032B (zh) * | 2016-05-12 | 2018-06-19 | 宁夏思科达生物科技有限公司 | 盐酸二甲双胍的合成方法 |
| CN110194727A (zh) * | 2018-12-05 | 2019-09-03 | 武汉武药制药有限公司 | 一种盐酸二甲双胍的精制方法 |
| CN110256300A (zh) * | 2019-06-26 | 2019-09-20 | 武汉大学 | 一种盐酸二甲双胍化合物及盐酸二甲双胍片组合物 |
| CN110256300B (zh) * | 2019-06-26 | 2022-04-05 | 武汉大学 | 一种盐酸二甲双胍化合物及盐酸二甲双胍片组合物 |
| CN112645845A (zh) * | 2021-01-05 | 2021-04-13 | 海南海力制药有限公司 | 盐酸二甲双胍的纯化方法、盐酸二甲双胍缓释片及其制备方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113248409B (zh) * | 2021-05-21 | 2023-01-03 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101450918B (zh) | 2011-08-10 |
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Address after: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee after: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Address before: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee before: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20170120 Granted publication date: 20110810 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017990000057 |
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