CN101450919B - 盐酸二甲双胍精制方法 - Google Patents
盐酸二甲双胍精制方法 Download PDFInfo
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- CN101450919B CN101450919B CN200710114761XA CN200710114761A CN101450919B CN 101450919 B CN101450919 B CN 101450919B CN 200710114761X A CN200710114761X A CN 200710114761XA CN 200710114761 A CN200710114761 A CN 200710114761A CN 101450919 B CN101450919 B CN 101450919B
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- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 title claims abstract description 67
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000000746 purification Methods 0.000 title claims description 12
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract description 12
- 229960004329 metformin hydrochloride Drugs 0.000 title abstract description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 56
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000012043 crude product Substances 0.000 claims abstract description 20
- 239000008213 purified water Substances 0.000 claims abstract description 18
- 239000000463 material Substances 0.000 claims description 33
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 16
- 230000006837 decompression Effects 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000012266 salt solution Substances 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012452 mother liquor Substances 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims description 8
- 238000012797 qualification Methods 0.000 abstract description 6
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 abstract description 4
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 238000007670 refining Methods 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010060766 Heteroplasia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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Abstract
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Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN200710114761XA CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
Applications Claiming Priority (1)
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CN200710114761XA CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
Publications (2)
Publication Number | Publication Date |
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CN101450919A CN101450919A (zh) | 2009-06-10 |
CN101450919B true CN101450919B (zh) | 2011-11-09 |
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CN200710114761XA Active CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
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CN (1) | CN101450919B (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
CN103435518B (zh) * | 2013-08-26 | 2015-02-18 | 青岛黄海制药有限责任公司 | 一种盐酸二甲双胍的制备方法 |
WO2016059507A1 (en) * | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
CN112645845A (zh) * | 2021-01-05 | 2021-04-13 | 海南海力制药有限公司 | 盐酸二甲双胍的纯化方法、盐酸二甲双胍缓释片及其制备方法 |
CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
CN113248409B (zh) * | 2021-05-21 | 2023-01-03 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
CN113292460A (zh) * | 2021-06-18 | 2021-08-24 | 天津应天成科技有限公司 | 一种盐酸二甲双胍的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1844093A (zh) * | 2006-05-10 | 2006-10-11 | 翟树军 | 盐酸二甲双胍的生产方法 |
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2007
- 2007-11-30 CN CN200710114761XA patent/CN101450919B/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1844093A (zh) * | 2006-05-10 | 2006-10-11 | 翟树军 | 盐酸二甲双胍的生产方法 |
Non-Patent Citations (2)
Title |
---|
肖传健等.盐酸二甲双胍最佳工艺路线研究.《湖北化工》.1997,(第4期), * |
陈战国等.盐酸二甲双胍合成过程中最佳条件的选择及提高产品纯度新途径.《陕西师范大学学报(自然科学版)》.2001,第29卷(第4期), * |
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Publication number | Publication date |
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CN101450919A (zh) | 2009-06-10 |
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Address after: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee after: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Address before: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee before: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20170120 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017990000057 |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20171114 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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Date of cancellation: 20190115 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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