CN101450919A - 盐酸二甲双胍精制方法 - Google Patents
盐酸二甲双胍精制方法 Download PDFInfo
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- CN101450919A CN101450919A CNA200710114761XA CN200710114761A CN101450919A CN 101450919 A CN101450919 A CN 101450919A CN A200710114761X A CNA200710114761X A CN A200710114761XA CN 200710114761 A CN200710114761 A CN 200710114761A CN 101450919 A CN101450919 A CN 101450919A
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- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 title claims abstract description 72
- 238000000034 method Methods 0.000 title claims abstract description 15
- 238000000746 purification Methods 0.000 title claims description 13
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title abstract description 12
- 229960004329 metformin hydrochloride Drugs 0.000 title abstract description 11
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000012043 crude product Substances 0.000 claims abstract description 22
- 239000008213 purified water Substances 0.000 claims abstract description 19
- IQDGSYLLQPDQDV-UHFFFAOYSA-N dimethylazanium;chloride Chemical compound Cl.CNC IQDGSYLLQPDQDV-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000000463 material Substances 0.000 claims description 33
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 18
- 238000001816 cooling Methods 0.000 claims description 16
- 230000006837 decompression Effects 0.000 claims description 16
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000012266 salt solution Substances 0.000 claims description 16
- 239000002904 solvent Substances 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 239000012452 mother liquor Substances 0.000 claims description 10
- 239000003153 chemical reaction reagent Substances 0.000 claims description 8
- 238000009833 condensation Methods 0.000 claims description 8
- 230000005494 condensation Effects 0.000 claims description 8
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 6
- 238000012797 qualification Methods 0.000 abstract description 6
- 238000003786 synthesis reaction Methods 0.000 abstract description 3
- 238000007670 refining Methods 0.000 abstract description 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- QGBSISYHAICWAH-UHFFFAOYSA-N dicyandiamide Chemical compound NC(N)=NC#N QGBSISYHAICWAH-UHFFFAOYSA-N 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 206010060766 Heteroplasia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960004756 ethanol Drugs 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
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Abstract
Description
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710114761XA CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710114761XA CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101450919A true CN101450919A (zh) | 2009-06-10 |
| CN101450919B CN101450919B (zh) | 2011-11-09 |
Family
ID=40733422
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200710114761XA Active CN101450919B (zh) | 2007-11-30 | 2007-11-30 | 盐酸二甲双胍精制方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101450919B (zh) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| CN103435518A (zh) * | 2013-08-26 | 2013-12-11 | 青岛黄海制药有限责任公司 | 一种盐酸二甲双胍的制备方法 |
| WO2016059507A1 (en) * | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
| CN112645845A (zh) * | 2021-01-05 | 2021-04-13 | 海南海力制药有限公司 | 盐酸二甲双胍的纯化方法、盐酸二甲双胍缓释片及其制备方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113292460A (zh) * | 2021-06-18 | 2021-08-24 | 天津应天成科技有限公司 | 一种盐酸二甲双胍的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100391939C (zh) * | 2006-05-10 | 2008-06-04 | 翟树军 | 盐酸二甲双胍的生产方法 |
-
2007
- 2007-11-30 CN CN200710114761XA patent/CN101450919B/zh active Active
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102153489A (zh) * | 2011-02-21 | 2011-08-17 | 寿光富康制药有限公司 | 一种盐酸二甲双胍的新晶型及其制备方法 |
| CN103435518A (zh) * | 2013-08-26 | 2013-12-11 | 青岛黄海制药有限责任公司 | 一种盐酸二甲双胍的制备方法 |
| CN103435518B (zh) * | 2013-08-26 | 2015-02-18 | 青岛黄海制药有限责任公司 | 一种盐酸二甲双胍的制备方法 |
| WO2016059507A1 (en) * | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
| CN106795104A (zh) * | 2014-10-13 | 2017-05-31 | 瑟勒特·库玛·卡玛瓦拉普 | 改进的制备高纯度二甲双胍的方法 |
| CN112645845A (zh) * | 2021-01-05 | 2021-04-13 | 海南海力制药有限公司 | 盐酸二甲双胍的纯化方法、盐酸二甲双胍缓释片及其制备方法 |
| CN112679389A (zh) * | 2021-01-05 | 2021-04-20 | 海南海力制药有限公司 | 盐酸二甲双胍的精制方法、盐酸二甲双胍缓释片及其制备方法 |
| CN113248409A (zh) * | 2021-05-21 | 2021-08-13 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| WO2022241978A1 (zh) * | 2021-05-21 | 2022-11-24 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113248409B (zh) * | 2021-05-21 | 2023-01-03 | 海南海力制药有限公司 | 盐酸二甲双胍的合成方法及应用 |
| CN113292460A (zh) * | 2021-06-18 | 2021-08-24 | 天津应天成科技有限公司 | 一种盐酸二甲双胍的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101450919B (zh) | 2011-11-09 |
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Owner name: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: SHANDONG FANGXING SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20120401 |
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Free format text: CORRECT: ADDRESS; FROM: 256207 BINZHOU, SHANDONG PROVINCE TO: 222000 LIANYUNGANG, JIANGSU PROVINCE |
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Effective date of registration: 20120401 Address after: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee after: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Address before: 256207 Shandong province Binzhou Zouping County Changshan town big province village Patentee before: Shandong Fangxing Science and Technology Development Co., Ltd. |
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Address after: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee after: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Address before: 222000 No. 29 Changjiang Road, Lianyungang Economic Development Zone, Lianyungang, Jiangsu Patentee before: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20170120 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017990000057 |
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Date of cancellation: 20171109 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017990000057 |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20171114 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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Date of cancellation: 20190115 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2017320000049 |
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Denomination of invention: Metformin hydrochloride purification method Effective date of registration: 20190121 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: JIANGSU DEYUAN PHARMACEUTICAL CO., LTD. Registration number: 2019320000058 |
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Date of cancellation: 20191211 Granted publication date: 20111109 Pledgee: China Merchants Bank Limited by Share Ltd Lianyungang branch Pledgor: Jiangsu Deyuan Pharmaceutical Co., Ltd. Registration number: 2019320000058 |
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