WO2014041566A3 - Improved process for the preparation of metformin hydrochloride - Google Patents

Improved process for the preparation of metformin hydrochloride Download PDF

Info

Publication number
WO2014041566A3
WO2014041566A3 PCT/IN2013/000558 IN2013000558W WO2014041566A3 WO 2014041566 A3 WO2014041566 A3 WO 2014041566A3 IN 2013000558 W IN2013000558 W IN 2013000558W WO 2014041566 A3 WO2014041566 A3 WO 2014041566A3
Authority
WO
WIPO (PCT)
Prior art keywords
metformin hydrochloride
preparation
improved process
metformin
hydrochloride
Prior art date
Application number
PCT/IN2013/000558
Other languages
French (fr)
Other versions
WO2014041566A2 (en
Inventor
Satyanarayana Chava
Seeta Ramanjaneyulu Gorantla
Venkata Sunil Kumar Indukuri
Narasimha Rao Ketavarapu
Veeraiah Chowdary GORANTLA
Original Assignee
Laurus Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laurus Labs Private Limited filed Critical Laurus Labs Private Limited
Publication of WO2014041566A2 publication Critical patent/WO2014041566A2/en
Publication of WO2014041566A3 publication Critical patent/WO2014041566A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/06—Purification or separation of guanidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The present invention relates to an improved process for the preparation of Metformin hydrochloride by removing solvent from a solution comprising metformin hydrochloride using agitated thin film dryer.
PCT/IN2013/000558 2012-09-17 2013-09-17 An improved process for the preparation of metformin hydrochloride WO2014041566A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3847/CHE/2012 2012-09-17
IN3847CH2012 2012-09-17

Publications (2)

Publication Number Publication Date
WO2014041566A2 WO2014041566A2 (en) 2014-03-20
WO2014041566A3 true WO2014041566A3 (en) 2014-05-08

Family

ID=50278802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000558 WO2014041566A2 (en) 2012-09-17 2013-09-17 An improved process for the preparation of metformin hydrochloride

Country Status (1)

Country Link
WO (1) WO2014041566A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016059507A1 (en) 2014-10-13 2016-04-21 Kamavarapu Sarath Kumar Improved process for the preparation of high pure metformine
WO2016144766A1 (en) * 2015-03-06 2016-09-15 The University Of North Carolina At Chapel Hill Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle
CN107245042B (en) * 2015-04-24 2019-03-05 韩光琨 A kind of method of double solvents production Metformin hydrochloride
CN105481726A (en) * 2015-12-17 2016-04-13 石家庄市普力制药有限公司 Preparation method of metformin hydrochloride
WO2021012274A1 (en) * 2019-07-25 2021-01-28 凯莱英生命科学技术(天津)有限公司 Preparation method for metformin hydrochloride
CN112010781B (en) * 2020-09-17 2022-10-21 重庆医药高等专科学校 Preparation method of metformin hydrochloride

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019661A1 (en) * 2007-08-07 2009-02-12 Ranbaxy Laboratories Limited Process for preparation of amorphous lopinavir
CN101450918A (en) * 2007-11-30 2009-06-10 山东方兴科技开发有限公司 Metformin hydrochloride purification method
WO2011064793A1 (en) * 2009-11-24 2011-06-03 Matrix Laboratories Ltd Process for the preparation of amorphous valganciclovir hydrochloride

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019661A1 (en) * 2007-08-07 2009-02-12 Ranbaxy Laboratories Limited Process for preparation of amorphous lopinavir
CN101450918A (en) * 2007-11-30 2009-06-10 山东方兴科技开发有限公司 Metformin hydrochloride purification method
WO2011064793A1 (en) * 2009-11-24 2011-06-03 Matrix Laboratories Ltd Process for the preparation of amorphous valganciclovir hydrochloride

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KLACZKOW, G ET AL.: "Determination ofimpurities in medical products containing metformin hydrochloride.", ACTA POLONIAE PHARMACEUTICA., vol. 67, no. 6, 2010, pages 593 - 598 *

Also Published As

Publication number Publication date
WO2014041566A2 (en) 2014-03-20

Similar Documents

Publication Publication Date Title
WO2014041566A3 (en) Improved process for the preparation of metformin hydrochloride
DK2879718T3 (en) Process for the preparation of carbohydrate-conjugated RNA substances
EP2714673A4 (en) Process for producing furfural from black liquor
IN2014CN03466A (en)
DK3434113T3 (en) Process for the preparation of beverages by removing acid
BR112015003101A2 (en) process for the preparation of a compound.
WO2014041560A3 (en) Process for the preparation of teneligliptin
DK3444238T3 (en) Process for the preparation of difluoromethylene compounds
EP2502901A4 (en) Novel process for synthesizing fingolimod hydrochloride
EP2788701B8 (en) Process for drying sludge
DK2785439T3 (en) Process for processing an aqueous lignin-containing solution
SG2014013718A (en) Process for removing substances from substrates
WO2011157390A3 (en) Process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
WO2013027220A3 (en) Process for dry-coating of flexogarphic surfaces
HK1199049A1 (en) Process for the removal of the solvent from a polymeric solution
BR112014028585A2 (en) process for making amino acid compounds.
BR112014014052A2 (en) process for the preparation of 5-hydroxymethylfurfural
WO2012140490A3 (en) Processes for preparing pitavastatin calcium
WO2012176214A3 (en) Process for bendamustine hydrochloride
HUE056148T2 (en) Process for extrakting an odorant extract using an alternative solvent compared to conventionel solvents
WO2013190357A8 (en) A process for the preparation of gabapentin
MY191759A (en) Processes for the preparation of pyrimidinylcyclopentane compounds
WO2014177978A3 (en) An improved process for the preparation of teriflunomide
WO2014102834A3 (en) Process for lurasidone
WO2013072938A3 (en) Process for the preparation of roflumilast

Legal Events

Date Code Title Description
122 Ep: pct application non-entry in european phase

Ref document number: 13837990

Country of ref document: EP

Kind code of ref document: A2