WO2014041566A3 - Improved process for the preparation of metformin hydrochloride - Google Patents
Improved process for the preparation of metformin hydrochloride Download PDFInfo
- Publication number
- WO2014041566A3 WO2014041566A3 PCT/IN2013/000558 IN2013000558W WO2014041566A3 WO 2014041566 A3 WO2014041566 A3 WO 2014041566A3 IN 2013000558 W IN2013000558 W IN 2013000558W WO 2014041566 A3 WO2014041566 A3 WO 2014041566A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- metformin hydrochloride
- preparation
- improved process
- metformin
- hydrochloride
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/06—Purification or separation of guanidine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The present invention relates to an improved process for the preparation of Metformin hydrochloride by removing solvent from a solution comprising metformin hydrochloride using agitated thin film dryer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3847/CHE/2012 | 2012-09-17 | ||
IN3847CH2012 | 2012-09-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2014041566A2 WO2014041566A2 (en) | 2014-03-20 |
WO2014041566A3 true WO2014041566A3 (en) | 2014-05-08 |
Family
ID=50278802
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2013/000558 WO2014041566A2 (en) | 2012-09-17 | 2013-09-17 | An improved process for the preparation of metformin hydrochloride |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2014041566A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016059507A1 (en) | 2014-10-13 | 2016-04-21 | Kamavarapu Sarath Kumar | Improved process for the preparation of high pure metformine |
WO2016144766A1 (en) * | 2015-03-06 | 2016-09-15 | The University Of North Carolina At Chapel Hill | Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle |
CN107245042B (en) * | 2015-04-24 | 2019-03-05 | 韩光琨 | A kind of method of double solvents production Metformin hydrochloride |
CN105481726A (en) * | 2015-12-17 | 2016-04-13 | 石家庄市普力制药有限公司 | Preparation method of metformin hydrochloride |
WO2021012274A1 (en) * | 2019-07-25 | 2021-01-28 | 凯莱英生命科学技术(天津)有限公司 | Preparation method for metformin hydrochloride |
CN112010781B (en) * | 2020-09-17 | 2022-10-21 | 重庆医药高等专科学校 | Preparation method of metformin hydrochloride |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009019661A1 (en) * | 2007-08-07 | 2009-02-12 | Ranbaxy Laboratories Limited | Process for preparation of amorphous lopinavir |
CN101450918A (en) * | 2007-11-30 | 2009-06-10 | 山东方兴科技开发有限公司 | Metformin hydrochloride purification method |
WO2011064793A1 (en) * | 2009-11-24 | 2011-06-03 | Matrix Laboratories Ltd | Process for the preparation of amorphous valganciclovir hydrochloride |
-
2013
- 2013-09-17 WO PCT/IN2013/000558 patent/WO2014041566A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009019661A1 (en) * | 2007-08-07 | 2009-02-12 | Ranbaxy Laboratories Limited | Process for preparation of amorphous lopinavir |
CN101450918A (en) * | 2007-11-30 | 2009-06-10 | 山东方兴科技开发有限公司 | Metformin hydrochloride purification method |
WO2011064793A1 (en) * | 2009-11-24 | 2011-06-03 | Matrix Laboratories Ltd | Process for the preparation of amorphous valganciclovir hydrochloride |
Non-Patent Citations (1)
Title |
---|
KLACZKOW, G ET AL.: "Determination ofimpurities in medical products containing metformin hydrochloride.", ACTA POLONIAE PHARMACEUTICA., vol. 67, no. 6, 2010, pages 593 - 598 * |
Also Published As
Publication number | Publication date |
---|---|
WO2014041566A2 (en) | 2014-03-20 |
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