CN101429200B - 用作抗心律失常剂的三环苯并吡喃化合物 - Google Patents
用作抗心律失常剂的三环苯并吡喃化合物 Download PDFInfo
- Publication number
- CN101429200B CN101429200B CN2008101707921A CN200810170792A CN101429200B CN 101429200 B CN101429200 B CN 101429200B CN 2008101707921 A CN2008101707921 A CN 2008101707921A CN 200810170792 A CN200810170792 A CN 200810170792A CN 101429200 B CN101429200 B CN 101429200B
- Authority
- CN
- China
- Prior art keywords
- amino
- carbonyl
- dihydro
- pyrans
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C**(C(C(C)C)=C(C(*)=C1*)N=C)C1=O Chemical compound C**(C(C(C)C)=C(C(*)=C1*)N=C)C1=O 0.000 description 7
- ZWPXRPBIZMQBSM-UHFFFAOYSA-N CC(C)(C(C1O)Br)Oc(cc2)c1c(cc1)c2nc1Cl Chemical compound CC(C)(C(C1O)Br)Oc(cc2)c1c(cc1)c2nc1Cl ZWPXRPBIZMQBSM-UHFFFAOYSA-N 0.000 description 1
- GCZLBNNLXGOXTQ-IBGZPJMESA-N CC(C)(C1=O)Oc2cc3nccnc3cc2[C@@H]1NCCc(cccc1)c1F Chemical compound CC(C)(C1=O)Oc2cc3nccnc3cc2[C@@H]1NCCc(cccc1)c1F GCZLBNNLXGOXTQ-IBGZPJMESA-N 0.000 description 1
- ZQVCYUZZJDKJOT-IBGZPJMESA-N CC(C)(C1=O)Oc2cc3nccnc3cc2[C@@H]1NCCc1ccccc1 Chemical compound CC(C)(C1=O)Oc2cc3nccnc3cc2[C@@H]1NCCc1ccccc1 ZQVCYUZZJDKJOT-IBGZPJMESA-N 0.000 description 1
- NXLDQSMPHXZKSG-UHFFFAOYSA-N CC(C)(C=Cc1c2)Oc1cc(c(C)c1)c2nc1C#N Chemical compound CC(C)(C=Cc1c2)Oc1cc(c(C)c1)c2nc1C#N NXLDQSMPHXZKSG-UHFFFAOYSA-N 0.000 description 1
- PWPOFEBQHYPUNV-ZYJPSCNZSA-N CC(C)([C@@H]([C@H](c1c2)NCC(c3ccccc3)O)O)Oc1cc1c2nccn1 Chemical compound CC(C)([C@@H]([C@H](c1c2)NCC(c3ccccc3)O)O)Oc1cc1c2nccn1 PWPOFEBQHYPUNV-ZYJPSCNZSA-N 0.000 description 1
- OXMHZVORVYGRFZ-FCHUYYIVSA-N CC(C)([C@@H]([C@H](c1c2)NCCc3ccccc3)O)Oc1cc(c(C)c1)c2nc1C(N)=O Chemical compound CC(C)([C@@H]([C@H](c1c2)NCCc3ccccc3)O)Oc1cc(c(C)c1)c2nc1C(N)=O OXMHZVORVYGRFZ-FCHUYYIVSA-N 0.000 description 1
- NGWVFMQMEXBFMD-FCHUYYIVSA-N CC(C)([C@@H]([C@H](c1c2)NCCc3ccccc3)O)Oc1cc(c(C)c1)c2nc1Cl Chemical compound CC(C)([C@@H]([C@H](c1c2)NCCc3ccccc3)O)Oc1cc(c(C)c1)c2nc1Cl NGWVFMQMEXBFMD-FCHUYYIVSA-N 0.000 description 1
- KOCXCSREADKFMD-VQTJNVASSA-N CC(C)([C@@H]([C@H]1NCCc2ccccc2)O)Oc(cc2N3)c1cc2OCC3=O Chemical compound CC(C)([C@@H]([C@H]1NCCc2ccccc2)O)Oc(cc2N3)c1cc2OCC3=O KOCXCSREADKFMD-VQTJNVASSA-N 0.000 description 1
- BKVTWNIIPHLARC-HZPDHXFCSA-N CC(C)([C@@H]1O[C@@H]1c1c2)Oc1cc(c(C)c1)c2nc1OC(C)=O Chemical compound CC(C)([C@@H]1O[C@@H]1c1c2)Oc1cc(c(C)c1)c2nc1OC(C)=O BKVTWNIIPHLARC-HZPDHXFCSA-N 0.000 description 1
- LMVGPQNBHMECBB-PKTZIBPZSA-N CC(C)([C@H]([C@@H](c1c2)NCCc3ccccc3)O)Oc1cc1c2nc(C)cc1C Chemical compound CC(C)([C@H]([C@@H](c1c2)NCCc3ccccc3)O)Oc1cc1c2nc(C)cc1C LMVGPQNBHMECBB-PKTZIBPZSA-N 0.000 description 1
- ACZVHCBJCSMHIL-RBUKOAKNSA-N CCCCCN[C@H]([C@H](C(C)(C)Oc1c2)O)c1cc1c2c(C)cc(Cl)n1 Chemical compound CCCCCN[C@H]([C@H](C(C)(C)Oc1c2)O)c1cc1c2c(C)cc(Cl)n1 ACZVHCBJCSMHIL-RBUKOAKNSA-N 0.000 description 1
- MYVHUOFUEJFCFI-MLTWYBDISA-N C[C@H]1C(C)(C/C(/C(O)=O)=C/C(O)=O)Oc2cc3cccnc3cc2[C@@H]1NCCc1ccccc1 Chemical compound C[C@H]1C(C)(C/C(/C(O)=O)=C/C(O)=O)Oc2cc3cccnc3cc2[C@@H]1NCCc1ccccc1 MYVHUOFUEJFCFI-MLTWYBDISA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004084605 | 2004-03-23 | ||
| JP084605/2004 | 2004-03-23 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800090295A Division CN1934116B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101429200A CN101429200A (zh) | 2009-05-13 |
| CN101429200B true CN101429200B (zh) | 2012-05-30 |
Family
ID=34962589
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101707921A Expired - Fee Related CN101429200B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
| CN2005800090295A Expired - Lifetime CN1934116B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
| CN2011100751168A Expired - Fee Related CN102190661B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800090295A Expired - Lifetime CN1934116B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
| CN2011100751168A Expired - Fee Related CN102190661B (zh) | 2004-03-23 | 2005-03-23 | 用作抗心律失常剂的三环苯并吡喃化合物 |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7652008B2 (https=) |
| EP (1) | EP1732929B1 (https=) |
| JP (1) | JP4840594B2 (https=) |
| KR (2) | KR101085979B1 (https=) |
| CN (3) | CN101429200B (https=) |
| AT (1) | ATE485299T1 (https=) |
| AU (2) | AU2005223612B2 (https=) |
| BR (1) | BRPI0508768A (https=) |
| CA (1) | CA2558139C (https=) |
| CY (1) | CY1111250T1 (https=) |
| CZ (1) | CZ2006598A3 (https=) |
| DE (1) | DE602005024245D1 (https=) |
| DK (1) | DK1732929T3 (https=) |
| EG (1) | EG27163A (https=) |
| ES (1) | ES2353021T3 (https=) |
| HR (1) | HRP20110005T1 (https=) |
| IL (1) | IL177950A (https=) |
| MX (1) | MXPA06010880A (https=) |
| NO (1) | NO339495B1 (https=) |
| NZ (2) | NZ585606A (https=) |
| PL (1) | PL1732929T3 (https=) |
| PT (1) | PT1732929E (https=) |
| RS (1) | RS51742B (https=) |
| RU (1) | RU2380370C2 (https=) |
| SI (1) | SI1732929T1 (https=) |
| SK (1) | SK287994B6 (https=) |
| TW (1) | TWI352704B (https=) |
| UA (1) | UA91189C2 (https=) |
| WO (1) | WO2005090357A1 (https=) |
| ZA (1) | ZA200607388B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101085979B1 (ko) * | 2004-03-23 | 2011-11-22 | 닛산 가가쿠 고교 가부시키 가이샤 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
| AU2007225765B2 (en) | 2006-03-10 | 2012-05-24 | Nissan Chemical Industries, Ltd. | Process for producing optically active chromene oxide compound |
| WO2010018867A1 (ja) * | 2008-08-14 | 2010-02-18 | 日産化学工業株式会社 | ジ置換ベンゾピラン化合物 |
| RU2523279C2 (ru) * | 2009-04-30 | 2014-07-20 | Ниссан Кемикал Индастриз, Лтд. | Новая кристаллическая форма соединения трициклического бензопирана и способ его производства |
| LT2445502T (lt) | 2009-06-25 | 2017-09-25 | Alkermes Pharma Ireland Limited | Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui |
| WO2014050613A1 (ja) * | 2012-09-27 | 2014-04-03 | 日産化学工業株式会社 | 含窒素複素環ｎ－オキシド化合物の製造方法 |
| CN104507949B (zh) * | 2012-09-27 | 2017-07-28 | 日产化学工业株式会社 | 高纯度的含氮杂环化合物的制造方法 |
| EP3026047A4 (en) * | 2013-07-25 | 2017-05-17 | Nissan Chemical Industries, Ltd. | Method for producing heterocyclic compound |
| EP3567044A4 (en) * | 2017-01-06 | 2020-06-10 | Korea University Research and Business Foundation, Sejong Campus | INNOVATIVE CHINOLINONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF ALLERGIC DISEASES LIKE ASTHMA OR ATOPIA THEREFORE AS AN ACTIVE SUBSTANCE |
| EP3761983A1 (en) | 2018-03-05 | 2021-01-13 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN108727261B (zh) * | 2018-06-21 | 2021-09-24 | 济南大学 | 一种硝基取代喹那啶的制备方法 |
| EP3903882B1 (en) * | 2018-12-28 | 2025-05-21 | Osaka University | Therapeutic agent for inherited bradyarrhythmia |
| RU2754610C1 (ru) | 2020-04-14 | 2021-09-03 | Георгий Викторович ТЕЦ | Препарат для лечения заболеваний, вызванных бактериями |
| CN115916201B (zh) * | 2020-06-26 | 2024-09-17 | 国立大学法人大阪大学 | 药剂诱发性心动过缓及心动过缓性心律失常治疗药 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0327127A1 (en) * | 1988-02-03 | 1989-08-09 | Nissan Chemical Industries Ltd. | Pyranobenzoxadiazole derivatives, preparation, use and compositions comprising them |
| EP0409165A2 (en) * | 1989-07-17 | 1991-01-23 | Nissan Chemical Industries Ltd. | Process for the optical resolution of pyranobenzoxadiazole compounds |
| EP0488107A2 (en) * | 1990-11-26 | 1992-06-03 | E.R. SQUIBB & SONS, INC. | Tricyclic benzodiazole analogs and their use in the treatment of cardiovascular disorders |
| WO1995034547A1 (en) * | 1994-06-10 | 1995-12-21 | Smithkline Beecham Plc | C-4 amide substituted compounds and their use as therapeutic agents |
| EP0693283A1 (en) * | 1993-04-02 | 1996-01-24 | Nissan Chemical Industries, Limited | Heart failure remedy |
| CN1169429A (zh) * | 1996-05-15 | 1998-01-07 | 赫彻斯特股份公司 | 氨磺酰－取代的苯并二氢吡喃,其制法,作为药物或诊断剂的应用及含有它的药物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZM7682A1 (en) | 1981-09-25 | 1983-05-23 | Beecham Group Plc | Active compounds |
| JPS5867683U (ja) | 1981-10-28 | 1983-05-09 | 株式会社ナムコ | 歩行ロボツト |
| JP2658198B2 (ja) * | 1988-06-23 | 1997-09-30 | 日産化学工業株式会社 | ピラノベンゾトリアゾール誘導体 |
| JP2876712B2 (ja) * | 1989-07-17 | 1999-03-31 | 日産化学工業株式会社 | 光学活性ピラノベンゾオキサジアゾール誘導体 |
| JPH07300414A (ja) * | 1993-04-02 | 1995-11-14 | Nissan Chem Ind Ltd | 心不全治療薬 |
| JP2734457B2 (ja) | 1994-02-23 | 1998-03-30 | 日産化学工業株式会社 | 不斉エポキシ化反応 |
| US6486178B1 (en) | 1998-06-03 | 2002-11-26 | Nissan Chemical Industries, Ltd. | Indane derivatives |
| AU5444499A (en) | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
| WO2000058300A1 (en) | 1999-03-25 | 2000-10-05 | Nissan Chemical Industries, Ltd. | Chroman derivatives |
| HUP0202690A3 (en) * | 1999-09-17 | 2005-02-28 | Nissan Chemical Ind Ltd | Benzopyran derivative having antiarrhytmic activity |
| US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| WO2001025224A1 (en) | 1999-10-05 | 2001-04-12 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| HUP0400362A3 (en) | 2001-06-25 | 2007-05-29 | Nissan Chemical Ind Ltd | Substituted benzopyran derivetives against arrhythmia |
| WO2003014113A1 (en) | 2001-08-06 | 2003-02-20 | Glenmark Pharmaceuticals Limited | Novel benzopyran compounds and process for their preparation and use |
| KR101085979B1 (ko) * | 2004-03-23 | 2011-11-22 | 닛산 가가쿠 고교 가부시키 가이샤 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
-
2005
- 2005-03-23 KR KR1020107027058A patent/KR101085979B1/ko not_active Expired - Fee Related
- 2005-03-23 CA CA2558139A patent/CA2558139C/en not_active Expired - Fee Related
- 2005-03-23 US US10/590,975 patent/US7652008B2/en active Active
- 2005-03-23 SI SI200531171T patent/SI1732929T1/sl unknown
- 2005-03-23 KR KR1020067021988A patent/KR101019402B1/ko not_active Expired - Lifetime
- 2005-03-23 WO PCT/JP2005/006004 patent/WO2005090357A1/en not_active Ceased
- 2005-03-23 PT PT05727581T patent/PT1732929E/pt unknown
- 2005-03-23 NZ NZ585606A patent/NZ585606A/en not_active IP Right Cessation
- 2005-03-23 PL PL05727581T patent/PL1732929T3/pl unknown
- 2005-03-23 UA UAA200611101A patent/UA91189C2/ru unknown
- 2005-03-23 ZA ZA200607388A patent/ZA200607388B/en unknown
- 2005-03-23 CN CN2008101707921A patent/CN101429200B/zh not_active Expired - Fee Related
- 2005-03-23 SK SK5079-2006A patent/SK287994B6/sk not_active IP Right Cessation
- 2005-03-23 CN CN2005800090295A patent/CN1934116B/zh not_active Expired - Lifetime
- 2005-03-23 CZ CZ20060598A patent/CZ2006598A3/cs unknown
- 2005-03-23 AT AT05727581T patent/ATE485299T1/de active
- 2005-03-23 HR HR20110005T patent/HRP20110005T1/hr unknown
- 2005-03-23 AU AU2005223612A patent/AU2005223612B2/en not_active Ceased
- 2005-03-23 JP JP2006530022A patent/JP4840594B2/ja not_active Expired - Lifetime
- 2005-03-23 TW TW094108962A patent/TWI352704B/zh not_active IP Right Cessation
- 2005-03-23 CN CN2011100751168A patent/CN102190661B/zh not_active Expired - Fee Related
- 2005-03-23 RU RU2006137284/04A patent/RU2380370C2/ru not_active IP Right Cessation
- 2005-03-23 DE DE602005024245T patent/DE602005024245D1/de not_active Expired - Lifetime
- 2005-03-23 RS RS20110028A patent/RS51742B/sr unknown
- 2005-03-23 ES ES05727581T patent/ES2353021T3/es not_active Expired - Lifetime
- 2005-03-23 DK DK05727581.0T patent/DK1732929T3/da active
- 2005-03-23 EP EP05727581A patent/EP1732929B1/en not_active Expired - Lifetime
- 2005-03-23 BR BRPI0508768-6A patent/BRPI0508768A/pt not_active Application Discontinuation
- 2005-03-23 MX MXPA06010880A patent/MXPA06010880A/es active IP Right Grant
- 2005-03-23 NZ NZ549570A patent/NZ549570A/en not_active IP Right Cessation
-
2006
- 2006-09-02 EG EGNA2006000900 patent/EG27163A/xx active
- 2006-09-07 IL IL177950A patent/IL177950A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064819A patent/NO339495B1/no not_active IP Right Cessation
-
2009
- 2009-11-17 US US12/591,353 patent/US7964623B2/en not_active Expired - Fee Related
-
2010
- 2010-07-08 AU AU2010202900A patent/AU2010202900B2/en not_active Ceased
-
2011
- 2011-01-19 CY CY20111100060T patent/CY1111250T1/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0327127A1 (en) * | 1988-02-03 | 1989-08-09 | Nissan Chemical Industries Ltd. | Pyranobenzoxadiazole derivatives, preparation, use and compositions comprising them |
| EP0409165A2 (en) * | 1989-07-17 | 1991-01-23 | Nissan Chemical Industries Ltd. | Process for the optical resolution of pyranobenzoxadiazole compounds |
| EP0488107A2 (en) * | 1990-11-26 | 1992-06-03 | E.R. SQUIBB & SONS, INC. | Tricyclic benzodiazole analogs and their use in the treatment of cardiovascular disorders |
| EP0693283A1 (en) * | 1993-04-02 | 1996-01-24 | Nissan Chemical Industries, Limited | Heart failure remedy |
| WO1995034547A1 (en) * | 1994-06-10 | 1995-12-21 | Smithkline Beecham Plc | C-4 amide substituted compounds and their use as therapeutic agents |
| CN1169429A (zh) * | 1996-05-15 | 1998-01-07 | 赫彻斯特股份公司 | 氨磺酰－取代的苯并二氢吡喃,其制法,作为药物或诊断剂的应用及含有它的药物 |
Non-Patent Citations (2)
| Title |
|---|
| JP特开平2-4791A 1990.01.09 |
| Wai N. Chan, et al..Conformational preference of the 6-acetyl group in novel anticonvulsant trans 4S-benzamido-benzo[b]pyran-3R-ols.Bioorganic & Medicinal Chemistry Letters.1997,7(12),1573-1576. * |
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