CN101410393B - 新颖的杂芳基取代的苯并噻唑 - Google Patents

新颖的杂芳基取代的苯并噻唑 Download PDF

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Publication number
CN101410393B
CN101410393B CN2007800112344A CN200780011234A CN101410393B CN 101410393 B CN101410393 B CN 101410393B CN 2007800112344 A CN2007800112344 A CN 2007800112344A CN 200780011234 A CN200780011234 A CN 200780011234A CN 101410393 B CN101410393 B CN 101410393B
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compound
benzothiazol
pyridin
alkyl
benzothiazole
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Expired - Fee Related
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Chinese (zh)
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CN101410393A (zh
Inventor
伊尔瓦·格雷文福斯
卡特林·乔纳森
乔纳斯·马尔姆斯特伦
冈纳·诺德瓦尔
戴维·派林
坎·斯利沃
丹尼尔·索恩
彼得·斯特罗姆
戴维·温斯博
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN2007800112344A 2006-01-27 2007-01-25 新颖的杂芳基取代的苯并噻唑 Expired - Fee Related CN101410393B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76265406P 2006-01-27 2006-01-27
US60/762,654 2006-01-27
PCT/SE2007/000068 WO2007086800A1 (en) 2006-01-27 2007-01-25 Novel heteroaryl substituted benzothiazoles

Publications (2)

Publication Number Publication Date
CN101410393A CN101410393A (zh) 2009-04-15
CN101410393B true CN101410393B (zh) 2012-01-25

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CN2007800112344A Expired - Fee Related CN101410393B (zh) 2006-01-27 2007-01-25 新颖的杂芳基取代的苯并噻唑

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US (2) US8163928B2 (https=)
EP (1) EP1981883A4 (https=)
JP (1) JP5289061B2 (https=)
KR (1) KR101406248B1 (https=)
CN (1) CN101410393B (https=)
AR (1) AR059178A1 (https=)
AU (1) AU2007207904C1 (https=)
BR (1) BRPI0707283A2 (https=)
CA (1) CA2640213A1 (https=)
EC (1) ECSP088645A (https=)
IL (1) IL192876A0 (https=)
NO (1) NO20083394L (https=)
NZ (1) NZ569667A (https=)
RU (1) RU2448106C2 (https=)
SA (1) SA07280009B1 (https=)
TW (2) TW201018678A (https=)
UA (1) UA95267C2 (https=)
UY (1) UY30112A1 (https=)
WO (1) WO2007086800A1 (https=)
ZA (1) ZA200806075B (https=)

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EP2699157B1 (en) * 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
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TW201946624A (zh) 2018-05-09 2019-12-16 新旭生技股份有限公司 雜芳基化合物及其用途
US11844846B2 (en) 2018-05-16 2023-12-19 Emory University Styrylbenzothiazole derivatives and uses in imaging methods
SMT202500291T1 (it) * 2019-01-31 2025-09-12 Spinogenix Inc Forme solide di un promotore di spinogenesi
GB201914989D0 (en) * 2019-10-16 2019-11-27 Karin & Sten Mortstedt Cbd Solutions Ab Selective ligands for TAU Aggregates
CN114728071B (zh) 2019-11-13 2024-12-06 新旭生技股份有限公司 用于降解tau蛋白聚集体的化合物及其用途
KR102682408B1 (ko) * 2021-05-12 2024-07-05 에이치케이이노엔 주식회사 신규한 벤조티아졸 유도체, 이의 제조방법 및 이의 간질환 예방 또는 치료 용도
CN114478431B (zh) * 2022-03-09 2024-07-02 台州学院 一种双取代苯并噻吩类钾离子通道激动剂的制备方法
CN114380731B (zh) * 2022-03-09 2024-07-02 台州学院 一种kcnq钾离子通道激动剂、药物组合物及其应用
JP2025540931A (ja) 2022-11-03 2025-12-17 セントニックス インコーポレイテッド タウ凝集体に対する選択的リガンド
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US20120207679A1 (en) 2012-08-16
US8163928B2 (en) 2012-04-24
NZ569667A (en) 2011-09-30
NO20083394L (no) 2008-10-02
AR059178A1 (es) 2008-03-12
ZA200806075B (en) 2012-12-27
TW200736252A (en) 2007-10-01
BRPI0707283A2 (pt) 2011-04-26
US8957215B2 (en) 2015-02-17
WO2007086800A1 (en) 2007-08-02
IL192876A0 (en) 2009-02-11
UA95267C2 (en) 2011-07-25
JP5289061B2 (ja) 2013-09-11
AU2007207904B2 (en) 2011-03-10
JP2009528271A (ja) 2009-08-06
CA2640213A1 (en) 2007-08-02
RU2448106C2 (ru) 2012-04-20
EP1981883A1 (en) 2008-10-22
TW201018678A (en) 2010-05-16
ECSP088645A (es) 2008-08-29
CN101410393A (zh) 2009-04-15
KR20080090542A (ko) 2008-10-08
EP1981883A4 (en) 2010-10-06
RU2008130965A (ru) 2010-03-10
AU2007207904A1 (en) 2007-08-02
AU2007207904C1 (en) 2011-10-13
US20090028787A1 (en) 2009-01-29
UY30112A1 (es) 2007-08-31
KR101406248B1 (ko) 2014-06-19
SA07280009B1 (ar) 2011-07-20

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