CN101247832B - 含有血管紧张素ⅱ受体拮抗剂和钙通道阻断剂的药物制剂 - Google Patents

含有血管紧张素ⅱ受体拮抗剂和钙通道阻断剂的药物制剂 Download PDF

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Publication number
CN101247832B
CN101247832B CN2006800309235A CN200680030923A CN101247832B CN 101247832 B CN101247832 B CN 101247832B CN 2006800309235 A CN2006800309235 A CN 2006800309235A CN 200680030923 A CN200680030923 A CN 200680030923A CN 101247832 B CN101247832 B CN 101247832B
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pharmaceutical formulation
angiotensin
formulation according
calcium channel
receptor antagonist
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CN101247832A (zh
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滨浦健司
菅野充
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Sankyo Co Ltd
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Sankyo Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2006800309235A 2005-06-27 2006-06-26 含有血管紧张素ⅱ受体拮抗剂和钙通道阻断剂的药物制剂 Ceased CN101247832B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP187251/2005 2005-06-27
JP2005187251 2005-06-27
PCT/JP2006/313175 WO2007001066A1 (en) 2005-06-27 2006-06-26 Pharmaceutical preparation containing an angiotensin ii receptor antagonist and a calcium channel blocker

Publications (2)

Publication Number Publication Date
CN101247832A CN101247832A (zh) 2008-08-20
CN101247832B true CN101247832B (zh) 2011-12-28

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ID=36975525

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CN2006800309235A Ceased CN101247832B (zh) 2005-06-27 2006-06-26 含有血管紧张素ⅱ受体拮抗剂和钙通道阻断剂的药物制剂

Country Status (10)

Country Link
US (3) US20080279942A1 (enExample)
EP (1) EP1898951B1 (enExample)
JP (1) JP5148296B2 (enExample)
KR (2) KR20130135994A (enExample)
CN (1) CN101247832B (enExample)
BR (1) BRPI0612674B8 (enExample)
CA (1) CA2613417C (enExample)
ES (1) ES2404939T3 (enExample)
TW (1) TWI405580B (enExample)
WO (1) WO2007001066A1 (enExample)

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TWI399223B (zh) * 2006-09-15 2013-06-21 Daiichi Sankyo Co Ltd 奧美沙坦酯及氨氯地平之固體劑型
TWI488658B (zh) * 2006-12-26 2015-06-21 Daiichi Sankyo Co Ltd 溶出性之改善方法
TWI402083B (zh) * 2006-12-26 2013-07-21 Daiichi Sankyo Co Ltd 固形製劑及其安定化方法
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CN101416966B (zh) * 2007-10-22 2010-11-10 鲁南制药集团股份有限公司 一种治疗高血压的药物组合物
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WO2009113420A1 (ja) * 2008-03-13 2009-09-17 第一三共株式会社 オルメサルタンメドキソミルを含む製剤の溶出性の改善
WO2009125987A2 (ko) * 2008-04-10 2009-10-15 한올제약주식회사 약제학적 제제
US20110123612A1 (en) * 2008-04-10 2011-05-26 Sung Wuk Kim Pharmaceutical preparation containing non-dihydropyridine calcium channel blocker and angiotensin-2 receptor blocker
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WO2009151295A2 (ko) * 2008-06-13 2009-12-17 한올제약주식회사 아젤니디핀과 ＨＭＧ－ＣｏＡ 환원효소 억제제 또는 안지오텐신 Ⅱ 수용체 차단제를 포함하는 약제학적 제제
JP5296456B2 (ja) * 2008-08-26 2013-09-25 大日本住友製薬株式会社 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠
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KR101148884B1 (ko) * 2010-02-01 2012-05-29 동성제약주식회사 용출율이 향상된 올메사탄 메독소밀 함유 고혈압 예방 또는 치료용 조성물
JP5421945B2 (ja) * 2010-03-10 2014-02-19 大日本住友製薬株式会社 イルベサルタンとアムロジピンまたはその塩を含有する医薬組成物
CN101862328B (zh) * 2010-06-21 2012-01-11 天津市汉康医药生物技术有限公司 缬沙坦氨氯地平胶囊药物组合物及其制备方法
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CN105645367B (zh) * 2015-12-26 2018-01-26 华润赛科药业有限责任公司 作为含苯磺酸氨氯地平的药物制剂辅料的磷酸氢钙的处理方式
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KR102274147B1 (ko) * 2016-08-11 2021-07-08 주식회사 인트로바이오파마 텔미사르탄을 포함하는 단층정 복합 제제
JP2017141299A (ja) * 2017-05-24 2017-08-17 大日本住友製薬株式会社 溶出が良好なイルベサルタン含有医薬組成物および口腔内崩壊錠
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US20110281823A1 (en) 2011-11-17
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BRPI0612674B8 (pt) 2021-05-25
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