CN101223186B - 通过无金属氧化17-(3-羟基丙基)-3,17-二羟基雄甾烷制备3-氧代-孕甾-4-烯-21,17-内酯的方法 - Google Patents

通过无金属氧化17-(3-羟基丙基)-3,17-二羟基雄甾烷制备3-氧代-孕甾-4-烯-21,17-内酯的方法 Download PDF

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CN101223186B
CN101223186B CN2006800263528A CN200680026352A CN101223186B CN 101223186 B CN101223186 B CN 101223186B CN 2006800263528 A CN2006800263528 A CN 2006800263528A CN 200680026352 A CN200680026352 A CN 200680026352A CN 101223186 B CN101223186 B CN 101223186B
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hydrogen
group
formula
oxyl
compound
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CN101223186A (zh
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C·塞尔兹
H·塞巴
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Bayer Pharma AG
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Bayer Pharma AG
Bayer Schering Pharma AG
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Priority claimed from US11/185,984 external-priority patent/US7319154B2/en
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Priority claimed from PCT/EP2006/007287 external-priority patent/WO2007009821A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
    • C07J53/002—Carbocyclic rings fused
    • C07J53/004—3 membered carbocyclic rings
    • C07J53/008—3 membered carbocyclic rings in position 15/16

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN2006800263528A 2005-07-21 2006-07-20 通过无金属氧化17-(3-羟基丙基)-3,17-二羟基雄甾烷制备3-氧代-孕甾-4-烯-21,17-内酯的方法 Active CN101223186B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05090214.7 2005-07-21
US11/185,984 US7319154B2 (en) 2005-07-21 2005-07-21 Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
EP05090214.7A EP1746101B2 (de) 2005-07-21 2005-07-21 Verfahren zur Herstellung von 3-Oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie Oxidation von 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanen
US11/185,984 2005-07-21
PCT/EP2006/007287 WO2007009821A1 (en) 2005-07-21 2006-07-20 Process for the production of 3-oxo-pregn-4-ene-21,17-carbolactones by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes

Publications (2)

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CN101223186A CN101223186A (zh) 2008-07-16
CN101223186B true CN101223186B (zh) 2012-09-05

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CN2006800263528A Active CN101223186B (zh) 2005-07-21 2006-07-20 通过无金属氧化17-(3-羟基丙基)-3,17-二羟基雄甾烷制备3-氧代-孕甾-4-烯-21,17-内酯的方法

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US (2) US20070049747A1 (https=)
EP (1) EP1746101B2 (https=)
JP (2) JP5345843B2 (https=)
CN (1) CN101223186B (https=)
AR (1) AR055993A1 (https=)
AT (1) ATE403668T1 (https=)
CY (1) CY1110411T1 (https=)
DE (1) DE502005004948D1 (https=)
DK (1) DK1746101T4 (https=)
DO (1) DOP2006000172A (https=)
ES (1) ES2311927T5 (https=)
GT (1) GT200600321A (https=)
MY (1) MY147795A (https=)
PE (2) PE20131303A1 (https=)
PL (1) PL1746101T5 (https=)
PT (1) PT1746101E (https=)
SI (1) SI1746101T2 (https=)
SV (1) SV2007002621A (https=)
TW (1) TWI392683B (https=)
UA (1) UA100092C2 (https=)
UY (1) UY29686A1 (https=)
ZA (1) ZA200801674B (https=)

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WO2009111574A2 (en) * 2008-03-05 2009-09-11 Evestra, Inc. BISMETHYLENE-17α CARBOLACTONES AND RELATED USES
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US8222237B2 (en) * 2008-11-25 2012-07-17 Evestra, Inc. Progestational 3-(6,6-ethylene-17B-hydroxy-3-oxo-17A-pregna-4-ene-17A-yl)propionic acid G-lactones
US8334375B2 (en) * 2009-04-10 2012-12-18 Evestra, Inc. Methods for the preparation of drospirenone
EP2266998B1 (en) 2009-06-16 2013-07-24 Crystal Pharma, S.A.U. Process for obtaining 17-spirolactones in steroids
CN101775057B (zh) * 2010-02-09 2014-07-16 浙江仙琚制药股份有限公司 屈螺酮及其中间体的制备方法
CN101830959B (zh) * 2010-05-27 2012-07-18 杭州龙山化工有限公司 一种曲螺酮的合成方法
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012107513A1 (en) 2011-02-10 2012-08-16 Crystal Pharma, S.A.U. Process for obtaining drospirenone
CN102746370A (zh) * 2011-04-22 2012-10-24 天津金耀集团有限公司 一种氧化合成孕甾11位酮基的新工艺
KR101672109B1 (ko) * 2012-01-13 2016-11-02 쌩-고벵 글래스 프랑스 단열 창유리 유닛용 스페이서
CN102887934B (zh) * 2012-09-20 2015-05-27 杭州福斯特药业有限公司 一种屈螺酮的制备方法
JP6469078B2 (ja) * 2013-04-12 2019-02-13 インドゥスティアーレ キーミカ エッセ．エッレ．エッレ． ドロスピレノン調製のためのプロセス
CN104163846A (zh) * 2013-05-17 2014-11-26 上海创诺制药有限公司 一种制备曲螺酮的方法
WO2015086457A2 (de) 2013-12-12 2015-06-18 Saint-Gobain Glass France Isolierverglasung mit verbesserter abdichtung
EP3080376A1 (de) 2013-12-12 2016-10-19 Saint-Gobain Glass France Abstandshalter für isolierverglasungen mit extrudiertem dichtprofil
CN104788524B (zh) * 2014-01-16 2016-07-06 浙江仙居君业药业有限公司 一种19-去甲-4-雄甾烯-3,17-二酮的制备方法
US10301868B2 (en) 2014-06-27 2019-05-28 Saint-Gobain Glass France Insulated glazing comprising a spacer, and production method
US10344525B2 (en) 2014-06-27 2019-07-09 Saint-Gobain Glass France Insulated glazing with spacer, related methods and uses
MX374373B (es) 2014-09-25 2025-03-06 Saint Gobain Separador para unidades de acristalamiento aislantes.
DK3265636T3 (da) 2015-03-02 2022-05-23 Saint Gobain Glasfiberforstærket afstandsholder til isoleringsrude, fremgangsmåde til fremstilling af denne og anvendelse af en sådan afstandsholder i flerlagsruder
CA2989975C (en) 2015-06-23 2021-10-12 Laboratorios Leon Farma Sa Drospirenone-based contraceptive for a female patient affected with excess weight
EP3108889A1 (en) 2015-06-23 2016-12-28 Philippe Perrin Drospirenone-based contraceptive for a female patient affected with excess weight

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CN1223662A (zh) * 1996-08-12 1999-07-21 舍林股份公司 制备Drospirenon(6β,7β;15β,16β－二亚甲基－3－氧代－17α孕甾－4－烯－21,17－羰内酯,DRSP)的方法以及该方法的中间产物7α－(3－羟基－1－丙基)－6β,7β;15β,16β－二亚甲基－5β－雄甾烷－3β,5,17β－三醇(ZK92836)和6β,7β,15β,16β－二亚甲基－5β－羟基－3－氧代－17α－雄甾烷－21,17羰内酯

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DE3026783C2 (de) 1980-07-11 1982-07-29 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden
DE3042136A1 (de) 1980-11-03 1982-06-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur herstellung von 3 (beta), 7 (beta) -dihydroxy- (delta) (pfeil hoch)5(pfeil hoch) -steroiden
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ITMI20040367A1 (it) 2004-03-01 2004-06-01 Ind Chimica Srl Processo per la preparazione di drospirenone
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US7319154B2 (en) * 2005-07-21 2008-01-15 Bayer Schering Pharma Ag Process for the production of 3-oxo-pregn-4-ene-21, 17-carbolactones by the metal free oxidation of 17-(3-hydroxypropyl)-3, 17-dihydroxyandrostanes
PT1746101E (pt) * 2005-07-21 2008-10-27 Bayer Schering Pharma Ag Processo para o fabrico de 3-oxo-pregn-4-eno-21,17-carbolactonas por meio de oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-di-hidroxiandrostanos
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CN1223662A (zh) * 1996-08-12 1999-07-21 舍林股份公司 制备Drospirenon(6β,7β;15β,16β－二亚甲基－3－氧代－17α孕甾－4－烯－21,17－羰内酯,DRSP)的方法以及该方法的中间产物7α－(3－羟基－1－丙基)－6β,7β;15β,16β－二亚甲基－5β－雄甾烷－3β,5,17β－三醇(ZK92836)和6β,7β,15β,16β－二亚甲基－5β－羟基－3－氧代－17α－雄甾烷－21,17羰内酯

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JP2013177450A (ja) 2013-09-09
MY147795A (en) 2013-01-31
EP1746101B1 (de) 2008-08-06
SI1746101T2 (sl) 2014-09-30
UY29686A1 (es) 2007-02-28
CY1110411T1 (el) 2015-04-29
PE20131303A1 (es) 2013-11-27
TW200716660A (en) 2007-05-01
PL1746101T3 (pl) 2009-01-30
JP5345843B2 (ja) 2013-11-20
PE20070215A1 (es) 2007-04-11
DK1746101T3 (da) 2008-11-24
EP1746101A1 (de) 2007-01-24
JP2009501753A (ja) 2009-01-22
ES2311927T5 (es) 2014-09-08
EP1746101B2 (de) 2014-05-14
SI1746101T1 (sl) 2009-02-28
US8658788B2 (en) 2014-02-25
PT1746101E (pt) 2008-10-27
ZA200801674B (en) 2009-08-26
ATE403668T1 (de) 2008-08-15
CN101223186A (zh) 2008-07-16
TWI392683B (zh) 2013-04-11
SV2007002621A (es) 2007-12-12
DOP2006000172A (es) 2007-02-15
PL1746101T5 (pl) 2014-11-28
ES2311927T3 (es) 2009-02-16
DE502005004948D1 (de) 2008-09-18
UA100092C2 (en) 2012-11-12
AR055993A1 (es) 2007-09-12
DK1746101T4 (da) 2014-08-11
US20110275796A1 (en) 2011-11-10
GT200600321A (es) 2007-02-23
US20070049747A1 (en) 2007-03-01

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