CN101115743B - 用于制备2h-色烯的新方法 - Google Patents

用于制备2h-色烯的新方法 Download PDF

Info

Publication number
CN101115743B
CN101115743B CN2006800039626A CN200680003962A CN101115743B CN 101115743 B CN101115743 B CN 101115743B CN 2006800039626 A CN2006800039626 A CN 2006800039626A CN 200680003962 A CN200680003962 A CN 200680003962A CN 101115743 B CN101115743 B CN 101115743B
Authority
CN
China
Prior art keywords
formula
compound
compounds
added
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2006800039626A
Other languages
English (en)
Chinese (zh)
Other versions
CN101115743A (zh
Inventor
彼得·施内德
彻奥拜·塔赫塔奥伊
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arpida AG
Original Assignee
Arpida AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arpida AG filed Critical Arpida AG
Publication of CN101115743A publication Critical patent/CN101115743A/zh
Application granted granted Critical
Publication of CN101115743B publication Critical patent/CN101115743B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2006800039626A 2005-02-18 2006-02-10 用于制备2h-色烯的新方法 Expired - Fee Related CN101115743B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP001695 2005-02-18
EP2005001695 2005-02-18
PCT/EP2006/001185 WO2006087143A1 (en) 2005-02-18 2006-02-10 Novel processes for the preparation of a 2h-chromene

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN2011100324952A Division CN102079727A (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法
CN2011100324933A Division CN102140094B (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法

Publications (2)

Publication Number Publication Date
CN101115743A CN101115743A (zh) 2008-01-30
CN101115743B true CN101115743B (zh) 2011-04-13

Family

ID=36283919

Family Applications (4)

Application Number Title Priority Date Filing Date
CN2006800039626A Expired - Fee Related CN101115743B (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的新方法
CN2011100324933A Expired - Fee Related CN102140094B (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法
CNA2006800039630A Pending CN101115746A (zh) 2005-02-18 2006-02-10 用于制备苯并呋喃的新方法
CN2011100324952A Pending CN102079727A (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2011100324933A Expired - Fee Related CN102140094B (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法
CNA2006800039630A Pending CN101115746A (zh) 2005-02-18 2006-02-10 用于制备苯并呋喃的新方法
CN2011100324952A Pending CN102079727A (zh) 2005-02-18 2006-02-10 用于制备2h-色烯的方法

Country Status (22)

Country Link
US (2) US20080161561A1 (enExample)
EP (3) EP2270003A1 (enExample)
JP (2) JP2009505943A (enExample)
KR (2) KR20070106635A (enExample)
CN (4) CN101115743B (enExample)
AU (2) AU2006215788B2 (enExample)
BG (2) BG109937A (enExample)
BR (2) BRPI0607758A2 (enExample)
CA (2) CA2596668A1 (enExample)
CZ (2) CZ2007537A3 (enExample)
EE (2) EE200700050A (enExample)
HU (2) HUP0700604A3 (enExample)
IL (2) IL184404A0 (enExample)
MX (2) MX2007009282A (enExample)
NO (2) NO20073678L (enExample)
NZ (1) NZ556800A (enExample)
RO (2) RO122853B1 (enExample)
RU (2) RU2007134583A (enExample)
TR (1) TR200705187T1 (enExample)
TW (2) TW200640912A (enExample)
WO (2) WO2006087140A1 (enExample)
ZA (2) ZA200706421B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0607758A2 (pt) * 2005-02-18 2010-03-23 Arpida Ag processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto
JP2011516509A (ja) * 2008-04-08 2011-05-26 アシノ ファーマ アーゲー 水性医薬製剤
US7947293B2 (en) 2008-04-08 2011-05-24 Arpida Ag Aqueous pharmaceutical formulation
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
CN110606831A (zh) * 2018-06-14 2019-12-24 上海度德医药科技有限公司 一种Iclaprim的新中间体及其制备方法和应用
CN110818693B (zh) * 2018-08-07 2023-06-02 上海度德医药科技有限公司 一种艾拉普林甲磺酸盐晶型b及其制备方法
CN109988156B (zh) * 2019-03-12 2021-12-28 广东中科药物研究有限公司 一种氨基嘧啶化合物
CN110372746A (zh) * 2019-07-11 2019-10-25 辽宁石油化工大学 一种合成β-胺基膦氧化合物的方法
CN110746361B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110790753B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110642792B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体的制备方法
CN110713483B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
CN110724108B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN113493461A (zh) * 2020-04-01 2021-10-12 上海医药工业研究院 一种七元杂环化合物或其盐、其制备方法及应用
CN117700410B (zh) * 2023-05-20 2025-07-04 山东康诺生物工程有限公司 一种3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2-a]嘧啶-4-酮的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051879A2 (en) * 1980-11-11 1982-05-19 The Wellcome Foundation Limited Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them
WO1997020839A1 (en) * 1995-12-04 1997-06-12 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
WO2005014587A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709634A1 (de) * 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
WO2003000657A1 (en) * 2001-06-20 2003-01-03 Daiichi Pharmaceutical Co., Ltd. Diamine derivatives
HUP0600114A2 (en) * 2003-07-11 2007-09-28 Arpida Ag Benzofuran derivatives and their use in the treatment of microbal infections
BRPI0607758A2 (pt) * 2005-02-18 2010-03-23 Arpida Ag processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0051879A2 (en) * 1980-11-11 1982-05-19 The Wellcome Foundation Limited Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them
WO1997020839A1 (en) * 1995-12-04 1997-06-12 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
CN1203600A (zh) * 1995-12-04 1998-12-30 弗·哈夫曼-拉罗切有限公司 二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途
EP1149834A1 (en) * 1995-12-04 2001-10-31 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
WO2005014587A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes

Also Published As

Publication number Publication date
US20080161561A1 (en) 2008-07-03
JP2009505943A (ja) 2009-02-12
TW200640914A (en) 2006-12-01
CN101115746A (zh) 2008-01-30
CN102079727A (zh) 2011-06-01
RO122853B1 (ro) 2010-03-30
NZ556800A (en) 2011-01-28
WO2006087143A1 (en) 2006-08-24
RU2397980C2 (ru) 2010-08-27
RU2007134583A (ru) 2009-03-27
NO20073678L (no) 2007-09-03
RU2007134584A (ru) 2009-03-27
AU2006215785A1 (en) 2006-08-24
ZA200706421B (en) 2008-11-26
RO122912B8 (ro) 2010-09-30
IL184404A0 (en) 2007-10-31
WO2006087140A1 (en) 2006-08-24
HUP0700605A3 (en) 2008-02-28
NO20073701L (no) 2007-09-03
WO2006087143A8 (en) 2008-11-27
BG109938A (bg) 2008-05-30
EE200700051A (et) 2007-12-17
CA2596669A1 (en) 2006-08-24
RO122912B1 (ro) 2010-04-30
US20080221324A1 (en) 2008-09-11
ZA200706422B (en) 2008-09-25
CN102140094A (zh) 2011-08-03
MX2007009283A (es) 2008-02-19
KR20070106635A (ko) 2007-11-02
CZ2007537A3 (cs) 2008-02-20
BRPI0607758A2 (pt) 2010-03-23
CN101115743A (zh) 2008-01-30
JP2008530156A (ja) 2008-08-07
CN102140094B (zh) 2012-06-06
HUP0700604A3 (en) 2008-02-28
IL184405A0 (en) 2007-10-31
CZ2007536A3 (cs) 2008-02-20
BG109937A (bg) 2008-05-30
TW200640912A (en) 2006-12-01
AU2006215788A1 (en) 2006-08-24
EE200700050A (et) 2007-12-17
EP1856106A1 (en) 2007-11-21
BRPI0607797A2 (pt) 2010-10-19
AU2006215788B2 (en) 2011-10-20
KR20070106636A (ko) 2007-11-02
MX2007009282A (es) 2008-02-19
HUP0700604A2 (en) 2008-01-28
HUP0700605A2 (en) 2008-01-28
TR200705187T1 (tr) 2007-11-21
EP1856109A1 (en) 2007-11-21
CA2596668A1 (en) 2006-08-24
EP2270003A1 (en) 2011-01-05

Similar Documents

Publication Publication Date Title
CN113372358B (zh) 噻吩并嘧啶衍生物的制备方法
CN100540526C (zh) 合成gaba类似物的酰氧基烃基衍生物的方法
CN101115743A (zh) 用于制备2h-色烯的新方法
JP6792069B2 (ja) ５ｒ−ベンジルオキシアミノピペリジン−２ｓ−ギ酸又はその誘導体の調製方法
WO2020108522A1 (zh) 一种氘代大环化合物的制备方法
CN101563312A (zh) 阿塞那平合成中间体的制备方法
JPH07304770A (ja) 新規ベンゾアゼピノン誘導体
KR20010099629A (ko) Ｔａｎ-1057 유도체
CN110845482A (zh) 制备吲哚化合物的方法
CN101376667A (zh) 一种合成齐多夫定的中间体及其制备方法和该中间体在合成齐多夫定中的应用
HK1111997A (en) Novel processes for the preparation of a 2h-chromene
KR100755625B1 (ko) 신경이완 활성을 갖는 5-(2-(4-(1,2벤즈이소티아졸-3-일)-1-피페라지닐)에틸)-6-클로로-1,3-디히드로-2ｈ-인돌-2-온의 아실 유도체
CN117362316A (zh) 一种四氢吡咯并噻唑类化合物的合成方法
CN102753534B (zh) 制备用于合成罗素伐他汀或其可药用盐的关键中间体的方法
CN111362852B (zh) 一种药物中间体1-叔丁氧羰基-3-氮杂环丁酮的制备方法
CA3214107A1 (en) New process for the synthesis of 5-{5-chloro-2-[(3s)-3- [(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
HK1111996A (en) Novell processes for the preparation of a benzofuran

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1111997

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110413

Termination date: 20130210

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1111997

Country of ref document: HK