RO122912B8 - Procedeu de preparare a unui derivat de 2h-cromen - Google Patents

Procedeu de preparare a unui derivat de 2h-cromen

Info

Publication number
RO122912B8
RO122912B8 ROA200700589A RO200700589A RO122912B8 RO 122912 B8 RO122912 B8 RO 122912B8 RO A200700589 A ROA200700589 A RO A200700589A RO 200700589 A RO200700589 A RO 200700589A RO 122912 B8 RO122912 B8 RO 122912B8
Authority
RO
Romania
Prior art keywords
formula
preparing
compound
chromene derivative
chromene
Prior art date
Application number
ROA200700589A
Other languages
English (en)
Other versions
RO122912B1 (ro
Inventor
Peter Schneider
Chouaib Tahtaoui
Original Assignee
Arpida Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arpida Ag filed Critical Arpida Ag
Publication of RO122912B1 publication Critical patent/RO122912B1/ro
Publication of RO122912B8 publication Critical patent/RO122912B8/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la un procedeu de preparare a unui derivat de 2H-cromen cu formula I: cu acţiune de inhibare a dihidrofolat reductazei, putând fi utilizat pentru controlul sau prevenirea bolilor infecţioase la mamifere, şi la intermediarii din acest procedeu. Procedeul conform invenţiei constă în reacţia unui compus cu formula 6: în care R reprezintă -C(CH)sau -CH(CH), după protejarea prealabilă a grupei fenol, cu o cetonă cu formula 8: urmată de reducerea compusului obţinut şi, în continuare, de ciclizare, cu obţinerea compusului cu formula 11: din care, după deprotejare, se obţine compusul dorit, cu formula I.
ROA200700589A 2005-02-18 2006-02-10 Procedeu de preparare a unui derivat de 2h-cromen RO122912B8 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2005001695 2005-02-18
PCT/EP2006/001185 WO2006087143A1 (en) 2005-02-18 2006-02-10 Novel processes for the preparation of a 2h-chromene

Publications (2)

Publication Number Publication Date
RO122912B1 RO122912B1 (ro) 2010-04-30
RO122912B8 true RO122912B8 (ro) 2010-09-30

Family

ID=36283919

Family Applications (2)

Application Number Title Priority Date Filing Date
ROA200700590A RO122853B1 (ro) 2005-02-18 2006-02-10 Procedeu de preparare a unui derivat de benzofuran
ROA200700589A RO122912B8 (ro) 2005-02-18 2006-02-10 Procedeu de preparare a unui derivat de 2h-cromen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ROA200700590A RO122853B1 (ro) 2005-02-18 2006-02-10 Procedeu de preparare a unui derivat de benzofuran

Country Status (22)

Country Link
US (2) US20080161561A1 (ro)
EP (3) EP1856106A1 (ro)
JP (2) JP2008530156A (ro)
KR (2) KR20070106636A (ro)
CN (4) CN101115746A (ro)
AU (2) AU2006215788B2 (ro)
BG (2) BG109938A (ro)
BR (2) BRPI0607797A2 (ro)
CA (2) CA2596668A1 (ro)
CZ (2) CZ2007537A3 (ro)
EE (2) EE200700051A (ro)
HU (2) HUP0700604A3 (ro)
IL (2) IL184405A0 (ro)
MX (2) MX2007009282A (ro)
NO (2) NO20073678L (ro)
NZ (1) NZ556800A (ro)
RO (2) RO122853B1 (ro)
RU (2) RU2397980C2 (ro)
TR (1) TR200705187T1 (ro)
TW (2) TW200640912A (ro)
WO (2) WO2006087140A1 (ro)
ZA (2) ZA200706422B (ro)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2006215788B2 (en) * 2005-02-18 2011-10-20 Acino Pharma Ag Novel processes for the preparation of a 2H-chromene
ATE542522T1 (de) * 2008-04-08 2012-02-15 Acino Pharma Ag Wässrige pharmazeutische formulierung
US7947293B2 (en) 2008-04-08 2011-05-24 Arpida Ag Aqueous pharmaceutical formulation
FR2949465B1 (fr) * 2009-09-01 2011-08-12 Pf Medicament Derives chromones, leur procede de preparation et leurs applications therapeutiques
CN110606831A (zh) * 2018-06-14 2019-12-24 上海度德医药科技有限公司 一种Iclaprim的新中间体及其制备方法和应用
CN110818693B (zh) * 2018-08-07 2023-06-02 上海度德医药科技有限公司 一种艾拉普林甲磺酸盐晶型b及其制备方法
CN109988156B (zh) * 2019-03-12 2021-12-28 广东中科药物研究有限公司 一种氨基嘧啶化合物
CN110372746A (zh) * 2019-07-11 2019-10-25 辽宁石油化工大学 一种合成β-胺基膦氧化合物的方法
CN110724108B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
CN110790753B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林对甲苯磺酸盐、其制备方法和应用
CN110724135B (zh) * 2019-11-18 2023-04-28 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN110642792B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体的制备方法
CN110713483B (zh) * 2019-11-18 2023-04-07 上海医药工业研究院 艾拉普林中间体及艾拉普林的制备方法
CN110746361B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 一种艾拉普林中间体及其制备方法
CN113493461A (zh) * 2020-04-01 2021-10-12 上海医药工业研究院 一种七元杂环化合物或其盐、其制备方法及应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2709634A1 (de) * 1977-03-05 1978-09-07 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
WO1997020839A1 (en) * 1995-12-04 1997-06-12 F. Hoffmann-La Roche Ag Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
US7365205B2 (en) * 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
CA2531757A1 (en) * 2003-07-11 2005-01-20 Arpida Ag Benzofuran derivatives and their use in the treatment of microbial infections
WO2005014586A1 (en) * 2003-08-08 2005-02-17 Arpida Ag Novel process for the preparation of 2h-chromenes
AU2006215788B2 (en) * 2005-02-18 2011-10-20 Acino Pharma Ag Novel processes for the preparation of a 2H-chromene

Also Published As

Publication number Publication date
NO20073678L (no) 2007-09-03
IL184405A0 (en) 2007-10-31
CN102140094B (zh) 2012-06-06
RU2397980C2 (ru) 2010-08-27
WO2006087143A8 (en) 2008-11-27
TW200640914A (en) 2006-12-01
HUP0700605A2 (en) 2008-01-28
EP1856109A1 (en) 2007-11-21
EP1856106A1 (en) 2007-11-21
US20080221324A1 (en) 2008-09-11
AU2006215788B2 (en) 2011-10-20
HUP0700604A3 (en) 2008-02-28
ZA200706422B (en) 2008-09-25
EE200700051A (et) 2007-12-17
MX2007009282A (es) 2008-02-19
BRPI0607758A2 (pt) 2010-03-23
KR20070106635A (ko) 2007-11-02
CN101115743B (zh) 2011-04-13
BRPI0607797A2 (pt) 2010-10-19
CN102079727A (zh) 2011-06-01
MX2007009283A (es) 2008-02-19
RU2007134583A (ru) 2009-03-27
BG109937A (bg) 2008-05-30
CA2596669A1 (en) 2006-08-24
JP2008530156A (ja) 2008-08-07
WO2006087143A1 (en) 2006-08-24
KR20070106636A (ko) 2007-11-02
EP2270003A1 (en) 2011-01-05
HUP0700605A3 (en) 2008-02-28
EE200700050A (et) 2007-12-17
CN101115746A (zh) 2008-01-30
JP2009505943A (ja) 2009-02-12
NZ556800A (en) 2011-01-28
US20080161561A1 (en) 2008-07-03
AU2006215785A1 (en) 2006-08-24
NO20073701L (no) 2007-09-03
RU2007134584A (ru) 2009-03-27
ZA200706421B (en) 2008-11-26
BG109938A (bg) 2008-05-30
CZ2007536A3 (cs) 2008-02-20
TW200640912A (en) 2006-12-01
AU2006215788A1 (en) 2006-08-24
RO122853B1 (ro) 2010-03-30
IL184404A0 (en) 2007-10-31
TR200705187T1 (tr) 2007-11-21
CA2596668A1 (en) 2006-08-24
WO2006087140A1 (en) 2006-08-24
CN102140094A (zh) 2011-08-03
CZ2007537A3 (cs) 2008-02-20
HUP0700604A2 (en) 2008-01-28
CN101115743A (zh) 2008-01-30
RO122912B1 (ro) 2010-04-30

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