CN1203600A - 二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 - Google Patents
二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 Download PDFInfo
- Publication number
- CN1203600A CN1203600A CN96198783A CN96198783A CN1203600A CN 1203600 A CN1203600 A CN 1203600A CN 96198783 A CN96198783 A CN 96198783A CN 96198783 A CN96198783 A CN 96198783A CN 1203600 A CN1203600 A CN 1203600A
- Authority
- CN
- China
- Prior art keywords
- compound
- dimethoxy
- alkyl
- chromene
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
化合物实施例序号 | 金黄色葡萄球菌ATCC 25923 | 金黄色葡萄球菌157/4696 | 卡氏肺囊虫 |
6 | 0.005 | 0.770 | 0.220 |
7 | 0.016 | 0.850 | 2.800 |
8 | 0.001 | 1.000 | 1.000 |
9 | 0.001 | 0.900 | 3.000 |
10 | 0.005 | 0.520 | 0.040 |
TMP | 0.007 | 2.250 | 5.500 |
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH3425/95 | 1995-12-04 | ||
CH342595 | 1995-12-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1203600A true CN1203600A (zh) | 1998-12-30 |
CN1092194C CN1092194C (zh) | 2002-10-09 |
Family
ID=4255709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96198783A Expired - Fee Related CN1092194C (zh) | 1995-12-04 | 1996-11-22 | 二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5773446A (zh) |
EP (2) | EP1149834A1 (zh) |
JP (1) | JP3309340B2 (zh) |
KR (1) | KR100417207B1 (zh) |
CN (1) | CN1092194C (zh) |
AT (1) | ATE212629T1 (zh) |
AU (1) | AU708578B2 (zh) |
BR (1) | BR9611871B1 (zh) |
CA (1) | CA2238521C (zh) |
DE (1) | DE69618986T2 (zh) |
DK (1) | DK0866791T3 (zh) |
ES (1) | ES2169272T3 (zh) |
MX (1) | MX9804416A (zh) |
PT (1) | PT866791E (zh) |
TR (1) | TR199801014T2 (zh) |
WO (1) | WO1997020839A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1098260C (zh) * | 1996-05-15 | 2003-01-08 | 巴斯利尔药物股份公司 | 2,4-二氨基嘧啶衍生物 |
CN1832942B (zh) * | 2003-08-08 | 2010-06-02 | 阿皮德公开股份有限公司 | 制备2h-苯并吡喃的方法 |
CN101115743B (zh) * | 2005-02-18 | 2011-04-13 | 阿皮德公开股份有限公司 | 用于制备2h-色烯的新方法 |
CN109988156A (zh) * | 2019-03-12 | 2019-07-09 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
CN110139648A (zh) * | 2016-11-11 | 2019-08-16 | 莫迪福生物科学股份有限公司 | 治疗细菌感染的制剂、方法、试剂盒和剂型 |
CN110498812A (zh) * | 2018-05-17 | 2019-11-26 | 上海医药工业研究院 | 一种艾拉普林的中间体化合物的制备方法 |
CN110606831A (zh) * | 2018-06-14 | 2019-12-24 | 上海度德医药科技有限公司 | 一种Iclaprim的新中间体及其制备方法和应用 |
CN113493461A (zh) * | 2020-04-01 | 2021-10-12 | 上海医药工业研究院 | 一种七元杂环化合物或其盐、其制备方法及应用 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6818649B2 (en) * | 2000-04-27 | 2004-11-16 | Basilea Pharmaceutica Ag | Chromenylmethyl pyrimidinediamines as antibacterial agents |
WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
US20090069357A1 (en) * | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched iclaprim |
CN102112108A (zh) * | 2008-04-08 | 2011-06-29 | 阿西诺药品有限公司 | 水性医药剂型 |
US7947293B2 (en) | 2008-04-08 | 2011-05-24 | Arpida Ag | Aqueous pharmaceutical formulation |
WO2017192744A1 (en) | 2016-05-04 | 2017-11-09 | Motif BioSciences Inc. | Systems and methods for treating bacterial infection |
CN110818693B (zh) * | 2018-08-07 | 2023-06-02 | 上海度德医药科技有限公司 | 一种艾拉普林甲磺酸盐晶型b及其制备方法 |
WO2020161284A1 (en) | 2019-02-07 | 2020-08-13 | Sandoz Ag | Crystalline form of iclaprim mesylate |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
-
1996
- 1996-11-22 JP JP52092597A patent/JP3309340B2/ja not_active Expired - Fee Related
- 1996-11-22 TR TR1998/01014T patent/TR199801014T2/xx unknown
- 1996-11-22 AT AT96939890T patent/ATE212629T1/de active
- 1996-11-22 EP EP01117420A patent/EP1149834A1/en not_active Withdrawn
- 1996-11-22 ES ES96939890T patent/ES2169272T3/es not_active Expired - Lifetime
- 1996-11-22 PT PT96939890T patent/PT866791E/pt unknown
- 1996-11-22 DE DE69618986T patent/DE69618986T2/de not_active Expired - Lifetime
- 1996-11-22 CA CA002238521A patent/CA2238521C/en not_active Expired - Fee Related
- 1996-11-22 KR KR10-1998-0704199A patent/KR100417207B1/ko not_active IP Right Cessation
- 1996-11-22 CN CN96198783A patent/CN1092194C/zh not_active Expired - Fee Related
- 1996-11-22 WO PCT/EP1996/005151 patent/WO1997020839A1/en active IP Right Grant
- 1996-11-22 AU AU76963/96A patent/AU708578B2/en not_active Ceased
- 1996-11-22 BR BRPI9611871-7A patent/BR9611871B1/pt not_active IP Right Cessation
- 1996-11-22 DK DK96939890T patent/DK0866791T3/da active
- 1996-11-22 EP EP96939890A patent/EP0866791B1/en not_active Expired - Lifetime
- 1996-12-02 US US08/758,993 patent/US5773446A/en not_active Expired - Lifetime
-
1998
- 1998-06-03 MX MX9804416A patent/MX9804416A/es unknown
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1098260C (zh) * | 1996-05-15 | 2003-01-08 | 巴斯利尔药物股份公司 | 2,4-二氨基嘧啶衍生物 |
CN1832942B (zh) * | 2003-08-08 | 2010-06-02 | 阿皮德公开股份有限公司 | 制备2h-苯并吡喃的方法 |
US7893262B2 (en) | 2003-08-08 | 2011-02-22 | Arpida Ag | Process for the preparation of 2H-chromenes |
CN101830890B (zh) * | 2003-08-08 | 2011-08-03 | 阿皮德公开股份有限公司 | 制备2h-苯并吡喃的新方法 |
CN101115743B (zh) * | 2005-02-18 | 2011-04-13 | 阿皮德公开股份有限公司 | 用于制备2h-色烯的新方法 |
CN110139648A (zh) * | 2016-11-11 | 2019-08-16 | 莫迪福生物科学股份有限公司 | 治疗细菌感染的制剂、方法、试剂盒和剂型 |
CN110498812A (zh) * | 2018-05-17 | 2019-11-26 | 上海医药工业研究院 | 一种艾拉普林的中间体化合物的制备方法 |
CN110498812B (zh) * | 2018-05-17 | 2021-08-24 | 上海医药工业研究院 | 一种艾拉普林的中间体化合物的制备方法 |
CN110606831A (zh) * | 2018-06-14 | 2019-12-24 | 上海度德医药科技有限公司 | 一种Iclaprim的新中间体及其制备方法和应用 |
CN109988156A (zh) * | 2019-03-12 | 2019-07-09 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
CN109988156B (zh) * | 2019-03-12 | 2021-12-28 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
CN113493461A (zh) * | 2020-04-01 | 2021-10-12 | 上海医药工业研究院 | 一种七元杂环化合物或其盐、其制备方法及应用 |
Also Published As
Publication number | Publication date |
---|---|
EP0866791B1 (en) | 2002-01-30 |
BR9611871A (pt) | 1999-02-17 |
DE69618986D1 (de) | 2002-03-14 |
DK0866791T3 (da) | 2002-04-22 |
JP3309340B2 (ja) | 2002-07-29 |
EP1149834A1 (en) | 2001-10-31 |
AU708578B2 (en) | 1999-08-05 |
CA2238521A1 (en) | 1997-06-12 |
KR19990071912A (ko) | 1999-09-27 |
BR9611871B1 (pt) | 2010-11-03 |
TR199801014T2 (xx) | 1998-09-21 |
MX9804416A (es) | 1998-09-30 |
US5773446A (en) | 1998-06-30 |
AU7696396A (en) | 1997-06-27 |
PT866791E (pt) | 2002-05-31 |
KR100417207B1 (ko) | 2004-04-17 |
DE69618986T2 (de) | 2002-06-20 |
JP2000501399A (ja) | 2000-02-08 |
CN1092194C (zh) | 2002-10-09 |
WO1997020839A1 (en) | 1997-06-12 |
ATE212629T1 (de) | 2002-02-15 |
CA2238521C (en) | 2005-08-16 |
EP0866791A1 (en) | 1998-09-30 |
ES2169272T3 (es) | 2002-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: APIDA STOCK COMPANY Free format text: FORMER OWNER: FUEL HA FUMAN-LALUOQI LTD. Effective date: 20020227 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20020227 Address after: Switzerland, Ming Xing, Shi Taiyin Applicant after: F. HOFFMANN-LA ROCHE AG Address before: Basel, Switzerland Applicant before: F. Hoffmann-La Roche AG |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: AXINUO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ADI PULA COMPANY Effective date: 20110810 Owner name: ADI PULA COMPANY Free format text: FORMER OWNER: APIDA COMPANY Effective date: 20110810 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110810 Address after: Lanfen Group Patentee after: Asino Pharmaceutical Co.,Ltd. Address before: Switzerland, Ming Xing, Shi Taiyin Patentee before: ADI AG Effective date of registration: 20110810 Address after: Switzerland, Ming Xing, Shi Taiyin Patentee after: ADI AG Address before: Mingxing, Switzerland Patentee before: F. HOFFMANN-LA ROCHE AG |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20021009 Termination date: 20121122 |