CN1092194C - 二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 - Google Patents
二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 Download PDFInfo
- Publication number
- CN1092194C CN1092194C CN96198783A CN96198783A CN1092194C CN 1092194 C CN1092194 C CN 1092194C CN 96198783 A CN96198783 A CN 96198783A CN 96198783 A CN96198783 A CN 96198783A CN 1092194 C CN1092194 C CN 1092194C
- Authority
- CN
- China
- Prior art keywords
- compound
- dimethoxy
- chromene
- formula
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
化合物实施例序号 | 金黄色葡萄球菌ATCC 25923 | 金黄色葡萄球菌157/4696 | 卡氏肺囊虫 |
6 | 0.005 | 0.770 | 0.220 |
7 | 0.016 | 0.850 | 2.800 |
8 | 0.001 | 1.000 | 1.000 |
9 | 0.001 | 0.900 | 3.000 |
10 | 0.005 | 0.520 | 0.040 |
TMP | 0.007 | 2.250 | 5.500 |
Claims (7)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH342595 | 1995-12-04 | ||
CH3425/95 | 1995-12-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1203600A CN1203600A (zh) | 1998-12-30 |
CN1092194C true CN1092194C (zh) | 2002-10-09 |
Family
ID=4255709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN96198783A Expired - Fee Related CN1092194C (zh) | 1995-12-04 | 1996-11-22 | 二氨基嘧啶,含它们的药物组合物和其作为抗菌药物的用途 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5773446A (zh) |
EP (2) | EP0866791B1 (zh) |
JP (1) | JP3309340B2 (zh) |
KR (1) | KR100417207B1 (zh) |
CN (1) | CN1092194C (zh) |
AT (1) | ATE212629T1 (zh) |
AU (1) | AU708578B2 (zh) |
BR (1) | BR9611871B1 (zh) |
CA (1) | CA2238521C (zh) |
DE (1) | DE69618986T2 (zh) |
DK (1) | DK0866791T3 (zh) |
ES (1) | ES2169272T3 (zh) |
MX (1) | MX9804416A (zh) |
PT (1) | PT866791E (zh) |
TR (1) | TR199801014T2 (zh) |
WO (1) | WO1997020839A1 (zh) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW438796B (en) * | 1996-05-15 | 2001-06-07 | Hoffmann La Roche | 2,4-diaminopyrimidine derivatives, the manufacture process thereof, and the antibiotically-active pharmaceutical composition containing the same |
KR20020093966A (ko) * | 2000-04-27 | 2002-12-16 | 바실리어 파마슈티카 아게 | 항균제로서의 크로메닐메틸 피리미딘디아민 |
WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
WO2005014586A1 (en) * | 2003-08-08 | 2005-02-17 | Arpida Ag | Novel process for the preparation of 2h-chromenes |
EE200700051A (et) * | 2005-02-18 | 2007-12-17 | Arpida Ag | Meetod 2H-kromeeni valmistamiseks ning vahehendid |
US20090069357A1 (en) * | 2007-09-09 | 2009-03-12 | Protia, Llc | Deuterium-enriched iclaprim |
JP2011516509A (ja) * | 2008-04-08 | 2011-05-26 | アシノ ファーマ アーゲー | 水性医薬製剤 |
US7947293B2 (en) | 2008-04-08 | 2011-05-24 | Arpida Ag | Aqueous pharmaceutical formulation |
WO2017192744A1 (en) | 2016-05-04 | 2017-11-09 | Motif BioSciences Inc. | Systems and methods for treating bacterial infection |
WO2018144086A1 (en) * | 2016-11-11 | 2018-08-09 | Motif Biosciences, Inc. | Formulations, methods, kit, and dosage forms for treating bacterial infection |
CN110498812B (zh) * | 2018-05-17 | 2021-08-24 | 上海医药工业研究院 | 一种艾拉普林的中间体化合物的制备方法 |
CN110606831A (zh) * | 2018-06-14 | 2019-12-24 | 上海度德医药科技有限公司 | 一种Iclaprim的新中间体及其制备方法和应用 |
CN110818693B (zh) * | 2018-08-07 | 2023-06-02 | 上海度德医药科技有限公司 | 一种艾拉普林甲磺酸盐晶型b及其制备方法 |
WO2020161284A1 (en) | 2019-02-07 | 2020-08-13 | Sandoz Ag | Crystalline form of iclaprim mesylate |
CN109988156B (zh) * | 2019-03-12 | 2021-12-28 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
CN113493461A (zh) * | 2020-04-01 | 2021-10-12 | 上海医药工业研究院 | 一种七元杂环化合物或其盐、其制备方法及应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0051879A2 (en) * | 1980-11-11 | 1982-05-19 | The Wellcome Foundation Limited | Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them |
-
1996
- 1996-11-22 ES ES96939890T patent/ES2169272T3/es not_active Expired - Lifetime
- 1996-11-22 JP JP52092597A patent/JP3309340B2/ja not_active Expired - Fee Related
- 1996-11-22 BR BRPI9611871-7A patent/BR9611871B1/pt not_active IP Right Cessation
- 1996-11-22 CA CA002238521A patent/CA2238521C/en not_active Expired - Fee Related
- 1996-11-22 DK DK96939890T patent/DK0866791T3/da active
- 1996-11-22 EP EP96939890A patent/EP0866791B1/en not_active Expired - Lifetime
- 1996-11-22 PT PT96939890T patent/PT866791E/pt unknown
- 1996-11-22 TR TR1998/01014T patent/TR199801014T2/xx unknown
- 1996-11-22 CN CN96198783A patent/CN1092194C/zh not_active Expired - Fee Related
- 1996-11-22 AU AU76963/96A patent/AU708578B2/en not_active Ceased
- 1996-11-22 EP EP01117420A patent/EP1149834A1/en not_active Withdrawn
- 1996-11-22 AT AT96939890T patent/ATE212629T1/de active
- 1996-11-22 DE DE69618986T patent/DE69618986T2/de not_active Expired - Lifetime
- 1996-11-22 WO PCT/EP1996/005151 patent/WO1997020839A1/en active IP Right Grant
- 1996-11-22 KR KR10-1998-0704199A patent/KR100417207B1/ko not_active IP Right Cessation
- 1996-12-02 US US08/758,993 patent/US5773446A/en not_active Expired - Lifetime
-
1998
- 1998-06-03 MX MX9804416A patent/MX9804416A/es unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0051879A2 (en) * | 1980-11-11 | 1982-05-19 | The Wellcome Foundation Limited | Substituted pyrimidines, their synthesis and compositions containing them, their use in medicine and intermediates for making them |
Also Published As
Publication number | Publication date |
---|---|
CA2238521C (en) | 2005-08-16 |
JP2000501399A (ja) | 2000-02-08 |
AU708578B2 (en) | 1999-08-05 |
US5773446A (en) | 1998-06-30 |
CA2238521A1 (en) | 1997-06-12 |
ES2169272T3 (es) | 2002-07-01 |
KR19990071912A (ko) | 1999-09-27 |
BR9611871B1 (pt) | 2010-11-03 |
MX9804416A (es) | 1998-09-30 |
BR9611871A (pt) | 1999-02-17 |
JP3309340B2 (ja) | 2002-07-29 |
KR100417207B1 (ko) | 2004-04-17 |
DE69618986T2 (de) | 2002-06-20 |
EP0866791A1 (en) | 1998-09-30 |
TR199801014T2 (xx) | 1998-09-21 |
EP0866791B1 (en) | 2002-01-30 |
AU7696396A (en) | 1997-06-27 |
CN1203600A (zh) | 1998-12-30 |
DE69618986D1 (de) | 2002-03-14 |
ATE212629T1 (de) | 2002-02-15 |
DK0866791T3 (da) | 2002-04-22 |
WO1997020839A1 (en) | 1997-06-12 |
PT866791E (pt) | 2002-05-31 |
EP1149834A1 (en) | 2001-10-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: APIDA STOCK COMPANY Free format text: FORMER OWNER: FUEL HA FUMAN-LALUOQI LTD. Effective date: 20020227 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20020227 Address after: Switzerland, Ming Xing, Shi Taiyin Applicant after: F. HOFFMANN-LA ROCHE AG Address before: Basel, Switzerland Applicant before: F. Hoffmann-La Roche AG |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: AXINUO PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: ADI PULA COMPANY Effective date: 20110810 Owner name: ADI PULA COMPANY Free format text: FORMER OWNER: APIDA COMPANY Effective date: 20110810 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20110810 Address after: Lanfen Group Patentee after: Asino Pharmaceutical Co.,Ltd. Address before: Switzerland, Ming Xing, Shi Taiyin Patentee before: ADI AG Effective date of registration: 20110810 Address after: Switzerland, Ming Xing, Shi Taiyin Patentee after: ADI AG Address before: Mingxing, Switzerland Patentee before: F. HOFFMANN-LA ROCHE AG |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20021009 Termination date: 20121122 |