RU2007134583A - Новые способы получения бензофурана - Google Patents
Новые способы получения бензофурана Download PDFInfo
- Publication number
- RU2007134583A RU2007134583A RU2007134583/04A RU2007134583A RU2007134583A RU 2007134583 A RU2007134583 A RU 2007134583A RU 2007134583/04 A RU2007134583/04 A RU 2007134583/04A RU 2007134583 A RU2007134583 A RU 2007134583A RU 2007134583 A RU2007134583 A RU 2007134583A
- Authority
- RU
- Russia
- Prior art keywords
- formula
- ylmethyl
- chloro
- carboxylic acid
- pyrimidin
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 4
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical compound C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 claims 11
- AQEFLFZSWDEAIP-UHFFFAOYSA-N di-tert-butyl ether Chemical compound CC(C)(C)OC(C)(C)C AQEFLFZSWDEAIP-UHFFFAOYSA-N 0.000 claims 4
- 239000000543 intermediate Substances 0.000 claims 4
- QAWZRNLQJHNKIN-UHFFFAOYSA-N 3-[[4-[[2,4-bis(2,2-dimethylpropanoylamino)pyrimidin-5-yl]methyl]-6,7-dimethoxy-1-benzofuran-2-yl]methyl]-5-chloro-n,n-dimethyl-1-(4-methylphenyl)sulfonylindole-2-carboxamide Chemical compound C=12C=C(CC=3C4=CC(Cl)=CC=C4N(C=3C(=O)N(C)C)S(=O)(=O)C=3C=CC(C)=CC=3)OC2=C(OC)C(OC)=CC=1CC1=CN=C(NC(=O)C(C)(C)C)N=C1NC(=O)C(C)(C)C QAWZRNLQJHNKIN-UHFFFAOYSA-N 0.000 claims 2
- -1 5-chloro-3- [4- (2,4-diaminopyrimidin-5-ylmethyl) -6,7-dimethoxybenzofuran-2-carbonyl] -1H-indole-2-carboxylic acid mesylate dimethylamide Chemical compound 0.000 claims 2
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 claims 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 229910000033 sodium borohydride Inorganic materials 0.000 claims 2
- 239000012279 sodium borohydride Substances 0.000 claims 2
- MUZCTARMAPIEKB-UHFFFAOYSA-N 2-methyl-n-[2-(2-methylpropanoylamino)-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-yl]propanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)C)=NC=2)NC(=O)C(C)C)=C1 MUZCTARMAPIEKB-UHFFFAOYSA-N 0.000 claims 1
- HPBMLSXMXOUCLX-UHFFFAOYSA-N 3-(2-bromoacetyl)-5-chloro-2-(dimethylcarbamoyl)indole-1-carboxylic acid Chemical compound ClC1=CC=C2N(C(O)=O)C(C(=O)N(C)C)=C(C(=O)CBr)C2=C1 HPBMLSXMXOUCLX-UHFFFAOYSA-N 0.000 claims 1
- MTRGYVUWRVFGOM-UHFFFAOYSA-N 3-(2-bromoacetyl)-5-chloro-n,n-dimethyl-1-(4-methylphenyl)sulfonylindole-2-carboxamide Chemical compound CN(C)C(=O)C1=C(C(=O)CBr)C2=CC(Cl)=CC=C2N1S(=O)(=O)C1=CC=C(C)C=C1 MTRGYVUWRVFGOM-UHFFFAOYSA-N 0.000 claims 1
- FTXHJIVBKVOKES-UHFFFAOYSA-N 3-(2-bromoacetyl)-5-chloro-n,n-dimethyl-1h-indole-2-carboxamide Chemical compound C1=C(Cl)C=C2C(C(=O)CBr)=C(C(=O)N(C)C)NC2=C1 FTXHJIVBKVOKES-UHFFFAOYSA-N 0.000 claims 1
- QYGFXZLFWCLICH-UHFFFAOYSA-N 3-[4-[[2,4-bis(2,2-dimethylpropanoylamino)pyrimidin-5-yl]methyl]-6,7-dimethoxy-1-benzofuran-2-carbonyl]-5-chloro-2-(dimethylcarbamoyl)indole-1-carboxylic acid Chemical compound CC(C(=O)NC1=NC=C(C(=N1)NC(C(C)(C)C)=O)CC1=CC(=C(C2=C1C=C(O2)C(=O)C2=C(N(C1=CC=C(C=C21)Cl)C(=O)O)C(N(C)C)=O)OC)OC)(C)C QYGFXZLFWCLICH-UHFFFAOYSA-N 0.000 claims 1
- PCYHRPSFYGFARO-UHFFFAOYSA-N 3-[4-[[2,4-bis(2-methylpropanoylamino)pyrimidin-5-yl]methyl]-6,7-dimethoxy-1-benzofuran-2-carbonyl]-5-chloro-n,n-dimethyl-1-(4-methylphenyl)sulfonylindole-2-carboxamide Chemical compound C=12C=C(C(=O)C=3C4=CC(Cl)=CC=C4N(C=3C(=O)N(C)C)S(=O)(=O)C=3C=CC(C)=CC=3)OC2=C(OC)C(OC)=CC=1CC1=CN=C(NC(=O)C(C)C)N=C1NC(=O)C(C)C PCYHRPSFYGFARO-UHFFFAOYSA-N 0.000 claims 1
- PQQCPTAUCZPGKQ-UHFFFAOYSA-N 3-[[4-[[2,4-bis(2,2-dimethylpropanoylamino)pyrimidin-5-yl]methyl]-6,7-dimethoxy-1-benzofuran-2-yl]methyl]-5-chloro-2-(dimethylcarbamoyl)indole-1-carboxylic acid Chemical compound C=12C=C(CC=3C4=CC(Cl)=CC=C4N(C(O)=O)C=3C(=O)N(C)C)OC2=C(OC)C(OC)=CC=1CC1=CN=C(NC(=O)C(C)(C)C)N=C1NC(=O)C(C)(C)C PQQCPTAUCZPGKQ-UHFFFAOYSA-N 0.000 claims 1
- LALOZSQSGLXLKC-UHFFFAOYSA-N 3-acetyl-5-chloro-n,n-dimethyl-1-(4-methylphenyl)sulfonylindole-2-carboxamide Chemical compound CN(C)C(=O)C1=C(C(C)=O)C2=CC(Cl)=CC=C2N1S(=O)(=O)C1=CC=C(C)C=C1 LALOZSQSGLXLKC-UHFFFAOYSA-N 0.000 claims 1
- AWECPUZOTCMHMP-UHFFFAOYSA-N 3-acetyl-5-chloro-n,n-dimethyl-1h-indole-2-carboxamide Chemical compound C1=C(Cl)C=C2C(C(C)=O)=C(C(=O)N(C)C)NC2=C1 AWECPUZOTCMHMP-UHFFFAOYSA-N 0.000 claims 1
- 229910015900 BF3 Inorganic materials 0.000 claims 1
- KJTLSVCANCCWHF-UHFFFAOYSA-N Ruthenium Chemical compound [Ru] KJTLSVCANCCWHF-UHFFFAOYSA-N 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- YQHKOVRQYOQBMQ-UHFFFAOYSA-N n-[2-(2,2-dimethylpropanoylamino)-5-[(2-formyl-3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-yl]-2,2-dimethylpropanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)(C)C)=NC=2)NC(=O)C(C)(C)C)=C1C=O YQHKOVRQYOQBMQ-UHFFFAOYSA-N 0.000 claims 1
- OQBPNKPSHJYTQF-UHFFFAOYSA-N n-[2-(2,2-dimethylpropanoylamino)-5-[(2-formyl-3-hydroxy-4,5-dimethoxyphenyl)methyl]pyrimidin-4-yl]-2,2-dimethylpropanamide Chemical compound OC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)(C)C)=NC=2)NC(=O)C(C)(C)C)=C1C=O OQBPNKPSHJYTQF-UHFFFAOYSA-N 0.000 claims 1
- DCZWZARHHVYRSA-UHFFFAOYSA-N n-[2-(2,2-dimethylpropanoylamino)-5-[(2-iodo-3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-yl]-2,2-dimethylpropanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)(C)C)=NC=2)NC(=O)C(C)(C)C)=C1I DCZWZARHHVYRSA-UHFFFAOYSA-N 0.000 claims 1
- INFXPVQENJOZPC-UHFFFAOYSA-N n-[2-(2,2-dimethylpropanoylamino)-5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidin-4-yl]-2,2-dimethylpropanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)(C)C)=NC=2)NC(=O)C(C)(C)C)=C1 INFXPVQENJOZPC-UHFFFAOYSA-N 0.000 claims 1
- BFYDHJGMGVPGEA-UHFFFAOYSA-N n-[5-[(2-formyl-3,4,5-trimethoxyphenyl)methyl]-2-(2-methylpropanoylamino)pyrimidin-4-yl]-2-methylpropanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)C)=NC=2)NC(=O)C(C)C)=C1C=O BFYDHJGMGVPGEA-UHFFFAOYSA-N 0.000 claims 1
- YYQAJVHVJBLONA-UHFFFAOYSA-N n-[5-[(2-formyl-3-hydroxy-4,5-dimethoxyphenyl)methyl]-2-(2-methylpropanoylamino)pyrimidin-4-yl]-2-methylpropanamide Chemical compound OC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)C)=NC=2)NC(=O)C(C)C)=C1C=O YYQAJVHVJBLONA-UHFFFAOYSA-N 0.000 claims 1
- KYSCILSNRJBNJJ-UHFFFAOYSA-N n-[5-[(2-iodo-3,4,5-trimethoxyphenyl)methyl]-2-(2-methylpropanoylamino)pyrimidin-4-yl]-2-methylpropanamide Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(NC(=O)C(C)C)=NC=2)NC(=O)C(C)C)=C1I KYSCILSNRJBNJJ-UHFFFAOYSA-N 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 239000007858 starting material Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2005/001695 | 2005-02-18 | ||
| EP2005001695 | 2005-02-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007134583A true RU2007134583A (ru) | 2009-03-27 |
Family
ID=36283919
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007134583/04A RU2007134583A (ru) | 2005-02-18 | 2006-02-10 | Новые способы получения бензофурана |
| RU2007134584/04A RU2397980C2 (ru) | 2005-02-18 | 2006-02-10 | Новые способы получения 2н-хромена |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007134584/04A RU2397980C2 (ru) | 2005-02-18 | 2006-02-10 | Новые способы получения 2н-хромена |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20080161561A1 (enExample) |
| EP (3) | EP2270003A1 (enExample) |
| JP (2) | JP2009505943A (enExample) |
| KR (2) | KR20070106635A (enExample) |
| CN (4) | CN101115743B (enExample) |
| AU (2) | AU2006215788B2 (enExample) |
| BG (2) | BG109937A (enExample) |
| BR (2) | BRPI0607758A2 (enExample) |
| CA (2) | CA2596668A1 (enExample) |
| CZ (2) | CZ2007537A3 (enExample) |
| EE (2) | EE200700050A (enExample) |
| HU (2) | HUP0700604A3 (enExample) |
| IL (2) | IL184404A0 (enExample) |
| MX (2) | MX2007009282A (enExample) |
| NO (2) | NO20073678L (enExample) |
| NZ (1) | NZ556800A (enExample) |
| RO (2) | RO122853B1 (enExample) |
| RU (2) | RU2007134583A (enExample) |
| TR (1) | TR200705187T1 (enExample) |
| TW (2) | TW200640912A (enExample) |
| WO (2) | WO2006087140A1 (enExample) |
| ZA (2) | ZA200706421B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0607758A2 (pt) * | 2005-02-18 | 2010-03-23 | Arpida Ag | processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto |
| JP2011516509A (ja) * | 2008-04-08 | 2011-05-26 | アシノ ファーマ アーゲー | 水性医薬製剤 |
| US7947293B2 (en) | 2008-04-08 | 2011-05-24 | Arpida Ag | Aqueous pharmaceutical formulation |
| FR2949465B1 (fr) * | 2009-09-01 | 2011-08-12 | Pf Medicament | Derives chromones, leur procede de preparation et leurs applications therapeutiques |
| CN110606831A (zh) * | 2018-06-14 | 2019-12-24 | 上海度德医药科技有限公司 | 一种Iclaprim的新中间体及其制备方法和应用 |
| CN110818693B (zh) * | 2018-08-07 | 2023-06-02 | 上海度德医药科技有限公司 | 一种艾拉普林甲磺酸盐晶型b及其制备方法 |
| CN109988156B (zh) * | 2019-03-12 | 2021-12-28 | 广东中科药物研究有限公司 | 一种氨基嘧啶化合物 |
| CN110372746A (zh) * | 2019-07-11 | 2019-10-25 | 辽宁石油化工大学 | 一种合成β-胺基膦氧化合物的方法 |
| CN110746361B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN110790753B (zh) * | 2019-11-18 | 2023-04-07 | 上海医药工业研究院 | 艾拉普林对甲苯磺酸盐、其制备方法和应用 |
| CN110642792B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体的制备方法 |
| CN110713483B (zh) * | 2019-11-18 | 2023-04-07 | 上海医药工业研究院 | 艾拉普林中间体及艾拉普林的制备方法 |
| CN110724135B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN110818694B (zh) * | 2019-11-18 | 2023-04-21 | 上海医药工业研究院有限公司 | 艾拉普林中间体及其应用 |
| CN110724108B (zh) * | 2019-11-18 | 2023-04-28 | 上海医药工业研究院有限公司 | 一种艾拉普林中间体及其制备方法 |
| CN113493461A (zh) * | 2020-04-01 | 2021-10-12 | 上海医药工业研究院 | 一种七元杂环化合物或其盐、其制备方法及应用 |
| CN117700410B (zh) * | 2023-05-20 | 2025-07-04 | 山东康诺生物工程有限公司 | 一种3-(2-氯乙基)-2-甲基-9-羟基-4H-吡啶并[1,2-a]嘧啶-4-酮的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2709634A1 (de) * | 1977-03-05 | 1978-09-07 | Basf Ag | Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel |
| US4438267A (en) * | 1980-11-11 | 1984-03-20 | Daluge Susan M | Monoheteroring compounds and their use |
| WO1997020839A1 (en) * | 1995-12-04 | 1997-06-12 | F. Hoffmann-La Roche Ag | Diaminopyrimidines, pharmaceutical compositions containing them and their use as antibacterial |
| WO2002010156A1 (en) * | 2000-07-29 | 2002-02-07 | Arpida Ag | Benzofuran derivatives and their use as antibacterial agents |
| WO2003000657A1 (en) * | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Diamine derivatives |
| HUP0600114A2 (en) * | 2003-07-11 | 2007-09-28 | Arpida Ag | Benzofuran derivatives and their use in the treatment of microbal infections |
| WO2005014586A1 (en) * | 2003-08-08 | 2005-02-17 | Arpida Ag | Novel process for the preparation of 2h-chromenes |
| BRPI0607758A2 (pt) * | 2005-02-18 | 2010-03-23 | Arpida Ag | processos para a fabricaÇço do composto e para a reduÇço do composto, e, composto |
-
2006
- 2006-02-10 BR BRPI0607758-7A patent/BRPI0607758A2/pt not_active IP Right Cessation
- 2006-02-10 KR KR1020077021394A patent/KR20070106635A/ko not_active Ceased
- 2006-02-10 RU RU2007134583/04A patent/RU2007134583A/ru not_active Application Discontinuation
- 2006-02-10 AU AU2006215788A patent/AU2006215788B2/en not_active Ceased
- 2006-02-10 BR BRPI0607797-8A patent/BRPI0607797A2/pt not_active IP Right Cessation
- 2006-02-10 CN CN2006800039626A patent/CN101115743B/zh not_active Expired - Fee Related
- 2006-02-10 JP JP2007555507A patent/JP2009505943A/ja active Pending
- 2006-02-10 CA CA002596668A patent/CA2596668A1/en not_active Abandoned
- 2006-02-10 RO ROA200700590A patent/RO122853B1/ro unknown
- 2006-02-10 RO ROA200700589A patent/RO122912B8/ro unknown
- 2006-02-10 US US11/816,157 patent/US20080161561A1/en not_active Abandoned
- 2006-02-10 EP EP10184131A patent/EP2270003A1/en not_active Withdrawn
- 2006-02-10 EP EP06706809A patent/EP1856109A1/en not_active Withdrawn
- 2006-02-10 CZ CZ20070537A patent/CZ2007537A3/cs unknown
- 2006-02-10 CN CN2011100324933A patent/CN102140094B/zh not_active Expired - Fee Related
- 2006-02-10 KR KR1020077021395A patent/KR20070106636A/ko not_active Withdrawn
- 2006-02-10 MX MX2007009282A patent/MX2007009282A/es not_active Application Discontinuation
- 2006-02-10 CZ CZ20070536A patent/CZ2007536A3/cs unknown
- 2006-02-10 WO PCT/EP2006/001179 patent/WO2006087140A1/en not_active Ceased
- 2006-02-10 HU HU0700604A patent/HUP0700604A3/hu unknown
- 2006-02-10 EE EEP200700050A patent/EE200700050A/xx unknown
- 2006-02-10 EE EEP200700051A patent/EE200700051A/xx unknown
- 2006-02-10 MX MX2007009283A patent/MX2007009283A/es unknown
- 2006-02-10 US US11/816,150 patent/US20080221324A1/en not_active Abandoned
- 2006-02-10 WO PCT/EP2006/001185 patent/WO2006087143A1/en not_active Ceased
- 2006-02-10 CN CNA2006800039630A patent/CN101115746A/zh active Pending
- 2006-02-10 EP EP06706815A patent/EP1856106A1/en not_active Withdrawn
- 2006-02-10 CN CN2011100324952A patent/CN102079727A/zh active Pending
- 2006-02-10 NZ NZ556800A patent/NZ556800A/en not_active IP Right Cessation
- 2006-02-10 AU AU2006215785A patent/AU2006215785A1/en not_active Abandoned
- 2006-02-10 RU RU2007134584/04A patent/RU2397980C2/ru not_active IP Right Cessation
- 2006-02-10 CA CA002596669A patent/CA2596669A1/en not_active Abandoned
- 2006-02-10 HU HU0700605A patent/HUP0700605A3/hu unknown
- 2006-02-10 TR TR2007/05187T patent/TR200705187T1/xx unknown
- 2006-02-10 JP JP2007555504A patent/JP2008530156A/ja active Pending
- 2006-02-17 TW TW095105426A patent/TW200640912A/zh unknown
- 2006-02-17 TW TW095105425A patent/TW200640914A/zh unknown
-
2007
- 2007-07-04 IL IL184404A patent/IL184404A0/en unknown
- 2007-07-04 IL IL184405A patent/IL184405A0/en unknown
- 2007-07-17 NO NO20073678A patent/NO20073678L/no not_active Application Discontinuation
- 2007-07-18 NO NO20073701A patent/NO20073701L/no not_active Application Discontinuation
- 2007-08-01 ZA ZA200706421A patent/ZA200706421B/xx unknown
- 2007-08-01 ZA ZA200706422A patent/ZA200706422B/xx unknown
- 2007-08-10 BG BG109937A patent/BG109937A/bg unknown
- 2007-08-10 BG BG109938A patent/BG109938A/bg unknown
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