CN101096368A - 新的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途 - Google Patents

新的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途 Download PDF

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Publication number
CN101096368A
CN101096368A CNA2007101278476A CN200710127847A CN101096368A CN 101096368 A CN101096368 A CN 101096368A CN A2007101278476 A CNA2007101278476 A CN A2007101278476A CN 200710127847 A CN200710127847 A CN 200710127847A CN 101096368 A CN101096368 A CN 101096368A
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China
Prior art keywords
alkyl
methyl
triazole
diazole
phenyl
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Pending
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CNA2007101278476A
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English (en)
Chinese (zh)
Inventor
L·爱德华兹
M·伊萨克
M·约翰松
A·凯斯
J·马尔姆伯格
D·麦莱奥德
A·米尼迪斯
K·斯塔夫
A·斯拉西
T·斯特法纳克
T·斯托尔曼
D·温斯博
忻涛
J·阿罗拉
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AstraZeneca AB
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AstraZeneca AB
NPS Pharmaceuticals Inc
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Publication of CN101096368A publication Critical patent/CN101096368A/zh
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    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
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  • Biomedical Technology (AREA)
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  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
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  • Diabetes (AREA)
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  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2007101278476A 2004-02-18 2005-02-15 新的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途 Pending CN101096368A (zh)

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US60896004P 2004-02-18 2004-02-18
US60/608960 2004-02-18

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CNA2005800043063A Pending CN1984907A (zh) 2004-02-18 2005-02-15 新的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途

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US (6) US7585881B2 (https=)
EP (2) EP1723144B1 (https=)
JP (1) JP4912157B2 (https=)
CN (2) CN101096368A (https=)
AT (1) ATE483706T1 (https=)
AU (1) AU2005270208A1 (https=)
BR (1) BRPI0507497A (https=)
CA (1) CA2555566A1 (https=)
CY (1) CY1110965T1 (https=)
DE (1) DE602005023963D1 (https=)
DK (1) DK1723144T3 (https=)
ES (1) ES2352110T3 (https=)
HR (1) HRP20100654T1 (https=)
IL (1) IL177394A0 (https=)
NO (1) NO20063599L (https=)
NZ (1) NZ548954A (https=)
PL (1) PL1723144T3 (https=)
PT (1) PT1723144E (https=)
RS (1) RS51516B (https=)
RU (1) RU2370495C2 (https=)
SG (1) SG146657A1 (https=)
SI (1) SI1723144T1 (https=)
UA (1) UA84318C2 (https=)
UY (1) UY28766A1 (https=)
WO (1) WO2006014185A1 (https=)
ZA (1) ZA200606551B (https=)

Cited By (5)

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CN107427476A (zh) * 2015-03-10 2017-12-01 奥瑞基尼探索技术有限公司 作为免疫调节剂的3‑取代的‑1,2,4‑噁二唑和噻二唑化合物
CN111448181A (zh) * 2017-11-16 2020-07-24 蒙特多力士有限公司 单脒和二脒核酸内切-外切酶抑制剂和抑制核酸内切-外切酶活性的方法
CN114269340A (zh) * 2019-05-03 2022-04-01 普拉克西斯精密药物股份有限公司 Kcnt1抑制剂和使用方法
CN115175900A (zh) * 2020-01-07 2022-10-11 达萨玛治疗公司 Sarm1的抑制剂
US12583849B2 (en) 2020-02-28 2026-03-24 Praxis Precision Medicines, Inc. KCNT1 inhibitors and methods of use

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