CN100518733C - 用于治疗和预防糖尿病的组合物 - Google Patents

用于治疗和预防糖尿病的组合物 Download PDF

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Publication number
CN100518733C
CN100518733C CNB2004800275244A CN200480027524A CN100518733C CN 100518733 C CN100518733 C CN 100518733C CN B2004800275244 A CNB2004800275244 A CN B2004800275244A CN 200480027524 A CN200480027524 A CN 200480027524A CN 100518733 C CN100518733 C CN 100518733C
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CN
China
Prior art keywords
egcg
ppar
rosiglitazone
insulin
ligustilide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800275244A
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English (en)
Chinese (zh)
Other versions
CN1856303A (zh
Inventor
丹尼尔·雷德尔斯多夫
桑德拉·雷娜塔·泰克赛拉
王英
彼得·韦伯
斯文·沃尔夫拉姆
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DSM IP Assets BV
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DSM IP Assets BV
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Publication of CN1856303A publication Critical patent/CN1856303A/zh
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Publication of CN100518733C publication Critical patent/CN100518733C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB2004800275244A 2003-09-23 2004-09-15 用于治疗和预防糖尿病的组合物 Expired - Fee Related CN100518733C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03021447 2003-09-23
EP03021447.2 2003-09-23

Publications (2)

Publication Number Publication Date
CN1856303A CN1856303A (zh) 2006-11-01
CN100518733C true CN100518733C (zh) 2009-07-29

Family

ID=34354421

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800275244A Expired - Fee Related CN100518733C (zh) 2003-09-23 2004-09-15 用于治疗和预防糖尿病的组合物

Country Status (6)

Country Link
US (1) US7691420B2 (https=)
EP (1) EP1662906A1 (https=)
JP (1) JP2007505854A (https=)
KR (1) KR20060121887A (https=)
CN (1) CN100518733C (https=)
WO (1) WO2005027661A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1605336A (zh) 2003-10-10 2005-04-13 中国医学科学院药物研究所 左旋丁基苯酞在制备预防和治疗脑梗塞的药物中的应用
KR20080020617A (ko) * 2005-06-07 2008-03-05 디에스엠 아이피 어셋츠 비.브이. (-)-에피갈로카테킨 갈레이트의 신규 용도
US20090202659A1 (en) * 2005-06-10 2009-08-13 Gimble Jeffrey M Modulation of Peripheral Clocks in Adipose Tissue
EA200802090A1 (ru) * 2006-03-31 2010-04-30 ДСМ АйПи АССЕТС Б.В. Новое применение соединений и комбинаций соединений для улучшения внешнего вида
CN101516386B (zh) * 2006-07-14 2013-05-15 帝斯曼知识产权资产管理有限公司 包含玫瑰果和其它活性剂的用于治疗炎性病症的组合物
US20100215782A1 (en) * 2008-10-22 2010-08-26 Metaproteomics, Llc Novel mitochondrial uncoupling methods and compositions for enhancing adipocyte thermogenesis
WO2011000593A1 (en) * 2009-06-30 2011-01-06 Unilever Plc Method for determining susceptibility of individuals to polyphenols
EP2332427A1 (en) * 2009-12-07 2011-06-15 Nestec S.A. low caloric fat replacers
WO2011162320A1 (ja) * 2010-06-23 2011-12-29 国立大学法人九州大学 Egcgまたはメチル化egcgとpde阻害剤との組み合わせ
RU2451506C1 (ru) * 2011-06-02 2012-05-27 Сергей Юрьевич Лешков Комбинация для лечения сахарного диабета и его осложнений
JP5877731B2 (ja) * 2012-02-28 2016-03-08 丸善製薬株式会社 Ｕｃｐ−３発現促進剤
JP6034107B2 (ja) * 2012-09-25 2016-11-30 日本メナード化粧品株式会社 幹細胞から褐色脂肪細胞への分化促進剤
JP2015155383A (ja) * 2014-02-19 2015-08-27 株式会社東洋新薬 受容体発現亢進剤
CN107446882B (zh) * 2016-05-20 2021-06-22 东华大学 亚丁基苯酞的应用
WO2021263072A1 (en) * 2020-06-25 2021-12-30 Dana-Farber Cancer Institute, Inc. Methods of treating disease
CN119656183A (zh) * 2024-09-30 2025-03-21 唐宁医药科技(济南)有限公司 一种归知糖疽有效成分配方在治疗糖尿病引起的周围神经病变中的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02243622A (ja) 1989-03-16 1990-09-27 Nippon Oil & Fats Co Ltd 血中コレステロール低下用油脂組成物
JPH05292886A (ja) 1992-04-21 1993-11-09 Fuji Oil Co Ltd 被マイグレーション防止能を有する油脂及びそれを含有 した食品並びに油脂含有食品のマイグレーション防止法
WO2002039822A2 (en) * 2000-11-17 2002-05-23 Kao Corporation Packaged beverages
WO2002072086A2 (en) * 2001-03-12 2002-09-19 Consorzio Per Gli Studi Universitari Use of epigallocatechin-3-gallate or its derivatives in the prevention and treatment of neurodegenerative diseases
WO2004041257A2 (en) * 2002-11-07 2004-05-21 Dsm Ip Assets B.V. Novel nutraceutical compositions comprising epigallocatechin gallate

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions
JPH01207233A (ja) 1988-02-12 1989-08-21 Tsumura & Co 抗動脈硬化症剤
US5318986A (en) * 1989-10-19 1994-06-07 Mitsui Norin Co., Ltd. Method of inhibiting the activity of α-amylase
JPH03228664A (ja) * 1990-02-02 1991-10-09 Meiji Seika Kaisha Ltd 脂質の消化吸収抑制機能を有する食品
JP3088787B2 (ja) * 1991-07-08 2000-09-18 三井農林株式会社 シュクラーゼ活性阻害剤
JPH05292885A (ja) * 1992-04-22 1993-11-09 Asahi Denka Kogyo Kk チョコレート組成物
IN178310B (https=) 1993-06-25 1997-03-22 Mobius Consultancy Pty Ltd
US5536499A (en) * 1995-02-24 1996-07-16 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Cosmetic compositions for reducing or preventing signs of cellulite
CN1069036C (zh) * 1995-07-21 2001-08-01 崔景岳 灵芝仙饮
JPH1118722A (ja) * 1997-07-03 1999-01-26 Lotte Co Ltd 記憶力および学習能力を増強させる効果を有する脳機能を活性化する飲食物
JP3496483B2 (ja) * 1997-11-04 2004-02-09 三菱化学フーズ株式会社 密封容器入り茶類飲料
US6428818B1 (en) * 1999-03-30 2002-08-06 Purdue Research Foundation Tea catechin formulations and processes for making same
US6410061B1 (en) * 1999-03-30 2002-06-25 Purdue Research Foundation Tea catechins as cancer specific proliferation inhibitors
US6299925B1 (en) * 1999-06-29 2001-10-09 Xel Herbaceuticals, Inc. Effervescent green tea extract formulation
CN1182127C (zh) 2000-06-28 2004-12-29 中国医学科学院药物研究所 新的取代的2-苯并[c]呋喃酮化合物,其制备方法以及包含它们的药物组合物
US6455078B1 (en) * 2000-10-18 2002-09-24 Tzu-Sheng Wu Medicinal herbal composition for treating liver diseases and HIV
JP3756438B2 (ja) * 2001-03-02 2006-03-15 花王株式会社 容器詰飲料
AU2002235731A1 (en) * 2001-03-07 2002-09-19 Novo Nordisk A/S Combined use of derivatives of glp-1 analogs and ppar ligands
WO2002080936A1 (en) * 2001-04-04 2002-10-17 Ortho Mcneil Pharmaceutical, Inc. Combination therapy comprising glucose reabsorption inhibitors and ppar modulators
DE10131057A1 (de) 2001-06-29 2003-01-23 Shandong Luya Pharmaceutical C Weiche, Angelikaöl enthaltende Gelkapsel und deren Herstellung
US6447814B1 (en) * 2001-08-28 2002-09-10 Yung Shin Pharma Ind. Co. Ltd. Chinese herbal composition for improving blood circulation and the method of preparing the same
JP4324335B2 (ja) * 2001-09-07 2009-09-02 花王株式会社 カテキン含有飲料
JP2003095942A (ja) * 2001-09-21 2003-04-03 Ito En Ltd 脂肪細胞におけるグルコース取込阻害剤及びｇｌｕｔ４トランスロケーション抑制剤、筋肉細胞におけるグルコース取込活性化剤並びに脂肪軽減飲食物
JP3403400B1 (ja) * 2001-09-28 2003-05-06 花王株式会社 容器詰飲料
US6855346B2 (en) * 2001-10-05 2005-02-15 Tzu-Sheng Wu Pharmaceutical composition having prophylactic effects on lamivudine-related disease relapse and drug resistance and methods of using the same
JP3643081B2 (ja) * 2002-02-13 2005-04-27 株式会社京都栄養化学研究所 健康食品の製造方法
US20030165580A1 (en) * 2002-03-04 2003-09-04 Xinxian Zhao Safe pharmaceutical composition for treatment and prevention of gynecological disease
US20050256178A1 (en) * 2002-08-23 2005-11-17 Eggersdorfer Manfred L Novel nutraceutical compositions comprising boitin
KR100504408B1 (ko) 2002-10-29 2005-07-27 주식회사 코리아나화장품 생큐노라이드 ａ를 포함하는 피부 미백용 화장료 조성물

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02243622A (ja) 1989-03-16 1990-09-27 Nippon Oil & Fats Co Ltd 血中コレステロール低下用油脂組成物
JPH05292886A (ja) 1992-04-21 1993-11-09 Fuji Oil Co Ltd 被マイグレーション防止能を有する油脂及びそれを含有 した食品並びに油脂含有食品のマイグレーション防止法
WO2002039822A2 (en) * 2000-11-17 2002-05-23 Kao Corporation Packaged beverages
WO2002072086A2 (en) * 2001-03-12 2002-09-19 Consorzio Per Gli Studi Universitari Use of epigallocatechin-3-gallate or its derivatives in the prevention and treatment of neurodegenerative diseases
WO2004041257A2 (en) * 2002-11-07 2004-05-21 Dsm Ip Assets B.V. Novel nutraceutical compositions comprising epigallocatechin gallate

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Effect of simultaneous docosahexaenoic acid and catachinintakes on the plasma and liver lipids in low-and high-fat dietfed mice. Nobuya Shirai,等.Nutrition Research,Vol.23 No.7. 2003 *

Also Published As

Publication number Publication date
US7691420B2 (en) 2010-04-06
US20070042057A1 (en) 2007-02-22
EP1662906A1 (en) 2006-06-07
WO2005027661A1 (en) 2005-03-31
JP2007505854A (ja) 2007-03-15
CN1856303A (zh) 2006-11-01
KR20060121887A (ko) 2006-11-29

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Granted publication date: 20090729