CN1004002B - 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 - Google Patents

制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 Download PDF

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Publication number
CN1004002B
CN1004002B CN85101921.8A CN85101921A CN1004002B CN 1004002 B CN1004002 B CN 1004002B CN 85101921 A CN85101921 A CN 85101921A CN 1004002 B CN1004002 B CN 1004002B
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CN
China
Prior art keywords
lincomycin
chloride
compound
chloromethylene
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
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CN85101921.8A
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English (en)
Chinese (zh)
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CN85101921A (zh
Inventor
道格拉斯·阿伦·利文斯顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
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Upjohn Co
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Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Priority to CN85101921.8A priority Critical patent/CN1004002B/zh
Publication of CN85101921A publication Critical patent/CN85101921A/zh
Publication of CN1004002B publication Critical patent/CN1004002B/zh
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C07H15/16—Lincomycin; Derivatives thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN85101921.8A 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法 Expired CN1004002B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN85101921.8A CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67615784A 1984-11-29 1984-11-29
CN85101921.8A CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法

Publications (2)

Publication Number Publication Date
CN85101921A CN85101921A (zh) 1987-01-10
CN1004002B true CN1004002B (zh) 1989-04-26

Family

ID=24713464

Family Applications (2)

Application Number Title Priority Date Filing Date
CN85101921.8A Expired CN1004002B (zh) 1984-11-29 1985-04-01 制备7-卤-7-去氧林可霉素及其类似化合物的改进方法
CN85108244A Expired CN1016694B (zh) 1984-11-29 1985-11-14 7-卤-7-脱氧林肯霉素的合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN85108244A Expired CN1016694B (zh) 1984-11-29 1985-11-14 7-卤-7-脱氧林肯霉素的合成

Country Status (19)

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US (1) US4710565A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0183505B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0649714B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR930003492B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (2) CN1004002B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE50265T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU574232B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1238319A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3575930D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK165010C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8605817A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI78708C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR852861B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU199497B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL76778A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX162251A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT81496B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (1) SU1405705A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA858117B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins
JP2531877Y2 (ja) * 1988-12-15 1997-04-09 日東工器株式会社 電磁式ダイアフラムポンプ
JP2531876Y2 (ja) * 1988-12-15 1997-04-09 日東工器株式会社 電磁式ダイアフラムポンプ用マグネットホルダ
JP2544782Y2 (ja) * 1988-12-27 1997-08-20 日東工器株式会社 電磁式ダイアフラムポンプ用マグネットホルダ
US6544555B2 (en) 2000-02-24 2003-04-08 Advancis Pharmaceutical Corp. Antibiotic product, use and formulation thereof
US6565882B2 (en) 2000-02-24 2003-05-20 Advancis Pharmaceutical Corp Antibiotic composition with inhibitor
US20020068078A1 (en) 2000-10-13 2002-06-06 Rudnic Edward M. Antifungal product, use and formulation thereof
US6541014B2 (en) 2000-10-13 2003-04-01 Advancis Pharmaceutical Corp. Antiviral product, use and formulation thereof
DE60204897T2 (de) * 2001-08-28 2006-05-11 Pharmacia Corp. Kristalline freie base von clindamycin
MXPA05001689A (es) * 2002-08-15 2005-05-27 Vicuron Pharm Inc Derivados de lincomicina que poseen actividad antibacteriana.
US7199105B2 (en) * 2002-08-15 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
JP4828404B2 (ja) 2003-01-24 2011-11-30 ステフェル リサーチ オーストラリア プロプライエタリー リミティッド リン酸クリンダマイシン発泡体
US7256177B2 (en) 2003-06-17 2007-08-14 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antibacterial activity
US7199106B2 (en) 2003-06-17 2007-04-03 Vicuron Pharmaceuticals, Inc. Lincomycin derivatives possessing antimicrobial activity
AU2004258949B2 (en) 2003-07-21 2011-02-10 Shionogi, Inc. Antibiotic product, use and formulation thereof
EP1648407A4 (en) 2003-07-21 2011-08-31 Middlebrook Pharmaceuticals Inc ANTIBIOTIC PRODUCT, CORRESPONDING USE AND FORMULATION
CA2533358C (en) 2003-07-21 2014-03-11 Advancis Pharmaceutical Corporation Antibiotic product, use and formulation thereof
WO2005016311A1 (en) 2003-08-11 2005-02-24 Advancis Pharmaceutical Corporation Robust pellet
WO2005016278A2 (en) 2003-08-12 2005-02-24 Advancis Pharmaceuticals Corporation Antibiotic product, use and formulation thereof
JP5686494B2 (ja) 2003-08-29 2015-03-18 シオノギ インコーポレイテッド 抗生物質製剤、その使用法及び作成方法
US8460710B2 (en) 2003-09-15 2013-06-11 Shionogi, Inc. Antibiotic product, use and formulation thereof
US7361743B2 (en) * 2004-02-11 2008-04-22 Pfizer Inc Lincomycin derivatives possessing antibacterial activity
WO2006014427A1 (en) 2004-07-02 2006-02-09 Advancis Pharmaceutical Corporation Tablet for pulsed delivery
US8778924B2 (en) 2006-12-04 2014-07-15 Shionogi Inc. Modified release amoxicillin products
US8357394B2 (en) 2005-12-08 2013-01-22 Shionogi Inc. Compositions and methods for improved efficacy of penicillin-type antibiotics
US20100228020A1 (en) * 2006-02-28 2010-09-09 V.B Medicare Pvt. Ltd Novel Chlorination Reagent and a Novel Process for Chlorination of Sugars Using Thionyl Chloride
ES2582654T3 (es) 2006-03-31 2016-09-14 Stiefel Research Australia Pty Ltd Gel en suspensión espumable
US8299052B2 (en) 2006-05-05 2012-10-30 Shionogi Inc. Pharmaceutical compositions and methods for improved bacterial eradication
CN101205245B (zh) * 2007-12-06 2011-04-06 河南天方药业股份有限公司 盐酸克林霉素的制备方法
CN102675146A (zh) * 2012-05-22 2012-09-19 山东凯盛新材料股份有限公司 新型固体氯化剂（氯亚甲基）二甲基氯化铵的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496163A (en) * 1965-02-08 1970-02-17 Upjohn Co 7-halo-7-deoxylincomycins and process for preparing the same
US3435025A (en) * 1966-03-18 1969-03-25 Upjohn Co 7-deoxylincomycin and analogs and isomers thereof and process for making the same
US3580904A (en) * 1969-04-03 1971-05-25 Upjohn Co 7-halo-7-deoxy-lincomycin derivatives
US3574186A (en) * 1969-10-08 1971-04-06 Upjohn Co Process for making 7-chloro-7-deoxylincomycin and related compounds and novel intermediates produced therein
US4568741A (en) * 1984-05-15 1986-02-04 The Upjohn Company Synthesis of 7-halo-7-deoxylincomycins

Also Published As

Publication number Publication date
JPS61137892A (ja) 1986-06-25
JPH0649714B2 (ja) 1994-06-29
CN85108244A (zh) 1986-08-20
KR930003492B1 (ko) 1993-05-01
EP0183505A2 (en) 1986-06-04
DK165010B (da) 1992-09-28
PT81496A (en) 1985-12-01
KR860004077A (ko) 1986-06-16
AU4883785A (en) 1986-06-05
DE3575930D1 (de) 1990-03-15
HUT40806A (en) 1987-02-27
PT81496B (pt) 1987-11-11
HU199497B (en) 1990-02-28
DK542785A (da) 1986-05-30
AU574232B2 (en) 1988-06-30
DK165010C (da) 1993-02-22
DK542785D0 (da) 1985-11-22
FI78708C (fi) 1989-09-11
CN85101921A (zh) 1987-01-10
ATE50265T1 (de) 1990-02-15
ES8605817A1 (es) 1986-04-01
IL76778A0 (en) 1986-02-28
FI854711L (fi) 1986-05-30
CN1016694B (zh) 1992-05-20
US4710565A (en) 1987-12-01
MX162251A (es) 1991-04-17
GR852861B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1986-03-28
FI854711A0 (fi) 1985-11-28
SU1405705A3 (ru) 1988-06-23
IL76778A (en) 1991-09-16
ZA858117B (en) 1986-06-25
FI78708B (fi) 1989-05-31
CA1238319A (en) 1988-06-21
EP0183505A3 (en) 1987-06-24
ES548152A0 (es) 1986-04-01
EP0183505B1 (en) 1990-02-07

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Free format text: CORRECT: PATENTEE; FROM: UPJOHN COMPANY TO: FARMACIA AND THE UPJOHN CO.

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