CN100349867C - 制备r,r(或s,s)构型的格隆铵－立体异构体的方法 - Google Patents

制备r,r(或s,s)构型的格隆铵－立体异构体的方法 Download PDF

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Publication number
CN100349867C
CN100349867C CNB2003801098187A CN200380109818A CN100349867C CN 100349867 C CN100349867 C CN 100349867C CN B2003801098187 A CNB2003801098187 A CN B2003801098187A CN 200380109818 A CN200380109818 A CN 200380109818A CN 100349867 C CN100349867 C CN 100349867C
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China
Prior art keywords
formula
solvent
isomers
diastereomer
diastereomer mixture
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Expired - Fee Related
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CNB2003801098187A
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English (en)
Chinese (zh)
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CN1751022A (zh
Inventor
C·R·诺埃
M·R·瓦尔特
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Meda Pharma GmbH and Co KG
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PHARMACON FORSCHUNG und BERATU
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/06—Anti-spasmodics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
CNB2003801098187A 2002-12-18 2003-12-18 制备r,r(或s,s)构型的格隆铵－立体异构体的方法 Expired - Fee Related CN100349867C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1896/2002 2002-12-18
AT0189602A AT412088B (de) 2002-12-18 2002-12-18 Verfahren zur herstellung der r,r oder s,s konfigurierten glycopyrronium-isomere

Publications (2)

Publication Number Publication Date
CN1751022A CN1751022A (zh) 2006-03-22
CN100349867C true CN100349867C (zh) 2007-11-21

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ID=31192804

Family Applications (1)

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CNB2003801098187A Expired - Fee Related CN100349867C (zh) 2002-12-18 2003-12-18 制备r,r(或s,s)构型的格隆铵－立体异构体的方法

Country Status (15)

Country Link
US (1) US7569598B2 (enExample)
EP (1) EP1572641B1 (enExample)
JP (1) JP2007524565A (enExample)
CN (1) CN100349867C (enExample)
AT (2) AT412088B (enExample)
AU (1) AU2003290075B2 (enExample)
CA (1) CA2510280C (enExample)
DK (1) DK1572641T3 (enExample)
ES (1) ES2383799T3 (enExample)
NO (1) NO330851B1 (enExample)
NZ (1) NZ541098A (enExample)
PL (1) PL214802B1 (enExample)
PT (1) PT1572641E (enExample)
RU (1) RU2337096C2 (enExample)
WO (1) WO2004054971A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0504463D0 (en) 2005-03-03 2005-04-13 Arakis Ltd Method of crystallisation and purification
JP5902612B2 (ja) * 2009-04-09 2016-04-13 ノバルティス アーゲー ピロリジニウム塩の調製方法
WO2011157387A1 (en) * 2010-06-14 2011-12-22 Chiesi Farmaceutici S.P.A. Crystal form of glycopyrronium chloride
CN103159659A (zh) * 2011-12-19 2013-06-19 沈阳药科大学 一种毒蕈碱受体拮抗剂格隆溴铵的制备方法
DK2607351T3 (en) * 2011-12-22 2017-06-06 Cerbios-Pharma S A CONTINUOUS PROCEDURE FOR ALKYLICATION OF CYCLIC TERTIARY AMINES
CN102627595A (zh) * 2012-03-09 2012-08-08 徐奎 一种制备格隆溴铵的方法
US8558008B2 (en) 2013-02-28 2013-10-15 Dermira, Inc. Crystalline glycopyrrolate tosylate
KR20150119468A (ko) 2013-02-28 2015-10-23 더미라, 인코포레이티드 글리코피롤레이트 염
US9006462B2 (en) 2013-02-28 2015-04-14 Dermira, Inc. Glycopyrrolate salts
CN104586841A (zh) * 2013-10-30 2015-05-06 中国药科大学 (3r,2’r)-格隆溴铵作为m3毒蕈碱性受体拮抗剂在制药中的用途
CN107304178B (zh) * 2016-04-21 2020-03-27 辽宁药联制药有限公司 一种毒蕈碱受体拮抗剂格隆溴铵手性对映体的制备方法
CN107345945B (zh) * 2016-05-05 2019-12-17 辽宁药联制药有限公司 一种拆分格隆溴铵对映体及杂质检查的高效液相色谱方法
CN113234003B (zh) * 2021-04-23 2024-02-02 广东嘉博制药有限公司 一种格隆溴铵及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237159A (zh) * 1996-11-11 1999-12-01 克里斯琴R·诺埃 对映导构纯的碱性芳基－环烷基－羟基羧酸酯,其制备方法及其在药品中的应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237159A (zh) * 1996-11-11 1999-12-01 克里斯琴R·诺埃 对映导构纯的碱性芳基－环烷基－羟基羧酸酯,其制备方法及其在药品中的应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Use of cyclodextrins as chiral selector for the chiral separationof anticholonergic drugs such as anisodamine andglycopyrronium in capillary zone electrophoresis. wang zhi et.al.J. high resolut. Chromatogr,Vol.19 No.12. 1996 *

Also Published As

Publication number Publication date
NZ541098A (en) 2008-08-29
RU2337096C2 (ru) 2008-10-27
ATA18962002A (de) 2004-02-15
PL214802B1 (pl) 2013-09-30
PT1572641E (pt) 2012-06-15
US20060167275A1 (en) 2006-07-27
ES2383799T3 (es) 2012-06-26
AT412088B (de) 2004-09-27
EP1572641B1 (de) 2012-03-07
JP2007524565A (ja) 2007-08-30
WO2004054971A1 (de) 2004-07-01
NO330851B1 (no) 2011-08-01
CA2510280C (en) 2011-09-27
CN1751022A (zh) 2006-03-22
AU2003290075B2 (en) 2009-01-29
EP1572641A1 (de) 2005-09-14
PL377441A1 (pl) 2006-02-06
AU2003290075A1 (en) 2004-07-09
CA2510280A1 (en) 2004-07-01
US7569598B2 (en) 2009-08-04
NO20053473L (no) 2005-09-19
ATE548348T1 (de) 2012-03-15
DK1572641T3 (da) 2012-07-02
RU2005122497A (ru) 2006-01-20
NO20053473D0 (no) 2005-07-15

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C06 Publication
PB01 Publication
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Owner name: MEHTA MEDICINE LIMITED PARTNERSHIP

Free format text: FORMER OWNER: PHARMACON FORSCHUNG UND BERATU

Effective date: 20080731

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Effective date of registration: 20080731

Address after: German Homburg

Patentee after: MEDA Pharma GmbH & Co.KG

Address before: Austria scharding

Patentee before: PHARMACON-FORSCHUNG UND BERATUNG GmbH

CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20071121

Termination date: 20211218